Conference Program
 
Myelin
May 4-9, 2008
Il Ciocco Hotel and Resort
Lucca (Barga), Italy
Chair:
Peter J. Brophy

Vice Chair:
Wendy B. Macklin

Our understanding of the biology of myelinating cells in the nervous system continues to expand rapidly. Since the last meeting in Ventura, CA, USA in 2006 there has been a significant move towards utilizing the insights gained from the basic biology of myelinating cells in the development and understanding of the potential for myelin repair in the adult CNS and PNS. The realization that the adult nervous system contains populations of stem cells and neural precursors capable of generating new myelin has propelled studies on the genesis and differentiation of myelinating cells to the forefront of biomedical research. The program for the 9th Gordon Conference on Myelin "Development and Diseases of Myelin" is designed to capitalize on these advances and further accelerate research in this area. We will make a concerted effort to invite investigators at the junior faculty level to be speakers at this meeting. The more senior investigators have been encouraged to act as session chairs and provide overviews of the field. This will allow young investigators a unique opportunity to present their work, and become known to their scientific peers. Few other venues offer such an opportunity. Appropriate attention will be paid to ensure gender balance in the roster of speakers. We are also committed to fostering trainees in the field of myelin biology and to specifically encourage their participation we will offer stipends for travel and registration as funds permit. All attendees will be expected to contribute to an oral presentation or present a poster. We believe that poster sessions are a key element in fostering productive interactions between scientists with different expertise. In keeping with the goals of the Gordon Conference such interactions will provide impetus and direction to the field of myelin biology.


Contributors

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 8:00 pmIntroductory Comments by GRC Site Staff / Welcome: Peter Brophy (University of Edinburgh, UK)
8:00 pm - 9:30 pmKeynote Lecture
8:00 pm - 8:15 pmIntroduction: Wendy Macklin (Lerner Research Institute, Cleveland Clinic Foundation, USA)
8:15 pm - 9:15 pmDavid Colman (Montreal Neurological Institute, Canada), Bruce Trapp (Cleveland Clinic Foundation, USA) and Boris Zalc (INSERM, Salpetriere Hospital, France)
"Myelination and Demyelination: Progress, and Major Unsolved Questions"
9:15 pm - 9:30 pmDiscussion
9:30 pmReception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmJunctional complexes, axo-glial interactions and assembly of the node of Ranvier
Discussion Leaders: Steven Scherer (University of Pennsylvania, Philadelphia USA) and Ori Peles (Weizmann Institute, Rehovot, Israel)
9:00 am - 9:10 am Introductory Remarks: Steven Scherer
9:10 am - 9:30 am Lori Isom (University of Michigan, Ann Arbor, USA)
"Sodium channel beta subunits: roles in channel modulation and axo-glial communication"
9:30 am - 9:50 am Matt Rasband (Baylor College of Medicine, Houston, USA)
"Mechanisms of CNS node of Ranvier formation"
9:50 am - 10:10 am Will Talbot (Stanford University, USA)
"Genetic analysis of myelination in zebrafish"
10:10 am - 10:30 am Discussion
10:30 am - 11:15 am Group Photo / Coffee Break
11:15 am - 11:30 am Commentary and Discussion: Ori Peles
11:30 am - 11:50 am Tim Kennedy (Montreal Neurological Institute, Canada)
"Moving Beyond Axon Guidance: Netrin Function During Oligodendrocyte Maturation and Myelination"
11:50 am - 12:10 pm Charles Abrams (State University of New York - Downstate Medicine Center, New York, USA)
"Connexins in Myelinating Glia"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmPeripheral neuropathies: lessons for Schwann cell biology
Discussion Leaders: Kristjan Jessen (University College, London) and Dies Meijer (Erasmus University, Rotterdam, The Netherlands)
5:30 pm - 5:40 pm Introductory remarks: Kristjan Jessen
5:40 pm - 6:00 pm Ueli Suter (ETH Zurich, Switzerland)
"Concepts learned from disease mechanisms in inherited peripheral neuropathies"
6:00 pm - 6:20 pm Hugh Willison (Glasgow University, UK)
"Glycolipid targets for inflammatory injury to Schwann cells in human autoimmune neuropathies"
6:20 pm - 6:30 pm Commentary and Discussion: Dies Meijer
6:30 pm - 6:50 pm Laura Feltri (San Raffaele Scientific Institute, Milan, Italy)
"New roles for dystroglycan in myelination"
6:50 pm - 7:10 pm Joao Relvas (Swiss Federal Institute of Technology, Zurich, Switzerland)
"Regulation of PNS myelination by integrin-linked-kinase (ILK) and associated molecules"
7:10 pm - 7:30 pm Discussion
8:00 pmDinner
9:30 pmPoster Session
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling and transcriptional regulation in developing myelinating glia
Discussion Leaders: Nancy Ratner (Cincinnati Children's Hospital Medical Center, USA) and Jim Salzer (New York University School of Medicine, USA)
9:00 am - 9:10 am Introductory remarks: Nancy Ratner
9:10 am - 9:30 am Haesun Kim (Rutgers University, Newark, USA)
"Receptor tyrosine kinase signaling that regulates myelination"
9:30 am - 9:50 am Mark Verheijen (Vrije Universiteit, Amsterdam, The Netherlands)
"Schwann cell SCAP and SREBP are required for proper myelination"
9:50 am - 10:00 am Akiko Nishiyama (University of Connecticut, Storrs, USA)
"The fate of NG2 cells"
10:00 am - 10:10 am Leda Dimou (Ludwig-Maximilians-Universität Munich, Germany)
"Lineage analysis and genetic manipulation of glia cells in health and disease"
10:10 am - 10:30 am Discussion
10:30 am - 10:50 am Coffee Break
10:50 am - 11:00 am Commentary and Discussion: Jim Salzer
11:00 am - 11:20 am Jeff Milbrandt (Washington University School of Medicine, St. Louis, USA)
"Transcriptional Regulation of Myelination"
11:20 am - 11:40 am Michael Wegner (University of Erlangen-Nuremberg, Erlangen, Germany)
"Unwrapping the role of Sox proteins in myelination"
11:40 am - 12:00 pmHuiliang Li (University College London, UK)
"Post-translational regulation of olig2 function in oligodendrocyte development"
12:00 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmWhite matter diseases: lessons for MS?
Discussion Leaders: David Rowitch (University of California, San Francisco, USA) and Charles ffrench-Constant (University of Edinburgh, UK)
5:30 pm - 5:40 pm Introductory remarks: David Rowitch
5:40 pm - 6:00 pm Kleopas Kleopa (The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus)
"CNS demyelination in CMT1X patients and in gap junction mutant mice"
6:00 pm - 6:20 pm Julia Edgar (University of Glasgow, UK)
"A role for the oligodendrocyte in supporting the axon: Implications for the demyelinated axon?"
6:20 pm - 6:30 pm Commentary and Discussion: Charles ffrench-Constant
6:30 pm - 6:50 pm Odile Boespflug-Tanguy (INSERM, Clermont-Ferrand, France)
"Genes involved in leukodystrophies: a glance at glial functions"
6:50 pm - 7:10 pm Severine Boillee
"Microglial involvement in motor neuron degeneration in models of ALS"
7:10 pm - 7:30 pm Discussion
8:00 pmDinner
9:30 pmPoster Session
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRepair and regeneration in vivo
Discussion Leaders: Marie Filbin (Hunter College of CUNY, New York, USA) and Anne Baron-Van Evercooren (INSERM, Salpetriere Hospital, Paris, France)
9:00 am - 9:10 am Introductory remarks: Marie Filbin
9:10 am - 9:30 am Martin Kerschensteiner (Ludwig-Maximilians-University, Munich, Germany)
"Imaging neuro-glial pathology in vivo"
9:30 am - 9:50 am Bruce Appel (Vanderbilt University, Nashville, USA)
"In vivo imaging and genetic analysis of axon wrapping by oligodendrocytes"
9:50 am - 10:10 am Mary Bunge (University of Miami, Miami, USA)
"Novel transplantation strategies to repair the injured spinal cord"
10:10 am - 10:30 am Discussion
10:30 am - 10:50 am Coffee Break
10:50 am - 11:00 am Commentary and Discussion: Anne Baron-Van Evercooren
11:00 am - 11:20 am Alain Chedotal (Université Paris 6, Paris, France)
"Myelin Semaphorins"
11:20 am - 11:40 am Hans-Werner Mueller (University of Duesseldorf, Germany)
"Inhibition of scarring and neuroprotective intervention to promote spinal cord repair"
11:40 am - 12:00 pm Frank Walsh (Wyeth Discovery Research, Collegeville, USA)
"Novel approaches for the treatment of MS - moving beyond immunomodulation"
12:00 pm - 12:30 pm Discussion, including 5 minutes from Leanne Rivers (University College London, UK)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmExtracellular signaling and myelination in CNS and PNS
Discussion Leaders: Robert Miller (Case Western Reserve University,Cleveland, USA) and Klaus-Armin Nave (Max-Planck- Institute of Experimental Medicine, Göttingen, Germany)
5:30 pm - 5:40 pm Introductory remarks: Robert Miller
5:40 pm - 6:00 pm Carla Taveggia (New York Medical Center, USA)
"Regulation of myelination by Neuregulin 1"
6:00 pm - 6:20 pm Hugo Cabedo (Instituto de Neurociencias de Alicante, Spain)
"Regulation of cholesterol biosynthesis in Schwann cells by NRG1"
6:20 pm - 6:30 pm Commentary and Discussion: Klaus-Armin Nave
6:30 pm - 6:50 pm Jonah Chan (University of Southern California, Los Angeles, USA)
"Strength in numbers: Working together to promote oligodendrocyte differentiation"
6:50 pm - 7:10 pm Holly Colognato (State University of New York, Stony Brook, USA)
"Thinking outside the cell: How extracellular matrix molecules influence oligodendrocyte development"
7:10 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pmDinner
9:30 pmPoster Session
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGlial cell death and axonal pathology
Discussion Leaders: Larry Wrabetz (San Raffaele Institute, Milan, Italy) and David Attwell (University College London)
9:00 am - 9:05 am Introductory remarks: Larry Wrabetz
9:05 am - 9:25 am Randal Kaufman (University of Michigan Medical Center, Ann Arbor, USA)
"The Unfolded Protein Response: To live or to die?"
9:25 am - 9:35 am Alex Gow (Wayne State University School of Medicine, Detroit, USA)
"The unfolded protein response in vivo"
9:35 am - 9:55 am Brian Popko (University of Chicago, USA)
"ER stress modulates the response of oligodendrocytes to inflammation"
9:55 am - 10:10 am Lucia Notterpek (University of Florida, Gainesville, USA)
"Intermittent fasting diet enhances protein homeostatic mechanisms and improves motor performance of hereditary neuropathic mice"
10:10 am - 10:30 am Discussion
10:30 am - 10:50 am Coffee Break
10:50 am - 11:00 am Commentary and Discussion: David Attwell
11:00 am - 11:20 am Scott Brady (University of Illinois, Chicago, USA)
"Myelinating glia and regulation of axonal transport"
11:20 am - 11:40 am Ragnhildur Karadottir (University of Cambridge, UK)
"Neurotransmitter signalling to oligodendrocytes and their precursors"
11:40 am - 12:00 pm Maria Kukley (University of Bonn, Germany)
"Vesicular release of glutamate along the axons: a new form of fast signalling from neurons to oligodendroglial cells in white matter"
12:00 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmAnimal models of demyelination: have we learned anything useful?
Discussion Leaders: Robin Franklin (Cambridge University, UK) and Richard Reynolds (Imperial College, London, UK)
5:30 pm - 5:40 pm Introductory remarks: Robin Franklin
5:40 pm - 6:00 pm Christine Stadelmann (Göttingen University, Germany)
"Myelin damage and repair in multiple sclerosis and experimental models: new insights"
6:00 pm - 6:20 pm Ian Duncan (University of Wisconsin, Madison, USA)
"CNS myelin mutants; what have they told us about myelination and human disease"
6:20 pm - 6:30 pm Commentary and Discussion: Richard Reynolds
6:30 pm - 6:50 pm Lesley Probert (Hellenic Pasteur Institute, Athens, Greece)
"Targeting of neuronal protection pathways in transgenic mice and its effect upon CNS myelination".
6:50 pm - 7:10 pm Scott Zamvil (University of California, San Francisco, USA)
"Regulatory APC that modulate T cell-mediated CNS autoimmunity"
7:10 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by NS061503 from the National Institute of Neurological Disorders and Stroke (NINDS) and the Office of Rare Diseases (ORD). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.