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Conference Program
 
Natural Products
July 20-25, 2008
Tilton School
Tilton, NH

The 57th Natural Products Gordon Research Conference will continue a tradition of excellence in a broad range of areas relating to natural products chemistry and isolation, novel synthetic methods, bioorganic and medicinal chemistry. While remaining true to its foundation of organic synthesis of natural products, the speakers in this years' outstanding lineup will deliver lectures in topics as diverse as catalytic synthetic methodology, the use of natural product like molecules as tools to probe and better understand biological systems, and recent advances in drug discovery. Topics of special interest will include the latest advances in catalytic methodology applicable to natural product synthesis, chemical communication and the development of novel approaches toward new therapeutic agents for cancer. Continuing a trend that has held for many years, the conference will have geographically diverse representation and will include speakers from both academic and industrial settings around the world. Consistent with previous meetings, this year's Natural Products GRC will also include a series of poster presentations that will afford an ideal opportunity to exchange of findings and ideas in an informal setting. It is anticipated that the exciting topics, diverse range of speakers and attendees and highly interactive tradition of this conference will make this year's conference both memorable and enjoyable.

As in recent years, the 2008 Natural Products GRC will be held at the Tilton School in Tilton, New Hampshire. The accommodations at Tilton are comfortable, the staff is friendly and the setting will provide abundant opportunity for recreation and relaxation in the afternoons.


SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 7:45 pmChair's Welcome by Scott Gilbertson (University of Texas Medical Branch)
7:45 pm - 9:30 pmCatalysis and Synthetic Methodology I
Discussion Leader: Dee Ann Casteel (Bucknell University)
7:45 pm - 8:20 pm M. Christina White (University of Illinois at Urbana-Champaign)
"Streamlining Synthesis via C-H Oxidation"
8:20 pm - 8:25 pm Discussion
8:25 pm - 9:15 pm David W.C. MacMillan (Princeton University)
"Enantioselective Organo-SOMO Catalysis"
9:15 pm - 9:30 pm Discussion
9:30 pm Chair's Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:25 amCatalysis and Synthetic Methodology II
Discussion Leader: Fred Luzzio (University of Louisville)
9:00 am - 9:35 am Ohyun Kwon (University of California, Los Angeles)
"Phosphine-Catalyzed Annulations"
9:35 am - 9:40 am Discussion
9:40 am - 10:20 am Matthew Gaunt (University of Cambridge)
"New Catalytic Strategies for the Chemical Synthesis of Natural Products"
10:20 am - 10:25 am Discussion
10:25 am - 10:50 am Coffee Break / Group Photo
10:50 am - 12:30 pmCatalysis and Synthetic Methodology III
Discussion Leader: Cynthia McClure (Montana State University)
10:50 am - 11:30 am Tamio Hayashi (Kyoto University)
"Recent Advances in the Rhodium-Catalyzed Asymmetric Carbon-Carbon Bond Formation"
11:30 am - 11:35 am Discussion
11:35 am - 12:00 pm Timothy Towne (Abbott Laboratories)
"Process development of (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:25 pm Tehshik P. Yoon (University of Wisconsin)
"New Reactions of Oxaziridines"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmNovel Synthetic Methods
Discussion Leader: Paul Blakemore (Oregon State University)
7:30 pm - 8:10 pm Jeffrey Bode (University of Pennsylvania)
"Catalytic, Enantioselective Annulation Reactions"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Marlys Hammond (GlaxoSmithKline)
"Design and Synthesis of Orally Active Selective Progesterone Receptor Ligands"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:25 pm Kevin Moeller (Washington University)
"You Want to Build it Where? New Umpolung Chemistry for the Construction of Addressable Molecular Libraries"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:10 amSynthesis of Biologically Active Molecules I
Discussion Leader: Sylvie Asselin (Amgen)
9:00 am - 9:30 am Chen Cheng (Merck Research Laboratories)
"Practical asymmetric syntheses of complex drug targets"
9:30 am - 9:35 am Discussion
9:35 am - 10:05 am Melvin Yu (Eisai)
"Natural Product Optimization Strategies"
10:05 am - 10:10 am Discussion
10:10 am - 10:30 am Coffee Break
10:30 am - 12:30 pmNatural Products Isolation and Biosynthesis
Discussion Leader: Amarnath Natarajan (UTMB)
10:30 am - 11:05 am Jeffrey L.C. Wright (University of North Carolina Wilmington)
"Poisons, peptides, and polyethers: building a diverse chemical library"
11:05 am - 11:10 am Discussion
11:10 am - 11:45 am Sarah O'Connor (Massachusetts Institute of Technology)
"Alkaloid Biosynthesis in Madagascar Periwinkle"
11:45 am - 11:50 am Discussion
11:50 am - 12:25 pm Kirk R. Gustafson (National Cancer Institute)
"New Natural Product Inhibitors of Cancerous Processes and Phenotypes"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmNatural Products Synthesis
Discussion Leader: David Uehling (GlaxoSmithKline)
7:30 pm - 8:05 pm Craig J. Forsyth (The Ohio State University)
"Total Synthesis of Complex Marine Natural Products"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:45 pm Erik J. Sorensen (Princeton University)
"Rapid formation of molecular complexity in natural product synthesis"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:25 pm Deukjoon Kim (Seoul National University)
"Substrate-Controlled Asymmetric Total Synthesis of Medium-Sized Oxacyclic Marine Natural Products"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:20 amSynthesis of Biologically Active Molecules II
Discussion Leader: Grace Arhancet (Pfizer)
9:00 am - 9:35 am Jeffrey Aube (University of Kansas)
"Natural Products from Azides"
9:35 pm - 9:40 am Discussion
9:40 am - 10:15 am Frederick G. West (University of Alberta)
"Recent Progress in the Chemical Synthesis of Cyclooctane-Containing Natural Products"
10:15 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 12:30 pmSynthesis of Biologically Active Molecules III
Discussion Leader: Nancy Totah (Syracuse University)
10:40 am - 11:00 am Scott A. Snyder (Columbia University)
"Achieving Synthetic Control When Nature Abandons Selectivity"
11:00 am - 11:05 am Discussion
11:05 am - 11:40 am John A. Porco (Boston University)
"New Synthetic Methods Inspired by Complex Natural Products"
11:40 am - 11:45 am Discussion
11:45 am - 12:20 pm Jef K. De Brabander (UT Southwestern Medical Center)
"Natural Product Synthesis - A Platform for Discovery"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:30 pm - 9:30 pmTransition Metal Catalysis
Discussion Leader: Cheng-Wei Tom Chang (Utah State University)
7:30 pm - 8:05 pm Vladimir Gevorgyan (University of Illinois at Chicago)
"New Transition Metal-Catalyzed Synthetic Methodologies"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:45 pm Robert Singer (Pfizer)
"Development of Nonproprietary Pd-Catalyzed Processes for Industry"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:25 pm F. Dean Toste (University of California, Berkeley)
"Development and Applications of Gold-Catalyzed Reaction for Organic Synthesis"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:25 amSynthesis of Active Molecules and Natural Products I
Discussion Leader: Rima S. Al-Awar (Ontario Institute for Cancer Research)
9:00 am - 9:20 am Michael Burkart (University of California, San Diego)
"Investigations on medium ring polyketides"
9:20 am - 9:25 am Discussion
9:25 am - 9:45 am Louis Barriault (University of Ottawa)
"Recent progress toward the total synthesis of a compact diterpene: vinigrol"
9:45 am - 9:50 am Discussion
9:50 am - 10:20 am Eric Bercot (Amgen)
"Discovery and Development of a Scaleable Route to an 11b-HSD1 Inhibitor"
10:20 am - 10:25 am Discussion
10:25 am - 10:40 am Coffee Break
10:40 am - 12:30 pmSynthesis of Active Molecules and Natural Products II
Discussion Leader: Michael Calter (Wesleyan University)
10:40 am - 11:15 am Gary A. Sulikowski (Vanderbilt University)
"Natural Products as Targets of Opportunity in Synthetic and Bioorganic Chemistry"
11:15 am - 11:20 am Discussion
11:20 am - 11:50 am Brian S.J. Blagg (University of Kansas)
"Redesigning Old Drugs for the Inhibition of New Targets, a Case Study with Novobiocin"
11:50 am - 11:55 am Discussion
11:55 am - 12:25 pm Katherine Seley-Radtke (University of Maryland Baltimore County)
"Exploring Structural Diversity in Nucleoside Drug Design"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
2:00 pm - 4:00 pmAnnual Academic vs. Industrial All-Stars Softball Game
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmPerspectives and Studies in Synthesis and Med Chem
Discussion Leader: Richard Taylor (Notre Dame University)
7:30 pm - 8:05 pm Christopher A. Lipinski (Melior Discovery)
"Natural products, hype and hope: straight talk from a medicinal chemistry veteran"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Thomas Engler (Eli Lilly and Company)
"Phenotypic Drug Discovery: New Tricks For an Old Dog"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:25 pm Andrew G. Myers (Harvard University)
"Addressing Problems in Human Health with Complex Synthesis"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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