Gordon Research Conferences
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Conference Program
 
NOX Family NADPH Oxidases
June 1-6, 2008
Colby-Sawyer College
New London, NH
Chair:
William M. Nauseef

Vice Chair:
Miklos Geiszt

Reactive oxygen species (ROS) figure prominently in a broad array of biological contexts, including antimicrobial activity, signal transduction, vascular tone, oxygen sensing, endothelial cell function, cell growth and differentiation, fibrosis and tissue remodeling, wound healing, carcinogenesis, thyroid hormone synthesis, vestibular function, plant innate immunity, microbial differentiation, and a host of post-translational changes in biomolecules. The NADPH oxidase (Nox) proteins, a recently identified family of homologues structurally related to gp91phox in phagocytes, provide the non-mitochondrial ROS that contribute to many physiologic functions as well as participate in significant plant and animal pathophysiology. This meeting will examine the structure, cellular and tissue distribution, biochemistry, regulation, and physiology of the members of the Nox protein family. Included in the meeting's purview are the contributions of Nox proteins to the biology of unicellular organisms, plants, and animals, with a strong emphasis on the latter. Sessions encompass ongoing work in specific organ systems (cardiovascular, neurologic, pulmonary, immunologic, and endocrine), plant as well as non mammalian animal biology, fundamental aspects of oxidant-dependent cell signaling and beyond! The program will also include: (1) late-breaking work that surfaces just prior to the meeting and (2) shorter presentations selected from the abstracts submitted by attendees as part of the application process. Effort will be made in this way to highlight and to promote the ongoing work of younger scientists in the field.


Contributors
National Institutes of Health (NIAID and NHLBI)
GenKyoTex / Eclosion
March of Dimes Birth Defects Foundation
Merck Research Laboratories
Schering-Plough/Schering Corporation
Servier France
Vasopharm GMBH
Pfizer, Inc.
Carl Storm Underrepresented Minority Fellowship
Carl Storm International Diversity Fellowship
D.A.I. Scientific

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmIntroductory Comments by GRC Site Staff / Welcome by Bill Nauseef (University of Iowa)
7:40 pm - 9:30 pmNOX FLAVOPROTEINS: BIOCHEMICAL INSIGHTS, BIOLOGICAL PRINCIPLES, & GAPS IN CURRENT UNDERSTANDING
7:40 pm - 7:50 pm Discussion Leader: Karl-Heinz Krause (Centre Medical Universitaire, Geneva, Switzerland)
7:50 pm - 8:20 pm Bettie Sue Masters (University of Texas Health Science Center at San Antonio)
"Roles of Heme- and Flavin-Requiring Proteins in Xeno/Endobiotic Metabolism and Cell Signaling"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Rikard Holmdahl (Lund University, Sweden)
"From disease to genes: revealing an oxidation path"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Miklós Geiszt (Semmelweis University, Budapest, Hungary)
"Nox/Duox family of NADPH oxidases: gaps in knowledge"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNOX2 IN PHAGOCYTES & THEIR RELATIVES
9:00 am - 9:10 am Discussion Leader: Françoise Morel (UJF-CHU, Grenoble, France)
9:10 am - 9:30 am Françoise Morel (UJF-CHU, Grenoble, France)
"Revisiting the phagocyte NADPH oxidase Nox2"
9:30 am - 9:45 am Discussion
9:45 am - 10:00 am Susan Smith (Emory University)
"(Homology) Models and (Evolutionary) Design: Project Nox"
10:00 am - 10:05 am Discussion
10:05 am Coffee Break / Group Photo
10:30 am - 11:00 am Edgar Pick (Tel Aviv University, Israel)
"Identification of the binding site(s) for p67phox on Nox2 - A methodological journey (Dr. Lambeth, I presume?)"
11:00 am - 11:15 am Discussion
11:15 am - 11:45 am Sebastian Amigorena (INSERM, Paris, France)
"Regulation of the phagosomal pH in dendritic cells"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Ellen Van Beek (Sanquin, Amsterdam, Netherlands)
"Negative regulation of the phagocyte NADPH oxidase by signal regulatory protein alpha"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Katharina Von Loehneysen (The Scripps Research Institute, USA)
"Mutagenesis of p22phox defines regions critical for Nox4 versus Nox2 function"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmNOX REGULATION
7:30 pm - 7:40 pm Discussion Leader: Robert A. Clark (University of Texas Health Science Center at San Antonio)
7:40 pm - 8:05 pm Mark Quinn (Montana State University)
"Transcriptional Regulation of the Phagocyte NADPH Oxidase"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Becky Diebold (Emory University)
"14-3-3 Proteins Regulate Nox Activation"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Mary Dinauer (Indiana University)
"Regulation of the phagocyte NADPH oxidase"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOXIDANT-MEDIATED SIGNALING & ITS CONSEQUENCES
9:00 am - 9:10 am Discussion Leader: Ulla G. Knaus (Scripps Research Institute, La Jolla)
9:10 am - 9:35 am Ben Boivin (Cold Spring Harbor)
"Redox regulation of protein tyrosine phosphatase function"
9:35 am - 9:50 am Discussion
9:50 am - 10:00 am Stanislas C. Morand (LHD, NIAID, NIH)
"Duox maturation factors are co-transported to the cell surface with Duox enzymes and affect the specifity of extracellular reactive oxygen generation"
10:00 am - 10:05 am Discussion
10:05 am Coffee Break
10:30 am - 10:55 am Philip Eaton (The Rayne Institute, London, UK)
"Thiol-based redox sensing and signaling in the cardiovascular system"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am Francis Miller (University of Iowa)
"Nox1 and the Signaling Endosome: Compartmentalization of ROS"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pm Karl-Heinz Krause (Centre Medical Universitaire, Geneva, Switzerland)
"NOX1, the mystery NOX: it's called the hidden paw"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmNOX IN NON MAMMALS
7:30 pm - 7:40 pm Discussion Leader: Dave Lambeth (Emory University)
7:40 pm - 8:05 pm Chris Chang (University of California, Berkeley)
"Chemical Tools for Probing Hydrogen Peroxide in Living Systems"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Jesus Aguirre (Instituto de Fisiología Celular-UNAM, Mexico City)
"NADPH Oxidases Regulate Cell Differentiation and Growth in Fungi"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Harald Schmidt (Monash University, Clayton, Australia)
"Comparison of chemically distinct NADPH oxidase inhibitors and their applicability for pharmacological proof-of-principle studies"
9:20 pm - 9:30 pm Discussion
9:30 pm Wine & Cheese Reception
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNOXES BEYOND PHAGOCYTES
9:00 am - 9:10 am Discussion Leader: Kathy Griendling (Emory University)
9:10 am - 9:35 am John Englehardt (University of Iowa)
"Endosomal Regulation of Nox2 in Health and Disease"
9:35 am - 9:50 am Discussion
9:50 am - 10:00 am Alicia N. Lyle (Emory University)
"NoxR1, a Novel Regulator of Nox4 Localization in Vascular Smooth Muscle Cells"
10:00 am - 10:05 am Discussion
10:05 am Coffee Break
10:30 am - 10:55 am Agnes Görlach (German Heart Center, Munich)
"NADPH oxidases in cellular stress signaling"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am Gregory E. Conner (University of Miami)
"Bacterial challenge and Duox2: regulation of epithelial host defense"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pm Botond Banfi (University of Iowa)
"Therapeutic potentials of altered NADPH oxidase activity"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:15 pm - 7:20 pmBusiness Meeting (Part 1)
(Nominations for the next Vice Chair)
7:20 pm - 9:30 pmNOXES IN PHYSIOLOGY I
7:20 pm - 7:30 pmDiscussion Leader: Ralf P. Brandes (J.W. Goethe-University, Frankfurt am Main, Germany)
7:30 pm - 7:55 pm Ajay Shah (King's College London, UK)
"Contrasting cardiovascular roles of Nox2 and Nox4 in gene-modified mice"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Masuko Ushio-Fukai (University of Illinois at Chicago)
"Role of NADPH oxidase in Neovascularization and Stem/Progenitor Cell Function"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pm Kathy Griendling (Emory University)
"Distinct roles of Nox1 and Nox4 in vascular biology"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Stephanie Carnesecchi Acker (Centre Medical Universitarie, Geneva, Switzerland)
"The NADPH oxidase NOX1 plays a crucial role in hyperoxia-induced lung injury"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting (Part 2)
(Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmNOXES IN PHYSIOLOGY II
9:00 am - 9:10 am Discussion Leader: Ajay Shah (King's College, London, UK)
9:10 am - 9:35 am Albert van der Vliet (University of Vermont)
"Dual oxidase in the airway epithelium: Not just for host defense"
9:35 am - 9:50 am Discussion
9:50 am - 10:00 am Xavier De Deken (Universite Libre de Bruxelles, Brussels, Belgium)
"Dual oxidase 1 activity is directly regulated via phosphorylations by the protein kinase A"
10:00 am - 10:05 am Discussion
10:05 am Coffee Break
10:30 am - 10:55 am Victor Thannickal (University of Michigan)
"Nox Enzymes in Lung Injury, Repair, and Fibrosis"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am Patty Lee (Yale University)
"Toll-like Receptor 4 and Nox 3 in the Lung: An Untold Story"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pm Isabel Fabregat (Fundació Institut d'Investigació Biomèdica de Bellvitge, Barcelona, Spain)
"Role of Nox4 in the apoptosis induced by TGF in hepatocytes: implications in hepatocarcinogenesis"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session IV
6:00 pmDinner
7:30 pm - 9:30 pmDUOX & NOX5: ACTIVITY AND FUNCTION
7:30 pm - 7:40 pm Discussion Leaders: Miklós Geiszt (Semmelweis University, Budapest, Hungary)
7:40 pm - 8:05 pm François Miot (Université Libre de Bruxelles, Brussels, Belgium)
"How are Duox activities regulated?"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Tom Leto (National Institute of Allergy & Infectious Diseases, NIH)
"Function of Duox isozymes as extracellular reactive oxygen species generators"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Tsukasa Kawahara (Emory University)
"Evolutionary history of Nox/Duox: functional characterization of conserved regions"
9:15 pm - 9:25 pm Discussion
9:25 pm - 9:30 pm Bill Nauseef (University of Iowa) & Miklós Geiszt (Semmelweis University, Budapest, Hungary)
"Closing Comments"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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