Nobel Laureates Earl Sutherland, Edwin Krebs, Edmond Fischer and Al Gilman started the Gordon Research Conference on “Phosphorylation and G-Protein Regulated Signaling Networks” in 1970. This conference has been held annually without disruption for the past 37 years. This strong track record establishes the meeting as a premier forum for the discussion of the latest discoveries in signal transduction.

There has been a recent explosion in our knowledge on how the flow of information through intracellular signaling networks regulate normal or aberrant cell growth, metabolic functions, motility, and cell fate decisions, such as survival, death, senescence and differentiation. Indeed, the emerging understanding of the basic mechanism controlling intracellular and cell-to-cell communication is providing an unprecedented opportunity to understand physiological processes at the molecular, cellular, and organismal levels, thereby identifying novel targets for pharmacological intervention of a myriad of diseases. In response to this explosion of information, the 2008 meeting will discuss Signaling Networks in Nutrient Sensing and Metabolism, in Inflammation and Stress, and in Cellular Architecture, with emphasis on their impact on Cancer, Diabetes, Innate Immunity, and Responses to Therapy. In addition, the speakers will discuss Emerging Technologies, including live-cell and intra-vital imaging of signaling events and state-of-the-art genomic and proteomic techniques, enabling Network Modeling and higher-order integration of signal transduction mechanisms.

Besides the scheduled talks, short talks on late breaking news will be included in every evening’s sessions. There will be at least three poster sessions that are essential elements of the conference and to which all attendees are encouraged to contribute. With an intellectually robust program and outstanding speakers, consisting of a mix of junior investigators and international experts, we expect the conferees to interact in an exciting and collegial atmosphere. We are confidant that the 2008 conference will draw active and vitally interested participants. The attendance of this popular conference is limited so early registration is strongly advised.