Gordon Research Conferences
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Conference Program
 
Photosensory Receptors & Signal Transduction
January 27 - February 1, 2008
Crowne Plaza
Ventura, CA

Photosensory receptors are at an intriguing crossroad of natural- and life sciences. First, using their light-absorbing chromophores, they can transform photon energy into protein structural changes, raising fundamental questions about the mechanism and progress of elementary chemical reactions (i.e. isomerization, electron transfer, etc.). Second, they are the ideal vehicles to study dynamic alterations in protein structure, as many can easily be switched between conformations that have different abilities to coordinate intra- and inter-protein signal transfer. Thirdly, they control a wide variety of biological processes, organized in complex non-linear networks that can only be resolved with the most advanced genomics technologies.

Light-induced signal transduction has key functions in organisms from all ‘Domains of Life’. Although photo-sensory receptors come in a wide variety of forms, most can be classified into six major families. Our understanding of the signaling properties of these proteins, however, varies widely, ranging from the ability to numerically simulate the entire process of light-induced generation of the signaling state and the transfer of this information to a downstream signaling partner (e.g. rhodopsins), to first glimpses of the basic mechanism of photoactivation (e.g. cryptochromes).

Research is confronting many of the same challenges in elucidating photosensory signal transduction mechanisms, and their application in life science research. These common challenges will be discussed at the fifth Gordon Research Conference on “"Photosensory Receptors and Signal Transduction"”, to be held in Ventura, California, USA, from January 27 to February 1, 2008. This meeting will be composed of a balanced mix of oral and poster presentations and formal and informal discussions. Established investigators, post-docs, as well as graduate students are encouraged to apply for the meeting and present their most recent and exciting unpublished work. We hope to be able to provide financial assistance to students and post-doctoral fellows.


Contributors
Genencor
The Swammerdam Institute for Life Sciences, University of Amsterdam
The Science Faculty, University of Amsterdam

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmStructure and mechanism of signal generation in BLUF domains
Discussion Leader: Carl Bauer (Indiana University)
7:40 pm - 8:00 pm Hua Yuan (Indiana University)
"Blue-light-mediated Signal Transduction of the BLUF Photoreceptor PixD (Slr1694)"
8:00 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Shinji Masuda (Tokyo Institute of Technology)
"Site-directed mutagenesis study of BLUF proteins"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Ilme Schlichting (Max Planck Institute for Medical Research, Heidelberg)
"Structural Basis of signaling by BLUF domains"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Gabriele Klug (University of Giessen)
"Light-dependent signal transmission by the AppA protein in R. sphaeroides"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFrom structure to signal transduction chain in the phytochromes
Discussion Leader: Eberhard Schaefer (Universität Freiburg)
9:00 am - 9:15 am Eberhard Schaefer (Universität Freiburg)
"Introduction to phytochrome signaling"
9:15 am - 9:35 am Christian Fankhauser (University of Lausanne)
"Phytochromes modulate the transcriptional network by directly regulating the stability of bHLH transcription factors"
9:35 am - 9:45 am Discussion
9:45 am - 10:05 am Andreas Hiltbrunner (Universität Freiburg)
"Early events of phytochrome controlled signaling in Arabidopsis"
10:05 am - 10:15 am Discussion
10:15 am - 11:00 am Coffee Break / Group Photo
11:00 am - 11:20 am Karen Halliday (The University of Edinburgh)
"Integration of light and temperature signalling through PIF3-like bHLH TFs"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Katrina Forest (University of Wisconsin-Madison)
"Why Knot? The 3D Structure of Phytochrome"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Lars-Oliver Essen (Phillips University)
"The tripartite chromophore binding site of phytochromes"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmFrom structure to function in visual rhodopsins
Discussion Leader: Kris Palczewski (Case Western Reserve University)
7:30 pm - 7:50 pm Kris Palczewski (Case Western Reserve University)
"Where the field is and new funding from the lab"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Robert Birge (University of Connecticut)
"Nature of the counterion switch in rhodopsin and cone pigment activation"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Kevin Ridge (University of Texas Medical School at Houston)
"NMR Analysis of Rhodopsin Activation and G protein Interactions"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Adriana Briscoe (University of California at Irvine)
"Butterfly color vision"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew techniques for the study of photosensory signal transduction
Discussion Leader: Pill-Soon Song (Cheju National University)
9:00 am - 9:05 am Pill-Soon Song (Cheju National University)
"Introduction to Session"
9:05 am - 9:25 am John Kennis (Vrije Universiteit Amsterdam)
"Ultra-fast spectroscopy of photosensory proteins"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Masahide Terazima (Kyoto University)
"Time-resolved studies on conformation changes and energies of photosensor proteins in solution"
9:55 am - 10:05 am Discussion
10:05 am - 10:25 am Joachim Heberle (Bielefeld University)
"FTIR spectroscopy as a tool to study photosensory signal transduction"
10:25 am - 10:35 am Discussion
10:35 am - 11:00 am Coffee Break
11:00 am - 11:20 am Keith Moffat (The University of Chicago)
"Structural and mechanistic similarities among photoreceptors"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Kevin Gardner (UT Southwestern Medical Center)
"Application of solution NMR methods to study blue-light photoreception"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Takahisa Yamato (Nagoya University)
"Computational studies of Photoreceptor function: From primary photochemistry to protein-structural changes"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmMicrobial Rhodopsins: Diversity, structure, and mechanism of signal generation and transfer
Discussion Leader: John Spudich (University of Texas Medical School at Houston)
7:30 pm - 7:50 pm John Spudich (University of Texas Medical School at Houston)
"Mechanisms of Signaling by Microbial Sensory Rhodopsins"
7:50 pm - 7:55 pm Discussion
7:55 pm - 8:15 pm Martin Engelhard (Max Planck Institute for Molecular Biology, Dortmund)
"From retinal isomerisation to activation of a HAMP domain"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:40 pmTsutomu Kouyama (Nagoya University)
"Crystallographic studies of squid rhodopsin and archaeal rhodopsins"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Hudel Luecke (University of California at Irvine)
"Sensory rhodopsins and their transducers"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Hideki Kandori (Nagoya Institute of Technology)
"The determinants of light-energy and light-signal conversion in rhodopsins"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe mechanism of signal transfer mediated by LOV domains
Discussion Leader: Roberto Bogomolni (UC Santa Cruz)
9:00 am - 9:10 am Roberto Bogomolni (UC Santa Cruz)
"Introduction to LOV"
9:10 am - 9:30 am Satoru Tokutomi (Osaka Prefecture University)
"Structural basis of the light regulation of phototropin kinase"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 am John M. Christie (University of Glasgow)
"Phototropin receptor function and application"
10:00 am - 10:10 am Discussion
10:10 am - 10:30 am Winslow Briggs (Carnegie Institution of Washington)
"The phototropin LOV domain: A chromophore module serving many masters"
10:30 am - 10:40 am Discussion
10:40 am - 11:10 am Coffee Break
11:10 am - 11:30 am Masamitsu Wada (National Institute for Basic Biology, Okazaki)
"Phototropin function in chloroplast movement"
11:30 am - 11:40 am Discussion
11:40 am - 12:00 pm Brian Crane (Cornell University)
"Photochemistry and conformational change in the LOV protein Vivid"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Hironao Kataoka (Tohoku University)
"AUREOCHROME: the newly discovered blue-light receptor of Stramenopiles"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmBlue-light photoreception
Discussion Leader: Michael Cusanovich (University of Arizona)
7:30 pm - 7:50 pm Mikio Kataoka (Nara Institute of Science and Technology)
"Structure of the photointermediate of PYP and the propagation mechanism of structural change"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Wouter Hoff (Oklahoma State University)
"Energy surfaces for folding and function of photoactive yellow protein"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Jasper van Thor (Imperial College London)
"Light-induced reactions in Phytochrome and Photoactive Yellow Protein"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm John Kyndt (University of Arizona)
"Ppr: a blue light-red light optical switch"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmTakato Imaizumi (UCSD)
"FKF1: Blue-light photoreceptor for seasonal flowering regulation in Arabidopsis"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe mechanism of signal generation in cryptochromes
Discussion Leader: Peter Hegemann (Humboldt Universität zu Berlin)
9:00 am - 9:10 amPeter Hegemann (Humboldt Universität zu Berlin)
"Introduction to the session"
9:10 am - 9:30 am Alfred Batschauer (Philipps-University, Marburg)
"Structure-function analysis of plant cryptochromes"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 am Eva Wolf (Max-Planck-Institute of Molecular Physiology, Dortmund)
"Photoreaction mechanism of the circadian photoreceptor Drosophila cryptochrome"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:00 am Thorsten Ritz (University of California at Irvine)
"Cryptochrome and light-dependent magnetoreception"
11:00 am - 11:10 am Discussion
11:10 am - 11:30 am Margaret Ahmad (Université Paris VI)
"Cryptochrome Photoreceptor Mechanism of Light Activation"
11:30 am - 11:40 am Discussion
11:40 am - 11:55 am Marcela Avila Perez (University of Amsterdam)
"Light-activation of the stress response in the chemotrophic bacterium Bacillus subtilis: Colorful & Complex"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:15 pmYi Wu (University of North Carolina)
"Genetically encoded caging - a photoactivatable Rac1"
12:15 pm - 12:30 pm Discussion & General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session IV
6:00 pmDinner
7:30 pm - 9:30 pmOn the application of light-sensing proteins
Discussion Leader: Georg Nagel (University of Würzburg)
7:30 pm - 7:50 pm Georg Nagel (University of Würzburg)
"Introduction to the Session, to Channelrhodopsins and to PACs"
7:50 pm - 8:10 pm Clark Lagarias (University of California at Davis)
"Phytochromes: Sensors of Bilins and Light"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Hongjun Liang (University of California at Santa Barbara)
"Assembly and applications of integrated lipid-proteorhodopsin patterned arrays"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:00 pm Alexander Gottschalk (Johann Wolfgang Goethe-University Frankfurt)
"Using Channelrhodopsin for the analysis of neural networks and synaptic transmission in the C. elegans nervous system"
9:00 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Martin Schwärzel (Saarland University)
"cAMP dependent memory processing in fruit flies: expanding experimental limits in the temporal and sub-cellular domain by use of transgenic photo-activated cyclase"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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