Gordon Research Conferences
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Conference Program
 
Pineal Cell Biology
Mechanisms of Circadian Rhythmicity and Melatonin Action
April 20-25, 2008
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chair:
Jorg H. Stehle

Vice Chair:
David R. Weaver

The major topic of the Gordon Research Conference on 'Pineal Cell Biology - Mechanisms of Circadian Rhythmicity & Melatonin Action' (April 20-25, 2008; Il Ciocco, Italy) will be the exploration of molecular and cellular function of the pineal gland and how the rhythmic synthesis and release of the hormone melatonin contributes to the internal dissemination of circadian time. This GRC meeting will cover topics over a wide range of disciplines, including molecular and cellular studies, pharmacology, animal behavior, and human/clinical studies, and will unite a unique interdisciplinary group of scientists. In the planning of this meeting, a concerted effort will be made to represent both investigators that are traditionally aligned with this field and new investigators that come from related fields (for example, retinal phototransduction, chronobiology, brain development, neuronal signaling) that will provide a fresh perspective on the topics covered. In particular, it is expected that this interaction will promote integration of basic research results on the mechanisms of circadian rhythm generation with appreciation of the clinical impact of rhythm disturbance, such as the effects of shift work on mental health. The possibility that manipulation of circadian rhythms may be of therapeutic benefit in several arenas will be explored. The importance of signaling mechanisms related to chronobiology has only recently become recognized. The future advances in the rapidly developing fields of chronopharmacology and chronomedicine, and the payback for a society that is constantly 'jet-lagged' by its working habits, will heavily rely on and prosper from achievements in basic research and on clinically-related studies within the very near future. Young scientists at the graduate and early post-doc level that work in areas broadly related to the research field of this GRC will be actively integrated, which will hopefully bring a fresh and enthusiastic approach to understanding regulatory mechanisms and molecular details of rhythmic melatonin synthesis in the pineal gland and dissemination of circadian time cues throughout the body.


Contributors

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:15 pm - 7:25 pmWelcome / Introductory Comments by GRC Site Staff and GRC Chair (Jörg H. Stehle)
7:25 pm - 8:30 pmREGULATION OF PINEAL MELATONIN SYNTHESIS - NEW TWISTS IN AN OLD STORY
Discussion Leader: Helena Illnerova (Academy of Sciences, Czech Republic)
7:25 pm - 7:35 pm Opening remarks
7:35 pm - 7:55 pm Steve Coon (National Institutes of Health, USA)
"Twist and Turns in AANAT Evolution"
7:55 pm - 8:15 pm Anthony Ho (University of Alberta, Canada)
"Histone modifications and Aa-nat gene expression"
8:15 pm - 8:30 pm Discussion
8:30 pm - 9:30 pmKEYNOTE TALK I
Discussion Leader: Debra Skene (University of Surrey, United Kingdom)
8:30 pm - 8:40 pm Opening remarks
8:40 pm - 9:20 pm Josephine Arendt (University of Surrey, United Kingdom)
"The Impact of Melatonin on Human Health"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 amTHE MELATONIN MESSAGE AND DISEASE
Discussion Leader: Joseph Takahashi (Northwestern University, USA)
9:00 am - 9:10 am Opening remarks
9:10 am - 9:30 am Thomas Bourgeron (Institut Pasteur, France)
"Abnormal synapses and melatonin synthesis in autism spectrum disorders"
9:30 am - 9:50 am Dick Swaab (The Netherlands Institute for Neuroscience, The Netherlands)
"Melatonin receptor localization in the human brain in health and disease"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo
10:30 am - 12:30 pmMELATONIN RECEPTORS - WHAT ARE THEY GOOD FOR?
Discussion Leader: David R. Weaver (University of Massachusetts Medical School, USA)
10:30 am - 10:40 am Opening remarks
10:40 am - 11:00 am Ralf Jockers (University Paris-Descartes, France)
"Regulation of the melatonin receptors by associated protein complexes"
11:00 am - 11:20 am Jean Boutin (Institut de Recherches Servier, France)
"Melatonin binding site MT3 is QR2: facts and consequences"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Shantha Rajaratnam (Monash University, Australia)
"Phase-shifting and sleep-promoting effects of melatonin and its analogues"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Jonathan Johnston (University of Surrey, United Kingdom)
"Developmental plasticity of melatonin receptor expression"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmMANAGEMENT OF TIME IN HUMAN CHRONOBIOLOGY
Discussion Leader: Alfred Lewy (Oregon Health Sciences University, USA)
5:30 pm - 5:40 pm Opening remarks
5:40 pm - 6:00 pm Debra Skene (University of Surrey, United Kingdom)
"Ageing and nonvisual light responses in humans"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:30 pm Steven Lockley (Harvard Medical School, USA)
"The role of photic and non-photic time cues on circadian organisation in humans"
6:30 pm - 6:40 pm Discussion
6:40 pm - 7:00 pm Till Roenneberg (Ludwig-Maximilians-University Munich, Germany)
"Physiology and genetics of human daily behaviour - an approach of system biology in human"
7:00 pm - 7:10 pm Discussion
7:10 pm - 7:30 pm General Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:00 pmRETINA AND MELATONIN - SEEING THE CLOCK?
Discussion Leader: Ignacio Provencio (University of Virginia, USA)
9:00 am - 9:10 am Opening remarks
9:10 am - 9:30 am Gianluca Tosini (Morehouse School of Medicine, USA)
"Role of melatonin and melatonin receptors in the regulation of retinal circadian rhythms"
9:30 am - 9:50 am Michael Iuvone (Emory University, USA)
"Dopamine and circadian organization of the mouse retina"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
Discussion Leader: Michael Iuvone (Emory University, USA)
10:30 am - 10:40 amOpening remarks
10:40 am - 11:00 am Ignacio Provencio (University of Virginia, USA)
"Melanopsin - more than just a circadian photopigment"
11:00 am - 11:10 am Discussion
11:10 am - 11:30 am Russel Foster (University of Oxford, United Kingdom)
"VA opsin - more than just a teleost photopigment"
11:30 am - 11:40 am Discussion
11:40 am - 11:50 am General Discussion
11:50 am - 12:30 pmHOT TOPICS I
Session Chair: Carla Green (University of Virginia, USA)
11:50 am - 12:00 pm Opening remarks
12:00 pm - 12:10 pm Chad Jackson (Emory University, Atlanta, USA)
"Essential roles of dopamine D4 receptors and the type 1 adenylyl cyclase in photic control of cyclic AMP in retinal photoreceptor cells"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Shahar Alon (Tel Aviv University, Israel)
"In-silico identification and in-vivo validation of a new DNA binding site governing pineal-specific expression"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
5:30 pm - 7:30 pmRHYTHMS IN THE PERIPHERY - THE ROLE OF MELATONIN
Discussion Leader: Michael Menaker (University of Virginia, USA)
5:30 pm - 5:40 pm Opening remarks
5:40 pm - 6:00 pm Andries Kalsbeek (The Netherlands Institute of Brain Research, The Netherlands)
"Interplay of central, pineal and peripheral clocks and metabolic rhythms"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:30 pm David Hazlerigg (University of Aberdeen, United Kingdom)
"Wrestling with melatonin-dependent transcriptional control"
6:30 pm - 6:40 pm Discussion
6:40 pm - 7:00 pm Sandrine Dupré (University of Manchester, United Kingdom)
"Controlling seasonal rhythms in mammals: Identification of new genes and pathways in the sheep pars tuberalis"
7:00 pm - 7:10 pm Discussion
7:10 pm - 7:30 pm General Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:00 pmPINEAL REGULATORS DURING EVOLUTION, THROUGH LIFE-SPAN, WITH SEASON, DAY-BY-DAY
Discussion Leader: Carla Green (University of Virginia, USA)
9:00 am - 9:10 am Opening remarks
9:10 am - 9:30 am Elise Cau (University of Toulouse, France)
"Specification of neuronal subtypes in the zebrafish pineal gland"
9:30 am - 9:50 am Yoav Gothilf (Tel Aviv University, Israel)
"The zebrafish clock sheds light on the mechanism of entrainment"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Martin Rath (University of Copenhagen, Denmark)
"Developmental and diurnal dynamics of Pax4 expression in the rat pineal gland and retina"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Joseph Takahashi (Northwestern University, USA)
"Clock genes, cell autonomy and circadian organization in mouse"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am General Discussion
11:50 am - 12:30 pmSHORT TALKS
Session Chair: Andrew Loudon (University of Manchester, United Kingdom)
11:50 am - 12:00 pm Opening remarks
12:00 pm - 12:10 pm Martine Migaud (INRA CNRS UMR 1291, Nouzilly, France)
"Melatonin and melatonin receptors: how do they cope together in the brain?"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Husam Abu-Soud (Wayne State University, Detroit, USA)
"Melatonin is a Potent Inhibitor of Myeloperoxidase"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session III
5:30 pm - 7:10 pmLINKING MELATONIN AND CLOCKS WITH DISEASE AND THE IMMUNE SYSTEM
Discussion Leader: George Brainard (Jefferson Medical College, USA)
5:30 pm - 5:40 pm Opening remarks
5:40 pm - 6:00 pm David Blask (Bassett Research Institute, USA)
"Role of Melatonin in Circadian Cancer Prevention"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:30 pm Marina Antoch (Cleveland Clinic Foundation, USA)
"Circadian proteins, ageing and tumorigenesis"
6:30 pm - 6:40 pm Discussion
6:40 pm - 7:00 pm Eus van Someren (Netherlands Institute for Neuroscience, The Netherlands)
"Chronic melatonin and light treatment in demented elderly"
7:00 pm - 7:10 pm Discussion
7:10 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:10 amTHE ROLE OF THE PINEAL IN CLOCKING SEASONAL ADAPTATION
Discussion Leader: David Kennaway (University of Adelaide, Australia)
9:00 am - 9:10 am Opening remarks
9:10 am - 9:30 am Annika Herwig (Rowett Institute, Aberdeen, United Kingdom)
"Cool clocks"
9:30 am - 9:50 am Gerald Lincoln (Queen's Medical Research Institute, Edinburgh, United Kingdom)
"Melatonin signals and circannual clocks"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Valerie Simonneaux (University of Strasbourg, France)
"Melatonin-mediated expression of hypothalamic genes involved in the regulation seasonal reproduction?"
10:50 am - 11:00 am Discussion
11:00 am - 12:30 pmHOT TOPICS II
Discussion Leader: Elizabeth Maywood (MRC-Cambridge, United Kingdom)
11:00 am - 11:10 am Opening remarks
11:10 am - 11:20 am Sandra Lesny (University Frankfurt, Germany)
"Melatonin affects daily patterns of hippocampal clock gene expression and spatial learning in the mouse"
11:20 am - 11:25 am Discussion
11:25 am - 11:35 am Tolga Uz (University of Illinois, Chicago, USA)
"Melatonin through melatonin receptors regulates cocaine/dopamine system-induced neuronal signaling and addictive behaviors in mice"
11:35 am - 11:40 am Discussion
11:40 am - 11:50 am Marco Koch (University of Frankfurt)
"The rat pineal gland comprises an endocannabinoid system"
11:50 am - 11:55 am Discussion
11:55 am - 12:05 pm James Olcese (Florida State University College of Medicine, Tallahassee, USA)
"Melatonin and the timing of human birth"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Steven Hill (Tulane University School of Medicine, New Orleans, USA)
"Melatonin suppression of breast tumor cell invasion is mediated via the MT1 Receptor"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session IV
5:30 pm - 6:30 pmHOT TOPICS III
Session Chair: Peter Morgan (Rowett Institute, United Kingdom)
5:30 pm - 5:40 pm Opening remarks
5:40 pm - 5:50 pm Gad Vatine (Tel Aviv University, Israel)
"Light-induced expression of zebrafish Period2"
5:50 pm - 5:55 pm Discussion
5:55 pm - 6:05 pm Kazuhiro Shimomura (Northwestern University, Evanston, USA)
"Does melatonin suppress the Clock mutation in mouse?"
6:05 pm - 6:10 pm Discussion
6:10 pm - 6:20 pm Katrin Ackermann (University of Frankfurt, Germany)
"New aspects in regulation of melatonin synthesis in the human pineal gland"
6:20 pm - 6:25 pm Discussion
6:25 pm - 6:30 pm Break
6:30 pm - 7:30 pmKEYNOTE TALK II
Discussion Leader: David R. Weaver (University of Massachusetts Medical School, USA)
6:30 pm - 6:40 pm Opening remarks
6:40 pm - 7:20 pm Steven M. Reppert (University of Massachusetts Medical School, USA)
"The Ancestral Circadian Clock of Monarch Butterflies: Role in Sun Compass Orientation"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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