Gordon Research Conferences
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Conference Program
 
Prolactin & Growth Hormone Family
February 10-15, 2008
Ventura Beach Marriott
Ventura, CA
Chair:
Hallgeir Rui

Vice Chair:
Vincent Goffin

The 2008 Prolactin and Growth Hormone Gordon Family Research Conference will provide a forum for the presentation and active discussion of the most cutting-edge information and ideas on Prolactin, Growth Hormone and related peptides. The Gordon Research Conference format will bring together investigators that are international leaders in the structural, biochemical, cell signaling, physiological, developmental and clinical-pathological aspects of these hormone ligands and their receptors. This conference will provide a thorough and in-depth coverage of prolactin and growth hormone biology, thus continuing the tradition of being the premier meeting in this field.

The peptide ligands and receptors for PRL and GH have been shown to mediate critical biological actions related to reproduction and growth, respectively. However, PRL also affects many nonreproductive targets, such as modulating behavior, promoting neurogenesis, inducing tumorigenesis, regulating angiogenesis and bone formation, and impacting the immune system. Similarly, GH biology extends beyond its classical IGF-1-stimulatory and growth-promoting effects. Indeed, the GH/IGF-1 system has been implicated in carcinogenesis, cellular maintenance and repair, metabolism, obesity, diabetes, longevity and aging pathways. While these recent advances have provided important insights into PRL and GH actions, nevertheless the precise mechanisms by which these two hormones mediate their effects remain unanswered.

We encourage basic, clinician, and industry scientists at all career stages interested in these areas to attend the PRL and Growth Hormone Family GRC.


Contributors
We gratefully acknowledge the generous contributions from the following organizations:

Endocrine Society
Genentech
Genzyme Corporation
HistoRx
Ipsen
National Institutes of Health
Novo Nordisk
Pfizer
Sandoz
SPI-BIO
Institut de Recherches Int'les Servier
Tercica

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmOpening Remarks - Hallgeir Rui (Conference Chair)
7:40 pm - 7:50 pmWelcome / Introductory Comments by GRC Site Staff
7:50 pm - 9:20 pm Transcriptional Control of PRL and GH genes
Discussion Leader: Hallgeir Rui (Thomas Jefferson University, USA)
7:50 pm - 8:30 pmArthur Gutierrez-Hartmann (University of Colorado, USA)
"Combinatorial Mechanisms Governing Prolactin Gene Transcription"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:20 pmNancy Cooke (University of Pennsylvania, USA)
"Long-range activation of the human growth hormone gene cluster"
9:20 pm - 9:30 pm Discussion
9:20 pm Welcome Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:55 am PRL & GH Pathway Mutations and Polymorphisms
Discussion Leader: Stephen Liebhaber (University of Pennsylvania, USA)
9:05 am - 9:30 amAnders Juul (University of Copenhagen, Denmark)
"d3-GH receptor polymorphism: associations to pre- and postnatal growth"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 amRon Rosenfeld (Lucile Packard Foundation for Children’s Health, USA)
"Stat5 mutations and growth"
10:05 am - 10:15 am Discussion
10:15 am - 10:40 amAsta Försti (German Cancer Research Center, Germany)
"PRL and GH polymorphisms and human breast cancer risk"
10:40 am - 10:50 am Discussion
10:50 am - 11:20 am Coffee Break / Group Photo (11:15 am)
11:20 am - 11:45 amPhilippe Touraine (INSERM, France)
"PRLR polymorphisms and breast diseases"
11:45 am - 11:55 am Discussion
11:55 am - 12:25 pm Platform 1 and 2 talks
11:55 am - 12:05 pm Samantha Oakes (Garvan Institute of Medical Research, Australia)
"The Ets transcription factor Elf5 specifies mammary alveolar cell fate"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Kazuhito Sakamoto (University of Nebraska, USA)
"The ablation of Jak2 reduces mammary epithelial cell proliferation and protects against Her2/neu-induced mammary tumorigenesis"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:20 pm PRL & GH Intracellular Signaling
Discussion Leader: Linda Schuler (University of Wisconsin, USA)
7:35 pm - 8:00 pmChristin Carter-Su (University of Michigan, USA)
"The role of JAK2 phosphorylation sites and binding proteins in the actions of GH"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmCharles Streuli (University of Manchester, UK)
"PRL Signaling and extracellular matrix"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:10 pmTed Elsasser (United States Department of Agriculture,USA)
"GH associated nitration of Jak2: impact on signalling"
9:10 pm - 9:20 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:55 am Clinical and Pathological aspects of PRL and GH
Discussion Leader: Charles Clevenger (Northwestern University, USA)
9:05 am - 9:30 amMichael Thorner (University of Virginia, USA)
"The matrix of ghrelin, insulin, growth hormone and cortisol in metabolic regulation in man"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 amA.J. van der Lely (Erasmus Medical Centre, Netherlands)
"Clinical use of GH receptor antagonists: recent insight"
10:05 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:10 amGeorge Bright (Tercica, USA)
"IGF-1 treatment in severe growth failure"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 amKen Ho (Garvan Institute of Medical Research, Australia)
"Modulation of GH action by sex steroids"
11:45 am - 11:55 am Discussion
11:55 am - 12:25 pm Platform 1 and 2 talks
11:55 am - 12:05 pm Shigeru Okada (Ohio University, USA)
"Proteomic analysis of serum from patients with acromegaly"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Estelle Tallet (INSERM, France)
"A New Surface Plasmon Resonance Set Up To Characterize The Interactions Within Prl-Prlr Complexes"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:20 pm Stem Cells in GH and PRL target organs
Discussion Leader: Kay-Uwe Wagner (University of Nebraska, USA)
7:35 pm - 8:00 pmGabriela Dontu (University of Michigan, USA)
"GH regulation of self-renewal of mammary stem cells"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmGil Smith (National Institute of Health, USA)
"Stem Cells and the Mammary Microenvironment"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:10 pmMichael Waters (University of Queensland, Australia)
"GH regulation of neural stem cell number"
9:10 pm - 9:20 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:55 am PRL/GH Target Organs
Discussion Leader: Geula Gibori (University of Illinois, USA)
9:05 am - 9:30 amNadine Binart (INSERM, France)
"PRL and ovary"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 amPeter Lobie (University of Auckland, New Zealand)
"GH and breast cancer promotion"
10:05 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:10 amMichael Freemark (Duke University, USA)
"Metabolic actions of PRL and GH"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 amSeung Kim (Stanford University School of Medicine, USA)
"Prolactin signaling controls pancreatic beta-cell menin levels and proliferation in pregnant mice"
11:45 am - 11:55 am Discussion
11:55 am - 12:30 pm Platform 1 and 2 talks
11:55 am - 12:05 pmIsabelle Broutin (Université Paris Descartes, France)
"X-ray structures of the 2:1 complex between PRL and its receptor"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pmJiamao Zheng (Northwestern University, USA)
"The peptidyl-prolyl isomerase cyclophilin A regulates activation of the prolactin receptor/Jak2 complex and the progression of human breast cancer"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:20 pm PRL and GH-related ligands
Discussion Leader: Carmen Clapp (Universidad Nacional Autonoma de Mexico, Mexico)
7:35 pm - 8:00 pmJoseph Martial (University of Liege, Belgium)
"PRL and GH-derived antiangiogenic peptides"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmPhilipp Fischer (Hannover Medical School, Germany)
"16K PRL in cardiac physiology and disease"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:10 pmRichard Ross (University of Sheffield, UK)
"A ligand-receptor fusion of growth hormone is a potent long-acting agonist"
9:10 pm - 9:20 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:55 am Pituitary and CNS
Discussion Leader: Julian Davis (University of Manchester, UK)
9:05 am - 9:30 amDave Grattan (University of Otago, New Zealand)
"Hormone-induced changes in PRL signal transduction in the rat hypothalamus during late pregnancy"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 amRobert Bridges (Tufts University, USA)
"Alterations in the Neuroendocrine Regulation and Neural Actions of Prolactin by Reproductive Experience"
10:05 am - 10:15 am Discussion
10:15 am - 10:45 am Coffee Break
10:45 am - 11:10 amGloria Mak (University of Calgary, Canada)
"The role of prolactin in male pheromone-induced neurogenesis"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 amShlomo Melmed (Cedars Sinai Medical Center, USA)
"Pituitary Tumorigenesis - New Insights"
11:45 am - 11:55 am Discussion
11:55 am - 12:25 pm Platform 1 and 2 talks
11:55 am - 12:05 pm Celina Garcia (Universidad Nacional Autonoma de Mexico, Mexico)
"Vasoinhibins prevent increased retinal vasopermeability associated with diabetic retinopathy via protein phosphatase 2A-dependent eNOS inactivation"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Maris Laan (University of Tartu, Estonia)
"Resequencing The Five Human Growth Hormone/Chorionic Somatomammotropin Genes At 17q22-24: Locus And Population-Specific Genetic Heterogeneity"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 8:35 pm Keynote Lecture
Discussion Leader: Vincent Goffin (INSERM, France)
7:35 pm - 8:20 pmMichael Lisanti (Thomas Jefferson University, USA)
"Caveolins, PRL and GH signaling"
8:20 pm - 8:35 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 5R13DK080508-01 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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