Gordon Research Conferences
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Conference Program
 
Protein Folding Dynamics
January 6-11, 2008
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chair:
Charles L. Brooks

Vice Chair:
Susan Marqusee

Protein folding, which comprises one of the outstanding problems in biology today, engages a highly multi- and interdisciplinary group of scientists working at the forefront of research in biological and biophysical methodologies and theory. Understanding the dynamical and energetic features of folding of single and multi-domain proteins in solution, the crowded cellular environment, at the ribosome during protein synthesis, and at membranes are keys to elucidating issues of protein function, design and the origin of diseases linked to protein misfolding. Emerging developments in fast spectroscopy, single molecule techniques, simulation approaches and molecular and cellular biology, together with established experiments utilizing NMR and other visible spectroscopy, are fueling investigations with increasingly more quantitative detail. Few other fields have seen such a successful blend of physical and biological sciences that are leading to advances in our fundamental quantitative understanding of the folding process. The Gordon Research Conference in Protein Folding Dynamics is holding its fourth biannual meeting and was established specifically to bring experiment and theory together to explore advances in the field. The current meeting is designed to provide a continuing forum to discuss existing and developing theoretical frameworks for folding as well as fundamental problems from polypeptide energetics and dynamics in a range of folding environments. The GRC in Protein Folding Dynamics will continue its strong tradition in supporting and encouraging the participation of younger scientists.


Contributors

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKEYNOTE LECTURES
7:40 pm - 7:50 pmChair: Peter Wolynes (University of California, San Diego)
7:50 pm - 8:25 pmS. Walter Englander (University of Pennsylvania School of Medicine)
"Folding and misfolding: mechanism and principles"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmDave Thirumalai (University of Maryland)
"New Frontiers, Where Shall We Head?"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmPROBING FOLDING AND MISFOLDING PATHWAYS
9:00 am - 9:10 amChair: Valerie Daggett (University of Washington)
9:10 am - 9:40 amRichard I. Morimoto (Northwestern University)
"Chaperone and Proteostasis Networks that Regulate Protein Misfolding in Neurodegenerative Disease and Aging"
9:40 am - 9:55 amDiscussion
9:55 am - 10:35 amCoffee Break
10:35 am - 10:50 amJana Khandogin (University of Oklahoma)
"Linking folding with aggregation in beta amyloid peptides"
10:50 am - 11:00 amDiscussion
11:00 am - 11:30 amBill Balch (The Scripps Research Institute)
"Protein Homeostasis and Trafficking Dynamics in the Secretory Pathway"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmJoan Shea (University of California, Santa Barbara)
"Peptide inhibitors of the self-assembly of the Alzheimer Abeta peptide into amyloid fibrils"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFAST FOLDING EVENTS
7:30 pm - 7:40 pmChair: William A. Eaton (Laboratory of Chemical Physics, Chief / NIDDK, NIH)
7:40 pm - 8:10 pmVictor Munoz (University of Maryland)
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:40 pmPeter Hamm (University of Zurich)
"Non-cooperative alpha helix folding"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmKen Dill (University of California, San Francisco)
"Folding physics & structure prediction using funnels and the zipping & assembly mechanism"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEXPLORING FOLDING LANDSCAPES AND MECHANISMS I
9:00 am - 9:10 amChair: Mikael Oliveberg (University of Stokholm)
9:10 am - 9:40 amJane Clark (University of Cambridge)
9:40 am - 9:55 amDiscussion
9:55 am - 10:10 amAlexander Schug (University of California, San Diego)
"Mutations as Trapdoors: The Rop-dimer with two Competing Native Conformations"
10:10 am - 10:20 amDiscussion
10:20 am - 10:35 amCoffee Break
10:35 am - 11:05 amBob Matthews (University of Massachusetts, Medical School)
"Hydrophobic Clusters and beta/alpha-hairpin Clamps: Sequence Effects on Folding, Stability and Structure in TIM Barrel Proteins"
11:05 am - 11:20 amDiscussion
11:20 am - 11:35 amLisa Lapidus (Michigan State University)
"Ruggedness in the energy landscape of Protein L"
11:35 am - 11:45 amDiscussion
11:45 am - 12:15 pmCecelia Clementi (Rice University)
"Prediction of protein functional states by multi-resolution protein modeling"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFOLDING LANDSCAPES AND MECHANISMS II
7:30 pm - 7:40 pmChair: Vijay Pande (Stanford University)
7:40 pm - 8:10 pmSheena Radford (University of Leeds)
"Exploring folding landscapes: combining ensemble and single molecule methods"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmMargaret Cheung (University of Houston)
"Simulating protein interactions in crowded and confined media"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmElizabeth Rhoades (Yale University)
"α-Synuclein interactions with model membranes"
9:05 pm - 9:15 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSINGLE MOLECULE FOLDING STUDIES
9:00 am - 9:10 amChair: Jose Onuchic (University of California, San Diego)
9:10 am - 9:40 amMatthias Reif (Physikdepartment der Technischen Universität München)
"Mechanical Control of Protein Conformation"
9:40 am - 9:55 amDiscussion
9:55 am - 10:10 amRobert Best (University of Cambridge)
"When is the pulling coordinate a good reaction coordinate for single molecule pulling experiments?"
10:10 am - 10:20 amDiscussion
10:20 am - 10:35 amCoffee Break
10:35 am - 11:05 amSophie Jackson (University of Cambridge)
"Evidence of an intermediate and parallel pathways in protein unfolding using single molecule fluorescence"
11:05 am - 11:20 amDiscussion
11:20 am - 11:35 amBen Schuler (Biochemisches Institut, Universität Zürich)
"Probing structure and dynamics of non-native proteins with single molecule spectroscopy"
11:35 am - 11:45 amDiscussion
11:45 am - 12:15 pmJulio Fernandez (Columbia University)
"Force-clamp spectroscopy dissection of the folding of ubiquitin"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmMEMBRANE MEDIATED FOLDING DYNAMICS
7:30 pm - 7:40 pmChair: Angel Garcia (R.P.I.)
7:40 pm - 8:10 pmFeng Gai (University of Pennsylvania)
"Membrane-mediated helix folding dynamics"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:40 pmWonpil Im (University of Kansas)
"Insertion, Folding, and Tilting of Transmembrane Helices"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmMei Hong (Iowa State)
"Membrane-induced changes of the oligomeric structure and conformation of cationic membrane peptides from solid-state NMR"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFLUCTUATIONS AND CONFORMATIONAL ENSEMBLES
9:00 am - 9:10 amChair: J. Winkler (California Institute of Technology)
9:10 am - 9:40 amVince Hilser (University of Texas, Medical Branch)
"Cooperativity and Communication in the Protein Ensemble"
9:40 am - 9:55 amDiscussion
9:55 am - 10:10 amMartin Sagermann (University of California, Santa Barbara)
"Engineering conformational changes: Introduction of pH-sensitive allostery into a protein"
10:10 am - 10:20 amDiscussion
10:20 am - 10:35 amCoffee Break
10:35 am - 11:05 amBertrand Garcia Moreno (Johns Hopkins University)
"Conformational fluctuations as determinants of electrostatic effects in proteins"
11:05 am - 11:20 amDiscussion
11:20 am - 11:35 amZoya Ignatova (Max-Planck Institute of Biochemistry)
"Translational Pausing - Role for Co-translational Folding and Secretion of Proteins"
11:35 am - 11:45 amDiscussion
11:45 am - 12:15 pmLynne Regan (Yale University)
"The affects of polyproline II structure on the behavior of the denatured state"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCHAPERONES AND CO-TRANSLATIONAL FOLDING
7:30 pm - 7:40 pmChair: Silvia Cavagnero (University of Wisconsin, Madison)
7:40 pm - 8:10 pmElke Deuerling (Ruprecht-Karls-Universität Heidelberg)
"Functions and mechanisms of ribosome-associated chaperones in protein folding"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:40 pmAdrian Elcock (University of Iowa)
"Molecular Simulations of Cotranslational and Chaperone-Mediated Folding"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmUlrich Hartl (Max Planck Institute of Biochemistry)
"Mechanisms of chaperone-assisted protein folding"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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