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Proteoglycans
Gordon Research Conference

Dates

July 6-11, 2008

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Thomas N. Wight

Vice Chair:
Marian F. Young

Meeting Description

The major purpose of this meeting will be to bring together scientists from around the world working in the area of proteoglycan research to present and discuss their most recent findings in each of nine (9) sessions which will include sessions on the biosynthesis, structure, interactions, and degradation of these molecules. These sessions will be complemented with other sessions designed to address how these molecules contribute to events fundamental to development and disease. Our goal will be to promote a further understanding of the role these molecules play in various aspects of human development and in pathologic events connected to inflammation and immunity. Specific sessions in this area will include involvement of proteoglycans in diseases of the musculoskeletal system, nervous system, vascular and lung systems, and cancer. A final session on current developments on the use of proteoglycans as therapeutics in the clinic is planned.

Contributors

The Organizers are Deeply Grateful and Appreciate the Following Agencies for their Generous Financial Support:

National Institutes of Health
Gordon Research Conferences
Genzyme Corporation
Halozyme Therapeutics, Inc
Hope Heart Institute
Ibex Pharmaceuticals, Inc.
Mizutani Foundation for Glycoscience
Pfizer, Inc.
Seikagaku Corporation
Sepracor Inc.
Zacharon Pharmaceuticals Inc.
Anonymous Donation

Meeting Program

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome by Conference Chair / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmRECENT BREAKTHROUGHS IN THE UNDERSTANDING OF MECHANISMS RELATED TO THE BIOSYNTHESIS OF GLYCOSAMINOGLYCANS
Discussion Leader: Vincent Hascall (Lerner Research Institute, Cleveland, USA)
7:40 pm - 8:00 pm Christian Götting (Herz- und Diabeteszentrum Nordrhein-Westfalen, Germany)
"Xylosyltransferases and their role in fibrosis and tissue remodeling"
8:00 pm - 8:05 pm Discussion
8:05 pm - 8:15 pm Marco Maccarana (Lund University, Sweden)
"Identification of a second DS-epimerase, genetically linked to bipolar disorder"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:40 pm Lena Kjellen (The Biomedical Center, Uppsala, Sweden)
"PAPS makes a difference"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Naoko Nagai (Aichi Medical University, Japan)
"Regulation of heparan sulfate 6-O-sulfation by β-secretase activity"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Alberto Passi (University of Insubria, Varese, Italy)
"Intracellular synthesis of hyaluronan"
9:20 pm - 9:25 pm Discussion
9:30 pm Discussion at Posters
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmINTERACTIONS AND OUTCOMES
Discussion Leader: Jeremy Turnbull (University of Liverpool, UK)
9:00 am - 9:20 am John Gallagher (University of Manchester, UK)
"Design and function of heparan sulfate"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Julie Leary (University of California, Davis, USA)
"New advances in ion mobility mass spectrometry for proteoglycan analysis"
9:50 am - 10:00 am Discussion
10:00 am - 10:10 am Deirdre Coombe (Curtin University of Technology, Perth, Australia)
"Characterization of the binding of heparin to Interleukin-5 (IL-5)"
10:10 am - 10:15 am Discussion
10:15 am - 10:25 am Dave Fernig (University of Liverpool, UK)
"Single molecule analysis of the dynamics of the formation of complexes of FGF2 with HS co-receptor and FGF receptor"
10:25 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 am Anthony Day (University of Manchester, UK)
"TSG-6- a pluripotent inflammatory mediato"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Matthew Nugent (Boston University School of Medicine, USA)
"Catalytic mechanisms involving heparan sulfate-fibronectin interactions"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Deanna Beauvais (University of Wisconsin - Madison, USA)
"Synstatin, a peptide derived from the syndecan-1 core protein, blocks syndecan-regulated αvβ3 integrin activation during angiogenesis"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Anne Woods (University of Alabama at Birmingham, USA)
"Syndecan-4 core protein binds fibronectin HepII domain and modulates focal adhesion formation"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPROCESSING AND DEGRADATION
Discussion Leader: Bruce Caterson (Cardiff University, Wales)
7:30 pm - 7:50 pm Hideaki Nagase (Imperial College London, UK)
"Key features regulating ADAMTS4 and 5 activity"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm Richard Kenagy (University of Washington, USA)
"Induction of ADAMTS4, tissue plasminogen activator, and hyaluronidase 2 by cell death plays a general role in vascular atrophy"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:25 pm Jennifer Velasco (Rush University Medical Center, USA)
"ADAMTS5 ablation alters migration and differentiation of cells in the activated synovium in murine OA"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm Thomas Hering (Case Western Reserve University, USA)
"Size and chondroitinase ABC susceptibility of calf and steer aggrecan monomers"
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Linda Troeberg (Kennedy Institute of Rheumatology, UK)
"The anti-arthritic agent calcium pentosan polysulfate inhibits aggrecanase-mediated breakdown of the cartilage extracellular matrix"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Jin-Ping Li (University of Uppsala, Sweden)
"Heparanase - key regulator of heparan sulfate metabolism and pathophysiology"
9:20 pm - 9:30 pm Discussion
9:30 pm Discussion at Posters
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDEVELOPMENT
Discussion Leader: Roberto Perris (University of Parma, Italy)
9:00 am - 9:20 am H. Joseph Yost (University of Utah School of Medicine, USA)
"Sulfotransferases in Zebrafish development"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am W. Scott Argraves (Medical University of South Carolina, USA)
"Versican-fibulin interaction and the development of the heart"
9:50 am - 10:00 am Discussion
10:00 am - 10:10 amHideto Watanabe (Aichi Medical University, Japan)
"In vivo function of versican/PG-M: analysis of knock-in mice"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amMariana Capurro (Sunnybrook Research Institute, Toronto, Canada)
"The regulation of embryo size by Glypican-3 is partially mediated by Indian Hedgehog signaling"
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 am Charles Emerson (Boston Biomedical Research Institute, USA)
"Sulfatases in neurogenesis"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Andreas Faissner (Ruhr University, Germany)
"A role for chondroitin sulfate in neural glial cell differentiation and neurogenesis"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pmBradley Olwin (University of Colorado, USA)
"Syndecan-3-dependent Notch signaling is required for cell fate regulation in muscle progenitor cells"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmKenneth Kramer (National Institutes of Health, Bethesda, MD, USA)
"A trafficking tool for dissecting the role of heparan sulfate"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPROTEOGLYCANS IN CELL BIOLOGY, PHENOTYPIC CONTROL & SIGNALING
Discussion Leader: Pascale Zimmermann (Catholic University Leuven, Belgium)
7:30 pm - 7:50 pm John Couchman (University of Copenhagen, Denmark)
"Syndecan signaling and integrin-mediated adhesion"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm Guido David (University of Leuven, Belgium)
"A novel syntenin-pathway, downstream of syndecan, supporting processes of vesicular 'budding'"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:25 pm Tarja Kinnunen (University of Liverpool, UK)
"C. elegans syndecan, SDN-1, and Wnt signalling function synergistically in neuron migration"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Markku Tammi (Kuopio University, Finland)
"Microvillus: A hyaluronan synthesizing organelle that influences cell shape"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm William Stallcup (Burnham Institute for Medical Research, La Jolla, CA, USA)
"Phosphorylation of NG2 regulates cell proliferation and migration"
9:20 pm - 9:30 pm Discussion
9:30 pm Discussion at Posters
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPROTEOGLYCANS AND INFLAMMATION
Discussion Leader: Liliana Schaefer (University of Frankfurt, Germany)
9:00 am - 9:20 am Pyong Park (Harvard Medical School, Boston, USA)
"Syndecan 1 shedding modulates inflammatory responses to infectious agents"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Jacob van den Born (University Medical Center Groningen, The Netherlands)
"Heparan sulfate and leukocyte invasion"
9:50 am - 10:00 am Discussion
10:00 am - 10:10 amJoanne Tobacman (University of Illinois at Chicago, USA)
"Silencing N-acetylgalactosamine 4-sulfatase reduces TNF-a stimulation of IL-8 secretion and Increases IL-8 sequestration by chondroitin-4-sulfate"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amCharles Frevert (University of Washington, Seattle, USA)
"The glycosaminoglycan-binding domain of CXC-chemokines controls neutrophil migration into the lungs of mice"
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 am Toshihiko Toida (Chiba University, Japan)
"Chondroitin sulfate in allergy and inflammation"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Paul Kubes (University of Calgary, Alberta, Canada)
"Hyaluronan complexes promote leukocyte recruitment and inflammation"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pmMary Chang (University of Washington, Seattle, USA)
"Altered proteoglycan expression associated with monocyte-to-macrophage differentiation: Potential role for macrophage proteoglycans in matrix stabilization"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmRashmin Savani (Univ. of Texas Southwestern Medical Center, USA)
"Transgenic overexpression of rhamm in macrophages results in increased inflammatory responses"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmPROTEOGLYCANS IN CARDIOVASCULAR DISEASE AND CANCER
Discussion Leader: Renato Iozzo (Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA)
7:30 pm - 7:50 pm Merv Merrilees (The University of Auckland, New Zealand)
"Versican and the inhibition of atherosclerosis"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm Sarah Wilcox-Adelman (Boston Biomedical Research Institute, USA)
"Syndecan-4 modulates components of the leading edge in migrating cells"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Eva Turley (University of Western Ontario, Canada)
"CD44-RHAMM interactions and the motility of breast cancer cells"
8:35 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Silvia Goldoni (Thomas Jefferson University, Philadelphia, USA)
"An anti-metastatic role for decorin in breast cancer"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Ralph Sanderson (University of Alabama at Birmingham, USA)
"Targeting the heparan sulfate/heparanase axis for cancer therapy"
9:20 pm - 9:30 pm Discussion
9:30 pm Discussion at Posters
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPROTEOGLYCANS IN THE MUSCULOSKELETAL SYSTEM
Discussion Leader: Anna Plaas (Rush University, Chicago, IL)
9:00 am - 9:20 am Alan Grodzinsky (Massachusetts Institute of Technology, Cambridge, USA)
"Aggrecan structure and molecular mechanics: a biomarker"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Katalin Mikecz (Rush University Medical Center, Chicago, USA)
"Visualization of joint inflammation in proteoglycan-induced arthritis"
9:50 am - 10:00 am Discussion
10:00 am - 10:10 amXingbin Ai (Boston Biomedical Research Institute, USA)
"Sulfs regulate angiogenesis during skeletal muscle regeneration"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amKazu Matsumoto (The Burnham Institute for Medical Research, La Jolla, CA, USA)
"BMP signaling is the major target for the regulatory function of heparan sulfate during skeletal development"
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 am Michael Sohaskey (University of California, Berkeley, USA)
"JAWS coordinates chondrogenesis and synovial joint positioning"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Anne Marie Malfait (Pfizer Global Research and Development, St. Louis, USA)
"Biological implications of ADAMTS4/TS5 inhibition"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pmCheryl Knudson (East Carolina University, Greenville, NC, USA)
"Reversible dedifferentiation alters BMP7 responsiveness"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmAimin Wang (The Cleveland Clinic Foundation, OH, USA)
"Is the Adipocyte the Trojan Horse of Diabetic Osteopenia?"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPROTEOGLYCANS IN TRANSLATIONAL RESEARCH: THERAPEUTICS
Discussion Leader: Marian Young (National Institute of Dental and Craniofacial Research, Bethesda, MD, USA)
7:30 pm - 7:50 pm Glen Prestwich (University of Utah, Salt Lake City, USA)
"Pragmatic hyaluronan hydrogels for cell therapy and reparative medicine"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm James Fawcett (University of Cambridge, UK)
"The use of chondroitinase therapy to treat spinal cord injury"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Robert Lindhardt (Rensselaer Polytechnic Institute, NY, USA)
"New avenues for developing glycosaminoglycan-based therapeutics"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Tim Hardingham (University of Manchester, UK)
"Chondrogenic differentiation of human stem cells to generate scaffold-free cartilage"
9:20 pm - 9:30 pm Discussion
9:30 pm Discussion at Posters
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
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