Gordon Research Conferences
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Conference Program
 
Radiation Oncology
Understanding the DNA Damage Response to Optimize Radiation Therapy
January 27 - February 1, 2008
Ventura Beach Marriott
Ventura, CA
Chair:
Simon N. Powell

Vice Chair:
William F. Morgan

The main theme of the meeting will be tumor specific differences in the DNA damage response, with a view to potential novel therapeutic strategies. Tumor factors affecting the DNA damage response include chromatin modifiers, cell cycle checkpoints and adaptation, replication fork stalling and recovery, tumors with defects in homologous recombination and competition between pathways of double-strand break repair, the effect of hypoxia on the DNA damage response and genomics of the DNA damage response. The goals are: (1) To provide a venue for scientists, who work on the DNA damage response to present and discuss current research in the field; (2) To provide students, postdoctoral fellows, and new investigators the opportunity to present their work to peers and interact with leaders in the field; (3) To enhance interactions between researchers and foster collaborations to address novel issues in the field of radiation oncology. There has been an explosion of interest in DNA repair in the last 15 years, but little of the work has addressed how this information could be used for new therapeutic strategies. There are many tumor-specific alterations to the DNA damage response: this meeting will emphasize established and novel mechanisms and how they can be harnessed to optimize therapy.


SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Harnessing Biology to Optimize Radiation Therapy
7:40 pm - 8:25 pmKeynote Lecturer: J. Martin Brown (Stanford University)
"DNA repair in cancer therapy: Exploitable or not"
8:25 pm - 8:35 pm Discussion
8:35 pm - 9:20 pmKeynote Lecturer: Michael B. Kastan (St. Jude Children’s Research Hospital)
"DNA Damage Response Mechanisms: Implications for human Disease"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Increasing the effects of DNA Damage in Tumors by Chromatin Modification
9:00 am - 9:25 amDiscussion Leader: Andre Nussensweig (National Institutes of Health)
"DNA damage response and chromosome integrity"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amJunjie Chen (Yale University School of Medicine)
"Coordinating protein phosphorylation and ubiquitination in DNA damage response"
10:05 am - 10:20 am Discussion
10:20 am - 10:45 amGary Kao (University of Pennsylvania School of Medicine)
"Integrating DNA damage-modifying agents with standard cancer therapy: Faster, Safer, Better?"
10:45 am - 11:00 am Discussion
11:00 am - 11:30 am Coffee Break / Group Photo (11:15 am)
11:30 am - 11:55 amXuetong Shen (MD Anderson Cancer Center)
"Chromatin responses to DNA damage"
11:55 am - 12:10 pm Discussion
12:10 pm - 12:20 pm Tej Pandita (Washington University)
"Histone Code and DNA Damage Response"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Modification of DNA Damage Checkpoints in Tumors and Normal Cells
7:30 pm - 7:55 pmDiscussion Leader: Helen Piwnica-Worms (Washington Univ. School of Medicine)
"Checkpoint Control in Normal and Cancer Cell Cycles"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmDavid Cortez (Vanderbilt University Medical Center)
"Regulation of Checkpoint Activation"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmMartin Lavin (Queensland Institute of Medical Research)
"ATM-dependent phosphorylation of members of the MRE11 complex signals DNA double strand breaks to the cell cycle checkpoints"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Fred Bunz (Johns Hopkins University)
"Uncoupling the DNA Damage Response Function from the Essential Function of Chk1"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Adaptation from Checkpoints
9:00 am - 9:25 amDiscussion Leader: William Kaufmann (University of North Carolina)
"Current status of checkpoint adaptation in normal and cancer cells"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 am Marco Foiani (University of Milan)
"Cellular pathways influencing checkpoint activation and inactivation in response to DSB formation"
10:05 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:05 amJiri Bartek (Danish Cancer Society)
"DNA damage checkpoints: Live cell imaging and involvement in human tumorigenesis"
11:05 am - 11:20 am Discussion
11:20 am - 11:45 amDavid Toczyscki (University of California, San Francisco)
"Turning the checkpoint on and off"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Robert Hromas (University of New Mexico)
"The NHEJ Repair Protein Metnase Improves Chromosomal Decatenation and Replication Fork Progression"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:30 pm Open Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm Stalled Replication, Fork Cleavage, Replication Restart
7:30 pm - 7:55 pmDiscussion Leader: Alan Lehmann (University of Sussex)
"The role of ubiquitination in the replication of damaged DNA"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmWolf-Dietrich Heyer (University of California)
"Recombination and DNA damage checkpoints: Joint efforts in replication fork support"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmBing Hui Shen (City of Hope National Medical Center)
"FEN-1: a possible target for radiation sensitization"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Guangbin Luo (Case Western Reserve University)
"Recql5 helicase is required for maintaining active replication forks in response to replication stress"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Poster Session
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Homologous Recombination Defects in Tumor Cells
9:00 am - 9:25 amDiscussion Leader: Alan Ashworth (The Institute of Cancer Research)
"Synthetic Lethal approaches to the treatment of cancers with DNA Repair Defects"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amAlan D’Andrea (Dana-Farber Cancer Institute)
"Targeting the Fanconi Anemia Pathway in Cancer Therapeutics"
10:05 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:05 amThomas Helleday (Radiobiology Research Institute / Churchill Hospital)
"DNA replication repair: Basic mechanisms to novel anti-cancer treatments"
11:05 am - 11:20 am Discussion
11:20 am - 11:45 amLei Li (MD Anderson Cancer Center)
"Repair of DNA interstrand crosslinks"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Phillip Connell (University of Chicago)
"Identification of a chemical compound that stimulates the DNA binding and recombination activities of human RAD51 protein"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:30 pm Open Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Competition Between DNA DSB Repair Pathways
7:30 pm - 7:55 pmDiscussion Leader: Rodney Rothstein (Columbia University Genetics & Development)
"Pursuing new pathways in the DNA damage response"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pmJac Nickoloff (The University of New Mexico)
"Co-Regulation of Double-Strand Break Repair by DNA-PKcs and ATM"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmMaria Jasin (Memorial Sloan-Kettering Cancer Center)
"Repairing double strand breaks in mammalian cells"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Jeremy Stark (Beckman Research Institute of the City of Hope)
"G2/M arrest in mammalian cells promotes chromosome break repair pathways that involve end processing"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:30 pm Poster Session
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Effects of Hypoxia on DNA Repair
Discussion Leader: Amato Giaccia (Stanford University)
9:00 am - 9:25 am Ester Hammond
"Hypoxia-induced signalling to the DNA damage signalling pathways"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amPeter Glazer (Yale University School of Medicine)
"Regulation of DNA repair pathways in hypoxic cells"
10:05 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:05 amRobert Bristow (Princess Margaret Hospital)
"Hypoxia and DNA-dsb repair in tumor cells: implications for genetic instability and novel treatments"
11:05 am - 11:20 am Discussion
11:20 am - 11:45 amRichard Kolesnick (Memorial Sloan-Kettering Cancer Center)
"Vascular dysfunction and acute hypoxia impair DSB repair in tumor stem cells"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Christopher Kemp (Fred Hutchinson Cancer Research Center)
“Rescue of DNA damage induced apoptosis and p21 expression in p53 null mice by elimination of DNA-PK”
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:30 pm Open Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Genomic Approaches to Studying the DNA Damage Response
7:30 pm - 7:55 pmDiscussion Leader: Janet Hall (Institut Curie)
"The association of sequence variants in DNA repair and cell cycle genes with altered cancer risk"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Al Fornace (Georgetown University)
"Roles for p38 MAP kinase signaling in responses to ionizing radiation"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmPatrick Concannon (University of Virginia)
"Radiation exposure, genetic susceptibility, and second primary breast cancer"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Matthew Coleman (Lawerence Livermore National Laboratory)
"Identification of TP53 regulated networks induced by ionizing Radiation in human lymphoblastoid cells"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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