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Reproductive Tract Biology
August 3-8, 2008
Proctor Academy
Andover, NH
Chair:
Thomas E. Spencer

Vice Chair:
Richard R. Behringer

This Gordon Research Conference focuses on physiological, hormonal and cellular aspects of Reproductive Tract Biology. The focus of this conference will be on both male and female reproductive tract development, function and disease and will encompass biology of the testis, epididymis, ovary, uterus, cervix, and placenta. This Gordon Conference will bring together cutting-edge experts and young investigators in these areas to discuss mechanistic concepts and their translation to basic problems in development, function and disease across a broad spectrum of mammalian animal models. The highly multidisciplinary and integrative environment that will be created during this meeting in formal and informal settings is intentionally designed to encourage and facilitate cross-fertilization and development of significant new ideas. The program will include state-of-the-art discussions of important areas such as new paradigms in reproductive tract developmental biology, stem cells, reproductive immunobiology, male reproductive tract biology with an emphasis on the epididymis, ovarian biology with emphasis on follicle development and ovarian cancer, implantation biology, uterine regulation of placental development, uterine dysfunction and disease with emphasis on endometriosis and fibroids, placentation and fetal growth, and parturition.

A new aspect of this Conference is the inclusion of at least eight open slots for platform presentations of late breaking data (10 min plus 5 min discussion) to be selected from abstracts. If competing abstracts are considered equally novel, preference for oral presentation will be given to trainees and early stage investigators, but investigators at all stages of their career are encouraged to submit abstracts. Due to GRCs policy of open sharing of unpublished data, there will be no publication or citation of abstracts or presentations.

We encourage basic, clinical, and industry scientists at all career stages interested in the subject matter in above program to attend the Reproductive Tract Biology GRC.

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKEYNOTE LECTURES
Discussion Leader: Tom Spencer (Texas A&M University)
7:40 pm - 8:25 pm Graham Burton (University of Cambridge, United Kingdom)
"New Paradigms in Uterine Regulation of Human Early Placental Development"
8:25 pm - 8:35 pm Discussion
8:35 pm - 9:20 pm Fuller W. Bazer (Texas A&M University)
"Mammalian Genital Tract Secretions to Reproductive Tract Biology: Perspectives on the Evolution of Knowledge of Reproductive Biology Over 35 Years"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmDEVELOPMENTAL BIOLOGY
Discussion Leader: Richard R. Behringer (U.T. M.D. Anderson Cancer Center)
9:00 am - 9:30 am Marilyn Renfree (University of Melbourne, Australia)
"Sexual differentiation in three unconventional mammals: spotted hyenas, elephants and tammar wallabies"
9:30 am - 9:35 am Discussion
9:35 am - 9:45 am Heather Franco (Baylor College of Medicine, Houston, Texas)
"Ablation of Wnt4 in the uterus demonstrates its critical role in normal uterine function and in the development of the uterine epithelium"
9:45 am - 9:50 am Discussion
10:00 am Coffee Break
10:30 am - 11:00 am Humphrey H. Yao (University of Illinois-Champaign)
"Conserved Epithelium-Mesenchyme Interaction in the Development of Wolffian Duct and Fetal Testis Cord"
11:00 am - 11:05 am Discussion
11:05 am - 11:35 am Liang Ma (Washington University School of Medicine)
"Endocrine Disruptors and Reproductive Tract Development"
11:35 am - 11:40 am Discussion
11:40 am - 12:10 pm Frank F. Bartol (Auburn University)
"Postnatal Reproductive Tract Differentiation: Estrogen Receptors and Relaxin"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm James K. Pru (Massachusetts General Hospital, Harvard Medical School)
"Identification of adult epithelial stem/progenitor cells in the murine endometrium"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmSTEM CELLS
Discussion Leader: Linda Giudice (University of California, San Francisco)
7:30 pm - 7:55 pm David Albertini (University of Kansas Medical Center)
"The limitations of current ovarian stem cell research and the prospect of clinical translation"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Susan Kasper (Vanderbilt University)
"Generation of human prostate cancer from cells with stem cell characteristics"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Caroline Gargett (Monash University, Australia)
"Uterine Stem Cells: What is the evidence?"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Thaddeus G. Golos (University of Wisconsin)
"Embryonic Stem Cell Models for Placental morphogenesis"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMALE REPRODUCTIVE BIOLOGY
Discussion Leader: Barry Hinton (University of Virginia)
9:00 am - 9:25 am Derek J. McLean (Washington State University)
"Spermatogonial stem cell transplantation and testicular function"
9:25 am - 9:30 am Discussion
9:30 am - 9:55 am Marty Matzuk (Baylor College of Medicine)
"Identification of Genes for Male Infertility"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:40 am Kim Lehmann (The Hamner Institutes for Health Sciences)
"Gene profiling the fetal mouse ovary and testis reveals sex-specific genetic biomarkers and candidate molecular signaling pathways controlling gonad development"
10:40 am - 10:45 amDiscussion
10:45 am - 11:10 am Janette Dufour (Texas Tech University Health Sciences Center)
"Use of immunoprotective Sertoli cells for islet transplantation"
11:10 am - 11:15 am Discussion
11:15 am - 11:40 am Joel Drevet (CNRS and Blaise Pascal University, Clermont, France)
"Glutathione peroxidases, oxidative stress and post-testicular sperm maturation in mouse"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Wei Hu (Laboratory of Cellular and Developmental Biology, National Institutes of Health)
"Ectopic expression of FIGLA in male germ cells causes spermatogenic defects and male infertility"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:25 pm Gail Cornwall (Texas Tech University Health Science Center)
"Amyloidogenesis in the Epididymis"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmOVARIAN BIOLOGY
Discussion Leader: JoAnn S. Richards (Baylor College of Medicine)
7:30 pm - 7:55 pm George W. Smith (Michigan State University)
"Functional genomics studies of oocyte competence"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Sergio Ojeda (Oregon Primate Research Center)
"Regulation of Early Follicle Development"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Lonnie D. Shea (Northwestern University)
"Engineering the follicle microenvironment"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Barbara Vanderhyden (Ottawa Health Research Institute, Canada)
"Mouse models of ovarian cancer"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIMPLANTATION BIOLOGY
Discussion Leader: Franco J. DeMayo (Baylor College of Medicine)
9:00 am - 9:30 am Milan K. Bagchi (University of Illinois)
"Steroid-regulated gene networks in implantation"
9:30 am - 9:35 am Discussion
9:35 am - 9:45 am Amrita Das (University of Ilinois)
"P450 aromatase-derived intra-uterine estrogen is critical for decidualization"
9:45 am - 9:55 amDiscussion
9:55 am Coffee Break
10:00 am - 10:25 am Greg A. Johnson (Texas A&M University)
"Osteopontin, Multi-Functional Contributions at the Maternal-Placental Interface"
10:25 am - 10:30 am Discussion
10:30 am - 10:55 am Brent M. Bany (Southern Illinois University)
"Conceptus Regulation of Decidualization"
10:55 am - 11:00 am Discussion
11:00 am - 11:25 am B. Anne Croy (Queen's University, Canada)
"Uterine natural killer cells: their choices, their missions"
11:25 am - 11:30 am Discussion
11:30 am - 11:40 am Irit Granot (Kaplan Medical Center, Israel)
"Local injury induces recruitment of antigen presenting cells to the endometrium"
11:40 am - 11:45 amDiscussion
11:45 am - 12:15 pm D. Randall Armant (Wayne State University School of Medicine)
"Integration of Extrinsic Information from the Uterine Environment by the Developing Blastocyst"
12:15 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmUTERINE DYSFUNCTION AND DISEASE
Discussion Leader: Asgi Fazleabas (University of Illinois at Chicago)
7:30 pm - 7:55 pm Linda Giudice (University of California at San Francisco)
"Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Kevin Osteen (Vanderbilt University)
"Mouse models of endometriosis"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Julie M. Hastings (University of Illinois at Chicago)
"Epigenetics and Endometriosis"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Cheryl L. Walker (UT-M.D. Anderson Cancer Center)
"Developmental Programming and Uterine Leiomyoma: Estrogen-induced Modulation of Histone Methyltransferase Activity"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPLACENTATION AND FETAL GROWTH
Discussion Leader: Stuart Handwerger (University of Cincinnati)
9:00 am - 9:25 am Kevin Sinclair (University of Nottingham, United Kingdom)
"Modeling the developmental origins of health and disease in the early embryo"
9:25 am - 9:30 am Discussion
9:30 am - 9:55 am Thomas Jansson (University of Cincinnati)
"'Placental nutrient sensing and regulation of fetal growth"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:40 am Philip Jessmon (C.S. Mott Center for Human Growth and Development)
"HBEGF-induced downstream regulators of trophoblast functions"
10:40 am - 10:45 amDiscussion
10:45 am - 11:10 am Yoel Sadovsky (Magee Womens Research Institute, University of Pittsburgh)
"The pleiotropic function of PPAR gamma in the placenta"
11:10 am - 11:15 am Discussion
11:15 am - 11:25 am Julie Shaw (University of Toronto)
"Hormonal regulation of human tissue kallikrein-related peptidases (KLK) during the menstrual cycle: potential roles for KLKs in vaginal epithelial cell desquamation and in the remodeling of the cervix"
11:25 am - 11:30 amDiscussion
11:30 am - 11:55 am Eugene Albrecht (University of Maryland School of Medicine)
"Regulation of trophoblast invasion of uterine spiral arteries by estrogen during baboon pregnancy"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:25 pm Cindy A. Morris (Tulane University Medical Center)
"Effects of human cytomegalovirus on placentation: 3-dimensional trophoblast cultures and insights into mechanisms"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmPARTURITION AND DISEASE
Discussion Leader: Graham Burton (University of Cambridge)
7:30 pm - 7:55 pm Sam Mesiano (University Hospitals Case Medical Center)
"The physiology of term and preterm birth: lessons from comparative and evolutionary biology"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Robert C. Burghardt (Texas A&M University)
"Integration of Cellular Responses to Mechanical Forces of Pregnancy"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Mala Mahendroo (University of Texas Southwestern Medical School)
"Cervical Remodeling during Pregnancy and Parturition"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Chuck R. Wira (Dartmouth University)
"Epithelial cells in the female reproductive tract: a central role as sentinels of immune protection"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
 
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