Gordon Research Conferences
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Conference Program
 
Spirochetes, Biology of
January 20-25, 2008
Ventura Beach Marriott
Ventura, CA
Chair:
Sven A. Bergstrom

Vice Chair:
Richard P. Ellen

The Gordon Research Conference on the Biology of Spirochetes is devoted to discussions on basic research of all medically important and biologically relevant spirochetes, a unique group of Eubacteria. Many spirochetes are pathogens and cause a variety of diseases, including syphilis, Lyme borreliosis, relapsing fever borreliosis, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Certain nonpathogenic spirochetes are also of great interest, such as the termite gut symbionts. The purpose of this conference is to assemble the most active and productive investigators in all areas of spirochete biology to share research advances at the leading edge of the field, to develop collaborations, and to delineate common research objectives. Thus, the intention is to provide a forum for exchange of ideas among groups working on different spirochetes and an opportunity for senior graduate students, postdoctoral fellows, and new investigators in the field to develop international contacts and collaborative networks. The application of genetic advancements, high throughput technology, and the availability of genomic sequences for Borrelia burgdorferi, B. garinii, Treponema pallidum, T. denticola, Leptospira spp. and other spirochetes are providing a wealth of new information. Combined, these data are being integrated into ongoing studies on the biology, physiology, structure-function, chemotaxis, pathogenesis, gene regulation, and immunobiology as well as invasion and evasion strategies of these bacteria.

If you would like to be on the mailing list for further information about this conference, please contact: Sven Bergström (sven.bergstrom@molbiol.umu.se).


SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm GENE EXPRESSION AND DIVERSITY IN SPIROCHETES
7:40 pm - 7:50 pmDiscussion Leader: Brian Stevenson (University of Kentucky, Lexington, KY)
7:50 pm - 8:20 pmJeffrey Miller (UCLA, Los Angeles, CA)
"Bacterial tropism switching mediated by diversity-generating retroelements"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmLorenzo Giacani (University of Washington, Seattle, WA)
"Mechanisms of transcriptional regulation of the tpr genes of T. pallidum subsp. pallidum"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmIra Schwarz (New York Medical College, Valhalla, NY)
"Transcriptional profiling of Borrelia burgdorferi"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm BIOLOGY RELATED TO RISK FOR INFECTION
9:00 am - 9:10 amDiscussion Leader: Richard Zuerner (National Animal Disease Center Ames, IA)
9:10 am - 9:50 amSarah Randolph (University of Oxford, Oxford UK)
"Climate change and emerging infection"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 amJoseph Vinetz (University of California San Diego School of Medicine, San Diego, CA)
"Global impact of Leptospirosis"
10:20 am - 10:30 am Discussion
10:30 am - 11:30 am Coffee Break / Group Photo (11:15 am)
11:30 am - 11:50 amMaria Diuk-Wasser (Yale School of Medicine New Haven, CT, USA)
"Evolutionary ecology of B. burgdorferi"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmJean-François Trapé (Institut de Recherche pour le Developpement, Dakar, Senegal)
"Risk factors for relapsing fever in Africa"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pm INVASION and EVASION STRATEGIES of SPIROCHETAL PATHOGENS
Discussion Leader: Barbara J. B. Johnson (CDC, Fort Collins, CO)
7:30 pm - 7:50 pmJorge Benach (Stony Brook University, Stony Brook, NY)
"Regulation of Borrelia burgdorferi penetration and host-inflammatory response"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmKazuyuki Ishihara (Tokyo Dental College, Chiba, Japan)
"Protease activity and the invasion/ systemic dissemination of T. denticola"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmJennifer C. Miller (University of Utah, Salt Lake City UT)
"A novel role for Type I IFN in Lyme arthritis"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmCaroline Cameron (University of Victoria, BC, Canada)
"Insight into the process of Treponema pallidum dissemination"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm SPIROCHETAL TRANSPORT, ENVIRONMENTAL SIGNALS and METABOLISM
9:00 am - 9:10 amDiscussion Leader: Wolfram Zueckert (Univ of Kansas; Kansas City, KS)
9:10 am - 9:30 amFrank Gherardini (Rocky Mountain Labs NIAID, Hamilton, MT)
"Redox and oxidatative stress in B. burgdorferi"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 amFelipe Cabello (New York Medical College, Valhalla, NY)
"Regulation of growth in Borrelia burgdorferi"
10:00 am - 10:10 am Discussion
10:10 am - 11:00 am Coffee Break
11:00 am - 11:20 amJacques Izard (The Forsyth Institute, Boston, MA)
"Cytoskeleton of treponemes"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 amJanakiram Seshu (The University of Texas at San Antonio, TX)
"Oxygen stress regulation in B. burgdorferi"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pmJuan Anguita (University of Massachusetts at Amherst. Amherst, MA)
"Pathways of Borrelia burgdorferi-mediated cardiac inflammation"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pm Past Chairs' Forum: Conceptual Leaps Forward, Spirochetal Research in the 21st Century
This is a special forum in which past chairs of the GRC will debate theoretical biology that will impact future directions in research. The session is intended to provoke debate and discussion among GRC participants.
7:30 pm - 7:40 pmDiscussion Leader: Ben Adler (Monash Univ., Melbourne, Australia)
Nyles Charon: Spirochetal motility
Alan Barbour: Borrelia, genetic diversity
Steve Norris: Comparative genomic/proteomic analysis
Sheila Lukehart: Treponema, protein diversity, infectivity
Janis Weiss: Disease models and immunity
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm SPIROCHETE BIOLOGY & DIVERSITY
9:00 am - 9:10 amDiscussion Leader: Annette Moter (Charité University Medicine, Berlin, Germany)
9:10 am - 9:30 am MA Motaleb (West Virginia University, Morgantown, WV)
"Motility and chemotaxis of Borrelia burgdorferi, the Lyme disease spirochete"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 amTom Schwan (Rocky Mountain Labs NIAID, Hamilton, MT)
"Relapsing fever infection biology"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:00 amCathrine Brissette (University of Kentucky, Lexington, KY USA)
"Innate immunity resistance of Treponema denticola"
11:00 am - 11:10 am Discussion
11:10 am - 11:30 amBetty Guo (Umeå University, Umeå, Sweden)
"Relapsing fever Borrelia blood cell interaction"
11:30 am - 11:40 am Discussion
11:40 am - 12:00 pmJames Carroll (University of Pittsburgh School of Medicine, Pittsburgh, PA)
"Proteome analysis of B. burgdorferi"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm INTERACTION WITH HOST CELLS, IMMUNOPATHOLOGY
7:30 pm - 7:40 pmDiscussion Leader: Linda Bockenstedt (Yale University, New Haven, CT)
7:40 pm - 8:00 pmMario Philipp (Tulane National Primate Research Center, Tulane University, LA)
"Glial cells and neurons in the pathogenesis of Lyme neuroborreliosis"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pmRuth Montgomery (Yale University, New Haven, CT)
"Recruitment of macrophages in Lyme carditis"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:00 pmAllen Steere (Harvard Medical School, Boston, MA)
"Clinical and immunological aspects on Lyme borreliosis"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:30 pm General Discussion: Spirochete diversity and interaction with host cells/immune systems
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm ADVANCES IN GENOMES, GENETICS, BIOLOGICAL PARADIGMS
9:00 am - 9:10 amDiscussion Leader: Sherwood Casjens (University of Utah Medical Center)
9:10 am - 9:30 amPatricia Rosa (Rocky Mountain Labs NIAID, Hamilton, MT)
"The role of plasmids in the B. burgdorferi life cycle"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 amFloyd Dewhirst (The Forsyth Insitute, Boston, MA,)
"Genome sequence and deduced biology of Treponema lecithinolyticum"
10:00 am - 10:10 am Discussion
10:10 am - 10:30 amJustin Radolf (University of Connecticut Health Center, CT)
"The Quest for Treponema pallidum Outer Membrane Proteins: A Reappraisal"
10:30 am - 10:40 am Discussion
10:40 am - 11:10 am Coffee Break
11:10 pm - 11:30 pmGeorge Chaconas (University of Calgary, Canada)
"Studies on B. burgdorferi antigenic variation and studies on adhesion to and escape from the vasculature of a living host by real-time high resolution 3D imaging"
11:30 am - 11:40 am Discussion
11:40 am - 12:00 pmDavid Haake (UCLA Los Angeles, CA)
"From the Environment to the Host - Lives of a Leptospiral Pathogen"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:30 pm General Discussion: Genome, genetics and biology
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pm LATE BREAKING SESSION
Speaker and Titles (Selected from submitted abstracts)
Discussion Leaders: Kit Tilly (Rocky Mountain Labs., Hamilton MT) and Jenifer Coburn (Tufts Univ., Boston, MA)
7:30 pm - 7:40 pmX Frank Yang (University of Indiana, Indianapolis, IN)
"Abrogation of OspA constitutively activates the RpoN-RpoS regulatory network of Borrelia burgdorferi"
7:40 pm - 7:45 pm Discussion
7:45 pm - 7:55 pmGerald L Murray (Monash University, Monashj, Australia)
"Transposon mutagenesis of Leptospira interrogans identifies an attenuated lipopolysaccharide mutant"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmMichael Matthias (University of California, San Diego, California)
"Human Leptospirosis Caused by a New, Antigenically Unique Leptospira Associated with a Rodent Reservoir in the Peruvian Amazon"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmLoic Coutte (University of Texas Medical School at Houston, Houston, Texas)
"Analysis of the Borrelia burgdorferi B31 vlsE genetic recombination during mouse infection"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmTeresa Francescutti (University of Victoria, Victoria, Canada)
"Heterologous expression of the Treponema pallidum laminin-binding adhesin Tp0751 in the culturable spirochete Treponema phagedenis"
8:40 pm- 8:45 pmDiscussion
8:45 pm - 8:55 pmHoward F. Jenkinson (University of Bristol, UK)
"A family of Treponema denticola fibronectin-interacting proteins interfacing bacterial cell surface function with host extracellular matrix"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMarco A. Magalhães (University of Toronto, Toronto, Canada)
"The major outer sheath protein of Treponema denticola selectively inhibits Rac1 activation in murine neutrophils"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmRobert Fischer (Rocky Mountain Labs NIAID, Hamilton, MT)
"Purine Salvage by Borrelia hermsii in the Mammalian Host Environment"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by R13AI075924-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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