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Conference Program
 
Stereochemistry
July 27 - August 1, 2008
Salve Regina University
Newport, RI

Stereochemistry: Chemistry is often referred to as the central discipline, one which effectively interfaces in numerous ways with many of the modern developments in science and engineering. Within chemistry, stereochemistry is not only a focal point but also represents an intersection of the various roads leading to and from biology, materials science, synthesis, and medicine. The Gordon Research Conference on Stereochemistry provides a unique forum for the discussion of the modern discoveries and intellectual advances pertaining to this most relevant, timely topic. It is a topic that ignites interest at both the theoretical and applied level in academia and industry. In dealing with stereochemical problems in its various incarnations chemists, biochemists, and biologist stand to gain new insight into molecular structure and properties that have fundamental and economic relevance.

The GRC Conference: This year’s conference has been focused on two important areas whose developments are at the cutting edge of advances in stereochemistry: asymmetric synthesis and stereocontrolled chemistry. The selection of speakers in each of these disciplines was carried out with special emphasis to represent the very latest in mechanistic and structural aspects of chemistry and biology with stereochemistry at its core. It is the hope of the organizers that it is not the ticking of the clock that moves the conference forward on a day to day basis, but rather a healthy exchange of ideas and discussion that are expected to emanate from the presentations.

Scientific Events and Activities: There will also be poster sessions scheduled in the late afternoons.


SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmChair's Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm NEW REAGENTS AND METHODOLOGIES
Discussion Leader: Carl Johnson (Wayne State University)
7:40 pm - 8:10 pmFranklin Davis (Temple University)
"Asymmetric Synthesis of Nitrogen Heterocycles using Sulfinimines"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:50 pmIan Lennon (Dowpharma)
"The Quest for Phenyl-DuPhos"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:25 pmErick Carreira (ETH, Zurich)
"Discovery and Surprises in Synthesis"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm NOVEL STRATEGIES
Discussion Leader: Vittorio Farina (Johnson & Johnson Pharmaceutical R&D)
9:00 am - 9:30 amPeter Seeberger (ETH, Zurich)
"Automated Assembly of Oligosaccharides Using Sugars Derived by de novo Synthesis"
9:30 am - 9:40 am Discussion
9:40 am - 10:20 amDonna Blackmond (Imperial College London)
"Crystallization Models for the Origin of Biological Homochirality"
10:20 am - 10:30 am Discussion
10:30 am - 11:10 am Coffee Break / Group Photo
11:10 am - 11:40 amColin Nuckolls (Columbia University)
"Spring-Loaded Mobius Topology"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pmBart Kahr (Washington University)
"Chiroptics of Achiral Compounds"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm STEREOSELECTIVE SYNTHESIS
Discussion Leader: Chris McWilliams (Wyeth)
7:30 pm - 8:00 pmJeffrey Bode (University of Pennsylvania)
"Stereochemical Aspects of New Reactions and Processes"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmGlenn Micalizio (Yale University)
"Metal-Mediated Reactions for Carbon-Carbon Bond Formation: Fragment Assembly via Carbometalation"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmPeter Wipf (University of Pittsburgh)
"The Bicyclobutane Gateway to Heterocycles"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm ORGANIC PROCESSES
Discussion Leader: Roger Bakale (Cephalon, Inc.)
9:00 am - 9:30 amXumu Zhang (Rutgers University)
"Practical Asymmetric Hydrogenation and Hydroformylation Reactions"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Mike Martinelli (Arena Pharmaceuticals)
"Development of an Asymmetric Alkylation Based Chemical Process"
10:10 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 11:10 amWilliam Clark (GlaxoSmithKline)
"The Development of a Manufacturing Route to a Cathepsin K Inhibitor"
11:10 am - 11:20 am Discussion
Discussion Leader: Dhileep Krishnamurthy (Boehringer Ingelheim Pharmaceuticals, Inc)
11:20 am - 11:50 amStephane Caron (Pfizer)
"Process Research and Development of a Factor Xa Inhibitor"
11:50 am - 11:55 am Discussion
11:55 am - 12:25 pmOhyun Kwon (University of California, Los Angeles)
"Phosphine Catalysis of Allenes"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm CATALYSIS
Discussion Leader: Kai Rossen (Sanofi Aventis)
7:30 pm - 8:00 pmMelanie Sanford (University of Michigan)
"Development of New Palladium-Catalyzed Reactions for Organic Synthesis"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmCarl Busacca (Boehringer Ingelheim Pharmaceuticals, Inc.)
"Asymmetric Catalysis with the BIPI Ligands"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmAndreas Pfaltz (University of Basel)
"Recent Progress in Asymmetric Hydrogenation"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm NOVEL METHODOLOGY
Discussion Leader: Robert Waltermire (Bristol-Myers Squibb Company)
9:00 am - 9:30 amDavid Barnes (Abbott Laboratories)
"A Scaleable Asymmetric Synthesis of a PARP Inhibitor, Employing a Memory of Chirality Cyclization"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amJoerg Deerberg (Bristol-Myers Squibb Company)
"Practical Asymmetric Synthesis of a Challenging Drug Candidate"
10:10 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
Discussion Leader: Terry Rathman (T-Links)
10:40 am - 11:10 amYoshitaka Hamashima (RIKEN)
"Enantioselective Catalysis Based On Transition Metal Enolate Chemistry"
11:10 am - 11:20 am Discussion
11:20 am - 11:50 amMark Huffman (Merck Research Laboratories)
"Diels-Alder-Based Asymmetric Synthesis of a Drug Candidate"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session A: Scott Miller (Co-Vice Chair, Yale University)
6:00 pmDinner
7:30 pm - 9:30 pm SELECTIVE REACTIONS AND CATALYTIC PROCESSES
Discussion Leader: Amy Howell (University of Connecticut)
7:30 pm - 8:00 pmMohammad Movassaghi (Massachusetts Institute of Technology)
"Cascade Reactions in Complex Alkaloid Synthesis"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmChristina White (University of Illinois)
"Streamlining Synthesis via C-H Oxidation"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmEric Jacobsen (Harvard University)
"Cooperative Asymmetric Catalysis"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm BIOLOGICAL SYSTEMS
Discussion Leader: Janine Cossy (ESPCI, Paris)
9:00 am - 9:30 amBrian Stoltz (California Institute of Technology)
"Stereochemically Rich Natural Products as a Driving Force for Discovery in Organic Chemistry"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amArun Ghosh (Purdue University)
"Chemistry and biology of novel microtubule-stabilizing agents"
10:10 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
Discussion Leader: Nicola Pohl (Iowa State University)
10:40 am - 11:10 amMarco Ciufolini (University of British Columbia)
"Synthetic Studies on Heterocyclic Natural Products"
11:10 am - 11:20 am Discussion
11:20 am - 11:50 am Louis Jungheim (Lilly and Company)
"Multidrug Resistance Pump Inhibitors, the Stereochemistry Matters"
11:50 am - 11:55 am Discussion
11:55 am - 12:25 pmTimothy Jamison (Massachusetts Institute of Technology)
"Epoxide-Opening Cascades"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B: Jay Siegel (Co-Vice Chair, Universität Zürich)
6:00 pmDinner
7:30 pm - 9:30 pm STATERGIES AND TACTICS OF ORGANIC SYNTHESIS
Discussion Leader: Steve King (Abbott Laboratories)
7:30 pm - 8:20 pmLarry Overman (University of California, Irvine)
"Recent Studies in Stereocontrolled Synthesis"
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:20 pmBarry Trost (Stanford University)
"On the Design of Chiral Space for Asymmetric Induction in a Catalytic Synthetic Reactions"
9:20 pm - 9:25 pm Discussion
9:25 pm - 9:30 pm Chairs Closing Remarks
Co-Vice Chairs Remarks: Scott Miller and Jay Siegel
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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