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Conference Program
 
Synaptic Transmission
July 27 - August 1, 2008
University of New England
Biddeford, ME

Synaptic transmission is the main means of information transfer between nerve cells. Unravelling the way in which synapses work is of central importance for advancing our knowledge about information processing in neuronal networks. Recent years have witnessed major advances in understanding the molecular mechanisms of synapse function both pre- and postsynaptically, as well as in unravelling the mechanisms of short- and long-term synaptic plasticity. Research in synaptic transmission has been sparked by the development of novel optical and genetic tools for cellular imaging, which allow to image synapse function from the level of the single vesicle up to the mapping of long-range synaptic connections in the brain. The impact of synaptic plasticity on neuronal network processing is beginning to be addressed. Also, major discoveries about the molecular mechanisms that govern synapse assembly and synaptic connectivity are being made, and there is growing evidence that deficits in the wiring and the function of synapses is an early step in various neurological disorders and neurodegenerative diseases.

The conference aims at bringing together leading scientists and young researchers from all areas of synaptic transmission, and will serve as a forum for discussing new developments in this highly interdisciplinary area of brain research. The conference should be interesting for students and scientists in neuroscience, as well as for anyone interested in nervous system function. To enhance the possibility that exciting recent results will be presented at the meeting, four speakers for short presentations (10 mins + 5 mins discussion) will be selected from the applicants, based on the submitted abstracts. Ample time will be allowed for the presentation of posters. In addition, in a Data Blitz session, 4-5 short talks by PhD students (5 mins) will be selected based on the submitted abstracts.


Contributors

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm KEYNOTE LECTURES
Discussion Leader: Ralf Schneggenburger (EPFL, Switzerland)
7:40 pm - 8:20 pmRichard W. Tsien (Univ. Stanford)
"Unexpected features of cycling vesicles and adapting synapses"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pmJoshua R. Sanes (Univ. Harvard)
"Synaptic specificity in the visual system"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm CA2+ AND TRANSMITTER RELEASE
9:00 am - 9:05 amDiscussion Leader: Meyer Jackson (Univ. Wisconsin)
"Introductory remarks"
9:05 am - 9:30 amEd Chapman (Univ. Wisconsin)
"The enigmatic case of synaptotagmin-IV: where is it, and what does it do?"
9:30 am - 9:45 am Discussion
9:45 am - 10:10 amPeter Jonas (Univ. Freiburg, Germany)
"Tight coupling between Ca2+ channels and Ca2+ sensors of exocytosis at a central synapse"
10:10 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:25 amJianyuan Sun (Univ. Texas)
"A dual-Ca2+-sensor model for neurotransmitter release in a central synapse"
11:25 am - 11:40 am Discussion
11:40 am - 11:55 am Short Talk: David DiGregorio (Univ. Paris, France)
"Developmental changes in presynaptic calcium domains at the Calyx of Held"
11:55 am - 12:20 pm Lu-Yang Wang (Univ. Toronto, Canada)
"Tightening the coupling of presynaptic Ca2+ channels to vesicular release at the developing calyx of Held synapse"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pm TRANSPORTER FUNCTION IN TRANSMISSION
7:30 pm - 7:35 pmDiscussion Leader: David Attwell (Univ. College London, UK)
"Introductory remarks"
7:35 pm - 8:00 pmMargaret Lin Veruki (Univ. Bergen, Norway)
"Regulation of synaptic transmission through a presynaptic glutamate transporter in the retina"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:40 pmCraig Jahr (OHSU, Portland)
"Presynaptic NMDA receptors?"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:30 pm DATA BLITZ
Discussion Leader: Pablo Castillo (Albert Einstein College, New York)
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm SYNAPSES AND CODING OF SENSORY INFORMATION
9:00 am - 9:05 amDiscussion Leader: Felix Schweizer (UCLA)
"Introductory remarks"
9:05 am - 9:30 amElizabeth Glowatzki (Johns Hopkins Univ.)
"Calcium dependence of release at the inner hair cell afferent synapse in the cochlea"
9:30 am - 9:45 am Discussion
9:45 am - 10:10 amHenrique von Gersdorff (OHSU, Portland)
"Quantal size and multivesicular release at a sensory synapse"
10:10 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:25 amLarry Trussell (OHSU, Portland)
"Simple vs complex spike communication in an interneuron network"
11:25 am - 11:40 am Discussion
11:40 am - 11:55 am Short Talk: Martha Bagnall (Univ. California, San Diego)
"Frequency-independent transmission at the vestibular afferent synapse supports a linear behavior"
11:55 am - 12:20 pmJeff Isaacson (Univ. California, San Diego)
"Central circuits underlying olfaction"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pm MOLECULAR MECHANISMS OF PRESYNAPTIC FUNCTION
7:30 pm - 7:35 pmDiscussion Leader: Richard Tsien (Univ. Stanford)
"Introductory remarks"
7:35 pm - 8:00 pmStephan Sigrist (Univ. Würzburg, Germany)
"Bruchpilot, dense body formation and the vesicle cycle"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:40 pmJanet Richmond (Univ. Illinois, Chicago)
"Interactions between UNC-13, TOM-1 and UNC-18 in synaptic transmission"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmChristian Rosenmund (Baylor College of Medicine, Houston)
"Vesicular glutamate transporters: roles beyond glutamate uptake"
9:20 pm - 9.30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm SYNAPTIC CIRCUITS
9:00 am - 9:05 amDiscussion Leader: Chris McBain (NIH)
"Introductory remarks"
9:05 am - 9:30 am Massimo Scanziani (Univ. California, San Diego)
"Hippocampal Circuits and Dynamic Range"
9:30 am - 9:45 am Discussion
9:45 am - 10:10 am Barry Connors (Univ. Brown)
"Electrical synaptic circuits in the thalamocortical system"
10:10 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:25 am Karl Deisseroth (Univ. Stanford)
"Fast optical control of neural circuits: new tools and approaches"
11:25 am - 11:40 am Discussion
11:40 am - 11:55 am Short Talk: Leopoldo Petreanu (Janelia)
"Channelrhodopsin-2-assisted circuit mapping of cortical connections"
11:55 am - 12:20 pm George Augustine (Univ. Duke)
"Transgenic mice for optical interrogation of neural circuit function"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm DEVELOPMENT OF SYNAPSES AND CIRCUITS
7:30 pm - 7:35 pmDiscussion Leader: Wade Regehr (Univ. Harvard)
"Introductory remarks"
7:35 pm - 8:00 pmLynn Landmesser (Univ. Case Western Reserve, Ohio)
"NCAM isoforms in presynaptic maturation and function"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Vivian Budnik (Univ. Massachusetts)
"Trans-synaptic signaling through the Wnt pathway"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Mu-Ming Poo (Univ. California, Berkeley)
"Entrained rhythmic neuronal activity as short-term perceptual memory of time interval"
9:20 pm - 9.30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm SYNAPSES AND DISEASE
9:00 am - 9:05 amDiscussion Leader: Roberto Malinow (Cold Spring Harbor)
"Introductory remarks"
9:05 am - 9:35 amDavid Attwell (Univ. College London, UK)
"Neurotransmitter signalling to oligodendrocytes and their precursors in health an disease"
9:35 am - 9:50 am Discussion
9:50 am - 10:20 amJames Surmeier (Univ. Northwestern, Chicago)
"Dopaminergic modulation of striatal synaptic plasticity - the king has no clothes"
10:20 am - 10:40 am Discussion
10:40 am Coffee Break
11:10 am - 11:35 amJochen Herms (Univ. München LMU, Germany)
"In vivo 2-photon imaging in neurodegenerative diseases: Tracking down structural correlates of synaptic failure"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pmDavid Sulzer (Univ. Columbia, New York)
"Selection of individual cortical and dopamine terminals in the striatum"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session IV
6:00 pmDinner
7:30 pm - 9:30 pm SYNAPTIC PLASTICITY
7:30 pm - 7:35 pmDiscussion Leader: Pablo Castillo (Albert Einstein College, New York)
"Introductory remarks"
7:35 pm - 8:00 pm Yang Dan (Univ. California, Berkeley)
"Reverberation of recent visual experience in spontaneous cortical waves"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:40 pmChristian Lüscher (Univ. Geneva, Switzerland)
"Drug-induced synaptic plasticity in the mesolimbic dopamine system"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmAlison Barth (Univ. Pittsburgh)
"Sensory experience triggers NMDAR-dependent metaplasticity"
9:20 pm - 9.30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible in part by R13 NS062472 from the National Institute of Mental Health (NIMH), National Institute of Neurological Disorders and Stroke (NINDS), and National Institute on Drug Abuse (NIDA). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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