Gordon Research Conferences
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Conference Program
 
Mechanisms of Toxicity
July 27 - August 1, 2008
Bates College
Lewiston, ME
Chair:
Mary K. Walker

Vice Chair:
Ruth Roberts

There is growing evidence that environmental agents, such as pollutants, pesticides, and natural toxins, contribute to the etiology and pathogenesis of major chronic diseases in the U.S. and worldwide, including cancer, pulmonary disease, cardiovascular disease, and neurodegenerative disorders. In addition, the interaction of these environmental exposures with diet, pharmaceutical agents, genetics, and age, can have detrimental influences on disease incidence and prognosis. Thus, a new frontier in environmental sciences and human health is being defined by research into toxicant-risk factor interactions in chronic disease etiology and pathogenesis. At this Gordon Research Conference research presentations and discussions will focus on the interplay between environmental exposures and disease risk factors on the development and progression of chronic diseases. Abstract submissions for poster presentations are invited in any area of toxicology.


Contributors
Financial support for the meeting was generously provided by:

Astrazeneca
CIIT Center for Health Research
Cell Press
Eli Lilly and Company
International Society for the Study of Xenobiotics
Johnson & Johnson Corporate
National Institute of Environmental Health Sciences
Pfizer Inc.
Society of Toxicology
The Procter & Gamble Company

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pm Gene-Environment Interactions and Skin Cancer
Chair: Hollie I. Swanson (University of Kentucky)
Discussion Leader: Lori White (Rutgers University)
7:35 pm - 7:55 pmAdam Glick (The Pennsylvania State University)
"Regulation of tumor promotion and progression by TGFβ"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:25 pmDaret St. Clair (University of Kentucky)
"Mitochondria and skin cancer: New facet in an old partnership"
8:25 pm - 8:55 pm Discussion
8:55 pm - 9:15 pmRobert Smart (North Carolina State University)
"Multifaceted roles for C/EBPS in the DNA damage response network and skin tumorigenesis"
9:15 pm - 9:30 pm Discussion
9:30 pm Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Gene-Environment Interactions in Neurodegenerative Disease
Chair: Gary W. Miller (Emory University)
Discussion Leader: Richard F. Seegal (New York State Department of Health)
9:00 am - 9:30 amKurt D. Pennell (Georgia Institute of Technology)
"Analysis of persistent organic pollutants in postmortem brain samples"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 amCoffee Break / Group Photo (10:00 am)
10:15 am - 10:45 amAlberto Ascherio (Harvard School of Public Health)
"Epidemiological approaches to gene-environment interactions in neurodegenerative diseases"
10:45 am - 11:00 am Discussion
11:00 am - 11:30 amMike Caudle (University of Washington)
"Biomarkers of environmental exposure in Parkinson’s and Alzheimer’s disease"
11:30 pm - 11:45 am Discussion
11:45 am - 12:30 pm Late Breaking Research
Chair: Mike Gallo (Rutgers University)
Presenters:
Ron Hines (Medical College of Wisconsin)
Bhagavatula Moorthy (Baylor College of Medicine)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pm Global Pediatric Environmental Health
Chair: Tee Guidotti (George Washington University)
7:30 pm - 7:55 pmSusan L. Schanz (University of Illinois, Urbana-Champaign; FRIENDS Children's Environmental Health Center)
"Persistent Toxic Substances and the Risks to Children"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmMary S. Wolff (Mt. Sinai Children's Center)
"Endocrine disruptors, neurodevelopment, and children in the urban built environment"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Rosalba Rojas-Martinez (Instituto Nacional de Salud Publica Cuernavaca)
"Lung function growth in children and adolescents with long-term exposure to air pollutants in Mexico City"
9:15 pm - 9:30 pm Discussion
9:30 pm Reception
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Epigenomics of Environment and Disease
Chair: Ruth Roberts (Astrazeneca)
Discussion Leader: Jay Goodman (Michigan State University)
9:00 am - 9:30 amJonathan Moggs (Novartis, Basle)
"Perturbation of epigenetic status by drugs, diet and toxicants"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 amAlvaro Puga (University of Cincinnati)
"Chromatin remodeling by heavy metals"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:30 amRadhika Das (Duke University Medical Center)
"Adult disease susceptibility: epigenetic manifestation of environmental exposures"
11:30 pm - 11:45 am Discussion
11:45 am - 12:30 pm Late Breaking Research
Chair: Ron Hines (Medical College of Wisconsin)
Presenters:
Emma Taylor (Emory University)
Arthur Penn (Louisiana State University)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pm Transgenic Tools to Study Complex Disease Processes
Chair: Frank Gonzalez (NCI)
Discussion Leader: Lisa Cassis (University of Kentucky)
7:30 pm - 7:55 pmFrank Gonzalez (NCI)
"Humanized mouse models for xenobiotic receptors to assess human risk assessment and mechanism of toxicities of xenobiotics"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmDaniel Nebert (University of Cincinnati)
"Metal-induced disease: using mouse models to elucidate the etiology of testicular necrosis, renal proximal tubular metabolic acidosis, and osteomalacia"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmThomas N. Ferraro (University of Pennsylvania)
"Mouse models for studying genetic influences on complex traits and behaviors related to epilepsy"
9:15 pm - 9:30 pm Discussion
9:30 pm Reception
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Air Pollution, Genetics, and Cardiovascular Disease
Chair: Robert D. Brook (University of Michigan)
Discussion Leader: Sanjay Rajagopalan (Davis Heart & Lung Research Institute)
9:00 am - 9:30 amTimothy R. Nurkiewicz (West Virginia University)
"Induction of Extra-pulmonary Microvascular Inflammation by Airborne Particle Exposure"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 amJesus Araujo (University of California - Los Angeles)
"Genetic Footprint in the Cardiovascular Effects of Air Pollutants"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:30 amJoel Schwartz (Harvard School of Public Health)
"Genetic Determinants of Responses to Air Pollution in Humans"
11:30 pm - 11:45 am Discussion
11:45 am - 12:30 pm Late Breaking Research
Chair: Scott Burchiel (University of New Mexico)
Presenters:
Flavia Moreira-Leite (Astrazeneca)
Tom Cherng (University of New Mexico)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pm Genetics of Drug-Induced Hepatotoxicity
Chair and Discussion Leader: Ian Cotgreave (Astrazeneca)
7:30 pm - 7:55 pm Ann Daly (Newcastle University)
"Genetics of antimicrobial-induced cholestasis"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Raul Andrade (University of Malaga)
"HLA variance in human hepatic disease and drug toxicity"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Martin Armstrong (Astrazeneca)
"Genetic factors in the response of patients to Ximelagatran"
9:15 pm - 9:30 pm Discussion
9:30 pm Reception
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pm Role of Genetics and Air Pollution in Asthma
Chair: David Peden (University of North Carolina, Chapel Hill)
Discussion Leader: David Diaz-Sanchez (USEPA)
9:00 am - 9:30 am Steve Kleeberger (NIEHS)
"Air pollution toxicity in the lung: genetic susceptibility"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Frank Gilliland (University of Southern California)
"Role of genetic susceptibility to air pollutants in childhood asthma"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:30 am Neil E. Alexis (University of North Carolina)
"Investigation of Environmental Asthma: Human Studies Using Controlled Exposures to Airborne Pollutants"
11:30 am - 11:45 am Discussion
11:45 am - 12:30 pm Late Breaking Research
Chair: Dan Petersen (USEPA)
Presenters:
Autumn Bernal (Duke University)
Yasunobu Aoki (NIEHS)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 8:45 pm Keynote Speaker
7:30 pm - 7:35 pm Mary K. Walker (University of New Mexico Health Sciences Center)
7:35 pm - 8:25 pmLarry Marnett (Vanderbilt University)
"COX2 Inhibitors: The Promise and the Problems"
8:25 pm - 8:45 pm Discussion
8:45 pm Reception
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible by 5U13ES015077-03 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade name, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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