Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Viral Vectors for Gene Therapy, The Science of
March 2-7, 2008
Crowne Plaza
Ventura, CA
Chair:
Paul D. Robbins

Vice Chair:
Luigi Naldini

Gene transfer has the potential to treat innumerable genetic and acquired diseases. Although viral vectors remain the most efficient means of gene delivery, further progress in understanding the fundamental biology of viruses, their special relationships with the host including mechanisms of infection, persistence, gene expression and immune evasion is required for successful virus-mediated gene therapy. Thus the focus of this meeting is to examine the host response, in particular the immune response, to viral infection and how to regulate it. The meeting will bring together immunologists, virologists and gene therapists to discuss this important aspect of gene therapy. The gathering of experts in fields of gene therapy, basic virology and immunology offers a unique opportunity to find solutions to new challenges in this field of regulating the host immune response to viral gene transfer. The design of this conference is to provide a detailed scientific overview of specific aspects of virus biology that relate to the immune response and the use of this knowledge to enhance effective gene delivery, resulting in successful gene therapy. Each session will have speakers with expertise in viral vectors, the host response to viral infection or immunology. In addition to the invited speakers per session, additional speakers will be selected from the submitted abstracts.


Contributors

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:10 pm Immune Response to Viral Vectors
Discussion Leader: Paul Robbins (University of Pittsburgh)
7:50 pm - 8:50 pmKatherine High (The Children’s Hospital of Philadelphia)
"Host Responses to Viral Vectors: The Final Frontier?"
8:50 pm - 9:10 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Biodistribution and Targeting
Discussion Leader: John Engelhardt (The University of Iowa)
9:00 am - 9:25 am R. Jude Samulski (The University of North Carolina)
"Clinical Update from Gene Therapy Trial for DMD"
9:25 am - 9:35 am Discussion
9:35 am - 10:05 amRenata Pasqualini & Wadih Arap (The University of Texas)
"Ligand-Directed Vascular Targeting and Molecular Imaging"
10:05 am - 10:15 am Discussion
10:15 amGroup Photo
10:45 am Coffee Break
11:15 am - 11:40 amRichard Vile (The Mayo Clinic)
"Immune Cells as Carriers of Oncolytic Viruses to Treat Metastatic Tumours"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm David Schaffer (University of California at Berkeley)
"Molecular Evolution of Novel Viral Gene Delivery Vehicles"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pm Viral Entry and Nuclear Translocation
Discussion Leader: R. Jude Samulski (The University of North Carolina)
7:30 pm - 7:50 pmJohn Engelhardt (The University of Iowa)
"Endosomal Processing of rAAV2"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmArun Srivastava (The University of Florida)
"The Next Generation of Recombinant AAV Vectors"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Mark A. Kay (Stanford University School of Medicine)
"Combining Gene Therapy and RNAi for treating human disease"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Anthony Welch (National Cancer Institute)
"Developing Viral Vectors for Phase I Cancer Trials: Manufacturing and Toxicology Challenges"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Host Cell Response to Viral Infection
Discussion Leader: Joseph Glorioso (University of Pittsburgh)
9:00 am - 9:25 amKaren Mossman (McMaster University)
"The Innate Immune Response to Enveloped Virus Vectors"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Erik Falck-Pedersen (Weill Cornell Medical College)
"Antigen Presenting Cell Activation by Adenovirus Vectors"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 amPaola Grandi (University of Pittsburgh)
"Innate Immune Responses Limit HSV Oncolysis"
10:35 am - 10:45 am Discussion
10:45 am Coffee Break
11:10 am - 11:35 am Jay Nelson (Oregon Health & Sciences University)
"CMV encoded miRNAs"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 amJarrod Johnson (University of North Carolina)
"Subcellular processing of AAV2 generates a population of proteolytically modified virions that accumulate in the nucleolus and retain infectivity"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:20 pmMichael Holmes (Sangamo)
"Controlling HIV in vivo - Establishment of HIV Resistant CD4 T Cells by Engineered Zinc Finger Protein Nucleases"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pm Innate Immune Response to Viral Infection
Discussion Leader: James Wilson (The University of Pennsylvania)
7:30 pm - 7:50 pmDaniel Muruve (University of Calgary)
"The Innate Immune Response to DNA"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmGlen R. Nemerow (The Scripps Research Institute)
"Neutralization of Adenovirus by Naturally Occurring Antimicrobial Peptides"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmYiping Yang (Duke University Medical Center)
"Innate Immune Response to Viral Vectors"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Sander van Deventer (Amsterdam Molecular Therapuetics)
"Immunogenicity of AAV gene therapy vectors"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Adaptive Immune Response to Viral Infection
Discussion Leader: Luigi Naldini (Fondazione San Raffaele del Monte Tabor)
9:00 am - 9:25 amAndrea Amalfitano (Michigan State University)
"Adenovirus Interactions with the Innate and Adaptive Arms of the Immune System"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amJames Wilson (The University of Pennsylvania)
"The Impact of T Cell Responses on the Safety and Efficacy of DNA Viral Vectors"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 amLuca Guidotti (The Scripps Research Institute)
"Platelets Mediate Adaptive Immune Responses to Viral Vectors"
10:35 am - 10:45 am Discussion
10:45 am Coffee Break
11:10 am - 11:35 am Pedro Lowenstein (Cedars-Sinai Medical Center)
"The molecular and cell biology of T-cell mediated elimination of adenovirus transduced brain cells: implications for clinical gene therapy"
11:35 am - 11:45 am Discussion
11:45 am - 12:05 pmAbraham Scaria (Genzyme Corporation)
"Adaptive immune responses"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmAnn Galy (Genethon)
"Micro RNA 142.3p-regulated vectors enable long-term AAV1-mediated gene transfer in skeletal muscle through the active suppression of transgene-specific CD4 and CD8 T cell immune responses"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (if needed)
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Approaches to Blocking the Immune Response to Viral Infection
Discussion Leader: Malcolm Brenner (Texas Children’s Hospital)
7:30 pm - 7:50pmLuigi Naldini (Fondazione San Raffaele del Monte Tabor)
"Targeting Gene Transfer to Enhance the Efficacy and Safety of Gene Therapy for Inherited Diseases and Cancer"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmRoland Herzog (The University of Florida)
"Immune Tolerance Induction to Therapeutic Proteins by Heptatic Gene Transfer"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Maria Grazia Roncarolo (San Raffaele Telethon Institute for Gene Therapy)
"Role of tolerogenic cells to modulate immune response to transgenes"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm John Iacomini (Harvard Medical School)
"Developing gene therapy approaches to induce immunological tolerance"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Suppression of the Immune Response by Gene Transfer
Discussion Leader: Maria Grazia Roncarolo (Fondazione San Raffaele)
9:00 am - 9:25 amPaul Robbins (University of Pittsburgh)
"Treatment of autoimmune diseases using immunosuppressive DC-Derived Exosomes"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 amThierry VandenDriessche (University of Leuven)
"Viral transduction of antigen-presenting cells: a double-edged sword?"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 amDavid Scott (The University of Maryland)
"Gene Therapy for Autoimmunity and Hemophilia: Role of B Cells as Tolerogenic Antigen Presenting Cells"
10:35 am - 10:45 am Discussion
10:45 am Coffee Break
11:10 am - 11:35 amGarrison Fathman (Stanford University Medical Center)
"DC’s Expressing IL-4 to Prevent and Possibly Treat T1D in NOD Mice"
11:35 am - 11:45 am Discussion
11:45 am - 12:10 pm Barrie J. Carter, Ph.D (Targeted Genetics Corporation)
"Intra-articular delivery of an AAV vector for inflammatory joint disease: Comparison of preclinical and clinical studies"
12:10 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm Stimulation of the Immune Response by Gene Transfer
Discussion Leader: Garrison Fathman (Stanford University Medical Center)
7:30 pm - 7:50 pmCarl June (The University of Pennsylvania)
"Lentiviral Vectors with Antisense HIV Payloads: Hitting the Target?"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmMalcolm K. Brenner (Texas Children’s Hospital)
"Gene Transfer to Harness the Immune Response Against Cancer"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmGlenn Dranoff (Dana-Farber Cancer Institute)
"Balancing Tumor Immunity and Inflammatory Pathology"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmMarjorie Robert-Guroff (National Cancer Institute, NCI/NIH)
"Replication-Competent Adenovirus Vectors as Vehicles for HIV Vaccine Delivery"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL091555-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter