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Angiogenesis
August 2-7, 2009
Salve Regina University
Newport, RI
Chair:
Donald M. McDonald

Vice Chair:
Lena Claesson-Welsh

The 2009 Angiogenesis Gordon Conference brings together an interdisciplinary group of international scientists to examine state-of-the-art mechanisms of blood vessel formation, growth, regression, alteration in disease, and response to therapy. Use of angiogenesis inhibitors in cancer and eye disease has documented efficacy but has also led to puzzles, paradoxes, and controversies about the mechanism and consequences of their actions. In light of the evolving understanding and expectations, the conference explores the attributes and limitations of current strategies and downstream effects of promoting or blocking angiogenesis in pathological conditions.

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Keynote Presentations: Angiogenesis - Puzzles, Paradoxes & Controversies
7:40 pm - 7:50 pmDiscussion Leader: Donald McDonald (UCSF)
"Puzzles, paradoxes, and controversies in angiogenesis research"
7:50 pm - 8:30 pmKari Alitalo (University of Helsinki)
"Buzzing and puzzling about VEGFs and Ties"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:20 pm Andras Nagy (University of Toronto)
"VEGF-A is a double-edged sword"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Advances in Endothelial Cell Biology in Angiogenesis
9:00 am - 9:15 amDiscussion Leader: Lena Claesson-Welsh (Uppsala University)
"Endothelial cell adaptation: what's on the menu?"
9:15 am - 9:35 amMichael Detmar (ETH Zürich)
"Mechanisms of vascular lineage-specific differentiation and function"
9:35 am - 9:45 am Discussion
9:45 am - 9:55 am Victoria Bautch (University of North Carolina)
"The puzzle of VEGF-directed vessel patterning: gradients are not enough"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo (10:15 am)
10:30 am - 10:50 amLuisa Iruela-Arispe (University of California Los Angeles)
"Growth factor circuitry in vascular morphogenesis"
10:50 am - 11:00 am Discussion
11:00 am - 11:10 amRichard Hynes (Massachusetts Institute of Technology)
"Integrin redundancy in angiogenesis"
11:10 am - 11:15 am Discussion
11:15 am - 11:35 amRaghu Kalluri (Harvard University)
"Diverse role of mesenchymal cells in cancer progression and metastasis"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 amMichael Klagsbrun (Harvard Medical School)
"Multipotent tumor endothelial cells"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:20 pmCalvin Kuo (Stanford University)
"Mechanisms of CNS-specific angiogenesis regulation"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Advances in VEGF Biology in Angiogenesis
7:30 pm - 7:45 pmDiscussion Leader: Masabumi Shibuya (University of Tokyo)
"Puzzles and paradoxes in VEGF-VEGFR signaling"
7:45 pm - 8:05 pmNapoleone Ferrara (Genentech)
"G-CSF effects on VEGF-driven angiogenesis"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:35 pmHolger Gerhardt (London Research Institute - Cancer Research UK)
"VEGF and Notch in tip and stalk cell selection: a puzzle solved?"
8:35 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Ileana Cuevas (University of California San Francisco)
"Inhibition of angiogenesis by HoxA5"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmEli Keshet (Hebrew University, Jerusalem)
"Non-angiogenic functions of VEGF"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Advances in Non-VEGF Driven Angiogenesis
9:00 am - 9:15 amDiscussion Leader: Christer Betsholtz (Karolinska University)
"How many players are enough?"
9:15 am - 9:35 amRalf Adams (Max Planck Institute, Münster)
"Resolving the enigma of ephrin-B2 in angiogenesis"
9:35 am - 9:45 am Discussion
9:45 am - 9:55 am Rong Wang (University of California San Francisco)
"Endothelial signaling in arterial venous specification"
9:55 am - 10:00 am Discussion
10:00 am - 10:20 amGou Young Koh (KAIST, Daejeon, Korea)
"Interactive and counteractive roles between Angiopoietin-1 and Angiopoietin-2 in angiogenesis"
10:20 am - 10:30 am Discussion
10:30 am - 10:40 am Jon Oliner (Amgen)
"Contrasting but complementary actions of Angiopoietin-1 and Angiopoietin-2 inhibitors on tumor angiogenesis"
10:40 am - 10:45 am Discussion
10:45 am Coffee Break
11:15 am - 11:35 amHellmut Augustin (DKFZ and Heidelberg University)
"Pieces of the puzzle: New roles for old friends"
11:35 am - 11:45 am Discussion
11:45 am - 12:05 pm Michele De Palma (San Raffaele Telethon Institute, Milan)
"Monocyte heterogeneity in blood and tumors: implications for tumor angiogenesis and anti-angiogenic therapy"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pmCharlotte Rolny (Uppsala University)
"Altering macrophage phenotype inhibits tumor growth while tumor vessel functionality is improved"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Advances in Signaling in Angiogenesis
7:30 pm - 7:45 pmDiscussion Leader: Michael Simons (Yale University)
"What is my signal doing?"
7:45 pm - 8:05 pmPeter Carmeliet (University of Leuven)
"Oxygen sensors in angiogenesis: from genetic insights to therapeutic potentials"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:35 pmJan Kitajewski (Columbia University)
"Diverse mechanisms of Notch function in angiogenesis"
8:35 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Xin Ye (Johns Hopkins University)
"Norrin, Frizzled4, and Lrp5 signaling controls a genetic program for endothelial cell development"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmLaura Benjamin (ImClone Systems)
"Novel molecular pathways that regulate angiogenesis and lymphangiogenesis"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Advances in Angiogenesis in Development
9:00 am - 9:15 amDiscussion Leader: Roy Bicknell (University of Birmingham, UK)
"Functional controversies around endothelial genes"
9:15 am - 9:35 amEckhard Lammert (Heinrich-Heine-University of Düsseldorf)
"Vascular lumen formation in the dorsal aorta"
9:35 am - 9:45 am Discussion
9:45 am - 9:55 amKe Xu (University of Texas Southwestern Dallas)
"Requirement of endothelial-specific Ras effector Rasip1 for vascular lumen formation in mouse embryos"
9:55 am - 10:00 am Discussion
10:00 am - 10:20 amDean Li (University of Utah)
"Molecular mechanisms of endothelial tube formation"
10:20 am - 10:30 am Discussion
10:30 am - 10:40 am Ann Zovein (University of California Los Angeles)
"Keeping endothelial polarity on PAR with beta-1 integrin"
10:40 am - 10:45 am Discussion
10:45 am Coffee Break
11:15 am - 11:35 amBrant Weinstein (National Institutes of Health)
"Lipoproteins, VEGFR-1, and angiogenesis"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Shahin Rafii (Weill Cornell Medical College, New York)
"Contribution of the sinusoidal vascular niche to stem cell expansion"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:20 pmAnne Eichmann (INSERM, Collège de France, Paris)
"Lessons about vascular patterning in development"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Advances in Endothelial Barrier Function
7:30 pm - 7:45 pmDiscussion Leader: Harold Dvorak (Beth Israel Deaconess Medical Center, Harvard Medical School)
"Vascular permeability: three distinct types"
7:45 pm - 8:05 pmDavid Cheresh (University of California San Diego)
"VEGF actions on pericyte function"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:35 pmElisabetta Dejana (IFOM-IEO Campus, Milan)
"Wnt signaling in vascular development"
8:35 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Dörte Schulte (Max Planck Institute, Münster)
"Locking endothelial cell contacts via VE-cadherin"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmDietmar Vestweber (Max Planck Institute, Münster)
"VE-PTP as regulator of endothelial barrier function"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Advances in Angiogenesis in Tumor Invasion & Metastasis
9:00 am - 9:15 amDiscussion Leader: Gavin Thurston (Regeneron)
"Tumor cell behavior in a changing environment: threats and opportunities"
9:15 am - 9:35 amGabriele Bergers (University of California San Francisco)
"Pro-invasive growth of glioma during VEGF inhibition"
9:35 am - 9:45 am Discussion
9:45 am - 9:55 am Melanie Demers (Harvard Medical School)
"Targeting platelet function to improve drug delivery to tumors"
9:55 am - 10:00 am Discussion
10:00 am - 10:20 amOriol Casanovas (Catalan Institute of Oncology, Barcelona)
"Mechanisms of tumor aggressiveness after antiangiogenic therapies"
10:20 am - 10:30 am Discussion
10:30 am - 10:40 amBarbara Sennino (University of California San Francisco)
"Inhibition of tumor invasiveness by c-Met/VEGFR blockade"
10:40 am - 10:45 am Discussion
10:45 am Coffee Break
11:15 am - 11:35 amPeter Friedl (University of Nijmegen, The Netherlands)
"Vessel-associated collective cancer invasion and resistance"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Allison Betof (Duke University)
"Hypoxia markers and angiogenic signals predict anthracycline sensitivity in early stage breast cancer"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:20 pmSandra McAllister (Harvard Medical School)
"Osteopontin-dependent activation of dormant tumors"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Advances in Angiogenesis Inhibition
7:30 pm - 7:45 pmDiscussion Leader: Gerhard Christofori (University of Basel)
"Variations on angiogenesis inhibition"
7:45 pm - 8:05 pmRakesh Jain (Harvard University)
"Puzzles & surprises from pre-clinical and clinical studies of angiogenesis inhibitors"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:25 pmAndrew Reynolds (Institute of Cancer Research, London)
"Paradoxical pharmacodynamics of angiogenesis inhibitors"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Robert Kerbel (University of Toronto)
"A paradox in the making: will antiangiogenic drugs be more effective for metastatic disease than as neo-adjuvant or adjuvant therapies?"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmHerbert Hurwitz (Duke University)
"Puzzles and surprises in clinical use of angiogenesis inhibitors"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
 
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