Gordon Research Conferences
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Conference Program
 
Bioorganic Chemistry
June 14-19, 2009
Proctor Academy
Andover, NH

The Gordon Research Conference on Bioorganic Chemistry was founded in 1992 to bring together scientists from a range of disciplines to present and discuss cutting-edge research at the interface between chemistry and biology. Both fundamental and applied research relevant to academia and industry are highlighted. To maintain a balance between these areas, the conference is organized by two co-chairs, one from academia and one from industry. The conference emphasizes the presentation of techniques or approaches that are broadly applicable across multiple areas of chemical and biological research. Traditionally, small molecules that probe, modulate, or mimic cellular components or processes as well as studies of biology at the molecular level have been of particular interest.

The meeting in 2009 will continue the tradition of showcasing interdisciplinary biological research in the areas of metabolomics, medicinal chemistry and drug discovery, infectious disease, cell signaling, natural products, and peptides and biomaterials. All conferees are encouraged to present posters. Poster presenters should submit an abstract with their applications on the GRC web site. Eight poster presenters will be invited to present short talks. Given the popularity of this meeting, submission of applications by early 2009 is strongly encouraged.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:30 pm - 9:30 pm VIRAL SCOURGES: ADVANCING DRUG DESIGN
Discussion Leader: Alexey Lugovsky (BiogenIdec)
7:35 pm - 8:05 pmAnn Kwong (Vertex)
"Reducing Risk in Drug Discovery: Preclinical Development of the Hepatitis C Virus Protease Inhibitor Telaprevir (VX-950)"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pmDiane Joseph-McCarthy (AstraZeneca)
"Fragment Screening for Drug Discovery"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:25 pmCarlos Simmerling (Stony Brook)
"Computational studies of HIV-1 protease, a model system for the role of receptor dynamics in ligand binding and drug resistance"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm BACTERIAL TREASURE TROVES: MAKING THE GOLD
Discussion Leader: Edward Driggers (Agios)
9:00 am - 9:30 amJoseph Noel (Salk)
"Peeling Back the Layers of Time: Reconstructing the Evolutionary History of Nature's Biosynthetic Toolbox"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 am Poster Talk #1: Rebecca Butcher (Harvard Med)
"Small-molecule Pheromones Controlling C. elegans Development and their Biosynthesis"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:00 amDavid Cane (Brown)
"Nature's Dirty Secrets: Genome Mining in Streptomyces"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 amBrian Bachman (Vanderbilt)
"Dissecting and Directing Biosynthesis of Drugs by Bacteria"
11:40 am - 11:50 am Discussion
11:50 am - 12:05 pm Poster Talk #2: Clay Wang (USC)
"Mining the Fungal Secondary Metabolome Using Genetic Tools"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Poster Talk #3: Emily Weinert (UC Berkeley)
"Controlling Oxygen Affinity in Tt H-NOX: Progress Towards a Potential Blood Substitute"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm NEW MATERIALS: BLOOD, SWEAT & TEARS
Discussion Leader: Yomi Oyelere (Georgia Tech)
7:30 pm - 8:00 pmJerry Yang (UCSD)
"Designing Functional Molecular Assemblies on Biological Surfaces"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmGregory Tew (U Mass Amherst)
"Antimicrobial and Cell Penetrating Peptide Mimics From Simple Scaffolds: New Insight Into Molecule-Membrane Interactions"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmRon Kluger (Toronto)
"Keeping Artificial Blood Flowing: Enhanced Nitrite Reductase Activity of Chemically Altered Hemoglobins"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm MOLECULAR DIAMONDS: BUILDING MULTIFACETED PEPTIDES
Discussion Leader: Isaac Carrico (Stony Brook)
9:00 am - 9:30 amDehua Pei (Ohio State)
"Combinatorial Chemistry: From Cell Signaling to Catalyst Development"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 am Poster Talk #4: Joshua Kritzer (MIT/Tufts)
"Rapid chemical genetics using cyclic peptides: Application to cellular and animal models of Parkinson's disease"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:00 amFelicia Etzkorn (Virginia Tech)
"Conformational Regulation of the Cell Cycle: Cdc2 Kinase is Specific for Ser-trans-Pro Substrate"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 amJohn Robinson (Zurich)
"Protein Epitope Mimetics in Chemical Biology"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pmHelma Wennemers (Basel)
"Bioinspired Chemistry Using the Many Faces of Peptides"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm TRACKING CANCER AND PUTTING ON THE BRAKES
Discussion Leader: Zev Gartner (UCSF)
7:30 pm - 8:00 pmLisa Shewchuk (GSK)
"Discovery of an Inhibitor of IGF1R Activation: Implications for Cellular Potency and Selectivity over Insulin Receptor"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmPatrick Zarrinkar (Ambit)
"Unlocking Value in Chemical Libraries: Inhibitor Discovery Driven by High Throughput Kinase Profiling"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmMark Mulvihill (OSI)
"The Discovery of OSI-906: A Novel, Potent, Orally Bioavailable Imidazopyrazine-derived Insulin-Like Growth Factor-I Receptor (IGF-1R) Inhibitor with Antitumor Activity"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm BACTERIAL SCOURGES: TRYING TO OUTSMART THEM
Discussion Leader: Danica Fujimori (UCSF)
9:00 am - 9:30 amEric Brown (McMaster)
"Chemical Genomics: Charting Chemical-Genetic Interactions in Bacteria"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 am Poster Talk #5: Samantha Shanley (Oxford)
"A ‘GlycoPore’ for Bacterial Sensing"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:00 amGrant Walkup (AstraZeneca)
"Novel DNA Gyrase Inhibitors: Fragment-Based NMR Screening to Antibacterial Agents"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 amCarl Nathan (Cornell-Weill)
"Chemical Biology of Non-Replicating Mycobacterium Tuberculosis"
11:40 am - 11:50 am Discussion
11:50 am - 12:05 pm Poster Talk #6: Herman Sintim (U Maryland)
"New Isothermal Strategies for the Detection Of Disease Biomarkers - from Junction Probes to DNAzymes"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Poster Talk #7: Deborah Rothman (Novartis)
"Novel Targets for Disease Pathways: A Chemical Genetics Approach"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm MONITORING METABOLITES: NEEDLE IN THE HAYSTACK
Discussion Leader: Ranabir Sinha Roy (Merck)
7:30 pm - 8:00 pmAmy Palmer (Colorado)
"Tools for Real-Time Imaging of Host-Pathogen Interactions"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmMichelle Reyzer (Vanderbilt)
"MALDI Mass Spectrometry: A New Tool For Metabolite Imaging"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmPeter Beal (Davis)
"The Chemistry of RNA Recoding by Adenosine Deamination"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm INVASION OF MOLECULAR SYNTHESIS: TO ACTIVATORS & BEYOND!
Discussion Leader: Rami Hannoush (Genentech)
9:00 am - 9:30 amJim Hartman (Cytokinetics)
"Get Your Motors Runnin’: Activating Sarcomeres with Small Molecules"
9:30 am - 9:40 am Discussion
9:40 am - 9:55 am Poster Talk #8: Shin Mizuakmi (Osaka)
"Development of MRI Probes for Detecting Biological Signals"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:00 amSergey Kozmin (Chicago)
"Practical Organic Synthesis to Unravel Chemical Biology of Complex Natural Products"
11:00 am - 11:10 am Discussion
11:10 am - 11:40 amQing Lin (Buffalo)
"Photoinducible Bioorthogonal Chemistry: A New Tool for Chemical Biology"
11:40am - 11:50 am Discussion
11:50 am - 12:20 pmOrion Jankowski (Edison Pharma)
"Cellular Redox Signaling in Drug Discovery"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm FRONTIERS IN CHEMICAL BIOLOGY
Discussion Leader: Tamara Hendrickson (Wayne State)
7:30 pm - 8:00 pmBarbara Imperiali (MIT)
"Asparagine-linked Protein Glycosylation: Pathways and Processes"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmJoanna Fowler (Brookhaven National Lab)
"Imaging Addiction in the Human Brain"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmCarolyn Bertozzi (UC Berkeley)
"Interrogating the Glycome with Chemical Probes"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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