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Bones & Teeth
Stem Cells and Regulation of Bone Modeling and Regeneration
July 12-17, 2009
University of New England
Biddeford, ME
Chair:
Brendan F. Boyce

Vice Chair:
Bjorn R. Olsen
Related Meeting Information
The Bones & Teeth Gordon Research Conference was held in conjunction with the Bones & Teeth Gordon-Kenan Research Seminar. Please refer to the Bones & Teeth GKRS web page for more information.

The overall theme of the 2009 Bones and Teeth Gordon Research Conference will be ‘Stem cells and regulation of bone modeling and regeneration’ covering topics selected based on their emerging importance in skeletal biology (defined as bone, cartilage, teeth and associated soft tissue). The Program will include sessions on Cartilage Biology and Disease, Skeletal Development, Dental and Craniofacial Development, Genetics and Bone Diseases, Osteoblastic and Hematopoietic Stem Cells, Osteoimmunology, Bone Repair and Regeneration, and the Biological Basis of Bone Therapies. These sessions will be chaired by leaders in the field who will foster discussion among invited speakers and students and post-docs in a collegiate atmosphere. Through presentations and extensive discussion, new understanding of skeletal metabolism in health and disease will lead to continued development of new therapeutic strategies for common and rare bone diseases. A new development for the Bones and Teeth GRC this year is a Gordon Research Seminar. This will be a two-day seminar beginning on July 11, the day before the start of the GRC, to which post-docs and graduate students from the bone field will be invited to present their best unpublished research in the form of oral presentations and posters. The theme of the Seminar will be Advances in Understanding of Bone and Cartilage Development. Participants in the Seminar will be expected to remain for the whole of the GRC where they will have the opportunity to present their research and discuss their findings with senior members of the bone research community.

Contributors
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pm CARTILAGE BIOLOGY AND DISEASE
Discussion Leader: Bjorn R. Olsen (Harvard University, Boston, MA)
7:35 pm - 7:45 pm Bjorn Olsen: Overview
7:45 pm - 8:10 pmVeronique Lefebvre (Cleveland Clinic, Cleveland, OH)
"Roles of Sox genes in skeletogenesis"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:50 pmDanny Chan (The University of Hong Kong, Hong Kong, China)
"Mechanistic insights of an IHH mutation that causes digit abnormalities"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Lea Gunnell (University of Rochester Medical Center)
"Tak 1 Regulates Cartilage and Joint Development"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmMeina Wang (University or Rochester Medical Center)
"Overexpression of β-catenin in intervertebral disc cells leads to severe destruction of intervertebral disc tissue which is completely reversed by deletion of the Mmp13 gene"
9:25 pm - 9:30 pm Discussion
9:30 pm Welcome Reception
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm SKELETAL DEVELOPMENT
Discussion Leader: Yingzi Yang (National Institute of Health, Bethesda, MD)
9:00 am - 9:15 am Yingzi Yang: Overview
9:15 am - 9:45 amHenry M. Kronenberg (Harvard University, Boston, MA)
"The role of Gs alpha in osteoblast development"
9:45 am - 10:00 am Discussion
10:00 am - 10:15 am Coffee Break
10:15 am - 10:45 amXu Cao (University of Alabama at Birmingham, Birmingham, AL)
"TGFβ-Induced Migration of BMSCs to Couple Bone Resorption and Formation"
10:45 am - 11:00 am Discussion
11:00 am - 11:30 am Roland E. Baron (Harvard University, Boston, MA)
"Zinc Finger Protein 521: A new player in bone and cartilage"
11:30 am - 11:45 am Discussion
11:45 am - 11:55 amElazar Zelzer (Weizmann Institute of Science)
"Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pmXin Zhou (MD Anderson Cancer Center)
"Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
(Poster Numbers 1-44, ODD numbers presenting from 4:00 pm - 5:00 pm, EVEN Numbers presenting from 5:00 pm - 6:00 pm)
6:00 pmDinner
7:30 pm - 9:30 pm DENTAL AND CRANIOFACIAL DEVELOPMENT
Discussion Leader: Laurie Kay McCauley (University of Michigan, Ann Arbor, MI)
7:30 pm - 7:40 pm Laurie Kay McCauley: Overview
7:40 pm - 8:05 pm Yang Chai (University of Southern California, Los Angeles, CA)
"TGF-beta signaling and tooth development"
8:05 pm - 8:20 pm Discussion
8:20 pm - 8:45pmJan C. Hu (University of Michigan, Ann Arbor, MI)
"Genetic basis of enamel and dentin defects"
8:45 pm - 9:00 pm Discussion
9:00 pm - 9:10 pmYuji Mishina (University of Michigan, School of Dentistry)
"Smad-dependent BMP signaling through type IA receptor in cranial neural crest cells directs their cell fate towards chondrocytes"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmHwaseon Seo (University of Alabama at Birmingham)
"Tgfbr2 is required for development of the parietal bone"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm GENETICS AND BONE DISEASES
Discussion Leader: Brendan Lee (Baylor College of Medicine, Houston, TX)
9:00 am - 9:15 am Brendan Lee: Overview
9:15 am - 9:45 amFanxin Long (Washington University, St. Louis, MO)
"Notch as a brake for bone formation"
9:45 am - 10:00 am Discussion
10:00 am - 10:15 am Coffee Break
10:15 am - 10:45 amDaniel H. Cohn (University of California, Los Angeles, CA)
"Calcium channel defects in the skeletal dysplasias"
10:45 am - 11:00 am Discussion
11:00 am - 11:30 amValerie Cormier-Daire (INSERM, Paris, France)
"From the identification of ADAMTS10 and ADAMTSL2 mutations to the TGFβ signalling pathway"
11:30 am - 11:45 am Discussion
11:45 am - 11:55 amLeonie Huitema (Hubrecht Institute)
"Genetic screens to identify gene functions essential for bone formation"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pmMichael Sohaskey (University of California)
"Osteopotentia, a novel rER membrane protein, regulates osteoblast maturation and bone formation"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
(Poster Numbers 1-44, ODD numbers presenting from 5:00 pm - 6:00 pm, EVEN Numbers presenting from 4:00 pm- 5:00 pm)
6:00 pmDinner
7:30 pm - 9:30 pm BONE REPAIR AND REGENERATION
Discussion Leader: Regis J. O’Keefe (University of Rochester, Rochester, NY)
7:30 pm - 7:40 pm Regis J. O’Keefe: Overview
7:40 pm - 8:05 pm Johnny Huard (Children’s Hospital of Pittsburgh, Pittsburgh, PA)
"Bone Repair and Regeneration through Muscle Stem Cell Transplantation"
8:05 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Vicki Rosen (Harvard School of Dental Medicine, Boston, MA)
"BMPs and fracture healing"
8:45 pm - 9:00 pm Discussion
9:00 pm - 9:10 pmEric Hesse (Harvard School of Dental Medicine)
"Genetic Evidence of Runx2 Antagonism by Zfp521: Enhancement of the Cleidocranial Dysplasia Phenotype in Runx2 Heterozygous Mice and Partial Rescue of Long Bone Fractures in Col 1-Runx2 Transgenic Mice"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmChrista Maes (K.U.Leuven)
"Increased skeletal VEGF enhances beta-catenin activity and results in excessive ossification and disruption of the bone and marrow microenvironment"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm OSTEOIMMUNOLOGY
Discussion Leader: Yongwon Choi (University of Pennsylvania, Philadelphia, PA)
9:00 am - 9:05 am Yongwon Choi: Overview
9:05 am - 9:35 amHiroshi Takayanagi (Tokyo Medical and Dental University, Tokyo, Japan)
"New immune regulator of bone metabolism"
9:35 am - 9:50 am Discussion
9:50 am - 10:05 am Coffee Break
10:05 am - 10:35 amMichael Cancro (University of Pennsylvania, Philadelphia, PA)
"Bi-directional cross talk links osteoclastogenesis with long lived plasma cell differentiation"
10:35 am -10:50 am Discussion
10:50 am - 11:20 amGeorg Schett (University of Erlangen-Nuremberg, Erlangen, Germany)
"Control of bone mass by regulatory T cells"
11:20 am - 11:35 am Discussion
11:35 am - 11:45 amLaura Maile (University of North Carolina at Chapel Hill)
"Regulation of osteoclast formation by integrin associated protein"
11:45 am - 11:50 am Discussion
11:50 am - 12:00 pmToshifumi Sugatani (Washington University School of Medicine)
"Impaired MicroRNA Homeostasis Diminishes Osteoclast Formation and Activity"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:15 pmZhenqiang Yao (University of Rochester Medical Center)
"Axis of TRAF3 and NF-kappa B2 p100 Limits TNF-Induced Osteoclastogensis"
12:15 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
(Poster Numbers 45-88, ODD numbers presenting from 4:00 pm - 5:00 pm, EVEN Numbers presenting from 5:00 pm - 6:00 pm)
6:00 pmDinner
7:30 pm - 9:30 pm OSTEOBLASTIC AND HEMATOPOIETIC STEM CELLS
Discussion Leader: Paul J. Simmons (University of Texas, Houston, TX)
7:30 pm - 7:40 pm Paul J. Simmons: Overview
7:40 pm - 8:05 pmLinheng Li (Stowers Institute for Medical Research, Kansas City, MO)
"The stem cell niche in bone"
8:05 pm - 8:20 pm Discussion
8:20 pm - 8:45 pmPaolo Bianco (La Sapienza University, Rome, Italy)
"Microvascular niches in hematopoietic and non-hematopoietic systems"
8:45 pm - 9:00 pm Discussion
9:00 pm - 9:10 pmChristina Hammond (Hubrecht Institute)
"Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signaling"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pmSumithra Urs (Maine Medical Center Research Institute)
"Sproutyl Expression Influences PPARγ- Dependent Allocation of Mesenchymal Stem Cell Populations"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:40 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pm THE BIOLOGICAL BASIS OF BONE THERAPIES
Discussion Leader: Sundeep Khosla (Mayo Clinic, Rochester, MN)
9:00 am - 9:15 am Sundeep Khosla: Overview
9:15 am - 9:45 am Thomas Clemens (University of Alabama at Birmingham, Birmingham, AL)
"Insulin signaling in osteoblasts regulates bone and body composition"
9:45 am - 10:00 am Discussion
10:00 am - 10:15 am Coffee Break
10:15 am - 10:45 amMark Johnson (University of Missouri, Kansas City, MO)
"Targeting the Wnt Pathway for Skeletal Anabolic Therapy; When, Where and How"
10:45 am - 11:00 am Discussion
11:00 am - 11:30 amMerry Jo Oursler (Mayo Clinic, Rochester, MN)
"The osteoclast as a mediator of bone anabolism"
11:30 am - 11:45 am Discussion
11:45 am - 11:55 amJoachim Albers (University Medical Center Hamburg)
"Low bone formation and osteopenia in mice lacking the Wnt receptor Frizzled 9"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pmJochen Schulze (UKE-University Medical Center Hamburg-Eppendorf)
"Transgenic over-expression of the Wnt antagonist Kremen-2 in osteoblasts leads to severe impairment of bone formation and increased bone resorption"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
(Poster Numbers 45-88, EVEN numbers presenting from 5:00 pm - 6:00 pm, ODD Numbers presenting from 4:00 pm - 5:00 pm)
6:00 pmDinner
7:30 pm - 9:00 pm ARRA - A PALINDROME OF OPPORTUNITY
Discussion Leader: Brendan F. Boyce (University of Rochester, Rochester, NY)
7:30 pm - 8:30 pm Stephen I. Katz (NIAMS, Bethesda, MD)
8:30 pm - 8:45 pm Discussion
8:45 pm - 9:00 pm Closing Remarks
9:00 pm Closing Reception
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
Funding for this conference was made possible (in part) by R13AR057244-01 from National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institute on Aging (NIA), National Institute of Dental & Craniofacial Research (NIDCR). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
 
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