The program for the 2009 Conference on Cannabinoid Function in the CNS, the third in this series, will communicate new and exciting advances in the field, bringing together a range of established investigators, young investigators, and trainees from around the world to present and discuss a spectrum of topics related to the chemistry, biochemistry, physiology and pharmacology of the endogenous cannabinoid system. A distinctive feature in this year’s program is a special emphasis on the functions served by the endocannabinoids in the diseased brain and the opportunities offered by these lipid transmitters in drug discovery. Whenever possible, sessions combine research at multiple levels, e.g., from the molecular to the organ system and behavior, to encourage cross-pollination of ideas and introduce researchers to findings from fields outside their own. The broad range of topics will include the latest discoveries on the pathways of endocannabinoid metabolism, the roles played by the endocannabinoids in the control of neuronal circuits, and the connection between cannabinoids and schizophrenia. A special conference by Professor Robin Murray will address the medical impact of recreational cannabis use in the light of our new understanding of brain endocannabinoid transmission. In addition to outstanding leading-edge lectures and discussion, poster presentations will represent an integral part of the scientific program. A series of short talks will provide an opportunity for new investigators in the field to share their most exciting data.