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Cardiac Arrhythmia Mechanisms
Gordon Research Conference

Translational Aspects of Cardiac Arrhythmia Research

Dates

February 15-20, 2009

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Natalia A. Trayanova

Vice Chair:
James N. Weiss

Meeting Description

The theme of the 2009 GRC on Cardiac Arrhythmia Mechanisms is Translational Aspects of Cardiac Arrhythmias Research. The selection of proposed topics as well as speakers and discussion leaders reflects this emphasis. The organization of each session ensures that the sequence of speakers will lead the audience through what is known about a given subject at the level of the gene, the protein, the cell, the organ, and the organism in a systematic and didactic way, culminating with a presentation by a clinician/scientist that integrates and translates the presented topics into clinical research and practice. The presentations will define and analyze the latest and most important information on arrhythmia mechanisms and how these could result in novel anti-arrhythmia therapies and prevention.

Meeting Program

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff and the Chair, Dr. Natalia Trayanova
7:40 pm - 7:50 pmOpening remarks: Douglas Zipes
7:50 pm - 9:30 pmOXIDATIVE STRESS AND ARRHYTHMIAS I
Discussion Leader: Dario DiFrancesco (University of Milan)
7:50 pm - 8:25 pm Mark Anderson (University of Iowa)
"Oxidative stress and CaMKII"
8:25 pm - 8:40 pm Discussion
8:40 pm - 9:15 pm Zhilin Qu (UCLA)
"Chaotic Afterdepolarizations and Arrhythmias Induced by Oxidative Stress"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFIBROSIS AND ARRHYTHMOGENESIS
Discussion Leader: Jose Jalife (University of Michigan)
9:00 am - 9:10 am Trainee Presentation: Kathleen McDowell (Johns Hopkins University)
"Characterizing the arrhythmogenic substrate resulting from fibroblast-myocyte coupling in the infarcted heart"
9:10 am - 9:15 am Discussion
9:15 am - 9:50 am Wayne Giles (University of Calgary)
"Properties of Fibroblasts in the Heart"
9:50 am - 10:10 am Discussion
10:10 am Coffee Break / Group Photo
10:40 am - 11:15 am Stephan Rohr (University of Bern)
"Fibroblast-myocyte Interactions: Insights from Cell Culture Studies"
11:15 am - 11:35 am Discussion
11:35 am - 12:10 pm Jacques de Bakker (Interuniversity Cardiology Institute of the Netherlands)
"Fibrosis: A Clinical Perspective"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmOXIDATIVE STRESS AND ARRHYTHMIAS II
Discussion Leader: Glenn Fishman (NYU)
5:30 pm - 6:05 pm Brian O'Rourke (Johns Hopkins University)
"Role of Oxidative Stress in Ischemia-related Arrhythmias"
6:05 pm - 6:20 pm Discussion
6:20 pm - 6:55 pm Samuel Dudley (University of Chicago)
"Oxidative Stress in the Pathogenesis of Atrial Fibrillation"
6:55 pm - 7:10 pm Discussion
7:10 pm - 7:20 pmTrainee Presentation: Yin Hua Zhang (Oxford University)
"The role of nNOS-derived nitric oxide and NADPH oxidase in the positive inotropic response to mechanical stretch in the murine myocardium"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCHANNELOPATHIES: FROM GENES TO BEDSIDE
Discussion Leader: Yoram Rudy (Washington University at St. Louis)
9:00 am - 9:10 am Trainee Presentation: Thomas O'Hara (Washington University)
"Physiological Properties of hERG 1a/1b Heteromeric Currents and a hERG 1b-Specific Mutation Associated With Long-QT Syndrome"
9:10 am - 9:15 am Discussion
9:15 am - 9:50 am BumRak Choi (Brown University)
"Rabbit Models of LQTS"
9:50 am - 10:10 am Discussion
10:10 am Coffee Break
10:40 am - 11:15 am Steve Poelzing (University of Utah)
"Sodium Channel Mutations and Arrhythmogenesis"
11:15 am - 11:35 am Discussion
11:35 am - 12:10 pm Silvia Priori (Fondazione Salvatore Maugeri, Pavia)
"Mutations in calcium controlling proteins and arrhythmias"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmHEART FAILURE
Discussion Leader: Igor Efimov (Washington University St. Louis)
5:30 pm - 6:05 pm Shien-Fong Lin (Indiana University)
"Cardiac Automaticity and Heart Failure"
6:05 pm - 6:20 pm Discussion
6:20 pm - 6:55 pm Lance Wilson (Case Western Reserve)
"Heart Failure: A Clinician's Perspective"
6:55 pm - 7:10 pm Discussion
7:10 pm - 7:20 pmTrainee Presentation: Maria Storm (Case Western Reserve)
"Electrophysiological Consequences of Targeted Connexin43 Overexpression in the Failing and Normal Heart"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 9:10 am Industrial Presentation: Jeremy Rice (IBM)
"Multiscale Models of Cardiac ECGs with LQT1 Channelopathies"
9:10 am - 9:15 am Discussion
9:15 am - 12:30 pmALTERNANS AND SUCSEPTIBILITY TO ARRHYTHMIAS
Discussion Leader: David Rosenbaum (Case Western Reserve University)
9:15 am - 9:50 am David Christini (Weil Medical College of Cornell University)
"Heterogeneities in Alternans: Applications for Antiarrhythmia Therapy"
9:50 am - 10:10 am Discussion
10:10 am Coffee Break
10:40 am - 11:15 am David Eisner (University of Manchester)
"Alternans, Ca Waves, and Arrhythmogenesis"
11:15 am - 11:35 am Discussion
11:35 am - 12:10 pm Sanjiv Narayan (UCSD)
"Alternans: Insights from Patient Studies"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmARRHYTHMIAS IN THE HUMAN HEART
Discussion Leader: Robert Gilmour (Cornell University)
5:30 pm - 6:05 pm Kumaraswamy (Nanta) Nanthakumar (University of Toronto)
"What We Learned from Optical Mapping of the Human Heart"
6:05 pm - 6:20 pm Discussion
6:20 pm - 6:55 pm Nicholas Peters (Imperial College London)
"Arrhythmias in the Human Heart: A Clinical Perspective"
6:55 pm - 7:10 pm Discussion
7:10 pm - 7:20 pmTrainee Presentation: Christina Ambrossi (Washington University)
"Virtual Histology of the Human Heart Using Optical Coherence Tomography"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:15 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:15 am - 12:30 pmE-C COUPLING AND ARRHYTHMIAS
Discussion Leader: Guy Salama (University of Pittsburg)
9:15 am - 9:50 am Peter Backx (University of Toronto)
"Mechanistic links between transient outward K+ currents, excitation-contraction coupling and arrhythmias"
9:50 am - 10:10 am Discussion
10:10 am Coffee Break
10:40 am - 11:15 am Henk ter Keurs (University of Calgary)
"Myofibrillar Ca2+ as an Initiator of Cardiac Ca Waves"
11:15 am - 11:35 am Discussion
11:35 am - 12:10 pm Penelope Boyden (Columbia University)
"Mechanism of Abnormal Ca2+ Release and Cell-wide Wave Formation in Purkinje Cells"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmMECHANISMS AND MECHANISM-BASED THERAPIES FOR AF
Discussion Leader: Peng-Sheng Chen (Indiana University)
5:30 pm - 6:05 pm Ursula Ravens (Dresden University)
"Ca Signaling and Remodeling in AF"
6:05 pm - 6:20 pm Discussion
6:20 pm - 6:55 pm Sophie Demolombe (University of Nantes)
"AF and Aging: Any Clues from Genomics?"
6:55 pm - 7:10 pm Discussion
7:10 pm - 7:30 pmStudent Poster Awards Presentation and Closing Remarks
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1 R13 HL95207-01 from the National Institutes of Health, National Heart, Lung and Blood Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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