Conference Program
 
Cartilage Biology & Pathology
June 7-12, 2009
Les Diablerets Conference Center
Les Diablerets, Switzerland

The 2009 Gordon Conference on Cartilage Biology and Pathology will present cutting-edge research on the molecular and cellular aspects of cartilage formation, maintenance, repair and disease. Topics for discussion have been selected with a view to balance translational and basic research and stimulate work related to repair, regeneration and therapeutic approaches for major diseases of cartilage. The Conference program covers areas of active research and includes progress in understanding cartilage development and evolution, cartilage signaling and control mechanisms, genetic mechanisms of cartilage disease, molecular structure of cartilage matrix proteins, mechanobiological mechanisms in cartilage, degenerative cartilage disorders, and repair, regeneration and tissue engineering strategies in disorders of cartilage. A special keynote session will feature a discussion of biomechanical control mechanisms of cellular differentiation and behavior and autoimmune mechanisms in arthritis. The last session of the meeting will be devoted to research that defines new directions, challenges and opportunities.

Discussion leaders and invited speakers, representing a variety of scientific disciplines, are encouraged to present new, cutting edge science, keep reviews of published data short and emphasize new data and ideas. The Conference will provide opportunities for new investigators, postdoctoral trainees and graduate students to present their work in poster sessions and exchange ideas with experienced investigators who are at the forefront in their fields. The programmed discussion sessions will include short talks selected from submitted poster abstracts. The collegial atmosphere and opportunities for informal gatherings in the afternoons and evenings will promote brainstorming around new and old scientific problems and set the stage for the kind of cross-disciplinary collaborations that are needed to move research on cartilage forward and in new directions.


Contributors

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff and Meeting Chairs
7:40 pm - 9:30 pmDEVELOPMENT / EVOLUTION OF CARTILAGE
Discussion Leader: Karen Lyons (University of California, Los Angeles)
7:40 pm - 8:05 pm Raymond Boot-Handford (University of Manchester, UK)
"The Evolution Of Cartilage"
8:05 pm - 8:20 pm Discussion
8:20 pm - 8:40 pm Ryan Kerney (Dalhousie University, Canada)
"Thinking Outside The Mouse: De-Novo Cartilage Formation During Amphibian Metamorphosis"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:15 pm Matthew Harris (Max Planck Institute for Developmental Biology, Germany)
"The Zebrafish as a Genetic Model to Understand Developmental Mechanisms Underlying Patterning of the Adult Skeleton"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSIGNALING AND CONTROL MECHANISMS
Discussion Leader: Andrea Vortkamp (University Duisburg-Essen, Germany)
9:00 am - 9:25 am Fanxin Long (Washington University Medical School, USA)
"Intercellular Signals Controlling Bone Formation"
9:25 am - 9:40 am Discussion
9:40 am - 9:50 am Andrew Dudley (Northwestern University, USA)
"Chondrocyte polarity and the regulation of cartilage morphogenesis"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo
10:30 am - 10:55 am Elazar Zelzer (Weizmann Institute of Science, Israel)
"Struggling for Harmony- Skeletal Development as Part of the Musculoskeletal System"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am Susan Mackem (National Institutes of Health, National Cancer Institute, USA)
"Dissecting the Regulation of Limb Skeletal Patterning and Morphogenesis with Conditional Genetic Approaches"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pm Stefan Mundlos (Max Planck Institute for Molecular Genetics, Germany)
"A Network of Transcription Factors Regulate Bone Formation in the Limb"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmGENETIC MECHANISMS OF DISEASE
Discussion Leader: Matthew Warman (Children's Hospital, Boston, USA)
5:30 pm - 5:55 pm Patrick Smits (Children’s Hospital, Boston, USA)
"Mutations in the Golgin TRIP11 cause lethal skeletal dysplasias in mouse and human"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:35 pm Christine Hartmann (Research Institute of Molecular Pathology, Austria)
"Loss of Wnt Signaling Causes Osteoarthritis"
6:35 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Shiro Ikegawa (Center for Genomic Medicine, RIKEN, Japan)
"From Mouse to Human, from Monogenic to Polygenic Disease"
7:15 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMOLECULAR STRUCTURE
Discussion Leader: Erhard Hohenester (Imperial College London, UK)
9:00 am - 9:25 am Hideaki Nagase (Imperial College London, Kennedy Institute of Rheumatology, UK)
"Interaction of TIMP-3 and Aggrecanases"
9:25 am - 9:40 am Discussion
9:40 am - 9:50 am Andreas Tagariello (University Erlangen, Germany)
"Further functional characterization of UCMA"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Anthony Day (The University of Manchester, UK)
"Hyaluronan-protein interactions in joint inflammation"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am Erhard Hohenester (Imperial College London, UK)
"Structural Basis of Sequence-Specific Collagen-Protein Interactions"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pm Anders Aspberg (University of Copenhagen, Denmark)
"Functional Roles of the Aggrecan C-type Lectin"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMECHANOBIOLOGY
Discussion Leader: Christopher S. Chen (University of Pennsylvania, USA)
5:30 pm - 5:55 pm Dennis Discher (University of Pennsylvania, USA)
"Cell Mechanics, Matrix and Differentiation"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:20 pm Efrat Monsonego Ornan (Hebrew University, Israel)
"Multiple pathways mediating mechano-signaling in the growth-plate"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:40 pm Dean Wang (National Institute of Arthritis, and Musculoskeletal & Skin Diseases, National Institutes of Health, USA)
"Gene Therapy with Parathyroid Hormone-related Protein Protects Chondrocytes from Cyclic Tensile Strain-induced Injury"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Sudha Agarwal (The Ohio State University, USA)
"Biomechanical Control of Chondrocyte Signaling"
7:15 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDEGENERATIVE DISORDERS
Discussion Leader: Amanda Fosang (University of Melbourne and Murdoch Childrens Research Institute, Australia)
9:00 am - 9:25 am Elisabeth Morris (Articular Therapeutics, Wyeth Research, USA)
"Therapeutic Targets in Osteoarthritis"
9:25 am - 9:40 am Discussion
9:40 am - 9:50 am Stephanie Gauci (Royal Children's Hospital, Australia)
"Growth Plate Chondrocytes From Collagen II Knockin Mice (Bailey) Exhibit Inappropriate Terminal Differentiation"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Yefu Li (Harvard School of Dental Medicine, USA)
"Molecular Mechanisms of Progression in Osteoarthritis"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am Tonia L. Vincent (Kennedy Institute of Rheumatology, UK)
"Intrinsic Chondroprotective Pathways"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pm Danny Chan (The University of Hong Kong, Hong Kong)
"Developmental and Genetic Aspects of Intervertebral Disc Degeneration"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCELLULAR MECHANOBIOLOGY AND IMMUNE MECHANISMS IN DISEASE
Discussion Leader: Rocky Tuan (National Institute of Arthritis, and Musculoskeletal & Skin Diseases, National Institutes of Health, USA)
5:30 pm - 6:10 pm Rikard Holmdahl (Lund University, Sweden)
"Pathogenic Autoimmune Recognition of Cartilage"
6:10 pm - 6:30 pm Discussion
6:30 pm - 7:10 pm Christopher S. Chen (University of Pennsylvania, USA)
"Mechanotransduction in Stem Cell Differentiation"
7:10 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmREPAIR, REGENERATION AND TISSUE ENGINEERING
Discussion Leader: Vicki Rosen (Harvard School of Dental Medicine, USA)
9:00 am - 9:25 am Rocky Tuan (National Institute of Arthritis, and Musculoskeletal & Skin Diseases, National Institutes of Health, USA)
"Adult Stem Cells and Nanomaterials in Cartilage Tissue Engineering and Regeneration"
9:25 am - 9:40 am Discussion
9:40 am - 9:50 am Sebastian Koelling (Georg August University, Germany)
"Migratory Chondrogenic Progenitor Cells From Late Stages of Osteoarthritis Exhibit Gender Differences"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Ichiro Sekiya (Tokyo Medical and Dental University, Japan)
"Arthroscopic Transplantation of Synovial Stem Cells into Cartilage Defect"
10:55 am - 11:10 am Discussion
11:10 am - 11:20 am Damian Medici (Harvard School of Dental Medicine, USA)
"Vascular Endothelial Transdifferentiation to Multipotent Mesenchymal Stem-like Cells"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Jeroen Leijten (University of Twente, The Netherlands)
"Discriminating Growth Plate from Articular Cartilage"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Anthony Hollander (University of Bristol, UK)
"Claudia's Trachea: Engineering and Implantation of an Airway and Implications for Other Cartilage Sites"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmNEW DIRECTIONS
Discussion Leader: Kathryn Cheah (The University of Hong Kong, Hong Kong)
5:30 pm - 5:55 pm David Cox (Biotherapeutics and Bioinnovation Center, Pfizer Inc., USA)
"Genetic Risk Factors in Disease and Therapeutic Targets"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:25 pm Chris Murphy (Imperial College, UK)
"The role of microRNAs in chondrocyte function"
6:25 pm - 6:35 pm Discussion
6:35 pm - 6:55 pm Martin Stolz (Biozentrum/University of Basel)
"Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy"
6:55 pm - 7:05 pm Discussion
7:05 pm - 7:20 pm Patrik Onnerfjord (Lund University, Sweden)
"Quantitative proteomics of different human cartilage subtypes reveals unique patterns of protein composition"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1 R13AR057242-01 from NIAMS. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.