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Cell Biology of Metals
Metal Metabolism and Disease
August 9-14, 2009
Salve Regina University
Newport, RI
Chairs:
Valeria Culotta & Walter Schaffner

Vice Chair:
David P. Giedroc

The Cell Biology of Metals Gordon Conference provides a forum for which bioinorganic chemists, metallo-biologists and clinicians for metal related disorders all meet and discuss the latest advances in understanding cellular metal homeostasis. The complexity of how metal ions are taken up from the extracellular milieu and appropriately trafficked in a cell without causing toxicity is a field of growing importance. An increasing number of disorders are being attributed to disruptions in metal homeostasis at the cellular level. As such, the 2009 Cell Biology of Metals Gordon conference is dedicated to presenting the latest breakthroughs in the cell biology of metal transport, trafficking and detoxification. Talks from leaders in the field will cross multiple disciplines, from the very basic bioinorganic to applied studies of metals in diseases. Sample sessions include: imaging and biomonitoring of metals within organelles, metals and oxidative stress, and metals in microbial pathogenesis, neurodegeneration and hematopoietic disorders. In addition, new discoveries in understanding mechanisms of metal ion selectivity and metal co-factor assembly will be presented. Talks will be not only be from invited leaders in the field, but also from selected poster presentations and will expand from microbes to humans, cutting across multiple elements of biological importance.

Contributors
Metallomics
National Institutes of Health
Society of Biological Inorganic Chemistry
Universität Zürich
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Metals and Cancer
Discussion Leader: Valeria Culotta (Johns Hopkins University)
7:40 pm - 7:45 pm Introductions by Discussion Leader
7:45 pm - 8:15 pmThomas O’Halloran (Northwestern University)
"Metal Homeostasis Signatures in Development and Cancer"
8:15 pm - 8:30 pm Discussion
8:30 pm - 9:15 pmKeynote Speaker: Stephen Lippard (M.I.T.)
"Understanding and Improving Platinum Anticancer Drugs"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Metals and Oxidative Stress
Discussion Leader: Sabeeha Merchant (UCLA)
9:00 am - 9:25 amMichael Daly (Uniform Services University of the Health Sciences, Bethesda, MD)
"Manganous Phosphate Proteome-Shields in Deinococcus radiodurans"
9:25 am - 9:40 am Discussion
9:40 am - 9:55 am Eugen Urzica (UCLA)
"Transcriptome analysis of Chlamydomonas in different iron nutritional conditions"
9:55 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break / Group Photo (10:15 am)
10:30 am - 10:55 amVadim Gladyshev (U. Nebraska)
"Comparative genomics and evolution of metal utilization"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 amWayne Outten (U. South Carolina)
"The Suf pathway: Fe-S cluster biosynthesis at the convergence of iron starvation and oxidative stress"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pmJim Imlay (U. Illinois, Urbana-Champaign)
"Oxidative stress and mononuclear metalloenzymes"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Metals and Neurodegeneration
Discussion Leader: Caryn Outten (U. S Carolina)
7:30 pm - 7:55 pmGerd Multhaup (U. Berlin)
"Copper in Alzheimer’s disease"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmStephen Kaler (NICHD, NIH)
"Mechanisms of neurodegeneration in ATP7A copper transporter-related disorders"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmMichael Aschner (Vanderbilt U)
"Mechanisms of manganese transport and neurotoxicity"
9:15 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Cell Biology of iron disorders
Discussion Leader: Jodie Babitt (Harvard Medical School)
9:00 am - 9:15 am Jodie Babitt overview of session
9:15 am - 9:40 amRandall Peterson (Harvard Medical School)
"In vivo discovery of small molecules that modify iron homeostasis"
9:40 am - 9:50 am Discussion
9:50 am - 10:05 am Jonathan Silberg (Rice U)
"In vivo fluorescent detection of 2Fe2S clusters coordinated by human glutaredoxin 2"
10:05 am - 10:10 am Discussion
10:10 am - 10:30 am Coffee Break
10:30 am - 10:55 amAndrew Dancis (U. Pennsylvania)
"Fe/S clusters in the mitochondrial intermembrane space"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 amJan Abkowitz (U. Washington)
"Heme trafficking, erythropoiesis and iron homeostasis"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pmCaroline Philpott (NIDDK, NIH)
"The PCBP family of iron chaperones"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Metals and immunity
Discussion Leader: David Giedroc (Indiana University)
7:30 pm - 7:55 pmIvana De Domenico (U. Utah)
"The molecular basis of cellular iron export is linked to the transcriptional modulation of inflammation"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmIqbal Hamza (U. Maryland)
"To heme we bow: Transport and trafficking in eukaryotes"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmDavid Giedroc (Indiana University)
"Metal homeostasis and microbial pathogens"
9:15 pm - 9:30 Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Monitoring metal in cells
Discussion Leader: David Eide (U. Wisconsin, Madison)
9:00 am - 9:25 am Jim Penner-Hahn (U. Michigan, Ann Arbor)
"XRF explorations of inorganic physiology"
9:25 am - 9:40 am Discussion
9:40 am - 9:55 am Elisa Tomat (M.I.T.)
"Addressing Challenges of Mobile Zinc Detection in Biology Using Fluorescent Sensors"
9:55 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:55 amAmy Palmer (U. Colorado, Bolder)
"Genetically targeted zinc sensors for monitoring the spatial distributions of zinc in live cells"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 amChristoph Fahrni (Georgia Institute of Technology)
"Dynamic imaging of zinc by two-photon and x-ray fluorescence microscopy"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pmChris Chang (U. California, Berkeley)
"Molecular Imaging Approaches to Understanding Copper Biology in the Brain"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Metal ion selectivity in cells
Discussion Leader: Megan McEvoy (U. Arizona)
7:30 pm - 7:55 pmNigel Robinson (Newcastle University, UK)
"Protein-folding location determines whether Mn or Cu binds to structurally similar proteins"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmJaekwon Lee (U. Nebrasksa)
"Cadmium-transporting P-type ATPase in yeast"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmBarry Rosen (Florida International University)
"Evolution of metal(loid) binding sites in transcriptional repressors"
9:15 pm - 9:30 Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Metal co-factor biogenesis
Discussion Leader: Andrew Dancis (U. Pennsylvania)
9:00 am - 9:25 amWilliam Walden (U. Illinois, Urbana-Champaign)
"Cytosolic FeS cluster biogenesis: Mechanisms and link to cellular iron regulation"
9:25 am - 9:40 am Discussion
9:40 am - 9:55 am Forian Bittner (Technische U. Braunschweig)
"The mitochondrial ABC transporter ATM3 as crosspoint between extramitochondrial iron-sulfur cluster assembly and molybdenum cofactor biosynthesis"
9:55 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:55 amDennis Dean (Virginia Tech U)
"In vivo analysis of Fe-S protein maturation"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 amSimone Ciofi (U. Florence)
"Interplay between cysteine redox chemistry and metal binding in the assembly of cytochrome c oxidase"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pmJanneke Balk (Cambridge University, UK)
"The role of mitochondrial ABC transporters in metal cofactor biosynthesis"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Metal Metabolism and Development
Discussion Leader: Walter Schaffner (U. Zurich)
7:30 pm - 7:40 pm Introductions by Discussion Leader
7:40 pm - 8:10 pmJerry Kaplan (U. Utah)
"The origin and function of serum ferritin"
8:10 pm - 8:25 pm Discussion
8:25 pm - 9:15 pmKeynote Speaker: Dennis Thiele (Duke University)
"Cellular and Systemic Regulation of Copper Absorption in Mammals"
9:15 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 DK084587-01 from NIDDK and NIEHS. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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