Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Cell Growth & Proliferation
July 5-10, 2009
Colby College
Waterville, ME
Chair:
Sally Kornbluth

Vice Chair:
Johannes Walter

The 2009 Gordon Research Conference on Cell Growth and Proliferation will provide a forum for the discussion of the multiple cellular processes that contribute to cellular growth and division. Research at the forefront of our understanding of basic cell cycle processes including DNA replication, entry into, exit from and maintenance of mitosis and the various cell cycle checkpoints that restrain division when cell cycle events are disrupted wil be covered. In addition, the multiple signaling pathways that impact cellular growth will be discussed. Given the importance of unrestrained proliferation in carcinogenesis, significant time will also be devoted to consideration of how normal processes go awry during the development of cancers and how these cellular alterations promote tumorigenesis. Over the past several decades, dramatic progress in all of these areas has resulted from the cross-fertilization of ideas and observations made in multiple model systems (e.g. yeast, Xenopus, mammalian tissue culture models, flies, mice). Accordingly, a diverse group of international researchers working in multiple systems will attend the meeting to discuss their latest findings. Meeting attendees will be encouraged to contribute to these discussions and to present posters. In addition, short talk presenters will be selected from submitted abstracts.


SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session
Discussion Leader: Sally Kornbluth (Duke University School of Medicine)
7:40 pm - 8:40 pm John Diffley (London Research Institute, Clare Hall Laboratories)
"The initiation of DNA Replication: Mechanism, Regulation, and role in Genome stability"
8:40 pm - 9:15 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromosome Replication and S phase checkpoints
Discussion Leader: Johannes Walter (Harvard Medical School)
9:00 am - 9:25 am Anindya Dutta (University of Virginia)
"Genomic studies of mammalian DNA replication"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am David MacAlpine (Duke University School of Medicine)
"The role of local transcription and chromatin structure in establishing DNA Replication origins"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Mary Lilly (NIH)
"The Cdk inhibitor Dacapo regulates the meiotic S phase in Drosophila oogenesis"
10:35 am - 10:45 am Discussion
10:45 am Coffee Break
11:15 am - 11:40 am Maki Asano (Ohio State University)
"Regulation of Endoreplication in Drosophila"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pmAnja Bielinsky (University of Minnesota)
"The role of PCNA ubiquitination in lagging strand synthesis"
12:15 pm - 12:25 pm Discussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmMitosis I
Discussion Leader: Jonathon Pines (The Wellcome Trust / CR UK Gurdon Institute)
7:30 pm - 7:55 pm Hui Zou (UT Southwestern)
"Target separase to the chromosome cohesins in vertebrate cells"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Jonathon Pines (The Wellcome Trust / CR UK Gurdon Institute)
"Right protein, right place, right time: regulating mitosis by the APC/C"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Mary Dasso (NIH)
"SUMO control of chromosome segregation"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Kerry Bloom (UNC Chapel Hill)
"Chromatin Mechanics at the Centromere"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Cycle Engines and G1 control
Discussion Leader: Anindya Dutta (University of Virginia)
9:00 am - 9:25 am Frank Uhlmann (London Research Institute)
"Irreversibility of cell cycle transitions: why the clock never turns back"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Fred Cross (The Rockefeller University)
"Cell cycle control: wheels within wheels"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Steve Haase (Duke University)
"Cycling without cyclins: a transcription network oscillator"
10:35 am - 10:45 am Discussion
10:45 am Coffee Break
11:15 am - 11:40 am Nick Dyson (Mass General, Harvard)
"Uses, and abuses, of the E2F transcription factor"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Brian Dynlacht (New York University)
"Regulation of the centrosome cycle"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmOncogenes and Tumor Suppressors I
Discussion Leader: Michael Yaffe (MIT)
7:30 pm - 7:55 pm Gerard Evan (UCSF)
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Peter Jackson (Genentech)
"Cilia & Cysts: Linking Cell Polarity and Primary Cilia to Tumor Suppression"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Andrea McClatchey (Mass General, Harvard)
"Regulation of membrane receptor distribution and signaling at the cell cortex"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Hermann Steller (The Rockefeller University)
"Regulation of caspases by the ubiquitin-proteasome system"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Cycle Checkpoints
Discussion Leader: Steven Reed (The Scripps Research Institute)
9:00 am - 9:25 am Helen Piwinica-Worms (Washington University)
"Mammalian Cell Cycle and Checkpoint Contro"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Jean Gautier (Columbia University)
"Sensing and signaling from DNA damage"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Michael Yaffe (MIT)
"A Systems Biology Approach Connects DNA Damage Signaling to Cell Cycle Control and Apoptosis"
10:35 am - 10:45 am Discussion
10:45 am Coffee Break
11:15 am - 11:40 am Danny Lew (Duke University School of Medicine)
"Control of Cell Polarity in Yeast"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Robert Abraham (Wyeth)
"Replication stress and the response to cancer chemotherapeutic agents"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:30 pm - 9:30 pmOncogenes and Tumor Suppressor/Genome Stability
Discussion Leader: Angelika Amon (MIT)
7:30 pm - 7:55 pm David Pellman (Dana Farber Cancer Institute, Harvard)
"Polyploidy, Aneuploidy and Genome Stability"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Eileen White (Rutgers University)
"Connecting autophagy to suppression of inflammation and cancer"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Jing Yang (University of California, San Diego)
"Transcriptional Regulation of Tumor Invasion"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Jacqueline Lees (MIT)
"The dual roles of the retinoblastoma protein in cell cycle arrest and apoptosis"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMitosis II
Discussion Leader: Kerry Bloom (UNC, Chapel Hill)
9:00 am - 9:25 am Angelika Amon (MIT)
"Consequences of aneuploidy"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Todd Stukenberg (University of Virginia)
"Building and repairing kinetochore-microtubule interactions"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Hongtao Yu (UT Southwestern)
"Molecular mechanisms of the spindle checkpoint"
10:35 am - 10:45 am Discussion
10:45 am Coffee Break
11:15 am - 11:40 am Orna Cohen-Fix (NIH)
"Shaping the nucleus in closed and open mitosis"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Andrea Musacchio (IEO)
"Feedback control of mitosis: theory and practice"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmOncogenes and Tumor Suppressors II
Discussion Leader: Orna Cohen-Fix (NIH)
7:30 pm - 7:55 pm Tak Mak (Ontario Cancer Institutie)
"Cell Growth under metabolic stress"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Kornelia Polyak (Dana Farber Cancer Institute, Harvard)
"Diversity and evolution of breast tumors"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm Eric Weiss (Northwestern)
"Regulation of mRNA decay and translation by a cell fate control system"
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Adrian Halme (UC Berkeley)
"Retinoids function to coordinate regenerative growth and development"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Steven Reed (The Scripps Institute)
"Breaking down the Oncogene-Induced DNA Damage Response Barrier: the role of Cks proteins"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1R13CA130595-02 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter