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Cellular Osmoregulation & Mechanotransduction
Sensation, Transduction and Integration of Osmotic and Mechanical Signals
July 5-10, 2009
University of New England
Biddeford, ME
Chair:
Bert Poolman

Vice Chair:
Boris Martinac

The 2009 Gordon Conference on ‘Cellular Osmoregulation and Mechanotransduction’ will present cutting edge research on the molecular and cellular aspects of osmotic and mechanic stress in cells ranging from simple microbes to complex plant and mammalian systems. Mechanisms of osmosensing, signal transduction and cellular regulation will be presented from the biophysical and molecular (structural genomics) to the cellular (systems biology) perspective. As mechanotransduction is not only key to cellular osmostasis but also plays a role in human hearing and touch, and involves sensing of forces such as osmotic pressure, membrane stretch, vibration, and touch, these areas are included in the program. The Conference will bring together a collection of researchers who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promote cross-disciplinary collaborations in the various research areas represented.

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff and Conference Chair: Bert Poolman (University of Groningen)
7:40 pm - 9:30 pm OSMOTIC BALANCING AND CELLULAR ROLES OF AQUAPORINS
Discussion Leader: Bert Poolman (University of Groningen)
7:40 pm - 8:35 pmAlan Verkman (University of California, San Francisco)
"Expected and unexpected cellular roles of aquaporins"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:25 pmIan Booth (University of Aberdeen)
"Osmotic balancing: the mechanisms of solute pool adjustment to slow and rapid osmotic transients - how channels and transporters sense, respond and provide integrated pool management"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm CELLULAR RESPONSES TO OSMOTIC STRESS
Discussion Leader: Kevin Strange (Vanderbilt Medical Center)
9:00 am - 9:10 am Discussion Leader’s remarks
9:10 am - 9:35 amFrank Wehner (Max-Planck-Institut)
"Hypertonicity-induced cation channels in mammalian cells - role in cell proliferation vs apoptosis"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 amRainer Hedrich (Universität Würzburg)
"Molecular mechanism of guard cell volume control"
10:10 am - 10:20 am Discussion
10:20 am - 10:30 am Short Talk A: Ryszard Grygorczyk (University of Montreal)
"The hydrogel nature of mammalian cytoplasm contributes to osmosensing and extracellular pH sensing"
10:30 am - 10:35 am Discussion
10:35 am Coffee Break
11:05 am - 11:30 amMaik Böhmer (UC San Diego)
"Abscisic acid and CO2-mediated signal transduction in guard cells"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pmMiriam Goodman (Stanford University)
"An Unexpected Role for TRPV Channels in C. elegans Mechanical Nociceptors"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk B: Kay Marin (University of Cologne)
"A new mechanism of osmosensing: salt dependent protein-DNA interaction in the cyanobacterium Synechocystis sp. PCC 6803"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm OSMOSENSING AND TRANSDUCTION
Discussion Leader: Miriam Goodman (Stanford University School of Medicine)
7:30 pm - 7:40 pm Discussion Leader’s remarks
7:40 pm - 8:05 pmArmagan Kocer (University of Groningen)
"New approaches to understanding mechanosensation in procaryotes"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pmKevin Strange (Vanderbilt Medical Center)
"Regulation of an osmosensitive ClC anion channel by Ste20 kinase signaling"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmJanet Wood (University of Guelph)
"Escherichia coli modulates the osmoregulatory response by placing transporter ProP in the cardiolipin-rich environment at the cell poles"
9:15 pm - 9:25 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm MECHANISMS AND PHYSICS OF MECHANOTRANSDUCTION
Discussion Leader: Paul Blount (UT Southwestern Medical Center)
9:00 am - 9:10 am Discussion Leader’s remarks
9:10 am - 9:35 amAmanda Patel (IPMC, Valbonne)
"TRP channels in arterial mechanosensing"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 amSergei Sukharev (University of Maryland)
"The adaptive gating mechanism of MscS and its role in bacterial physiology"
10:10 am - 10:20 am Discussion
10:20 am - 10:30 am Short Talk C: Jacek Mika (University of Groningen)
"Slowed diffusion and barriers for mobility in osmotically stressed Escherichia coli"
10:30 am - 10:35 am Discussion
10:35 am Coffee Break
11:05 am - 11:30 amMasahiro Sokabe (Nagoya University School of Medicine)
"Role of actin cytoskeleton in mechanotransduction"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pmChing Kung (University of Wisconsin-Madison)
"Mechanosensitive TRP Channels"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk D: Zhenfeng Liu (California Institute of Technology)
"Crystal structure of MscL from Staphylococcus aureus and the structure-based gating mechanism"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm SIGNAL TRANSDUCTION CASCADES IN ANIMALS AND PLANTS
Discussion Leader: Maurice Burg (National Heart Lung and Blood Institute, NIH)
7:30 pm - 7:40 pm Discussion Leader’s remarks
7:40 pm - 8:05 pmNatalia Dmitrieva (National Heart Lung and Blood Institute, NIH)
"Cellular damages induced by osmotic stress"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pmBen Ko (The Chinese University of Hong Kong)
"Molecular mechanisms of nucleocytoplasmic trafficking of Osmotic Response Element-Binding Protein (OREBP"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmMoo Kwon (University of Maryland)
"Osmotic regulation of the mammalian transcription factor TonEBP in nuclear trafficking and post-translational modification"
9:15 pm - 9:25 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm (BIO)PHYSICAL CHEMISTRY OF (MACRO)MOLECULE-WATER INTERACTIONS
Discussion Leader: Wayne Bolen (The University of Texas Medical Branche)
9:00 am - 9:10 am Discussion Leader’s remarks
9:10 am - 9:35 amZoya Ignatova (University of Potsdam)
"Secondary osmolytes: From thermodynamic stabilization to modulation of aggregation pathways"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 amFrederick Sachs (University of Buffalo)
"Cell Volume Regulation - the cell as a sponge"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:45 am - 11:10 amAndrea Yool (Adelaide University)
"Gating of aquaporin water and ion channels"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 amMatthew Auton (Rice University)
"Osmolyte-dependent protein folding/unfolding cooperativity and protein solvation"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pmDon Rau (National Institute of Child Health and Human Dev, NIH)
"Water structuring and the exclusion of osmolytes and salts from macromolecules"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm SYSTEM ANALYSIS OF CELL VOLUME REGULATION
Discussion Leader: Boris Martinac (Victor Chang Cardiac Research Institute)
7:35 pm - 7:45 pm Discussion Leader’s remarks
7:45 pm - 8:10 pmElizabeth Haswell (Washington University in St. Louis)
"Structure and Function of MscS-Like Mechanosensitive Channels in Plants"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pmJesse Patterson (University of California at Berkeley)
"Living High on the HOG: Analysis of MAPK Signaling During Hyperosmotic Stress in S. cerevisiae"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmPaul Blount (UT Southwestern Medical Center)
"Structural rearrangements that occur upon gating the bacterial mechanosensitive channel MscL"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm STRUCTURAL ANALYSIS OF OSMOREGULATORY CHANNELS AND TRANSPORTERS
Discussion Leader: Reinhard Krämer (University of Cologne)
9:00 am - 9:10 am Discussion Leader’s remarks
9:10 am - 9:35 amChristine Ziegler (Max-Planck-Institut)
"Mechanism of osmolyte transport and regulation in the glycine betaine symporter BetP"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 amAnthony Lee (University of Southampton)
"How MscL interacts with its surrounding lipid molecules"
10:10 am - 10:20 am Discussion
10:20 am - 10:30 am Short Talk E: Chiliang Chen (Iowa State University)
"A catabolic ABC transporter Bcc from Pseudomonas spp. recruits multiple substrate-binding proteins for the efficient uptake of quaternary ammonium compounds"
10:30 am - 10:35 am Discussion
10:35 am Coffee Break
11:05 am - 11:30 amPreben Morth (University of Aarhus)
"Pumping Ions - P-type ATPases the driving force in the cell membranes"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pmMarcos Sotomayor (Harvard Medical School)
"Conformational transitions underlying tension-dependent gating in prokaryotic mechanosensitive channels"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk F: Stephan Grage (Karlsruhe Institute of Technology)
"Clustering and functional interaction of MscL channels"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm CELL MORPHOGENESIS
Discussion Leader: Boris Martinac (Victor Chang Cardiac Research Institute)
7:30 pm - 7:40 pm Discussion Leader’s remarks
7:40 pm - 8:05 pmKerwyn Casey Huang (Stanford University)
"Cell wall organization and cell shape determination in bacteria"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pmChristine Jacobs-Wagner (Yale University)
"Regulation of bacterial cell morphogenesis via mechanotransduction"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmPatrick Masson (University of Wisconsin-Madison)
"Molecular Genetics of Root Thigmomorphogenesis in Arabidopsis thaliana"
9:15 pm - 9:25 pm Discussion
9:25 pm - 9:30 pm Concluding remarks
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 DK084663-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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