Gordon Research Conferences
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Conference Program
 
Chronobiology
Molecular Mechanisms of Circadian Clocks
July 19-24, 2009
Salve Regina University
Newport, RI
Chair:
Joseph S. Takahashi

Vice Chair:
Martha Merrow

The 2009 Gordon Conference on Chronobiology will present cutting-edge research on the molecular, cellular and systems aspects of circadian biology. The Conference will feature a wide range of topics, such as the dynamics of transcription and cell cycles, molecular mechanisms of clocks, genetics of human clocks, metabolism and clocks, novel functions for clock genes, model organism clocks, entrainment mechanisms, and the neurobiology of the suprachiasmatic nucleus. Invited speakers represent a variety of scientific disciplines, including biochemistry, molecular genetics, genetics, genomics, structural biology, cell biology, imaging, modeling, sleep medicine, neuroscience, behavior and human biology. The Conference will bring together a collection of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Dynamics of Transcription and Cell Cycles
7:40 pm - 7:45 pm Opening Remarks: Joe Takahashi
7:45 pm - 8:10 pmJames McNally (National Cancer Institute, NIH)
"Fast and slow cycling of transcriptional activators"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:40 pmSharad Ramanathan (Harvard University)
"Dissecting timing variability in yeast meiosis"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:10 pmUeli Schibler (University of Geneva)
"Circadian transcriptional regulation"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:30 pm General Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:00 pm Molecular Clock Mechanisms
Session Chair: Susan Golden (UCSD)
9:00 am - 9:10 am Chair’s Introduction
9:10 am - 9:35 amTakao Kondo (Nagoya University)
"Dual control of the cyanobacterial circadian system"
9:35 am - 9:40 am Discussion
9:40 am - 10:05 amCarl Johnson (Vanderbilt)
"KaiABC oscillator: Core or periphery?"
10:10 am - 10:35 am Group Photo / Coffee Break
10:35 am - 11:00 amJay Dunlap (Dartmouth University)
"Proteomics and epigenetics of Neurospora clocks"
11:00 am - 11:05 am Discussion
11:05 am - 11:30 amChuck Weitz (Harvard)
"Proteomics of circadian clock protein complexes"
11:30 am - 11:35 am Discussion
11:35 am - 12:00 pm General Discussion
12:00 pm - 12:30 pm HOT TOPICS I
Session Chair: Martha Merrow (University of Groningen)
12:00 pm - 12:10 pm Elzbeita Kowalska (University of Zurich)
"Characterization of NONO - a new player in the circadian clock work and senescence"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Frederic Gachon (CNRS UPR1142)
"Circadian clock-coordinated ultradian regulation of translation in mouse liver"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Human Clock Genetics
Session Chair: Michael Young (Rockefeller University)
7:30 pm - 7:40 pm Chair’s Introduction
7:40 pm - 8:05 pmJulianne Winkelmann (Technical University of Munich)
"Genetics of restless legs syndrome"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmYing-Hui Fu (UCSF)
"Genetics of circadian sleep disorders in humans"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmThomas Bourgeron (Institut Pasteur)
"Genetics of autistic spectrum disorders: links to circadian pathways"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:30 pm General Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:00 pm Clocks and Metabolism
Session Chair: Joe Bass (Northwestern University)
9:00 am - 9:10 am Chair’s Introduction
9:10 am - 9:35 amRon Evans (Salk Institute)
"Circadian regulation of metabolism"
9:35 am - 9:40 am Discussion
9:40 am - 10:05 amPhilippe Froguel (Imperial College)
"Genetics of plasma glucose and type 2 diabetes risk: MTNR1B"
10:05 am - 10:10 am Discussion
10:10 am - 10:35 am Coffee Break
10:35 am - 11:00 amBenjamin Tu (UT Southwestern)
"Significance of metabolic cycles"
11:00 am - 11:05 am Discussion
11:05 am - 11:30 amZ. Jeffrey Chen (University of Texas, Austin)
"Growing around the clocks: Internal clocks promote growth vigor in hybrids and allopolyploids"
11:30 am - 11:35 am Discussion
11:35 am - 12:00 pm General Discussion
12:00 pm - 12:30 pm HOT TOPICS II
Session Chair: Carla Green (University of Virginia)
12:00 pm - 12:10 pm Karen Gamble (Vanderbilt University)
"Shiftwork in nurses: Contribution of phenotypes and genotypes to adaptation"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Allan James (University of Glasgow)
"Alternative Splicing of Components of the Arabidopsis Circadian Clock"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Emerging roles for clock genes
Session Chair: Martha Merrow (University of Groningen)
7:30 pm - 7:40 pm Chair’s Introduction
7:40 pm - 8:05 pmPaul Frenette (Mt. Sinai)
"Circadian trafficking of hematopoietic cells"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmBogi Anderson (UC Irvine)
"Circadian clock genes and the hair cycle"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmAndrew C. Oates (Max Planck Institute, Dresden)
"Synchrony dynamics of the segmental clock"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:30 pm General Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:00 pm Genetics of Drosophila Clocks
Session Chair: Amita Sehgal (University of Pennsylvania)
9:00 am - 9:10 am Chair’s Introduction
9:10 am - 9:35 amTrudy MacKay (North Carolina State University)
"Systems Genetics of Sleep in the Drosophila Genetic Reference Panel"
9:35 am - 9:40 am Discussion
9:40 am - 10:05 amPaul Taghert (Washington University, St. Louis)
"Coordination of circadian oscillator neurons by neuropeptide signaling in Drosophila"
10:05 am - 10:10 am Discussion
10:10 am - 10:35 am Coffee Break
10:35 am - 11:00 amRavi Allada (Northwestern University)
"Sleep in Drosophila"
11:00 am - 11:05 am Discussion
11:05 am - 11:30 amMichael Nitabach (Yale University)
"Neural regulation of Drosophila rhythms"
11:30 am - 11:35 am Discussion
11:35 am - 12:00 pm General Discussion
12:00 pm - 12:30 pm HOT TOPICS III
Session Chair: Ignacio Provencio (University of Virginia)
12:00 pm - 12:10 pm Erin Fortier (McGill University, Canada)
"T cell response is controlled by the circadian clock"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Oscar Castanon-Cervantes (Morehouse School of Medicine)
"Fatal effects of an immune challenge following repeated phase shifts"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Systems Biology of Circadian Clocks
Session Chair: Hiroki Ueda (RIKEN)
7:30 pm - 7:40 pm Chair’s Introduction
7:40 pm - 8:05 pmSteve Kay (UCSD)
"On the significance of circadian programs"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmJohn Hogenesch (University of Pennsylvania)
"Circadian network interactions"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmAchim Kramer (Charité, Berlin)
"Genome-wide circadian RNAi screens"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:30 pm General Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:00 pm Mammalian Clocks and the SCN
Session Chair: Michael Menaker (University of Virginia)
9:00 am - 9:10 am Chair’s Introduction
9:10 am - 9:35 amMichael Hastings (MRC, Cambridge)
"SCN: role of cAMP"
9:35 am - 9:40 am Discussion
9:40 am - 10:05 amSamer Hattar (Johns Hopkins University)
"Melanopsin cell pathways for entrainment"
10:05 am - 10:10 am Discussion
10:10 am - 10:35 am Coffee Break
10:35 am - 11:00 amSato Honma (Hokkaido University)
"Photic regulation of phase and tau; adaptive role of a kinase in the SCN"
11:00 am - 11:05 am Discussion
11:05 am - 11:30 amErik Herzog (Washington University, St. Louis)
"SCN oscillators: are they robust?"
11:30 am - 11:35 am Discussion
11:35 am - 12:00 pm General Discussion
12:00 pm - 12:30 pm HOT TOPICS IV
Session Chair: Martha Gillette (University of Illinois)
12:00 pm - 12:10 pm Ute Abraham (Charité, Berlin)
"Odor modulates circadian behavior independent of the SCN"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Kazuhiro Yagita (Osaka University)
"Circadian Clock Generation in Mouse ES Cell Differentiation and Reprogramming"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Perspectives
Session Chair: Martin Zatz (NIMH/NIH JBR)
7:30 pm - 7:40 pm Chair’s Introduction
7:40 pm - 8:05 pmMichael Rosbash (Brandeis University)
"On the Significance of Circadian Transcription"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmTill Roenneberg (University of Munich)
"Human chronotypes: phenotypes and genetics"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:05 pmCharalambos Kyriacou (University of Leicester)
"Clocks in the real world"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:30 pm General Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by NS065508 from the National Institute of Neurological Disorders and Stroke (NINDS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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