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Cilia, Mucus & Mucociliary Interactions
February 22-27, 2009
Il Ciocco Hotel and Resort
Lucca (Barga), Italy
Chairs:
George B. Witman & Win Sale

Vice Chairs:
Burton F. Dickey & Mary Rose

The fields of cilia, mucus, and mucociliary interactions represent different scientific disciplines that are highly relevant to each other, yet rarely combined into a common meeting. The importance of these areas with respect to normal development, physiology and disease is well recognized, and the recent explosion in basic understanding of ciliary function as well as mucus composition and secretion have greatly increased possibilities for therapeutic intervention in these diseases at the molecular level. This conference offers an opportunity for basic and clinical scientists involved in these areas to present their latest progress to each other, to exchange ideas, and to discuss new state-of-the-art technologies. Topics to be covered in 2009 include:

  • Cilia in Development
  • Development of Airway Mucus Cells
  • Signaling and Transcriptional Control
  • Centriole Duplication and Ciliary Assembly
  • Mucin Secretion
  • Cilia and Mucus in Disease (including primary ciliary dyskinesia, Bardet-Biedl syndrome, goblet cell hyperplasia, mucous cell metaplasia, etc.)
  • Mechanism and Control of Ciliary Motility
  • Mucociliary Interactions

The meeting will open Sunday night with two talks from senior, eminent scientists who will give complementary overviews of the field and lay out the challenges for the future. This will be followed by a total of 8 sessions from Monday morning through Thursday evening; each morning session will have at least 6 speakers and each evening session will have at least 4 speakers. The goal is to present new data not yet published according to the tradition of GRCs. Discussion leaders will give brief introductions to each session to provide a perspective on the topics to be covered. Speakers for some shorter talks will be selected from submitted abstracts in order to include the latest "hot" results. In addition to the platform presentations, there will be two poster sessions.

Contributors
SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmI. Prospects and Themes
7:40 pm - 7:45 pm Discussion Leaders: Win Sale (Emory University School of Medicine, Atlanta, GA) and Burton Dickey (MD Anderson Cancer Ctr, Houston TX)
"Introduction"
7:45 pm - 8:25 pm Peter Satir (Albert Einstein College of Medicine, Bronx, NY)
"40 years after the sliding-microtubule model for ciliary movement: Prospects for the next 40 years"
8:25 pm - 8:35 pm Discussion
8:40 pm - 9:20 pm Richard Boucher (University of North Carolina, Chapel Hill, NC)
"Mucus, cilia, mucociliary clearance and airway diseases"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmII. Development I - Morphogenesis and Differentiation
9:00 am - 9:05 am Discussion Leaders: Peter K. Jackson (Genentech, Inc., South San Francisco, CA) and Bill Snell (Univ. Texas Southwestern Medical Center, Dallas, TX)
"Introduction"
9:05 am - 9:25 am Brian Mitchell (Northwestern University, Evanston, IL)
"Planar cell polarity of cilia in the development of ciliated epithelia"
9:25 am - 9:35 am Discussion
9:35 am - 9:50 am Kimberly McDermott (UCSF, San Francisco, CA)
"Role of cilia in branching morphogenesis during lung development"
9:50 am - 9:55 am Discussion
9:55 am - 10:15 amTamara Caspary (Emory University School of Med., Atlanta, GA)
"Cilia and sonic hedgehog signaling"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break / Group Photo
10:55 am - 11:05 am Benedicte Durand (University of Lyon, France)
"Novel functions of primary cilia during mouse lung development"
11:05 am - 11:10 amDiscussion
11:10 am - 11:15 am Discussion Leaders: Peter K. Jackson (Genentech, Inc., South San Francisco, CA) and Bill Snell (Univ. Texas Southwestern Medical Center, Dallas, TX)
"Introduction"
11:15 am - 11:35 am Jeff Whitsett (Children's Hospital Medical Center, Cincinnati, Ohio)
"Induction of goblet cell hyperplasia in the airway epithelium"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pm Anand Patel (Washington University School of Medicine, St. Louis, MO)
"Molecular mechanism for hCLCA1 regulation of mucous cell metaplasia"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmYohannes Tesfaigzi (Lovelace Institute, Albuquerque, NM)
"Resolution of mucous cell metaplasia"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session A (first viewing)
5:30 pm - 7:30 pmIII. Signaling and transcriptional control of cilia and mucins
5:30 pm - 5:35 pm Discussion Leaders: Steven L. Brody (Washington University Sch. Med., St. Louis MO) and Mary C. Rose (Children's National Medical Center, Washington D.C.)
"Introduction"
5:35 pm - 5:55 pm Dave W. Burt (Roslin Institute (Edinburgh), Roslin, Midlothian, UK)
"A genetic analysis of Hedgehog signaling in the chicken embryo"
5:55 pm - 6:05 pm Discussion
6:05 pm - 6:25 pm Soeren Christensen (Institute for Molecular Biology and Physiology, University of Copenhagen, Denmark)
"The PDGFRαα signaling pathway in cilia"
6:25 pm - 6:35 pm Discussion
6:35 pm - 6:55 pm Christopher M. Evans (The University of Texas M. D. Anderson Cancer Center, Houston, TX)
"Function and control of Muc5ac gene expression in murine airways"
6:55 pm - 7:05 pm Discussion
7:05 pm - 7:25 pm Mary Chang (University of California, Davis)
"Regulation of MUC5B gene expression in the airways"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:55 amIV. Fundamental Processes in Cilia and Mucus I
A. Centrioles and Ciliary Assembly
9:00 am - 9:05 am Discussion Leader: Michel Bornens (Institut Curie, CNRS, Paris France)
"Introduction"
9:05 am - 9:25 am Juliette Azimzadeh (UCSF, San Francisco, CA)
"Basal body assembly and orientation: Planaria as a model for the airway"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Masafumi Hirono (University of Tokyo, Tokyo, Japan)
"Building a centriole"
9:55 am - 10:05 am Discussion
10:05 am - 10:25 am Michael McGuckin (Mater Medical Research Institute, Brisbane, Australia)
"Aberrant assembly of a secreted mucin leads to spontaneous inflammation"
10:25 am - 10:35 am Discussion
10:35 am - 10:55 am Coffee Break
10:55 am - 12:30 pmIV. Fundamental Processes in Cilia and Mucus I
B. Mucin Secretion
10:55 am - 11:00 am Discussion Leader: Yohannes Tesfaigzi (Lovelace Institute, Albuquerque, NM)
"Introduction"
11:00 am - 11:20 am Burton Dickey (M.D. Anderson Cancer Center, Houston, TX)
"Structure and function of the airway secretory cell exocytic machinery"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am C. William Davis (University of North Carolina, Chapel Hill, NC)
"Signal transduction pathways controlling mucin secretion"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Eduardo Lazarowski (University of North Carolina, Chapel Hill, NC)
"Coordinated release of nucleotides and mucin from human airway epithelial cells"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session A (second viewing)
5:30 pm - 7:30 pmV. Fundamental Processes in Cilia and Mucus II
5:30 pm - 5:35 pm Discussion Leaders: Sandra Gendler (Mayo Clinic College of Medicine, Scottsdale, AZ) and Susan K. Dutcher (Washington University School of Medicine, St. Louis, MO)
"Introduction"
5:35 pm - 5:55 pm Tim Stearns (Stanford University, Stanford, CA)
"Ciliogenesis in ciliated epithelial cells"
5:55 pm - 6:05 pm Discussion
6:05 pm - 6:25 pm Monica Bettencourt-Dias (Gulbenkian Institute, Portugal)
"Control of Centrosome assembly"
6:25 pm - 6:35 pm Discussion
6:35 pm - 6:55 pm K. Chul Kim (Lovelace Respiratory Research Institute, Albuquerque, NM)
"Epithelial barrier to infection: anti-inflammatory role of MUC1 mucin"
6:55 pm - 7:05 pm Discussion
7:05 pm - 7:25 pm Gunnar C. Hansson (University of Gothenburg, Sweden)
"Organization of the mucus in the large intestine with implications for the respiratory tract"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmVI. Cilia, Mucus and Disease I
9:00 am - 9:05 am Discussion Leaders: John Fahy (UCSF, San Francisco, CA) and Larry Ostrowski (Univ. North Carolina, Chapel Hill, NC)
"Introduction"
9:05 am - 9:25 am Heymut Omran (University Hospital Freiburg, Freiburg, Germany)
"Cilia defects and ciliopathies"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Serge Amselem (Institut National de la Santé et de la Recherche Médicale, Unité 654, Créteil, France)
"A novel PCD gene identifies a new class of ciliopathy proteins"
9:55 am - 10:05 am Discussion
10:05 am - 10:25 am Michael J. Welsh (Howard Hughes Medical Institute, Carver College of Medicine, University of Iowa, Iowa City, IA)
"Role of Bardet-Biedl syndrome proteins in airway cilia"
10:25 am - 10:35 am Discussion
10:35 am - 10:55 am Coffee Break
10:55 am - 11:00 am Discussion Leaders: John Fahy (UCSF, San Francisco, CA) and Larry Ostrowski (Univ. North Carolina, Chapel Hill, NC)
"Introduction"
11:00 am - 11:20 am Rosanna M. Forteza (University of Miami School of Medicine, FL)
"Hyaluronan depolymerization at apical surfaces during airway inflammation upregulates mucin gene expression"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am David Thornton (University of Manchester, England)
"Structure and function of polymeric mucins in airway mucus in health and disease"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Judith Voynow (Duke University Medical Center, Durham, NC)
"Mechanisms of mucin overproduction in neutrophil-dominated airway diseases"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session B (first viewing)
5:30 pm - 7:30 pmVII. Cilia, Mucus and Disease II
5:30 pm - 5:35 pm Discussion Leader: Martina Brueckner (Yale University, New Haven, CT)
"Introduction"
5:35 pm - 5:55 pm Michael R. Knowles (Univ. North Carolina, Chapel Hill, NC)
"Genetic causes of primary ciliary dyskinesia (PCD)"
5:55 pm - 6:05 pm Discussion
6:05 pm - 6:25 pm Cecilia Lo (NHLBI, NIH, Bethesda, MD)
"A central role for the cilium in congenital heart disease"
6:25 pm - 6:35 pm Discussion
6:35 pm - 6:55 pm Ilene K. Gipson (Schepens Eye Research Institute, Boston, MA)
"Mucins and ocular disease"
6:55 pm - 7:05 pm Discussion
7:05 pm - 7:25 pm Duncan Rodgers (Imperial College, London)
"Mucoactive agents for mucus hypersecretory airway diseases"
7:25 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next co-Vice Chairs; fill out Conference Evaluation Forms; discuss future site & scheduling preferences; election of the next co-Vice Chairs)
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmVIII. Mechanism and Control of Ciliary Motility
9:00 am - 9:05 am Discussion Leaders: David R. Mitchell (SUNY, Syracuse, NY) and Ritsu Kamiya (University of Tokyo)
"Introduction"
9:05 am - 9:25 am Daniela Nicastro (Brandeis University, Waltham, MA)
"Cryoelectron tomography and a structural basis for ciliary motility"
9:25 am - 9:35 am Discussion
9:35 am - 9:55 am Maureen Wirschell (Emory University School of Medicine, Atlanta, GA)
"Regulation of ciliary motility by the conserved I1 inner arm dynein"
9:55 am - 10:05 am Discussion
10:05 am - 10:25 am Elizabeth F. Smith (Dartmouth College, Hanover, NH)
"Calcium regulation of ciliary motility: role of the central pair/radial spokes"
10:25 am - 10:35 am Discussion
10:35 am - 11:00 am Coffee Break
11:00 am - 11:10 am Kent L. Hill (UCLA, Los Angeles, CA)
"Identification of a new DRC subunit and structure-function analysis of dynein regulatory proteins in Trypanosoma brucei"
11:10 am - 11:15 am Discussion
11:15 am - 11:35 am Matthias Salathe (University of Miami, Miami, FL)
"Soluble adenylyl cyclase in airway epithelial cells is an axonemal protein that mediates ciliary beat frequency response to changes in CO2/HCO"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 amStephen M. King (Univ. Connecticut Health Center, Farmington, CT)
"Schmidtea mediterranea: a model system for analysis of motile cilia"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmGaia Pigino (University of Siena, Italy)
"Electron tomographic analysis of intraflagellar transport complexes in situ"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmKarl Lechtreck (Univ. Massachusetts Medical Center, Worcester, MA)
"Mutations in Bardet-Biedl syndrome genes impair phototactic steering in Chlamydomonas"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session B (second viewing)
5:30 pm - 7:30 pmIX. Mucociliary Interactions
5:30 pm - 5:35 pm Discussion Leaders: Joseph H. Sisson (University of Nebraska Medical Center, Omaha, NE) and Richard Cone (Johns Hopkins University, Baltimore, MD)
"Introduction"
5:35 pm - 5:55 pm Marcus A. Mall (University of Heidelberg, Germany)
"Role of cilia, mucus and airway surface liquid in mucociliary dysfunction: lessons from mouse models"
5:55 pm - 6:05 pm Discussion
6:05 pm - 6:25 pm John Sheehan (University of North Carolina, Chapel Hill, NC)
"The airway mucus transport apparatus: Interactions of N-terminal domains of secreted mucins with cilia"
6:25 pm - 6:35 pm Discussion
6:35 pm - 6:55 pm Michael Rubenstein (University of North Carolina, Chapel Hill, NC)
"Mucoadhesion"
6:55 pm - 7:05 pm Discussion
7:05 pm - 7:25 pm Justin Hanes (Johns Hopkins University, Baltimore, MD)
"Particle transport in mucus"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Funding for this conference was made possible (in part) by 1R131HL 095264-01 from the National Institutes of Health, National Heart, Lung and Blood Institute And The Office of Rare Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
 
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