Conference Program
 
Developmental Biology
June 21-26, 2009
Proctor Academy
Andover, NH
Chair:
Alexander Schier

Vice Chair:
Claude R. Desplan

Developmental Biology is at the center of the Life Sciences. Developmental biologists discovered inductive tissue interactions, thus creating the field of cell-cell signaling. Developmental biologists have uncovered the basic biological processes of embryogenesis and pattern formation, organogenesis, neurogenesis and sex determination, aging and cell death, cell and tissue polarity, and epigenetics. Developmental biologists were the first to clone animals, revealing that adult nuclei contain all genetic information and setting up one of the major questions of biology - understanding the differential control of gene expression. Developmental biologists have discovered microRNAs and morphogens, defined and dissected the major signaling pathways, and uncovered fundamental principles of differential gene regulation. Developmental biologists have also provided important technological advances, from in situ hybridization and genome manipulation to in vivo imaging and RNAi. Developmental biologists have advanced our understanding of how organisms evolve (“EvoDevo”), have provided the foundations for stem cell biology and tissue engineering, have created the context to understand human birth defects and disease, and have started to provide a rich playing field for genomics and systems biology. The impact of the field is a result of the study of simple and complex whole organisms (rather than isolated cells or molecules) using a wide variety of technological and intellectual approaches. As these studies continue and expand into new areas such as regeneration, systems biology, and growth control, we can expect major contributions in the coming years. Hence, Developmental Biology has been and will continue to be a core discipline of the Life Sciences and is transforming the Medical Sciences.

The Gordon Research Conferences on Developmental Biology have been recognized for over thirty years as the preeminent mid-sized conferences for developmental biologists. The 5-day meeting will bring together ~150 outstanding senior and junior scientists for ~50 talks, ~80 posters and extensive discussions of the recent advances and future of the field. Speakers will cover classic topics and emerging areas in developmental biology: growth and patterning, stem cells and regeneration, axis formation, evolution, morphogenesis, signaling, organogenesis, and regulatory networks. In honor of the 40th anniversary of Lewis Wolpert’s Positional Information model, there will be a special session on Morphogen Gradients.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff and Chair
7:40 pm - 9:30 pm ASYMMETRY AND GROWTH
Discussion Leader: Kathryn Anderson (MSKCC)
7:40 pm - 8:00 pmMagdalena Zernicka-Goetz (Gurdon Institute Cambridge)
"Asymmetry and growth during early mouse embryogenesis"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pmJuergen Knoblich (IMBA Vienna)
"Asymmetric cell division and proliferation control in the Drosophila nervous system"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Erik Griffin (Johns Hopkins)
"Generation of asymmetry by PAR-1-dependent local regulation of protein diffusion"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:15 pmDominique Bergmann (Stanford)
"Asymmetry in stomatal development"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:00 pm REGULATORY NETWORKS AND EPIGENETICS
Discussion Leader: Marion Walhout (U Mass Worcester)
9:00 am - 9:20 amBarbara Meyer (UC Berkeley)
"Epigenetics in C. elegans"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amDenise Barlow (University of Vienna)
"Epigenetic imprinting in mouse"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 amSui Huang (University of Calgary)
"Waddington’s epigenetic landscape: from metaphor to molecules and mathematical model"
10:50 am - 11:00 am Discussion
11:00 am - 11:10 am Mary Donohue (Weill Cornell Medical College)
"X chromosome inactivation"
11:10 am - 11:15 am Discussion
11:15 am - 11:25 am Melissa Harrison (UC Berkeley)
"Transcriptional Regulation of the Early Zygotic Genome in Drosophila"
11:25 am - 11:30 am Discussion
11:30 am - 11:50 amPiali Sengupta (Brandeis)
"Generation of phenotypic diversity in C. elegans"
11:50 am - 12:00 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:15 pm EVOLUTION
Discussion Leader: Dominique Bergmann (Stanford)
7:30 pm - 7:50 pmMarie Anne Felix (Jacques Monod)
"Evolution of nematode development"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmArkhat Abzhanov (Harvard)
"Craniofacial evolution"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm Kari Baker (Princeton)
"TGF-beta signaling in asymmetric heart morphogenesis"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pmHopi Hoekstra (Harvard)
"Evolution of pigmentation in rodents"
9:05 pm - 9:15 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:00 pm TRANSCRIPTIONAL CONTROL
Discussion Leader: Barbara Meyer (UC Berkeley)
9:00 am - 9:20 amRichard Mann (Columbia)
"Hox genes in Drosophila"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amMarian Walhout (U Mass Worcester)
"Transcriptional networks in C. elegans"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 amMark Biggin (UC Berkeley)
"Transcriptional networks in Drosophila"
10:50 am - 11:00 am Discussion
11:00 am - 11:10 amPatrick Tschopp (Geneva)
"Uncoupling time and space in the collinear regulation of Hox genes"
11:10 am - 11:15 am Discussion
11:15 am - 11:25 amLisa Taneyhill (University of Maryland College Park)
"The role of Snail2 in neural crest cell emigration"
11:25 am - 11:30 am Discussion
11:30 am - 11:50 amSoo-Kyung Lee (Baylor)
"Transcriptional control of spinal cord patterning"
11:50 am - 12:00 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:15 pm ORGANOGENESIS
Discussion Leader: Amy Wagers (Harvard)
7:30 pm - 7:50 pmDenise Montell (Johns Hopkins)
"Drosophila oogenesis"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmClaude Desplan (NYU)
"Eye development"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm Mounia Lagha (Pasteur Institute)
"Pax/Foxc in dermomyotome development"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pmLee Niswander (U Colorado Denver)
"Mouse neurulation"
9:05 pm - 9:15 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
MORPHOGEN GRADIENTS AND POSITIONAL INFORMATION
Discussion Leader: Denise Montell (Johns Hopkins)
9:00 am - 9:20 amEric Wieschaus (Princeton)
"The bicoid morphogen"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amLewis Wolpert (UCL)
"Positional information re-revisited"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 amJames Briscoe (NIMR)
"The hedgehog morphogen"
10:50 am - 11:00 am Discussion
11:00 am - 11:10 am Matthew Gibson (Stowers Institute)
"Larval translucida: shaping the DPP morphogen gradient"
11:10 am - 11:15 am Discussion
11:15 am - 11:25 am Angela Stathopoulos (Caltech)
"Gastrulation in Drosophila"
11:25 am - 11:30 am Discussion
11:30 am - 11:50 amShigeru Kondo (Nagoya University)
"Positional information during pigmentation"
11:50 am - 12:00 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:15 pm SIGNALING
Discussion Leader: Lee Niswander (U Colorado Denver)
7:30 pm - 7:50 pmTrudi Schupbach (Princeton)
"EGF signaling in Drosophila"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmAlex Schier (Harvard)
"Nodal signaling in zebrafish"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm Daniel Constam (Ecole Polytechnique Federale De Lausanne)
"Nodal signaling in mouse"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pmKathryn Anderson (MSKCC)
"Hedgehog signaling and cilia in mouse"
9:05 pm - 9:15 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:00 pm MORPHOGENESIS
Discussion Leader: Trudi Schupbach (Princeton)
9:00 am - 9:20 amJeremy Nance (NYU)
"Gastrulation in C. elegans"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amErez Raz (Uni Muenster)
"Germ cell migration in zebrafish"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 amKen Irvine (Rutgers)
"Morphogenesis of imaginal discs"
10:50 am - 11:00 am Discussion
11:00 am - 11:10 am Guojun Sheng (Riken Kobe)
"Extra-embryonic mesoderm differentiation during early chick development"
11:10 am - 11:15 am Discussion
11:15 am - 11:25 am Saori Haigo (UC Berkeley)
"Follicle rotation in Drosophila"
11:25 am - 11:30 am Discussion
11:30 am - 11:50 amWill Talbot (Stanford)
"Myelination in zebrafish"
11:50 am - 12:00 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:15 pm STEM CELLS AND REGENERATION
Discussion Leader: Magdalena Zernicka-Goetz (Gurdon Institute Cambridge)
7:30 pm - 7:50 pmKen Poss (Duke)
"Fin and heart regeneration in zebrafish"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmAmy Wagers (Harvard)
"Muscle stem cells and regeneration"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm Allyson Spence (Stanford)
"Drosophila germ line stem cells"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pmAlejandro Sanchez-Alvarado (University of Utah)
"Regeneration in planarians"
9:05 pm - 9:15 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by Grant 1 R13 HD62039-01 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. government.