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Drinking Water Disinfection By-Products
August 9-14, 2009
Mount Holyoke College
South Hadley, MA
Chair:
Benjamin Blount

Vice Chair:
Manolis Kogevinas

Several epidemiologic studies indicate that there may be a risk of cancer from use of chlorinated tap water. However, to-date, the health effects observed in single-chemical animal toxicity studies (primarily liver cancer) have not been able to explain the effects observed in the human epidemiologic studies (primarily bladder cancer). More recent epidemiologic studies have focused on reproductive and developmental effects. And, although there have been associations observed between chlorinated tap water and these effects, it is not known which chemicals / disinfection by-products (DBPs) in the water may be responsible. Also, because previous toxicological research has focused on single chemical testing, it is not known how the complex mixture of DBPs (typically more than 300 chemicals) affects the overall toxicity and human health risk assessments (are the effects additive or non-additive?). Conference presentations will cover the latest DBP research focused on occurrence and formation, treatment, exposure, toxicity, and epidemiology, and stimulate dialog between chemists, toxicologists, epidemiologists, and engineers in this area.

Contributors
CDC Foundation
Center for Disease Control
National Institutes of Health
Carl Storm Underrepresented Minority Fellowships
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff and Conference Chair
7:40 pm - 9:30 pm OVERVIEW
Discussion Leader: Rex Pegram (National Health & Environmental Effects Research Lab, EPA)
7:40 pm - 8:20 pmSusan Richardson (National Exposure Research Laboratory, EPA)
"Roadmap for interdisciplinary research on water disinfection byproducts"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pmDavid DeMarini (National Health & Environmental Effects Research Laboratory, EPA )
"Overview of genotoxicity and carcinogenicity of new and emerging DBPs"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:45 amGroup Photo
9:00 am - 12:30 pm DBP FORMATION AND OCCURRENCE
Discussion Leader: Xing-Fang Li (University of Alberta)
9:00 am - 9:40 amWilliam Mitch (Yale University)
"Formation, occurrence, and control of emerging DBPs - similarities and differences to regulated DBPs"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 amDavid Reckhow (University of Massachusetts Amherst)
"Discovery of new and emerging DBPs of health concern"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmShane Snyder (Southern Nevada Water Authority)
"Oxidation Products from Alternative Water Sources"
12:10 pm - 12:30 pm Discussion
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm DBP FATE, TRANSPORT AND MONITORING
Discussion Leader: Jay Nuckols (Colorado State University)
7:30 pm - 8:10 pmPaul Westerhoff (Arizona State University)
"Sources and fate of emerging DBPs and their precursors in source waters"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pmStuart Krasner (Metropolitan Water District of Southern California)
"Quality control issues in obtaining DBP occurrence data"
9:10 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm TOX STUDIES
Discussion Leader: Jane Ellen Simmons (National Health & Environmental Effects Research Lab, EPA)
9:00 am - 9:40 amMichael Plewa (University of Illinois)
"Seeing the big picture: Integration of chemical SAR, in vitro toxicology and human toxicogenomics of DBPs"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 amSid Hunter (National Health & Environmental Effects Research Laboratory, EPA)
"Effects of a chlorinated source water on reproduction and development following multi-generational exposure"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmPeter Goebell (Friedrich-Alexander Universität)
"Current in vitro and ex vivo models to investigate the effects of disinfection by-products"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm EXPOSURE SCIENCE
Discussion Leader: Cristina Villanueva (Centre for Research in Environmental Epidemiology)
7:30 pm - 8:10 pmCliff Weisel (Environmental & Occupational Health Sciences Institute, UMDNJ)
"Predicting exposures across the spectrum of DBPs, populations and activities"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pmLesa Aylward (Summit Toxicology)
"Interpreting DBP human biomonitoring data in a health risk context using Biomonitoring Equivalents"
9:10 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm EPI STUDIES
Discussion Leader: Sylvaine Cordier (INSERM)
9:00 am - 9:40 amMark Nieuwenhuijsen (Centre for Research in Environmental Epidemiology)
"Disinfection by-products and reproductive epidemiology: systematic review and meta-analyses"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 amKen Cantor (National Cancer Institute)
"Critical review of cancer epidemiologic studies and future directions"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmWill King (Queen’s University)
"The application of intermediate endpoints to epidemiologic studies of DBPs"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm SWIMMING POOLS AND RECREATIONAL WATER DBP EXPOSURE AND EPIDEMIOLOGY
Discussion Leader: Cliff Weisel (Environmental & Occupational Health Sciences Institute, UMDNJ)
7:30 pm - 8:10 pmErnest Blatchley (Purdue University)
"Characterization of swimming pool DBPs"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pmManolis Kogevinas (Centre for Research in Environmental Epidemiology)
"Genotoxic and respiratory effects of swimming pool exposures"
9:10 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm REGULATION / PERSPECTIVES
Discussion Leader: Michael Wright (National Center for Environmental Assessment, EPA)
9:00 am - 9:40 amGary Emmert (University of Memphis)
"Exploring On-Line, Near Real-Time Options for Monitoring Drinking Water Disinfection By-Product Concentrations"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:10 amRita Schoeny (Office of Water, EPA)
"Data considerations for regulation of water contaminants"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pmCharles Haas (Drexel University)
"Disinfection risk benefit analysis and disinfection strategies to address emerging microbial threats"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm INTEGRATED DISCUSSION; STUDENT POSTER SESSION AWARDS; CONFERENCE AWARDS
Discussion Leaders: Philip Singer (University of North Carolina at Chapel Hill) and Ben Blount (Centers for Disease Control and Prevention)
7:30 pm - 9:00 pm Susan Richardson (U.S. EPA), David DeMarini (U.S. EPA), Ken Cantor (National Cancer Institute), Michael Plewa (University of Illinois at Urbana-Champaign), Rita Schoeny
"Integrated Discussion of Emerging DBPs"
9:00 pm - 9:30 pm Student poster session awards and conference awards
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible, in part, by the cooperative agreement award (1H13HM000729-01) from the Centers for Disease Control and Prevention. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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