Gordon Research Conferences
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Conference Program
 
Excitatory Synapses & Brain Function
September 6-11, 2009
Les Diablerets Conference Center
Les Diablerets, Switzerland

Perhaps no other structure is more fundamental to our understanding of the brain than the synapse. The structure, molecular organization, signaling function, and plasticity of excitatory synapses underlie developmental and experience-dependent changes in brain function. However, a fundamental understanding of synaptic function is also essential to progress in lessening the burden of human neurological disease and for predicting and improving mental health. This conference is unique in its focus on the excitatory synapse, and is directed at a multidisciplinary group of participants including structural biologists, molecular and developmental biologists, cell biologists, biochemists, cell/molecular imagers, biophysicists and physiologists. The conference is intended to relate fundamental insights in excitatory synaptic function to the impairments in synaptic function that occur in disease, as well as the maladaptive plasticity that follows brain injury or substance abuse. The program has been designed to highlight cutting edge approaches and to stimulate new concepts, methods and technologies within a sound biological framework of fundamental neuroscience. The conference will bring together experts worldwide in an environment that is conducive to discussion and exchange of ideas. Poster sessions will be matched with the topics of the platform sessions to stimulate exchange between all participants.

We have reserved up to 8 speakers slots for poster submitters for the meeting. We also have some funds to help with the cost of the meeting for poster presenters with preference given to graduate students, postdoctoral fellows and junior faculty. To be considered for these possibilities, you should apply as soon as possible, and no later than July 1, 2009.


Contributors

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm FROM EXOCYTOSIS TO SYNAPTIC SCALING
Discussion Leader: Christophe Mulle (CNRS, Bordeaux)
7:40 pm - 8:20 pmGina Turrigiano (Brandeis University)
"Homeostatic synaptic scaling"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pmReinhard Jahn (MPIBC, Göttingen)
"Mechanism of SNARE-mediated exocytosis of synaptic vesicles"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm GLUTAMATE RECEPTOR STRUCTURE AND EXCITATORY SYNAPTIC COMPLEXES
Discussion Leader: Mark Mayer (NIH, Bethesda)
9:00 am - 9:25 amEric Gouaux (Vollum Institute, Portland)
"Atomic structure and molecular mechanism at chemical synapses"
9:25 am - 9:40 am Discussion
9:40 am - 10:00 amXiaobing Chen (NIH, Bethesda)
"EM tomographic fine structure of the postsynaptic density"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break / Group Photo
10:30 am - 10:55 amSeth Grant (Wellcome Trust Sanger Institute, Cambridge)
"Synaptic evolution, molecular networks and the emergence of behavior"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 amJean-Philippe Pin (Institut de Génomique Fonctionnelle, Montpellier)
"Activation and allosteric modulation of metabotropic glutamate receptors"
11:35 am - 11:45 am Discussion
11:45 am - 12:05 pmPierre Paoletti (Ecole Normale Supérieure, Paris)
"How NR2 subunits differentially control NMDA receptor channel activity"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pmShort Talk: Gabriela Popescu (University of Buffalo)
"Distinct gating modes determine the biphasic relaxation of NMDA receptor currents"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pm TRAFFICKING AND MOLECULAR ORGANIZATION AT EXCITATORY SYNAPSES
Discussion Leader: Jeremy Henley (University of Bristol)
5:30 pm - 5:55 pmKatherine Roche (NINDS, Bethesda)
"Regulation of glutamate receptors: Trafficking and phosphorylation"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:35 pmMichael Ehlers (Duke University)
"Protein machinery for postsynaptic trafficking at glutamate synapses"
6:35 pm - 6:50 pm Discussion
6:50 pm - 7:15 pmDaniel Choquet (Institut Francois Magendie, Bordeaux)
"The interplay between the function and regulation of AMPAR trafficking"
7:15 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm EXCITATORY SYNAPSES - INSIGHTS FROM MODEL SYSTEMS
Discussion Leader: Andres Villu Maricq (University of Utah)
9:00 am - 9:15 amShort Talk: Nikolaj Klocker (University of Freiburg)
"Cornichons facilitate early anterograde transport of AMPARs"
9:15 am - 9:20 am Discussion
9:20 am - 9:35 amShort Talk: Thomas Blanpied (University of Maryland)
"Local dynamics of actin polymerization within dendritic spines"
9:35 am - 9:40 am Discussion
9:40 am - 10:05 amKang Shen (Stanford University)
"Synapse and circuit development in C. elegans"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:40 am - 11:05 amStephan Sigrist (Freie Universitat, Berlin)
"Shedding light on active zone structure and function in Drosophila"
11:05 am - 11:20 am Discussion
11:20 am - 11:45 amYishi Jin (University of California, San Diego)
"Synapse formation in C. elegans"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Short Talk: Michisuke Yuzaki (Keio University)
"Cbln family proteins and their receptors: unique presynaptic organizers in the cerebellum and hippocampus"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk: Clarissa Waites (Stanford University)
"Piccolo and Bassoon are required for the structural and functional integrity of excitatory synapses"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
5:30 pm - 7:30 pm VESICULAR AND PRESYNAPTIC MECHANISMS AT EXCITATORY SYNAPSES
Discussion Leader: Reinhard Jahn (MPIBC, Göttingen)
5:30 pm - 5:55 pmRichard Tsien (Stanford University)
"Presynaptic adaptation of unitary synaptic events"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:35 pmRobert Edwards (University of California, San Francisco)
"Synaptic vesicle recycling"
6:35 pm - 6:50 pm Discussion
6:50 pm - 7:15 pmYukiko Goda (University College London)
"Regulation of neurotransmitter release by synaptic adhesion proteins"
7:15 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm GLUTAMATE RECEPTOR SIGNALING AND MODULATION AT EXCITATORY SYNAPSES
Discussion Leader: Richard Tsien (Stanford University)
9:00 am - 9:25 amRyohei Yasuda (Duke University)
"Glutamate receptor signal transduction at single dendritic spines"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amAndres Villu Maricq (University of Utah)
"AMPAR signaling complexes"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:40 am - 11:05 amRoger Nicoll (University of California, San Francisco)
"How many TARPs bind to an AMPA receptor"
11:05 am - 11:20 am Discussion
11:20 am - 11:45 amHannah Monyer (University of Heidelberg)
"Novel proteins modulating AMPA receptor activity"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Short Talk: Regina Dahlhaus (University of British Columbia)
"Over-expression of Neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ratio of excitation to inhibition"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk: Nathalie Sans (Universite Bordeaux II)
"Scribble1 regulates neuronal maturation, synaptic plasticity and memory"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session III
5:30 pm - 7:30 pm STRUCTURAL AND FUNCTIONAL SYNAPTIC PLASTICITY
Discussion Leader: Gina Turrigiano (Brandeis)
5:30 pm - 5:55 pmValentin Nägerl (CNRS, Bordeaux)
"STED microscopy of living synapses"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:35 pmSuzanne Zukin (Albert Einstein College of Medicine)
"Epigenetic remodeling of synaptic AMPA receptor phenotype"
6:35 pm - 6:50 pm Discussion
6:50 pm - 7:15 pmChristian Luscher (University of Geneva)
"Drug-evoked synaptic plasticity: a key to addiction?"
7:15 pm - 7:30 pm Discussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm PATTERNS OF SYNAPTIC DYSFUNCTION AND DISEASE
Discussion Leader: Juan Lerma (Instituto de Neurociencias de Alicante)
9:00 am - 9:25 amTimothy Murphy (University of British Columbia)
"In vivo imaging of plastic changes to synapses/circuits during ischemia and recovery"
9:25 am - 9:40 am Discussion
9:40 am - 10:05 amMonica DiLuca (University of Milan)
"Role of ADAM10 in the glutamatergic postsynaptic density: bridging synaptic failure and amyloid cascade"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:40 am - 11:05 amNils Brose (MPIEM, Göttingen)
"Synaptic and behavioral dysfunction in animal models of mongenic heritable autism"
11:05 am - 11:20 am Discussion
11:20 am - 11:45 amClaudia Bagni (Katholieke Universiteit Leuven)
"Fragile X syndrome and synaptic function"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Short Talk: Yann Humeau (University of Strasbourg)
"Synaptic physiology in mouse models of mental retardation"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk (TBA)
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session IV
5:30 pm - 6:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
6:00 pm - 7:30 pm THE NEXT FRONTIER - APPROACHES TO NETWORKS
Discussion Leader: Gary Westbrook (Vollum Institute, Portland)
6:00 pm - 6:25 pmMichael Häusser (University College London)
"Dendritic computation"
6:25 pm - 6:40 pm Discussion
6:40 pm - 7:20 pm Edvard Moser (Norwegian University of Science and Technology, Trondheim)
"Grid cells, entorhinal circuits and hippocampal memory"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 MH086158-01 from the following institutes: National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute on Drug Abuse, and National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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