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Biological Molecules in the Gas Phase
Gordon Research Conference

And in Solution…
Note: This conference is currently known as "Biological Molecules in the Gas Phase and in Solution".

Dates

July 5-10, 2009

Location

Tilton School
Tilton, NH

Organizers

Chairs:
David Pratt & Joan-Emma Shea

Vice Chair:
Lars Konermann

Meeting Description

Cross disciplinary in nature, with emphasis on isolated biomolecules and biomolecular interactions, theory and experiment, this meeting will provide an international forum for the presentation and discussion of frontier research on molecules of biological interest in the gas phase, and in solution. The past few years have witnessed remarkable advances in this field, revealing important properties of the building blocks of life that have heretofore been obscured by surrounding condensed phase environments. Our conference will put these results in perspective by comparing the properties of isolated molecules with their properties in the condensed phase, especially in solution. Following a brief tutorial on modern experimental methods in high resolution spectroscopy and mass spectrometry, the meeting will begin with a keynote lecture on "The Challenges that Lie Ahead" and continue with sessions devoted to noncovalent interactions, hydration, peptides and proteins, enzymes, nucleic acids, energy transduction, carbohydrates, and biopolymers in cells. Each session will feature a discussion leader and three invited talks; one on spectroscopy, one on computational methods, and one on mass spectrometry, each focused on the central topic of the session. In this way, we will compare and contrast the experimental and theoretical methods, and what can be learned from the application of these very different techniques to similar systems. Additionally, a scientist working in the field will be assigned the role of “reflector” for the session, who will help all conferees put the talks in a biological perspective, and identify key future areas of interest in that field. “Hot Topics” and “Poster” Sessions also are planned. The meeting will therefore provide an opportunity for young scientists to grow and be stimulated by the discussion of future research activities in this interdisciplinary field.

Contributors

The Gordon Research Conference on Biomolecules in the Gas Phase (and in Solution) gratefully acknowledges financial support from Agilent Technologies; the Journal of Mass Spectrometry and Rapid Communications in Mass Spectrometry; the Carl Storm Underrepresented Minority Fellowships; The Gray Family Fund; an anonymous donor; and the National Institutes of Health (Award Number 1 R13 GM087749-01).

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmSETTING THE STAGE
Discussion Leaders: Joan-Emma Shea (UCSB) and David Pratt (U Pittsburgh)
7:40 pm - 8:05 pm Tim Zwier (Purdue U)
"Gas phase neutral molecules. Spectroscopy and dynamics"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Alan Marshall (Florida State U)
"Gas phase biomolecular ions. What can they tell us?"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Keynote Lecture: Greg Petsko (Brandeis U)
"The challenges that lie ahead"
9:20 pm - 9:30 pm Discussion
9:30 pm - Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNONCOVALENT INTERACTIONS
Discussion Leader: Steve Scheiner (Utah State U)
9:00 am - 9:30 am Michel Mons (Saclay)
"Secondary structures of small peptides via IR/UV double resonance spectroscopy"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Joel Moreno Ireta (UAM-I)
"Assessing the influences of hydrogen bonds on protein conformational space"
10:15 am - 10:30 am Discussion
10:30 am - 11:15 am Coffee Break / Group Photo
11:15 am - 11:45 am Alison Ashcroft (U Leeds)
"Biomolecular Assembly in the Gas Phase"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:30 pm Hot Topics
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmHYDRATION
Discussion Leader: Mark Johnson (Yale U)
7:30 pm - 8:00 pm Simon Ebbinghaus (U Illinois)
"The terahertz dance of water and proteins"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Evan Williams (UC Berkeley)
"Zwitterions in the gas phase"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Shekhar Garde (RPI)
"Water-mediated interactions in biology"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPEPTIDES AND PROTEINS
Discussion Leader: Chris Cheatum (U Iowa)
9:00 am - 9:30 am David Clemmer (Indiana U)
"Biomolecule conformations via ion mobility measurements"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Ryan Julian (UC Riverside)
"Dissecting proteins in the gas phase"
10:15 am - 10:30 am Discussion
10:30 am - 11:15 am Coffee Break
11:15 am - 11:45 am H.-S. Chan (U Toronto)
"Cooperativity principles in protein folding"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:30 pm Hot Topics
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmENZYMES
Discussion Leader: Rebecca Jockusch (U Toronto)
7:30 pm - 8:00 pm Katie Henzler-Wildman (Washington U)
"A hierarchy of time scales in protein dynamics"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Ben Schuler (U Zurich)
"Single molecule protein folding"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Sharon Hammes-Schiffer (Penn State U)
"Proton and hydrogen transfer reactions in enzymes"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNUCLEIC ACIDS
Discussion Leader: Marcus Wilhelmsson (Chalmers U.)
9:00 am - 9:30 am Daniele Fabris (UMBC)
"Higher-order structure of RNA by MS-based approaches"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Jiri Sponer (Czech Academy)
"Structure and dynamics of functional RNA"
10:15 am - 10:30 am Discussion
10:30 am - 11:15 am Coffee Break
11:15 am - 11:45 am Valerie Gabelica (U Brussels)
"IR and UV signatures of DNA structures in the gas phase"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:30 pm Hot Topics
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 3
6:00 pmDinner
7:30 pm - 9:30 pmENERGY TRANSDUCTION
Discussion Leader: Ralph Jimenez (JILA)
7:30 pm - 8:00 pm Steven Boxer (Stanford U)
"Electron transfer in photosynthetic reaction centers"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm David Beratan (Duke U)
"Fluctuations, electron transfer, and signalling"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Thomas Surrey (EMBL, Heidelberg)
"Motors and microtubule-end tracking proteins"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCARBOHYDRATES
Discussion Leader: Mark Wormald (Oxford U)
9:00 am - 9:30 am John Simons (Oxford U)
"Sugars in the gas phase"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Rob Woods (U Georgia)
"Combining Mass Spectrometry and Molecular Dynamics Simulations to Characterize Biomolecular Interactions"
10:15 am - 10:30 am Discussion
10:30 am - 11:15 am Coffee Break
11:15 am - 11:45 am Julie Leary (UC Davis)
"Glycosaminoglycan: protein interactions"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:30 pm Hot Topics
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
6:00 pmDinner
7:30 pm - 9:30 pmBIOLOGICAL SYSTEMS
Discussion Leader: Lars Konermann (U Western Ontario)
7:30 pm - 8:00 pm Filipp Oesterhelt (U Duesseldorf)
"AFM studies of single biomolecules"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Mike Bowers (UCSB)
"Amyloid formation in biological systems"
8:45 pm - 9:00 pm Discussion
9:00 pm - 9:30 pm Discussion and Reflections
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1 R13 GM087749-01 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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