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Conference Program
 
Genetic Toxicology
August 9-14, 2009
Colby-Sawyer College
New London, NH
Chair:
Samuel H. Wilson

Vice Chair:
Jessica A. Downs

Genetic toxicology represents the study of genetic damage, the agents that induce such damage, and the biological mechanisms that respond to the consequences of genetic damage. Genotoxic agents are abundant in the environment and are often linked to human activity. The effects these agents on humans include many of the common diseases. Because of the importance of this field and the rapid progress during the last decade, many disciplines in the public and private sectors are involved (e.g., structural, molecular and cellular biology, genetics, biochemistry, epidemiology, toxicology, adverse drug reactions, toxicogenomics and hazard assessment). Thus, individual scientists in both industry and academia can use this conference as a forum to exchange ideas and discuss cross-disciplinary collaborations and research opportunities.

The 2009 Gordon Research Conference on Genetic Toxicology will bring together a broad spectrum of scientists with the aim of disseminating current advances and stimulating debate to address future developments. Genetic toxicology ranges from basic research to applied research, including the transfer of knowledge for policy implications. Thus, the bringing together of basic and applied scientists from academia, industry and government is essential to drive this important field forward in an optimal manner. Participants will include those at the cutting edge of basic research and those driving technology developments within applied areas. In keeping with the ethos of Gordon Research Conferences, while information will be disseminated by speaker and poster presentations, vigorous discussion will be the key focus. Designated discussion leaders, recognized for their skills in each particular area, will guide the audience-based discussions. Special consideration will be given to strategies to improve interactions of junior and senior scientists during the conference.

The 2009 Gordon Research Conference on Genetic Toxicology will take place August 9-14, 2009 at Colby-Sawyer College, New London, New Hampshire, USA. Approximately 150 scientists will attend.


SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:20 pmKeynote Talks
Discussion Leaders: Samuel Wilson (Chapel Hill, NC, USA) / Jessica Downs
7:40 pm - 8:20 pm Anthony Carr (GDSC, UK)
"Using fission yeast to study the role of TopBP1 in ATR activation"
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:10 pm Myron Goodman (USC, USA)
"The Biochemical Basis of SOS-induced Mutation in Escherichia coli"
9:10 pm - 9:20 pm Discussion
9:20 pm Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Environment & Genotoxic Stress
Discussion Leaders: Philip Hanawalt (Stanford University, USA) / David Hunter
9:00 am - 9:25 am David Hunter (Harvard / NIH-NCI, USA)
"Genome-wide association studies - new clues to biologic function in human cancer"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Frederica Perera (Columbia, USA)
"Effect of prenatal environmental exposures on the genome and epigenome"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break / Group Photo
10:40 am - 11:05 am Philip Hanawalt (Stanford University, USA)
"Mechanistic approaches to genetic toxicology"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 am Nick Geacintov (NYU, USA)
"Structure-Function Relationships in Nucleotide Excision Repair of Bulky DNA Lesions"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Gerd Pfeifer (City of Hope, USA)
"Effect of environmental mutagens on the genome and epigenome"
12:15 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Names A-K)
6:00 pmDinner
7:30 pm - 9:30 pmEndogenous Genotoxic Stress
Discussion Leaders: Leona Samson (MIT, USA) / Susan Wallace
7:30 pm - 7:55 pm Leona Samson (MIT, USA)
"Complex Responses to Alkylating Agents"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Susan Wallace (U. Vermont, USA)
"Repair Processing of Oxidative DNA Damage"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Keith Caldecott (GDSC, UK)
"Identification of a novel tyrosyl phosphodiesterase"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Ben Van Houten (U. Pitt., USA)
"Reactive oxygen species & genotoxic stress"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMutagenesis & Lesion By-Pass (1)
Discussion Leaders: Thomas Kunkel (NIH-NIEHS, USA) / Larry Loeb
9:00 am - 9:25 am Marietta Lee (NY Med. Coll., USA)
"Modification of DNA polymerase delta in response to DNA damage"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Thomas Kunkel (NIH-NIEHS, USA)
"Efficiency of Repairing Polymerase- and Strand-Specific DNA Replication Errors"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:30 am - 10:55 am Andrei Chabes (Umea U., Sweden)
"Regulation of dNTP synthesis and DNA damage tolerance"
10:55 am - 11:05 am Discussion
11:05 am - 11:30 am Julian Sale (Cambridge, UK)
"The control of translesion synthesis"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pm Joann Sweasy (Yale, USA)
"Aberrant Base Excision Repair and Cancer"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Presentation: Dmitry Gordenin (NIH-NIEHS, USA)
"Damage-induced localized hypermutability"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Names A-K)
6:00 pmDinner
7:30 pm - 9:30 pmMutagenesis & Lesion By-Pass (2)
Discussion Leaders: Roger Woodgate (NIH-NICHD, USA) / Alan Lehmann
7:30 pm - 7:55 pm Alan Lehmann (GDSC, UK)
"The role of ubiquitination in the replication of DNA damage"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Roger Woodgate (NIH-NICHD, USA)
"Recent insights into the mechansims of spontaneous and damage-induced mutagenesis in Escherichia coli"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Shunichi Takeda (Kyoto U., Japan)
"Reverse Genetic Analysis of DNA polymerases in TLS"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Larry Loeb (U. Washington, USA)
"Random Mutations in Human Cancers: Origin and Consequences"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromatin & Links to Genotoxicity (1)
Discussion Leaders: Jessica Downs (GDSC, UK) / Michael Smerdon
9:00 am - 9:25 am Jessica Downs (GDSC, UK)
"Reorganizing chromatin at a DNA break"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Michael Smerdon (WSU, USA)
"DNA Excision Repair in Chromatin: Searching for the Key to Get In"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:30 am - 10:55 am Michael Bustin (NIH-NCI, USA)
"Chromatin Architectural Proteins and Genotoxic Stress"
10:55 am - 11:05 am Discussion
11:05 am - 11:30 am Craig Peterson (U. Mass., USA)
"Chromatin remodeling and genome stability"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pm Kevin Hiom (Canbridge, UK)
"DNA damage-associated changes in chromatin folding"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Presentation: William Thilly (MIT, USA)
"Adult human somatic mutants originate in fetal/juvenile metakaryotic stem cells"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Names L-Z)
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmChromatin & Links to Genotoxicity (2)
Discussion Leaders: Ben Van Houten (U. Pitt., USA) / Michael Bustin
7:30 pm - 7:55 pm Wim Vermeulen (Erasmus Medical Center
"UV-induced DNA damage signaling in mammalian cells")
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm K.J. Myung (NIH-NHGRI, USA)
"Suppression of genomic instability by conserved pathways"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Sang Eun Lee (UTHSC-SA, USA)
"Dynamics of DNA damage-induced chromatin reorganization"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Karen Vasquez (MD Anderson, USA)
"DNA structure-induced genetic instability and cancer"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDNA Damage & Cellular Decisions (1)
Discussion Leaders: Yosef Shiloh (Tel Aviv U., Israel) / Anthony Carr
9:00 am - 9:25 am Yosef Shiloh (Tel Aviv U., Israel)
"The ATM-Mediated DNA damage response: the system and the pathways"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am William Dunphy (Cal. Tech., USA)
"Role of ATR in Cell Cycle Checkpoints"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:30 am - 10:55 am David Cortez (Vanderbilt U., USA)
"Genome maintenance by the DNA damage response"
10:55 am - 11:05 am Discussion
11:05 am - 11:30 am Michael Yaffe (MIT, USA)
"Systems approaches to DNA damage signaling reveal a novel cytoplasmic checkpoint"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pm Dan Durocher (U. Toronto, Canada)
"Discovery of novel modulators of genome integrity by genome-scale RNA interference screening"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Presentation: Olga Lavrik (NSC, Russia)
"Interaction of repair proteins with apurinic/apyrimidinic sites of DNA"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session (Names L-Z)
6:00 pmDinner
7:30 pm - 9:30 pmDNA Damage & Cellular Decisions (2)
Discussion Leaders: Penny Jeggo (GDSC, UK) / Michael Resnick
7:30 pm - 7:55 pm Junjie Chen (Yale, USA)
"DNA damage signaling and DNA repair"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Penny Jeggo (GDSC, UK)
"The role of ATM signalling and the mediator proteins in the repair of radiation induced DNA double strand breaks"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Michael Resnick (NIH-NIEHS, USA)
"The expanding p53 universe of target genes"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Thomas Helleday (Oxford, UK)
"Repair and restart of stalled and collapsed replication forks"
9:25 pm - 9:30 pm Discussion
9:30 pm Reception
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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