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Glycobiology
Gordon Research Conference

Dates

January 18-23, 2009

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Christopher M. West

Vice Chair:
Hudson H. Freeze

Meeting Description

The 2009 Glycobiology Gordon Research Conference will be held January 18-23 at the Ventura Beach Marriott Hotel in Ventura, California. Please note the earlier date relative to recent years. The Glycobiology Gordon Conference offers a unique opportunity, in a collegial setting, to both contribute to and keep abreast of the latest developments in our multidisciplinary field. Many new glycan functions are rapidly emerging from the studies of tissues and organs of humans and model systems, as well as in the area of parasite-host interactions, and these advances are fueled by equally dramatic developments in glycan structural analysis technologies. Thirteen scientific sessions are currently planned to cover diverse areas of the field, including Structural glycobiology of enzymes and receptors, Mechanisms of glycosylation, Nerve and muscle glycobiology, Chemical glycobiology, Immune cell glycobiology, Vascular glycobiology, Developmental glycobiology, Cancer and cell regulation, Metabolic regulation, and Parasite glycobiology. In addition to the approximately 31 invited talks, ~26 short talks will be selected from poster abstracts, and eight Conference Awards will be available for outstanding abstracts submitted by graduate students, post-docs and new faculty members. All applicants are encouraged to present a poster. The size of the conference has been increased this year to 150 participants but, since registration is limited, early application is advised. We encourage participation of researchers new to the glycobiology field, as well as junior investigators, scientists from developing countries, racial/ethnic minorities, and disabled persons. Please join us for what promises to be an exciting and interactive meeting.

Contributors

Meeting Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff & Chair
7:35 pm - 9:30 pm Structural Glycobiology - Enzymes and Receptors
Discussion Leader: Carlos Hirschberg (Boston University School of Dental Medicine)
7:35 pm - 7:40 pmCarlos Hirschberg (Boston University School of Dental Medicine)
"Introduction"
7:40 pm - 8:03 pm Nancy M. Dahms (Medical College of Wisconsin)
"Lysosomal enzyme recognition and the P-type lectins"
8:03 pm - 8:08 pm Discussion
8:08 pm - 8:18 pm Poster Talk: Xiaoqiang Wang (Noble Foundation, Oklahoma)
"Structural basis of glycosylation of small molecules"
8:18 pm - 8:22 pm Discussion
8:22 pm - 8:44 pm David R. Rose (University of Toronto)
"Mapping the substrate binding subsites of Golgi Mannosidase II and implications for inhibitor development"
8:44 pm - 8:49 pm Discussion
8:49 pm - 8:59 pm Poster Talk: Binghe Wang (Georgia State University)
"Going after the ‘sweet spot’ in selecting aptamers for glycoproteins"
8:59 pm - 9:03 pm Discussion
9:03 pm - 9:25 pm Jian Liu (University of North Carolina)
"Engineering the sulfotransferases to modify heparan sulfate"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:00 pm Refreshments
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 am Mechanisms of Glycosylation I
Discussion Leaders: John Hanover (NIH) and Kelly Ten Hagen (NIH)
9:00 am - 9:05 amKelly Ten Hagen (NIH)
"Introduction"
9:05 am - 9:27 am Anant K. Menon (Cornell Medical College)
"Lipid flipping and protein N-glycosylation"
9:27 am - 9:32 am Discussion
9:32 am - 9:55 am Markus Aebi (Swiss Federal Institute of Technology)
"Some novel aspects of N-linked protein glycosylation in the ER"
9:55 am - 10:00 am Discussion
10:00 am - 10:30 am Group Photo / Coffee Break
10:30 am - 10:40 am Poster Talk: Julio J. Caramelo (Buenos Aires)
"The interplay between the diverse activities of calreticulin"
10:40 am - 10:45 am Discussion
10:45 am - 10:55 am Poster Talk: Christian Thiel (University Children’s Hospital Heidelberg)
"A mouse model for Congenital Disorder of Glycosylation Ia"
10:55 am - 11:00 am Discussion
11:00 am - 12:30 pm Mechanisms of Glycosylation II
Discussion Leader: Jacques Baenziger (Washington University)
11:00 am - 11:05 amJacques Baenziger (Washington University)
"Introduction"
11:05 am - 11:27 am Thierry Hennet (Zurich)
"Collagen glycosylation"
11:27 am - 11:32 am Discussion
11:32 am - 11:55 am Stuart Kornfeld (Washington University)
"New insights into UDP-GlcNAc:lysosomal enzyme N-acetyglucosamine-1-phosphotransferase from mouse models"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Poster Talk: Heather R. Flanagan-Steet (CCRC, University of Georgia)
"Investigation of the cartilage morphogenesis defects in Mucolipidosis-II zebrafish"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Poster Talk: Francois J.C. Foulquier (University of Lille 1/CNRS)
"Link between Golgi pH homeostasis and glycosylation: contribution of CDG-II patients"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I (Poster Chair: Kelley W. Moremen, Univ. of Georgia)
6:00 pmDinner
7:30 pm - 9:30 pm Infectious Disease - Eukaryotes
Discussion Leader: Richard D. Cummings (Emory)
7:30 pm - 7:35 pmRichard D. Cummings (Emory)
"Introduction"
7:35 pm - 7:58 pm James Stevens (Center for Disease Control)
"Receptor interactions of seasonal and pandemic potential influenza viruses"
7:58 pm - 8:03 pm Discussion
8:03 pm - 8:27 pm Michael A. Ferguson (Dundee)
"Novel aspects of African trypanosome oligosaccharyl- and glycosyl-transferases"
8:27 pm - 8:32 pm Discussion
8:32 pm - 8:55 pm Steve Beverley (Washington University)
"Synthesis of GDP-D-Ara(pyranose) by a novel bifunctional enzyme and its role in Leishmania biology and parasitism"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Poster Talk: John C. Samuelson (Boston University School of Dental Medicine)
"Evidence for a ‘wattle and daub’ model of the cyst wall of Entamoeba"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Poster Talk: Alexander Titz (ETH Zurich)
"Identification of a member of a novel galactosyltransferase family unravels the molecular basis of the nematotoxicity of fungal galectin CGL2"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:00 pm Poster Session I / Refreshments
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 am Immune & Vascular Glycobiology I
Discussion Leader: Jim C. Paulson (Scripps)
9:00 am - 9:05 am Jim C. Paulson (Scripps)
"Introduction"
9:05 am - 9:27 am Lijun Xia (Oklahoma Medical Research Foundation)
"Endothelial cell mucin-type O-glycans control establishment and maintenance of distinct blood and lymphatic vessel systems"
9:27 am - 9:32 am Discussion
9:32 am - 9:55 am John B. Lowe (Genentech)
"Notch-Notch ligand interactions, Notch signaling and Notch glycosylation in the immune system"
9:55 am - 10:00 am Discussion
10:00 am - 10:10 am Poster Talk: Lindsay Steirer (Washington University School of Medicine)
"The mannose/GalNAc-4-SO4 receptor and asialoglycoprotein receptor regulate steroid hormone production during sexual reproduction and pregnancy"
10:10 am - 10:15 am Discussion
10:15 am - 10:25 am Poster Talk: Hans H. Wandall (University of Copenhagen)
"Megakaryocytes package and deliver Golgi-associated glycosyltransferases into platelet granules enabling extra-cellular glycosylation"
10:25 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 12:30 pm Immune & Vascular Glycobiology II
Discussion Leader: Jim C. Paulson (Scripps)
11:00 am - 11:05 amJim C. Paulson (Scripps)
"Introduction"
11:05 am - 11:27 am Gabriel Rabinovich (Buenos Aires)
"Galectins at the crossroads of tolerance and inflammation: lessons from experimental models in vivo"
11:27 am - 11:32 am Discussion
11:32 am - 11:55 am Yvette van Kooyk (Vrije University)
"Dendritic cell C-type lectins modulators of immune responses"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Poster Talk: Sachiko Sato (Research Centre for Infectious Diseases, Quebec)
"Galectin-1 facilitates HIV-1 infection by stabilizing virion adhesion to susceptible cells"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Poster Talk: Jin-ichi Inokuchi (Tohoku Pharmaceutical University)
"Distinct ganglioside-species specific dependencies between CD4+ and CD8+ T cells in the TCR-mediated activation"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Excursion TBA
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pm Cancer & Cell Regulation
Discussion Leader: Jim Dennis (University of Toronto)
7:30 pm - 7:35 pmJim Dennis (University of Toronto)
"Introduction"
7:35 pm - 7:58 pm Melanie A. Simpson (University of Nebraska)
"Glucuronidation in prostate cancer: hyaluronan accumulation versus androgen inactivation"
7:58 pm - 8:03 pm Discussion
8:03 pm - 8:27 pm Steven D. Rosen (UCSF)
"The Sulfs in Cancer"
8:27 pm - 8:32 pm Discussion
8:32 pm - 8:55 pm Tatsuro Irimura (University of Tokyo)
"MUC21/Epiglycanin: the oldest cancer-associated mucin rediscovered"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Poster Talk: Kathryn E. Wellen (University of Pennsylvania)
"Hexosamine pathway activity regulates glutamine metabolism"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Poster Talk: Fionnuala M. Morrish (Fred Hutchinson Cancer Research Center)
"Oncogene regulation of substrate supply alters O-GlcNAc modification of proteins during cell cycle entry"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:00 pm Poster Session I / Refreshments
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 am Developmental Glycobiology I
Discussion Leader: Robert S. Haltiwanger (Stony Brook)
9:00 am - 9:05 amBob Haltiwanger (Stony Brook)
"Introduction"
9:05 am - 9:27 am Hamed Jafar-Nejad (University of Texas Health Sciences Center)
"Regulation of Notch signaling by the glycosyltransferase Rumi"
9:27 am - 9:32 am Discussion
9:32 am - 9:55 am Kenji Matsuno (Tokyo University of Science)
"The monosaccharide O-fucose modification of Notch contributes to its signaling activity"
9:55 am - 10:00 am Discussion
10:00 am - 10:10 am Poster Talk: Ellen K. LeMosy (Medical College of Georgia)
"The continuing saga of Pipe and glycosaminoglycans in Drosophila embryonic axis patterning: new input from biochemical and functional approaches"
10:10 am - 10:15 am Discussion
10:15 am - 10:25 am Poster Talk: Tabea Dierker (University of Muenster)
"New functions of heparan sulfate in Hedgehog signaling"
10:25 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 12:30 pm Developmental Glycobiology II
Discussion Leader: Jeffrey Esko (UCSD)
11:00 am - 11:05 amJeffrey Esko (UCSD)
"Introduction"
11:05 am - 11:27 am Hiroshi Nakato (University of Minnesota)
"Heparan sulfate proteoglycans in gradients and niche"
11:27 am - 11:32 am Discussion
11:32 am - 11:42 am Poster Talk: Hideyuki Takeuchi (Stony Brook)
"Novel specificity of a glycosyltransferase, Rumi, required for Notch signaling"
11:42 am - 11:47 am Discussion
11:47 am - 12:10 pm Pamela Stanley (Albert Einstein)
"O-fucose glycans of Notch in T cell development"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Poster Talk: Rebecca Baldwin (Paterson Institute for Cancer Research, UK)
"Heparan Sulphate epitopes can be used to fractionate defined lineages during embryonic stem cell differentiation"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II (Poster Chair: Kelley W. Moremen, Univ. of Georgia)
6:00 pmDinner
7:30 pm - 9:30 pm Structural Glycobiology - Glycans & Glycomics
Discussion Leader: Anne Dell (Imperial College)
7:30 pm - 7:35 pmAnne Dell (Imperial College)
"Introduction"
7:35 pm - 8:03 pm Xi Chen (UC Davis)
"Ligand specificity studies of Siglecs using combinatorial chemoenzymatically synthesized sialosides"
7:58 pm - 8:03 pm Discussion
8:03 pm - 8:27 pm Heather Desaire (University of Kansas)
"New methods of glycopeptide analysis for profiling HIV envelope glycoproteins"
8:27 pm - 8:32 pm Discussion
8:32 pm - 8:55 pm Lance Wells (CCRC, University of Georgia)
"Glycomic approaches for the analysis of embryonic Stem cells"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Poster Talk: Kevin Canis (Imperial College London)
"Towards a comprehensive glycan map of Von Willebrand Factor"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Poster Talk: Josef Voglmeir (Manchester)
"Glycosyltransferases and their application on peptide arrays"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:00 pm Poster Session II / Refreshments
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 am Infectious Disease - Prokaryotes
Discussion Leader: Phillips Robbins (Boston University School of Dental Medicine)
9:00 am - 9:05 amPhillips Robbins (Boston University School of Dental Medicine)
"Introduction"
9:05 am - 9:27 am Geert-Jan Boons (CCRC, University of Georgia)
"Click chemistry and glycoscience"
9:27 am - 9:32 am Discussion
9:32 am - 9:55 am Mario F. Feldman (Alberta)
"Extreme substrate promiscuity of a bacterial oligosaccharyltransferase involved in protein-O-linked glycosylation"
9:55 am - 10:00 am Discussion
10:00 am - 10:10 am Poster Talk: Ian C. Schoenhofen (National Research Council, Ottawa)
"Biosynthesis of a sialic acid mimic, legionaminic acid, using enzymes from Campylobacter jejuni"
10:10 am - 10:15 am Discussion
10:15 am - 10:25 am Poster Talk: Dennis M. Whitfield (National Research Council, Ottawa)
"Development of new glycosylation methodologies for the synthesis of archaeal derived glycolipid adjuvants"
10:25 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 12:30 pm Metabolic Regulation
Discussion Leader: Gerald W. Hart (Johns Hopkins School of Medicine)
11:00 am - 11:05 amGerald W. Hart (Johns Hopkins School of Medicine)
"Introduction"
11:05 am - 11:28 am Xiaoyong Yang (Yale University School of Medicine)
"O-GlcNAc: A sweet metabolic switch"
11:28 am - 11:33 am Discussion
11:33 am - 11:55 am Natasha Zachara (Johns Hopkins University School of Medicine)
"The sweet nature of the cellular stress response"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Poster Talk: Salil K. Ghosh (NIDDK)
"Altered O-GlcNAc cycling impacts nucleotide sugar metabolism, macronutrient storage and expression of C-type lectins"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Poster Talk: Line M. Gronning-Wang (University of Oslo)
"The nuclear receptor LXR is O-GlcNAc modified in response to glucose"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / Optional Excursion TBA
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Nerve and Muscle Glycobiology
Discussion Leader: Linda Baum (UCLA)
7:30 pm - 7:35 pmLinda Baum (UCLA)
"Introduction"
7:35 pm - 7:58 pm Karen J. Colley (Illinois)
"Requirements for protein specific polysialylation"
7:58 pm - 8:03 pm Discussion
8:03 pm - 8:26 pm J. Michael Pierce (University of Georgia)
"A tale of two sisters"
8:26 pm - 8:31 pm Discussion
8:31 pm - 8:55 pm Paul T. Martin (Ohio State)
"Cmah is a genetic modifier of disease progression in mdx mice"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Poster Talk: Gregory R. Moe (Children’s Hospital Oakland Research Institute)
"Acquisition of exogenous polysialic acid containing de-N-acetyl sialic acid by cancer cells produces large increases in surface expressed and intracellular de-N-acetyl sialic acid-modified antigens"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Poster Talk: Sander I. van Kasteren (University of Dundee)
"Glyconanoparticles for the early detection of brain disease"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:00 pm Poster Session II / Refreshments
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible in part by 1 R13 GM 086996 - 01 from the National Institute of General Medical Sciences (NIGMS), National Heart, Lung, And Blood Institute (NHLBI), Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute Of Diabetes And Digestive And Kidney Diseases (NIDDK). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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