Gordon Research Conferences
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Conference Program
 
Bioinorganic Chemistry (GRS)
Gordon Research Seminar
January 29 - February 1, 2009
Four Points Sheraton / Holiday Inn Express
Ventura, CA

Related Meeting Information
The Bioinorganic Chemistry Gordon Research Seminar was held in conjunction with the Metals in Biology Gordon Research Conference. Please refer to the Metals in Biology GRC web page for more information.

Bioinorganic chemistry covers a broad range of topics including, but not limited to, model complexes that mimic how a protein activates a substrate, studying how a particular organism deals with metal stress or deficiency, and biological sensors that utilize metal ions. The overlying theme, though, is the importance of metals and metal-ligand interactions in a biological context.

The Gordon Research Seminar in Bioinorganic Chemistry (GRS) was developed in 1996 in response to the consistent oversubscription of its “parent” meeting, the Gordon Research Conference on Metals in Biology (MIB). The two conferences overlap for one session with the GRS providing the concluding poster session for MIB. This is an excellent opportunity for young researchers to interact with leading principal investigators in the field.

This conference series has gained significant international recognition, attracting students from around the world. Given the multifaceted scope of this field, scientists new to this field of study are particularly benefited by interaction with researchers in other disciplines. We invite and encourage students from any sub-discipline in Bioinorganic Chemistry to submit abstracts for poster or oral presentations.

For those interested in attending, there will be two optional panel discussions at the conference: "Beyond the PhD: Getting and Succeeding in Your Postdoc" and "Beyond the PhD: Getting and Succeeding in Your First Academic Position".


Contributors

THURSDAY
4:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 8:45 pm JOINT SESSION WITH "METALS IN BIOLOGY"
Discussion Leader: David M. Dooley (Montana State University)
7:40 pm - 8:30 pmWilliam B. Tolman (University of Minnesota)
"Biomimetic Activation of O2 and N2O by Copper"
8:30 pm - 8:45 pm Discussion
8:45 pm Joint Poster Session (presented by the GRS: Bioinorganic Chemistry)
FRIDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm METALLOPROTEINS: FROM FUNCTION TO DE NOVO DESIGN
Discussion Leader: Catherine L. Drennan (M.I.T.)
9:15 am - 9:45 amJeremy D. Cook (Wayne State University)
"Identifying the Functional Details of Frataxin’s Contribution During Fe-S Cluster Bioassembly"
9:45 am - 9:50 am Discussion
9:50 am - 10:20 amSeung Jae Lee (University of Maryland)
"How does Iron Binding affect the function of Zinc Finger Proteins?"
10:20 am - 10:25 am Discussion
10:30 am - 10:45 am Coffee Break
10:45 am - 11:15 amEric N. Salgado (University of California, San Diego)
"Symmetry of Metal-induced Protein Assemblies Dictated by Metal Coordination Geometry Preferences"
11:15 am - 11:20 am Discussion
11:20 am - 11:50 amJolene V. Schuster (Dartmouth University)
"Investigation of Cu(I) Binding Thermodynamics of Cellular Proteins Ctr1, Hah1 and ATP7B"
11:50 am - 11:55 am Discussion
11:55 am - 12:25 pmBennett R. Streit (University of Notre Dame)
"Mechanistic and structure-activity study of the O-O bond forming, heme-dependent enzyme, chlorite dismutase"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm SPECTROSCOPY OF METALS IN BIOLOGY
Discussion Leader: David L. Tierney (University of New Mexico)
7:45 pm - 8:15 pmCaleb B. Bell (Stanford University)
"Spectroscopic elucidation of factors that tune binuclear non-heme iron active sites for diverse oxygen reactivity"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:50 pmSarah Bowman (University of Rochester)
"Insight into how the His-Fe(III) interaction in heme proteins modulates reactivity"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:25 pm Katherine M. Van Heuvelen (University of Wisconsin-Madison)
"Insights into the Mechanism of Methyl-Coenzyme M Reductase: Spectroscopic and Computational Studies of Ni-C Bonding in Cofactor F430"
9:25 pm - 9:30 pm Discussion
9:30 pm Poster Session
SATURDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm METALS IN INFECTION AND IMMUNOLOGY
Discussion Leader: Eric P. Skaar (Vanderbilt University)
9:15 am - 9:45 amSandhya Muralidharan (Wayne State University)
"The N-terminal domain of ZntA: its function as a metal chaperone to the transporter"
9:45 am - 9:50 am Discussion
9:50 am - 10:20 amClaire J Parker Siburt (Duke University)
"Hijacking Transferrin-bound Iron: Iron Transport from outside the cell to the periplasm of pathogenic Neisseria gonorrhoeae"
10:20 am - 10:25 am Discussion
10:30 am - 10:45 am Coffee Break
10:45 am - 11:15 amChristine M. Phillips (M.I.T.)
"Metal preference at the second metal binding site of E. coli NikR"
11:15 am - 11:20 am Discussion
11:20 am - 11:50 amNesha O. Andoy (Cornell University)
"Single Molecule Study of Metalloregulator-DNA Interactions"
11:50 am - 11:55 am Discussion
11:55 am - 12:25 pm Maura O’Neill (University of Maryland)
"Cytoplasmic Bingding Protein PhuS is Essential for Heme Homeostasis in Pseudomonas aeruginosa"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm BIOINORGANIC MATERIALS IN SENSING AND IMAGING
Discussion Leader: Christopher J. Chang (University of California, Berkeley)
7:45 pm - 8:15 pmKenia A. Parga (University of Puerto Rico - Rio Piedras Campus)
"Synthesis of Fe8-Based MRI Contrast Agents Targeted to Ovarian Cancer Cells"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:50 pmJan L. Vinkenborg (Eindhoven University)
"Intracellular zinc imaging using FRET-based sensor proteins"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:25 pmPhilip J. Dittmer (University of Colorado, Boulder)
"Genetically encoded FRET based sensors to elucidate spatial distribution of cellular zinc"
9:25 pm - 9:30 pm Discussion
9:30 pm Poster Session
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 am DNA, RNA AND METALS
Discussion Leader: Jacqueline K. Barton (Cal. Tech.)
9:15 am - 9:45 am Brian Zeglis (Cal. Tech.)
"Targeting Defects in DNA with Metalloinsertors"
9:45 am - 9:50 am Discussion
9:50 am - 10:20 am Nandini Nagraj (University of Illinois at Urbana-Champaign)
"Probing metal binding of the 8-17 DNAzyme using biophysical and biochemical methods"
10:20 am - 10:25 am Discussion
10:25 am - 10:55 pmSamuel Pazicni (University of Michigan)
"Identification and characterization of a tightly bound metal in the P4 helix of the metallo-ribozyme ribonuclease P"
10:55 am - 11:00 am Discussion
11:00 am - 11:10 am Coffee Break
11:10 am - 12:30 pm ENVIRONMENTAL BIOINORGANIC CHEMISTRY
Discussion Leader: Rachel N. Austin (Bates College)
11:20 am - 11:50 pmCheryl Saunders (Dalhousie University)
"Synthesis and Characterization of Lead-Amino Acid and Mercury-Amino Acid Complexes"
11:50 am - 11:55 am Discussion
11:55 am - 12:25 pm Kathy Batchler (Yale University)
"Siderophore Scavenging of Titanium"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pmDeparture

Funding for this conference was made possible in part by 5 R13 GM 074563-05 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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