Gordon Research Conferences
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Conference Program
 
Human Genetics & Genomics
July 19-24, 2009
University of New England
Biddeford, ME

Human genetics is in the midst of a revolution. With the complete sequencing of several human genomes and the exponential decrease in the costs of whole-genome sequencing, the promise of individual genome sequencing is imminent. Despite these advances, a large fraction of the genetic variation underling human disease and phenotypic variation remains unexplained. This Gordon Conference will bring together international leaders in the field of human genetics and genomics to discuss what has been learned and where the field is heading. Speakers will contrast the relative contribution of rare and common variation to disease, summarize the major advances in our understanding of the organization and function of our genome, discuss new insights into human genetic diversity and highlight the application of new sequencing technologies. The conference should be of interest to researchers and students in the fields of human and medical genetics as well as those interested in genome biology in the post-genomic era. It will also provide a venue for rapid exposure to the "state of the art" for investigators contemplating studies, or the utilization of tools, in this field.

Please note that student registration awards are available. Any interested student/postdoc need only to apply and include an abstract to be considered for these awards.

Additionally, a flyer has been created for this meeting and can be downloaded here. Right click, choose "Save Link As".


SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Landscape Setting Talks: "The Future of Human Genetics and Genomics"
Chair & Discussion Leader: Evan Eichler (University of Washington)
7:45 pm - 8:20 pm Mary-Claire King (University of Washington)
"Genetic basis of human disease"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:10 pm Eric Lander (The Broad Institute)
"The Future of Genetics & Genomics"
9:10 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm Genetics of Human Disease
Discussion Leader: Mary-Claire King (University of Washington)
9:00 am - 9:20 am Aravinda Chakravarti (Johns Hopkins University)
"Genes for the QT interval and sudden death"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am David Altshuler (The Broad Institute)
"Genetics of type 2 diabetes"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am David Goldstein (Duke University)
"The role of rare and common gene variants in human disease"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Anne Bowcock (Washington University)
"Genetics of psoriasis and psoriatic arthritis"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Selected abstract talk: Sekar Kathiresan (Massachusetts General Hospital)
"DNA sequence variants related to plasma high-density lipoprotein cholesterol and risk of myocardial infarction"
11:40 am - 11:45 am Discussion
11:45 am - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pm Human Evolution and Diversity
Discussion Leader: Aravinda Chakravarti (Johns Hopkins University School of Medicine)
7:30 pm - 7:50 pm Jim Noonan (Yale University)
"Genome-wide identification and characterization of human-specific developmental regulatory functions"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Carlos Bustamante (Cornell University)
"Population genetics for the personal genomics era"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Rick Sturm (The University of Queensland)
"Genes for human pigmentation diversity"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Selected abstract talk: Gill Bejerano (Stanford University)
"Human-specific loss of regulatory DNA and the evolution of human-specific traits"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Selected abstract talk: Philip D. Stahl (Washington University)
"TBC1D3- a hominoid specific gene that enhances cell proliferation"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Chromosome Dynamics
Discussion Leader: Evan Eichler (University of Washington)
9:00 am - 9:20 amGil McVean (University of Oxford)
"Allelic and non-allelic homologous recombination in genome evolution"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amHunt Willard (Duke University)
"What code connects genome sequence to epigenetic patterns?"
9:50 am - 10:00 amDiscussion
10:00 am Coffee Break
10:30 am - 10:50 amWendy Bickmore (Western General Hospital)
"Spatial nuclear organisation and the regulation of human gene expression"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amHaig Kazazian (University of Pennsylvania)
"Biology of human L1 retrotransposons"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 am Selected abstract talk: Chao-Ting Wu (Harvard Medical School)
"Studies of homolog pairing and ultraconserved elements"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Selected abstract talk: Grace Hobson (A.I. duPont Hospital for Children)
"Junction analysis of genomic rearrangements in Pelizaeus-Merzbacher disease suggests a DNA repair-based mechanism"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm Copy Number Variation and Disease
Discussion Leader: David Goldstein (Duke University)
7:30 pm - 7:50 pmJim Lupski (Baylor College of Medicine)
"Genomic disorders: Mechanisms and assays for CNVs in human disease"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmEvan Eichler (University of Washington)
"Duplication Architecture, Disease and Evolution"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSteve Scherer (Hospital for Sick Children and University of Toronto)
"Implicating copy number variations in autism spectrum disorders"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:30 pm General Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Personalized Genomes and Genome Technology
Discussion Leader: Len Pennacchio (Lawrence Berkeley National Laboratory)
9:00 am - 9:20 amGeorge Church (Harvard Medical School)
"Personalized genomics and emerging technologies"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amDebbie Nickerson (University of Washington)
"Sequencing the human exome"
9:50 am - 10:00 amDiscussion
10:00 am Coffee Break
10:30 am - 10:50 amGonçalo Abecasis (Center for Statistical Genetics)
"Sequencing 1,000s of Genomes"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amEric Green (National Human Genome Research Institute, NIH)
"Infusing large-scale genome sequencing into the clinical research enterprise"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 am Selected abstract talk: Jin Billy Li (Harvard Medical School)
"Targeted sequencing of human genomes, transcriptomes and methylomes"
11:40 am - 11:45 amDiscussion
11:45 am - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations and election of the next Vice Chair; Fill out conference evaluation forms; Discuss future site & scheduling preferences)
7:30 pm - 9:30 pm Functional Characterization of the Human Genome
Discussion Leader: Hunt Willard (Duke University)
7:30 pm - 7:50 pmLen Pennacchio (Lawrence Berkeley National Laboratory)
"Large-scale identification of tissue-specific enhancers in vivo"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pm Vivian Cheung (University of Pennsylvania)
"Genetics of natural variation in human gene expression"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRick Myers (HudsonAlpha Institute for Biotechnology)
"Global analysis of transcriptional regulation in human cells"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pm Eran Segal (Weizmann Institute of Science)
"Reading the human genome: From DNA sequence to gene regulation"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Models of Disease and Therapeutics
Discussion Leader: Rick Lifton (Yale University School of Medicine)
9:00 am - 9:20 am Niko Katsanis (Johns Hopkins University Institute of Genetic Medicine)
"The ciliopathies: Insights into disease architecture"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 am Susan A. Slaugenhaupt (Massachusetts General Hospital)
"From gene to treatment: The example of familial dysautonomia"
9:50 am - 10:00 amDiscussion
10:00 am Coffee Break
10:30 am - 10:50 am Stephanie Sherman (Emory University)
"Using Down syndrome to gain insights into congenital heart defects"
10:50 am - 11:00 amDiscussion
11:00 am - 11:10 am Selected abstract talk: Edwin Oh (Johns Hopkins University)
"Wnt and sonic hedgehog signaling in a stem cell model of Patau syndrome"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 am Selected abstract talk: Ana-Teresa Maia (Cambridge Research Institute CRUK)
"Differential allelic expression as a candidate modifier of BRCA2 risk in breast cancer"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 am Selected abstract talk: Sarah Calvo (The Broad Institute)
"Widespread translational repression by polymorphic uORFs"
11:40 am - 11:45 am Discussion
11:45 am - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm Closing Keynote
Vice Chair & Discussion Leader: Susan A. Slaugenhaupt (Massachusetts General Hospital)
7:30 pm - 8:30 pmRick Lifton (Yale University)
"From Genes to Medicine"
8:30 pm - 9:00 pm General Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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