Gordon Research Conferences
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Conference Program
 
Mammary Gland Biology
June 14-19, 2009
Salve Regina University
Newport, RI

The Conference will focus on intersections between development of the normal mammary gland and pathways that lead to carcinogenesis and breast cancer. Discussions will be led by experts in fields ranging from microRNAs, stem cells, hormone signaling, lactation and breast cancer. The contributions of genetic and environmental factors which influence lactation and risk of breast cancer will be included. In addition, the meeting has a tradition of exploring model systems and technological advances that can be adapted to enhance experimental approaches.

The overall goal of the meeting will be to enhance understanding of the fundamental connections between mammary gland development and the alterations that occur during tumorigenesis. The meeting format assures lively discussions as researchers exchange their most recent data and diverse perspectives. Participation of post-doctoral researchers, graduate students as well as senior investigators is encouraged through the selection of “short talks” from among the submitted abstracts. To submit an abstract, please follow the application process. There is also ample time set aside for poster sessions as well as leisurely discussions among participants during afternoons and following evening sessions.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Manipulating Tissue-Specific Stem Cells
7:40 pm - 8:00 pm Welcome and Introduction by Conference Chairs
Discussion Leader: D. Joseph Jerry (University of Massachusetts-Amherst)
8:00 pm - 9:00 pmLola Reid (University of North Carolina-Chapel Hill, USA)
"Human hepatic stem cells, their descendant maturational lineages of parenchymal cells, and their relations to other endodermal stem cell populations"
9:00 pm - 9:20 pm Discussion
9:30 pm Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Regulation of Development by Hormones & Growth Factors
9:00 am - 9:05 amDiscussion Leader: Chris Ormandy (Garvan Institute, Australia)
9:05 am - 9:40 amJohn Lydon (Baylor College of Medicine, USA)
"Mammary epithelial responses to progesterone: morphological, cellular and molecular insights from mouse studies"
9:40 am - 9:55 am Discussion
9:55 am - 10:05 am Short Talk: Rumela Chakrabarti (State University of New York at Buffalo)
"Elf5 deficiency in mammary epithelium leads to cell fate changes associated with altered notch activity"
10:05 am - 10:10 am Discussion
10:10 am Coffee Break / Group Photo (10:15 am)
10:35 am - 11:10 amSean Egan (Hospital for Sick Children, Canada)
"Notch signaling in mammary gland development and breast cancer"
11:10 am - 11:25 am Discussion
11:25 am - 12:00 pmChristine Watson (University of Cambridge, UK)
"Signaling and lineage commitment in mammary gland"
12:00 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk: Jessica McCready (Tufts University)
"Lactating derived stromal cells promote breast cancer development"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pm Stem Cells: Puppets or Puppeteers?
7:30 pm - 7:35 pmDiscussion Leader: Jeffrey Rosen (Baylor College of Medicine, USA)
7:35 pm - 8:10 pmJeffrey Rosen (Baylor College of Medicine, USA)
"Breast Cancer Stem Cells: To Believe or Not to Believe"
8:10 pm - 8:25 pm Discussion
8:25 pm - 9:00 pmAmar Klar (National Cancer Institute-Frederick, USA)
"Asymmetric cell division through selective chromatid segregation as a general mechanism for cellular differentiation"
9:00 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Short Talk: Brian Booth (Clemson University)
"Human embryonal carcinoma cells are differentiated by the mouse mammary microenvironment"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Parity: Protection or Prevention
9:00 am - 9:05 pm Discussion Leader: Daniel Medina (Baylor College of Medicine, USA)
9:05 am - 9:40 amPepper Schedin (University of Colorado Health Science Center, USA)
"The involution hypothesis and pregnancy-associated breast cancer"
9:40 am - 9:55 am Discussion
9:55 am - 10:05 am Short Talk: Rajkumar Lashmanaswamy (Texas Tech Univ. Health Sciences Center)
"Early pregnancy, hormones and breast cancer risk"
10:05 am - 10:10 am Discussion
10:10 am Coffee Break
10:35 am - 11:10 amMelissa Troester (University of North Carolina-Chapel Hill, USA)
"Population Variation in Parity-Associated Gene Expression"
11:10 am - 11:25 am Discussion
11:25 am - 12:00 pmKornelia Polyak (Dana-Farber Cancer Institute, USA)
"Microenvironmental regulation of breast cancer progression"
12:00 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk: Robert Clarke (University of Manchester)
"Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pm Breast Cancer Pathways
7:30 pm - 7:35 pmDiscussion Leader: John Hilkens (The Netherlands Cancer Institute)
7:35 pm - 8:10 pmAndrew Futreal (Wellcome Trust Sanger Institute, UK)
"Structural somatic genetics of breast cancer"
8:10 pm - 8:25 pm Discussion
8:25 pm - 9:00 pmJeffrey Green (National Cancer Institute, USA)
"Exploiting genomic analyses for pre-clinical testing in mouse models of mammary cancer"
9:00 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Short Talk: Jun-Lin Guan (University of Michigan)
"FAK signaling pathways in mammary stem cells and breast cancer"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Responses to Genotoxic Stress: DNA Repair & Autophagy
9:00 am - 9:05 amDiscussion Leader: D. Joseph Jerry (University of Massachusetts-Amherst, USA)
9:05 am - 9:40 amLisa Wiesmüller (University of Ulm, Germany)
"Specific DNA double-strand break repair defects in primary cells from breast cancer specimens and blood predict breast cancer risk"
9:40 am - 9:55 am Discussion
9:55 am - 10:05 am Short Talk: Esta Sterneck (National Cancer Institute)
"C/EBPdelta is a mammary tumor suppressor promoting DNA damage and hypoxia response"
10:05 am - 10:10 am Discussion
10:10 am Coffee Break
10:35 am - 11:10 amDavid Livingston (Dana Farber Cancer Institute, USA)
"Functional analysis of the BRCA1 gene products"
11:10 am - 11:25 am Discussion
11:25 am - 12:00 pmVassiliki Karantza-Wadsworth (UMDNJ-Robert Wood Johnson Medical School, USA)
"Role of autophagy in mammary gland biology and tumorigenesis"
12:00 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk: Kristine Klos (University of Wisconsin – Madison)
"Lineage-Specific Responses to Carcinogen Exposure in Mammary Epithelial Cell Populations"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Environmental Carcinogenesis
7:30 pm - 7:35 pmDiscussion Leader: Weston Porter (Texas A&M University, USA)
7:35 pm - 8:10 pmCheng Chi Lee (University of Texas-Houston Medical Center, USA)
"Circadian clock and cell growth regulation"
8:10 pm - 8:25 pm Discussion
8:25 pm - 9:00 pmMary Helen Barcellos-Hoff (New York University Langone School of Medicine, USA)
"Breast cancer and the environment: New ideas about radiation as a prototypical carcinogen"
9:00 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Short Talk: Cynthia Zahnow (The SKCCC at Johns Hopkins)
"Exposure of mammary epithelial cells to cigarette smoke leads to transformation, EMT and altered epigenetic regulation"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Adaptating to Lactation
9:00 am - 9:05 am Discussion Leader: Russ Hovey (University of California-Davis, USA)
9:05 am - 9:40 amSylvaine Cases (Gladstone Institute of Cardiovascular Disease)
"Role of adipocytes in mammary gland development and breast cancer: Lessons from DGAT1-deficient mice"
9:40 am - 9:55 am Discussion
9:55 am - 10:05 am Short Talk: Fabienne Le Provost (INRA)
"Characterization of microRNA functions in mouse mammary gland biology"
10:05 am - 10:10 am Discussion
10:10 am Coffee Break
10:35 am - 11:10 amNelson Horseman (University of Cincinnati, USA)
"Lactation Homeostasis: Physiological and Pathological Adaptations"
11:10 am - 11:25 am Discussion
11:25 am - 12:00 pmRoss Tellam (CSIRO, Australia)
"What does the Bos tarsus genome sequence say about the genes involved in mammalian lactation?"
12:00 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Short Talk: Darryl Hadsell (Baylor College of Medicine)
"A 4X nursing frequency in the mouse decreases milk production, but does not accelerate mammary involution, and has little effect on gene expression, mitochondrial function or IGF-I signaling during prolonged lactation"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pm Keynote Lecture: Perspectives in Mammary Gland Biology
7:30 pm - 7:45 pmDiscussion Leader: D. Joseph Jerry (University of Massachusetts-Amherst, USA)
7:45 pm - 8:45 pmBarbara Vonderhaar (National Cancer Institute, NIH, USA)
"Prolactin in breast development and cancer: a journey"
8:45 pm - 9:10 pm Discussion
9:30 pm Reception
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 5 R13CA128408-03 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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