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Mechanisms of Membrane Transport
June 14-19, 2009
Colby College
Waterville, ME
Chair:
Amy L Davidson

Vice Chair:
Joseph A. Mindell

The Gordon Research Conference on Mechanisms of Membrane Transport has distinguished itself in the past 40 years as a forum that brings together a diverse group of investigators with a common interest in the structure, function and regulation of membrane transporters and channels.

New structures of membrane transporters continue to emerge at a rapid pace, and mechanistic analyses guided by transporter structures are transforming the field. Accordingly, this offers us an unprecedented opportunity to link form with function and encourage productive interactions between young investigators - largely trained in the physical and biophysical sciences - with more established investigators whose experience is in areas such as physiology, cell biology and biochemistry.

All participants are asked to bring a poster which provides many opportunities for people at different stages in their careers to meet, mix, learn and establish new interdisciplinary collaborations. Our meeting is welcoming to graduate students and postdoctoral fellows. One session will be devoted entirely to talks selected from amongst attendees presenting posters.

Contributors
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmREGULATION OF ION CHANNELS
Discussion Leader: Joseph Mindell (NIH/NINDS)
7:40 pm - 8:05 pm David Yue (Johns Hopkins University)
"Competition at its finest - novel connectivity between the two signaling uber hubs of Ca2+ channels and calmodulin"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Rachelle Gaudet (Harvard University)
"Structural Insights into the Function of TRPV Channels"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm William Zagotta (University of Washington)
"Molecular mechanisms for regulation of ion channels by cyclic nucleotide"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNEUROTRANSMITTER TRANSPORTERS
Discussion Leader: Nancy Carrasco (Albert Einstein College of Medicine)
9:00 am - 9:35 am Gary Rudnick (Yale University)
"Conformational change we can believe in: Opening the cytoplasmic permeation pathway of neurotransmitter transporters"
9:35 am - 9:45 am Discussion
9:45 am - 10:20 am Baruch Kanner (Hebrew University)
"What is chloride doing to sodium-coupled neurotransmitter transporters?"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Coffee Break
10:50 am - 11:25 am Joseph Mindell (NIH/NINDS)
"Transporter dynamics in a bacterial 'glutamate' transporter"
11:25 am - 11:35 am Discussion
11:35 am - 12:10 pm Olga Boudker (Cornell University Medical School)
"Alternating access mechanism of glutamate transporters"
12:10 pm - 12:20 pm Discussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSELECTED POSTER TALKS: SESSION A
Discussion Leader: Chris Miller (Brandeis University)
(short talks selected from posters)
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMEMBRANE PROTEIN TRANSPORT AND ASSEMBLY
Discussion Leader: Stephen White (University of California, Irvine)
9:00 am - 9:35 am William Skach (Oregon Health Sciences University)
"Transport/assembly of aquaporin"
9:35 am - 9:45 am Discussion
9:45 am - 10:20 am Arnold Driessen (University of Groningen)
"Mechanism of lateral pore opening of the preprotein translocase"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Coffee Break
10:50 am - 11:25 am Nils Wiedemann (Universitat Freiburg)
"Biogenesis of Mitochondrial Membrane Proteins"
11:25 am - 11:35 am Discussion
11:35 am - 12:10 pm Jochen Zimmer (Harvard University)
"Structural Basis for SecA mediated protein translocation"
12:10 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLIPID PROTEIN INTERACTIONS
Discussion Leader: William Skach (Oregon Health Sciences University)
7:30 pm - 8:00 pmStephen White (University of California, Irvine)
"Lipid interactions of Kv Channels and Voltage-Sensor Domains"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmAlexey Ladokhin (University of Kansas)
"Thermodynamic and kinetic characterization of pH-triggered membrane protein insertion"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmZhe Lu (University of Pennsylvania)
"Clues to the pathogenesis of cystic fibrosis"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPUMPING ION: P-TYPE ATPASES
Discussion Leader: Amy Davidson (Purdue University)
9:00 am - 9:35 am Svetlana Lutsenko (Oregon Health Sciences University)
"Regulation of copper transport at the molecular and cellular level"
9:35 am - 9:45 am Discussion
9:45 am - 10:20 am Miguel Holmgren (NIH/NINDS)
"Na+ access kinetics to the Na/K ATPase"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Coffee Break
10:50 am - 11:25 am David Gadsby (Rockefeller University)
"Ion pathway through the Na,K-ATPase pump"
11:25 am - 11:35 am Discussion
11:35 am - 12:10 pm Jesper Vuust Møller (University of Aarhus)
"How SERCA pumps Ca2+ and can be targeted by thapsigargin"
12:10 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmION CHANNELS / SELECTED POSTER TALKS: SESSION B
Discussion Leader: William Zagotta (University of Washington)
7:30 pm - 8:00 pm (short talks selected from posters)
8:00 pm - 8:35 pm Ricarda Hilf (University of Zurich)
"Ion permeation and gating in prokaryotic pentameric ligand-gated ion channels"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:20 pm Rod Mackinnon (Rockefeller University)
"K+ channel structure and mechanism"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmION MOTIVE FORCE-DEPENDENT TRANSPORTERS
Discussion Leader: Joseph Mindell (NIH/NINDS)
9:00 am - 9:35 am Nancy Carrasco (Albert Einstein College of Medicine)
"The sodium/iodide symporter (NIS): an unending source of surprises"
9:35 am - 9:45 am Discussion
9:45 am - 10:20 am Salem Faham (David Geffen School of Medicine, UCLA)
"Crystal structure of SGLT reveals mechanism of Na+/Sugar cotransport"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Coffee Break
10:50 am - 11:25 am Chris Miller (Brandeis University)
"A virtual proton pump driven by arginine decarboxylation"
11:20 am - 11:35 am Discussion
11:35 am - 12:10 pm Ron Kaback (UCLA)
"The old man and the transporter"
12:10 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmABC TRANSPORT
Discussion Leader: Robert Tampé (Johann Wolfgang Goethe-Universität)
7:30 pm - 8:00 pm Joseph Bryan (Pacific NW Diabetes Research Inst.)
"Regulation of an ion channel: another role for a transporter"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm David Clarke (University of Toronto)
"Repair of folding defects in CFTR using pharmacological chaperones"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Jue Chen (Purdue University)
"Alternating access in the maltose transporter"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart
Funding for this conference was made possible (in part) by 1 R13 DK83766-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
 
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