Gordon Research Conferences
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Conference Program
 
Metals in Biology
January 25-30, 2009
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chair:
Peter M. Kroneck

Vice Chair:
John D. Lipscomb

Related Meeting Information
The Metals in Biology Gordon Research Conference was held in conjunction with the Bioinorganic Chemistry Gordon Research Seminar. Please refer to the Bioinorganic Chemistry GRS web page for more information.

Metals play key roles in maintaining life. You will have a hard time finding one important process within the living cell that does NOT depend on a metal ion in the context of either function or structure. Metals are located at the heart of sophisticated molecular machines, ready to conserve energy, ready to cope with toxic gases, or ready to send out signals to trigger or terminate important reactions. The highly interdisciplinary Metals in Biology Gordon Conference (MIB) is one of the longest-running in the GRC family. It provides a forum for leading researchers with expertise that spans from physical techniques and synthetic chemistry through biology and biomedicine to meet and discuss topics of common interest. Fostering new collaborations and friendships between scientists with a complementary skills and goals is a hallmark of this conference. Accordingly, it is our goal to diversify our meeting to the largest extent possible. For example, we will endeavour to mix established scientists and those who are making their first breakthroughs in the same session whenever feasible. In addition, extensive poster sessions will be held to facilitate discussions in an open atmopshere, thus providing excellent opportunities to present your latest results. The consistent oversubscription of MIB prompted our community to start the first Gordon Research Seminar (in Bioinorganic Chemistry) in 1996. This meeting typically draws graduate and postdoctoral students from a diverse array of laboratories studying metals in biology. It overlaps with MIB for one oral and one poster session to allow students to meet and interact with established scientists in their areas of research. We specifically encourage graduate students and postdocs to take advantage of these unique educational opportunities and to participate in either the MIB conference or the Bioinorganic Chemistry GRS.

Peter Kroneck will Chair the 2009 conference and John Lipscomb will Chair the 2010 conference. Faith Jacobsen will Chair the 2009 Bioinorganic Chemistry Gordon Research Seminar.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:45 pmWelcome & Introduction by Conference Chair Peter Kroneck (Universitaet Konstanz) / Introductory Comments by GRC Site Staff
7:45 pm - 9:30 pm METAL SITES AT ATOMIC RESOLUTION - A TRIBUTE TO HELMUT BEINERT
Discussion Leader: M. Claire Kennedy (Medical College of Wisconsin)
7:45 pm - 8:25 pm John D. Lipscomb (University of Minnesota)
"Learning from Helmut: If you speak too loud, you might not hear the answer"
8:25 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm Paola Turano (University of Florence)
"Learning about ferritin through NMR"
9:15 pm - 9:25 pm Discussion
9:25 pm - 9:35 pm Harry Gray (Caltech) & Dave Dooley (Montana State)
"Hans Freeman, Friend and Colleague"
9:35 pm Poster Session A / Chair’s Reception
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm SPECTROSCOPIC AND THEORETICAL METHODS
Discussion Leader: John H. Enemark (University of Arizona)
9:00 am - 9:30 am Sason Shaik (Hebrew University of Jerusalem)
"What Did We Learn From Theory on the Versatile Reactivity of Cytochrome P450 Enzymes?"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Anabella Ivancich (CNRS & CEA Saclay)
"Towards understanding the structural and functional features responsible for the dual activity of heme catalase-peroxidases (KatGs)"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:30 am Thomas Brunold (University of Wisconsin-Madison)
"Second-Sphere Tuning of Active-Site Properties of Mn- and Fe-Dependent Superoxide Dismutases"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Serena DeBeer George (Stanford University)
"X-ray absorption and emission spectroscopies as probes of iron active sites in biology"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm METALS INTERACTING WITH DNA AND RNA
Discussion Leader: Kim R. Dunbar (Texas A&M University)
7:30 pm - 8:00 pm Jacqueline K. Barton (CALTECH)
"DNA-mediated Signaling in Repair"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Yi Lu (University of Illinois at Urbana-Champaign)
"Biochemical and biophysical study of metal-binding sites in DNAzymes and their applications as metal ion sensors"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Anna Pyle (Yale)
"The crystal structure of an intact group II intron ribozyme reveals the basis for metal ion- catalyzed splicing in eukaryotic RNA processing"
9:20 pm - 9:30 pm Discussion
9:30 pm Poster Session A
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm ENVIRONMENTAL ASPECTS AND EARLY LIFE CATALYSTS
Discussion Leader: Alison Butler (UC Santa Barbara)
9:00 am - 9:30 am Kenneth N. Raymond (UC Berkeley)
"Siderophore Stealth: How Anthrax and Other Pathogens Evade the Human Immune System"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Saltman Lecture: Ann Valentine (Yale)
"Considering a Role for Titanium in Bioinorganic Chemistry"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:30 am Carsten Krebs (Pennsylvania State University)
"Formation and Function of the Heterobinuclear Mn/Fe Cofactor of /Chlamydia trachomatis/ ribonucleotide reductase"
11:30 am - 11:45 am Discussion
11:45 am - 12.15 pm Felisa Wolfe-Simon (Harvard University)
"Geobiochemistry and Metallomic Evolution: the Differential Responses of Prokaryotes and Eukaryotes to Fe-stress and Possible Evolutionary Implications"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm TRANSPORT AND CHANNELS
Discussion Leader: Judith P. Klinman (UC Berkeley)
7:30 pm - 8:00 pm Jan Saam (University of Illinois at Urbana-Champaign)
"Dynamic Oxygen Access Channels in Cyclooxygenase"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Catherine L. Drennan (MIT)
"Metal Selectivity of the Nickel Regulatory Protein NikR"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Dax Fu (Brookhaven National Laboratory)
"Structure and mechanism of the zinc transporter YiiP"
9:20 pm - 9:30 pm Discussion
9:30 pm Poster Session B
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm MEDICAL ASPECTS - Targets, Diagnosis, and Therapy
Discussion Leader: Chris Orvig (University of British Columbia)
9:00 am - 9:30 am Peter Caravan (Harvard Medical School)
"Protein targeted MRI contrast agents"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Elizabeth C. Theil (CHORI)
"Going for the Iron - the Good and the Bad"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:30 am Glenn L. Millhauser (UC Santa Cruz)
"Insights into the function of a deadly protein - how the prion protein interacts with metal ions"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Stephen J. Lippard (MIT)
"Understanding and Improving Platinum Anticancer Drugs"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting: (Chair John D. Lipscomb)
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm SILENT METALS - CALCIUM AND ZINC
Discussion Leader: Milan Vasak (Universitaet Zuerich)
7:30 pm - 8:00 pm Walter J. Chazin (Vanderbilt University)
"The complex dual sensor mechanism for calcium-dependent regulation of human cardiac voltage-gated sodium channel Nav1.5"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Kazuya Kikuchi (Osaka University)
"Design, Synthesis of Visualization Probes with Tunable Switches for Bio-imaging"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm David L. Tierney (University of New Mexico)
"Metallo-beta-Lactamases: Does Co Really Do the Same Chemistry as Zn?"
9:20 pm - 9:30 pm Discussion
9:30 pm Poster Session B
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm DINITROGEN AND NITROGEN OXIDE BIOCHEMISTRY
Discussion Leader: Lance C. Seefeldt (Utah State University)
9:00 am - 9:30 am Markus Ribbe (UC Irvine)
"Functions of NifEN"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Patrick L. Holland (University of Rochester)
"Paramagnetic Iron Dihydrogen and Dinitrogen Complexes: How does High-Spin Iron Bind Nitrogenase Substrates?"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:30 am Michael A. Marletta (UC Berkeley)
"Selective Sensing of NO in Biology: Chemistry to the Rescue"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm F. Ann Walker (University of Arizona)
"Dynamics of the Nitrophorins of a New World Blood-Sucking Insect"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm JOINT SESSION WITH GORDON RESEARCH SEMINAR
Discussion Leader: David M. Dooley (Montana State University)
7:30 pm - 8:30 pm William B. Tolman (University of Minnesota)
"Biomimetic Activation of O2 and N2O by Copper"
8:30 pm - 8:45 pm Discussion
8:45 pm Joint Poster Session with Gordon Research Seminar
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible in part by 5 R13 GM 074563-05 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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