Gordon Research Conferences
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Conference Program
 
Molecular Membrane Biology
July 5-10, 2009
Proctor Academy
Andover, NH
Chair:
Sean Munro

Vice Chair:
Charlie Barlowe

The Molecular Membrane Biology Gordon Conference covers advances in organelle biology and membrane traffic. This field is entering a particularly exciting phase as the basic principles of membrane traffic and organization have emerged to an extent where they can start to be applied to understanding the roles of organelles in important processes such as development, autophagy, familial diseases and the invasion of cells by pathogens. It is also becoming possible to link organelles into a larger picture of cellular organization via their associations with the cytoskeleton and with lipid traffic. This progress is being helped by new methodology including high throughput screening, super resolution microscopy and advanced biophysical methods. These developments will be covered by the invited speakers (listed below), along with the latest progress on the fundamental mechanisms of membrane biogenesis and organelle function.

All applicants, and especially those from under-represented demographics (i.e. women, minorities, junior investigators) are strongly encouraged to submit a brief abstract describing their work, and to indicate whether they would like their abstract to be considered for one of the eighteen short talks which are divided between all sessions.

We intend to select short talks from abstracts in mid-April and ask that applicants who would like their abstract to be considered for a talk submit their application by April 15th 2009.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm EXIT FROM THE ER IN HEALTH AND DISEASE
Discussion Leader: Charlie Barlowe (Dartmouth University)
7:40 pm - 8:00 pmRandy Schekman (University of California at Berkeley)
"A neural tube closure defect resulting from a lesion in ER export"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pmBen Glick (University of Chicago)
"Sec16 regulates ER export and transitional ER dynamics"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Elizabeth Miller (Columbia University)
"A novel Sec24 mutant links cargo capture to the GTP cycle of the COPII coat"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:15 pmBill Balch (The Scripps Research Institute)
"Managing traffic from the ER"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm TRANSLOCATION AND PROTEIN FOLDING IN THE ER
Discussion Leader: Tom Rapoport (Harvard Medical School)
9:00 am - 9:20 amRamanujan Hegde (NIH/NICHD)
"Tail-anchored membrane protein insertion into the ER"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amIneke Braakman (University of Utrecht)
"Factors determining protein folding in the ER"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 amJonathan Weissman (University of California at San Francisco)
"The anatomy of a cellular folding compartment: a high resolution view of protein folding in the ER provided by quantitative genetic interaction maps"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 amKarin Reinisch (Yale University)
"Insights into MHC class I peptide loading from the structure of the tapasin/ERp57 heterodimer"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 amCarolyn Sevier (MIT)
"Linking ER redox status and ER translocation activity"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 amShu-ou Shan (Caltech)
"Fidelity in co-translational protein targeting: binding, induced fit, and kinetic proofreading"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:20 pmBenoit Kornmann (University of California at San Francisco)
"The molecular hug between the ER and the mitochondria"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm NEW SYSTEMS AND TECHNOLOGIES FOR MEMBRANE BIOLOGY
Discussion Leader: Elizabeth Conibear (University of British Columbia)
7:30 pm - 7:50 pmChristian Eggeling (MPI Biophysical Chemistry, Goettingen)
"Fluorescence STED microscopy reveals nanoscale dynamics of membrane molecules"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmLucas Pelkmans (ETH Zurich)
"Regulation of membrane lipid composition and function in cell populations: it all depends on the context"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmMaya Schuldiner (Weizmann Institute)
"Genetics with a twist - novel methods for characterizing proteins required for folding in the secretory pathway"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Julie Brill (University of Toronto)
"Clathrin adaptors and PI4KII regulate secretory granule biogenesis in the Drosophila salivary gland"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Barth Grant (Rutgers University)
"Amp(h)ing up recycling: functional association of RME-1/Ehd and AMPH-1/Amphiphysin in recycling endosome to plasma membrane transport in C. elegans"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm LIPID BIOLOGY AND PATHOGENS
Discussion Leader: Sean Munro (MRC Laboratory of Molecular Biology)
9:00 am - 9:20 amJoost Holthuis (University of Utrecht)
"A ceramide sensor hiding in a family of sphingomyelin synthases"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amSarah Keller (University of Washington)
"Critical phenomena and asymmetric lipid membranes"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 amKai Simons (MPI-CBG Dresden)
"Lipid-protein interactions and rafts"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 amSergio Grinstein (University of Toronto)
"Determinants of phagosome formation and maturation"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 amGisou van der Goot (Global Health Institute, Lausanne)
"How anthrax toxin makes its way into cells"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Stefan Höning (University of Cologne)
"TIP47 functions in the biogenesis of lipid droplets"
12:10 pm - 12:15 pm Discussion
12:15 am - 12:25 pm Jairaj Acharya (National Cancer Institute)
"Ceramide transfer protein: CERT'nly different tales"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm SMALL G PROTEINS IN MEMBRANE DYNAMICS
Discussion Leader: Anne Spang (Biozentrum, Basel)
7:30 pm - 7:50 pmDavid Lambright (UMass Medical School)
"Mechanisms of trafficking-regulation by Rab and Arf GTPases"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmSuzanne Pfeffer (Stanford University)
"GTPases and ATPases in vesicle tethering at the Golgi"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmFrancis Barr (University of Liverpool)
"Every pot has its lid: matching GEFs and GAPs to Rabs"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Peter Novick (University of California at San Diego)
"A Rab GAP Cascade defines the boundary between two Rab GTPases on the secretory pathway"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Zheng Zhou (Baylor College of Medicine)
"A novel Rab GTPase that plays essential roles in the degradation of apoptotic cells"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm MEMBRANE TRAFFIC IN THE GOLGI APPARATUS
Discussion Leader: Ben Glick (University of Chicago)
9:00 am - 9:20 amSusan Ferro-Novick (University of California at San Diego)
"Mechanistic insights into the function of a multimeric Rab guanine nucleotide exchange factor"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amFred Hughson (Princeton University)
"A tale of two tethers"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 amJennifer Lippincott-Schwartz (NIH/NICHD)
"Kinetic and super-resolution analysis of Golgi structure and function"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 amGraham Warren (University of Vienna)
"Golgi biogenesis in a protozoan parasite"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 amBruno Antonny (University of Nice)
"How ALPS motifs help to organize membrane traffic"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm David Banfield (The Hong Kong University of Science and Technology)
"Identification of the sub-unit interactions and sorting signals that mediate COPI-dependent trafficking of yeast SNAREs"
12:10 pm - 12:15 pm Discussion
12:15 am - 12:25 pm Aki Nakano (RIKEN)
"Golgi and post-Golgi traffic as revealed by uniquely evolved plant systems"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm ORGANELLES AND THE MOTORS THAT MOVE THEM
Discussion Leader: Francis Barr (University of Liverpool)
7:30 pm - 7:50 pmAnna Akhmanova (University of Rotterdam)
"Bicaudal D - a cell-cycle regulated linker between cargo and microtubule motors"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmSteven Gross (University of California at Irvine)
"Exactly what is it that NudE and Lis1 do?"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pmGillian Griffiths (University of Cambridge)
"Controlling polarised secretion from lymphocytes"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Sandra Encalada (University of California at San Diego)
"Kinesin-1 mediates the axonal transport of Prion Protein containing vesicles"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Lois Weisman (University of Michigan)
"Secretory vesicle transport in yeast requires the direct binding of myosin V with multiple Rab GTPases"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm MEMBRANE BENDING AND FUSION
Discussion Leader: Fred Hughson (Princeton University)
9:00 am - 9:20 amDavid Chan (Caltech)
"Mitochondrial membrane fusion by a dynamin family protein"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 amSandy Schmid (The Scripps Research Institute)
"Dynamin and membrane fission"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 amTom Rapoport (Harvard Medical School)
"Formation of the tubular ER network"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:20 amChris Stroupe (Dartmouth University)
"Reconstitution of yeast vacuole fusion: 5 lipids, 4SNAREs, 3 chaperones, 2 nucleotides, and a Rab, all dancing in a ring"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 amElizabeth Chen (Johns Hopkins University)
"Defining a fusogenic synapse in myoblast fusion"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Ben Nichols (MRC Laboratory of Molecular Biology)
"The generation of membrane curvature within caveolae"
12:10 pm - 12:15 pm Discussion
12:15 am - 12:25 pm Thomas Wollert (NIDDK/NIH)
"Vesicle formation and scission by the ESCRT-III complex"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm ENDOSOMES AND AUTOPHAGY
Discussion Leader: Gillian Griffiths (University of Cambridge)
7:30 pm - 7:50 pmElizabeth Conibear (University of British Columbia)
"Global analysis of endosome recycling"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pmTamotsu Yoshimori (Osaka University)
"Mechanistic insight into membrane dynamics in mammalian autophagy"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:40 pmSharon Tooze (Cancer Research UK LRI)
"Trafficking and signalling pathways to autophagy"
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pmChristian Ungermann (University of Osnabrück)
"Regulation of HOPS complex localization to endosome-vacuole fusion sites by phosphorylation"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:20 pmScott Emr (Cornell University)
"ESCRTs and the ART of endocytosis"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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