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Conference Program
 
Molecular Pharmacology
Recent Advances in Basic and Translational Research on G Protein-Coupled Receptors and Signaling
May 31 - June 5, 2009
Il Ciocco Hotel and Resort
Lucca (Barga), Italy

The Gordon Research Conference (GRC) on Molecular Pharmacology is one of the most popular forums for the gathering of scientists from academia, government, and industry to discuss recent, cutting-edge advances in signal transduction research, receptors and other drug targets. The main focus of the 2009 Molecular Pharmacology GRC will be on membrane receptors and G protein-mediated signaling since other areas of interest in molecular pharmacology are covered by other conferences. The proposed program seeks to integrate basic and translational aspects of research and to encourage cross-fertilization among different approaches. The goal of the conference has been, and continues to be, to advance progress by providing an integrated approach among important "growth areas" in Molecular Pharmacology. The GRC on Molecular Pharmacology convenes every two years. To strengthen the international nature of the Molecular Pharmacology GRC, in 2003 it was decided (by a vote of the attendees) that the conference should alternate between Ventura, California and a GRC location in Europe. The 2009 Conference will be its 21st edition and it will take place at the Il Ciocco Conference Center in Barga (Pisa), Italy.

Three main aspects will be covered by the 2009 conference: i) structural features of receptors and monitoring of receptor function at the single molecule level, ii) signaling and regulatory networks in physiological settings and pathophysiological conditions (e.g., cancer, viral infections, endocrine and cardiovascular disorders, smell), and iii) pharmacology of the brain and metabolism, in particular in animal models. Many of the speakers and discussants are leaders in the field; some are more junior investigators. Session Chairs have been chosen for their contributions to the field and demonstrated history of promoting active exchange of information with younger participants at the meeting. Poster sessions organized by topic will be an integral part of the meeting and some talks will be selected from posters. Participants who are not speakers or session chairs/discussants are encouraged to present a poster. Our general goal for the 2009 Conference is to continue the focus on cutting-edge research, encouraging cross-fertilization of ideas and techniques, supporting the participation of junior scientists, and importantly, by insuring diversity among speakers in terms of career stage and venues in which the scientists work.


Contributors
We are extremely grateful to our contributors:

National Institutes of Health

H. Lundbeck A/S
Astrazeneca Canada Inc.
Sanofi-Aventis
Institut de recherches Servier
Allergan
Kontaktgruppe Fur Forschungsfragen, CH
(Roche, Novartis, Merck-Serono)
Cisbio International
Ipsen Innovation
F. Hoffmann-La Roche AG
Actelion Pharmaceuticals
Amgen, Inc.
Perkinelmer Life and Analytical Science
Theravance, inc.
Abbott Laboratories
Bristol-Myers Squibb
Aryx Therapeutics
Heptares Therapeutics
Cell Press

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmTowards crystal clear views of receptors
7:40 pm - 8:00 pmDiscussion Leader: Brian K. Kobilka (Stanford University, USA)
"Introduction"
8:00 pm - 8:25 pm Gebhard Schertler (MRC, UK)
"Structure of the thirdintracellular loop of the beta1-adrenergic receptor: Implications for pharmacology"
8:25 pm - 8:35 pm Discussion
8:35 pm - 9:00 pm Klaus-Peter Hofmann (University of Berlin, Germany)
"Signal transfer from receptor to G protein: Insights from spectroscopic and structural studies on rhodopsin"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Rob Lane (University of Leiden, The Netherlands)
"The crystal structure of the adenosine A2A receptor. Implications for GPCR drug design"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmActivation and molecular dynamics of signaling proteins
9:00 am - 9:10 am Discussion Leader: Ongun Onaran (University of Ankara, Turkey)
"Introduction"
9:10 am - 9:35 am Martin Lohse (University of Wuerzburg, Germany)
"Mechanisms and kinetics of G-protein-coupled receptor activation"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Jean-Philippe Pin (CNRS, Montpellier, France)
"Intramolecular transduction in metabotropic glutamate receptors"
10:10 am - 10:20 am Discussion
10:20 am - 11:00 am Coffee Break / Group Photo
11:00 am - 11:25 am Olivier Lichtarge (Baylor College of Medicine, USA)
"Separation of ligand binding and sensitivity in psychotropic receptors"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Francesca Fanelli (University of Modena and Reggio Emilia, Italy)
"Receptor impact on G protein dynamics"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Xavier Deupi (Universitat Autonoma de Barcelona, Spain)
"Impact of ligand entry pathways on selectivity in beta adrenergic receptors"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmMolecular organization of signaling proteins
5:30 pm - 5:40 pm Discussion Leader: Paul Insel (UCSD, USA)
"Introduction"
5:40 pm - 6:05 pm Jean-Louis Banères (University of Montpellier, France)
"Molecular organization of a GPCR dimer and its complex with G proteins"
6:05 pm - 6:15 pm Discussion
6:15 pm - 6:40 pm Roger Sunahara (University of Michigan, USA)
"Allosteric regulation of ligand binding by G proteins"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Francoise Bachelerie (Institut Pasteur, France)
"CXC chemokine receptors control of cell migration and human primary immunodeficiencies"
7:15 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling: a space and time perspective
9:00 am - 9:10 am Discussion Leader: Stefano Marullo (Institut Cochin, France)
"Introduction"
9:10 am - 9:35 am Michel Bouvier (University of Montreal, Canada)
"Assembly and conformational rearrangements of GPCR signalling modules underlying ligand-biased responses"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Graeme Milligan (University of Glasgow)
10:10 am - 10:20 am Discussion
10:20 am - 11:00 am Coffee Break
11:00 am - 11:25 am Gerald Zamponi (University of Calgary, Canada)
"Signaling complexes between N-type calcium channels and G-protein coupled receptors"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Eric Trinquet (CISBIO, France)
"New Fluorescent Technologies to address GPCR Complexity"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Maria Waldhoer (University of Graz, Austria)
"Signaling of GPR55: discovering 'old' ligands using the EPIC® technology"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
5:30 pm - 7:30 pmRegulatory mechanisms and trafficking of receptors
5:30 pm - 5:40 pm Discussion Leader: Mark Rasenick (University of Illinois Chicago, USA)
"Introduction"
5:40 pm - 6:05 pm Mark von Zastrow (UCSF, USA)
"Molecular sorting of GPCRs after endocytosis"
6:05 pm - 6:15 pm Discussion
6:15 pm - 6:40 pm JoAnn Trejo (UCSD, USA)
"Protease-selective signaling by protease-activated receptor-1"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Jeff Benovic (Thomas Jefferson University, USA)
"Novel functions of arrestins"
7:15 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDiversity of physio-pathological implications
9:00 am - 9:10 am Discussion Leader: Joan Heller Brown (UCSD, USA)
"Introduction"
9:10 am - 9:35 am J. Silvio Gutkind (NIH, USA)
"G-protein coupling in tumor growth and metastatic spread"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Martine Smit (University of Amsterdam, The Netherlands)
"Virus-encoded chemokine receptors activate inflammatory and oncogenic signaling pathways"
10:10 am - 10:20 am Discussion
10:20 am - 11:00 am Coffee Break
11:00 am - 11:25 am Diane Barber (UCSF, USA)
"Signaling to the cytoskeleton by pH sensing"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Sabine Costagliola (Université Libre de Bruxelles, Belgium)
"Glycoprotein hormone receptors: from mutations to diseases"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Federico Mayor (University of Madrid, Spain)
"A Role for G protein-coupled Receptor Kinase 2 in Cell Cycle Progression"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:30 pmFree Time
6:30 pm - 7:30 pmKeynote lecture
6:30 pm - 6:35 pm Discussion Leader: Paul Insel (UCSD)
"Introduction"
6:35 pm - 7:15 pm Robert J. Lefkowitz (Duke University, USA)
"New Paradigms for 7TM Receptor Signaling and Regulation: Challenges for the Structural Biology Era"
7:15 pm - 7:30 pm Discussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulation of brain functions and metabolism in animal models
9:00 am - 9:10 am Discussion Leader: Michael Freissmuth (University of Vienna, Austria)
"Introduction"
9:10 am - 9:35 am Marc Caron (Duke University, USA)
"Animal Models of Monoamine-Associated Behaviors: Signaling and drug actions"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Brigitte Kieffer (University of Strasbourg, France)
"Knock-in mice to track opioid receptors in vivo"
10:10 am - 10:20 am Discussion
10:20 am - 11:00 am Coffee Break
11:00 am - 11:25 am Bernhard Bettler (University of Basel, Switzerland)
"Molecular basis for functional and pharmacological heterogeneity among native GABA-B receptors"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Jurgen Wess (NIH, USA)
"Studies with muscarinic and V2 vasopressin receptor mutant mice"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Kristina Lorenz (University of Wuerzburg, Germany)
"G-beta/gamma-induced cardiac hypertrophy"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmDrug diversity and the receptorome
5:30 pm - 5:40 pm Discussion Leader: Ad IJzermann (University of Leiden)
"Introduction"
5:40 pm - 6:05 pm Bryan Roth (University of North Carolina Chapel Hill, USA)
"Evolving GPCRs for spatiotemporal control of neuronal signaling"
6:05 pm - 6:15 pm Discussion
6:15 pm - 6:40 pm Guy Servant (Senomyx, USA)
"The Identification of Novel Taste Modulators using Cell Based Assays for Taste Receptors"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Thue Schwartz (University of Copenhagen, Denmark)
"7TM chemo-sensors on enteroendocrine cells as drug targets"
7:15 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 DA026640-01 from the National Institute on Drug Abuse. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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