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Motile & Contractile Systems
Gordon Research Conference

Mechanical Basis of Cellular Function

Dates

July 12-17, 2009

Location

Colby-Sawyer College
New London, NH

Organizers

Chair:
Kerry Bloom

Vice Chair:
Dyche Mullins

Meeting Description

The Gordon Conference on Motile and Contractile Systems provides a major forum for integrating new developments in cytoskeletal components and their roles in cell motility, intracellular transport, cell division, cellular polarity and organization, and development. This meeting brings together investigators using a wide variety of experimental approaches including structural, quantitative fluorescence microscopy, modeling, biochemical, molecular and genetic techniques and those studying a wide variety of cell types. It affords the opportunity for investigators in actin and microtubule mediated cytoskeletal processes, nucleoskeletal function and prokaryotic cells to interact with each other. This meeting brings together scientists interested in understanding sub-cellular polymers in a variety of systems using different techniques and building physically accurate models. Significant technological advances have fueled studies demonstrating cross-talk between these nanopolymers and deeper understanding of how these polymer systems work in the world of the cell. The "Motile and Contractile Systems" Gordon Research Conference serves a critical role in facilitating the exchange of ideas between investigators working in overlapping disciplines. Several poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides ample opportunity for scientists from different disciplines to brainstorm and engage in cross-disciplinary collaborations.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session
Discussion Leader: Dennis Discher (University of Pennsylvania)
7:40 pm - 8:30 pm Dennis Discher (University of Pennsylvania)
"Matrix elasticity modulates contractility and directs differentiation and de-differentiation processes"
8:30 pm - 8:50 pm Discussion
8:50 pm - 9:10 pm Matthew J. Paszek (UC San Francisco Medical Center)
"Integrins alone could sense chemical and physical properties of the extracellular matrix"
9:10 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Separation
Discussion Leader: David Burgess (Boston University)
9:00 am - 9:20 am Bill Sullivan (University of Calif. Santa Cruz)
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am David Burgess (Boston University)
"Control of spindle positioning in dividing sea urchin eggs"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Fred Chang (Columbia University)
"Role of the endoplasmic reticulon in division site placement in cytokinesis"
10:20 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break / Group Photo
11:00 am - 11:25 am Harold Erickson (Duke University)
"FtsZ - cytoskeleton and motor all in one"
11:25 am - 11:45 am Discussion
11:45 am - 12:10 pm Amy Maddox (Institute for Research in Immunology and Cancer, Montreal)
"Anillin is essential for meiotic cytokinesis in C. elegans"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSpatial Regulation of Development and Division
Discussion Leader: Meg Titus (Univ. Minnesota)
7:30 pm - 7:50 pm Meg Titus (Univ. Minnesota)
"An unconventional myosin required for cell polarization and chemotaxis"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Martin Loose (BIOTEC TU Dresden)
"How molecules make waves: Self-organization of Min proteins in vitro"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Peter Lenart (European Molecular Biology Laboratory - EMBL, Heidelberg)
"The mechanism of actin-driven chromosome congression in starfish oocytes"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Nasser Rusan (UNC-Chapel Hill)
"Drosophila stem cells exhibit asymmetry in centrosome function"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell and Subcellular Orientation
Discussion Leader: Gregg Gundersen (Columbia University)
9:00 am - 9:25 am Gregg Gundersen (Columbia University)
"Mechanism of actin-dependent nulcear movement during centrosome polarization in migrating cells"
9:25 am - 9:35 am Discussion
9:35 am - 9:50 am Anna Akhmanova (Erasmus Medical Ctr. Rotterdam)
"Regulation of microtubule dynamics by EB proteins and their partners"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:50 am Jawdat Al-Bassam (Harvard University)
"The molecular mechanism of Cytoplasmic Linker Associated protein (CLASP) in stabilizing dynamic microtubules"
10:50 am - 11:00 am Discussion
11:00 am - 11:25 am Ahna Skop (University of Wisconsin)
"Anterior embryonic polarity is maintained by dynamin"
11:25 am - 11:45 am Discussion
11:45 am - 12:10 pm Phong Tran (University of Pennsylvania)
"Motors and MAPs and the Mechanics of Mitosis"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNovel Roles for Cellular Actin
Discussion Leader: Yu-Li Wang (Carnigie-Mellon, Pittsburgh)
7:30 pm - 7:50 pm Yu-Li Wang (Carnegie-Mellon, Pittsburgh)
"The Mechanism of Cellular Mechanical and Geometry Sensing"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Rong Li (Stowers Institute)
"A pathway of maintaining epithelial organization downstream of the polycystin-mediated fluid stress signaling"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Snezhka Oliferenko (Temasek Life Sciences Laboratory, Singapore)
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Margot Quinlan (UCLA)
"Regulation of the cytoskeleton during Drosophila oogenesis"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOrganelle and Chromosome Dynamics
Discussion Leader: Erika Holzbaur (University of Pennsylvania)
9:00 am - 9:20 am Erika Holzbaur (University of Pennsylvania)
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Linda Wordeman (University of Washington)
"Finding the Middle Ground: Motors that influence Chromosome Congression"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Pat Wadsworth (University of Mass. Amherst)
"Eg5/dynein antagonism during bipolar spindle formation requires overlapping centrosomal microtubules"
10:50 am - 11:00 am Discussion
11:00 am - 11:25 am Iva Tolic-Norrelykke (Max Planck Institute of Molecular Cell Biology and Genetics, Dresden)
"Nuclear centering in fission yeast mediated by kinesin-8 proteins"
11:25 am - 11:45 am Discussion
11:45 am - 12:10 pm David Pellman (DFCI Harvard U)
"Centrosomes and the Origin of Chromosome instability"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmPolymer Dynamics
Discussion Leader: Alexi Khodjakov (Wadsworth Ctr, Albany, NY)
7:30 pm - 7:50 pm Alexi Khodjakov (Wadsworth Ctr, Albany, NY)
"Of Kinetochores and Centrosomes"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Dan Fletcher (University of California, Berkeley)
"Force microscopy of actin networks: coupling mechanics and growth"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm David Odde (University of Minnesota)
"Microtubule Assembly Dynamics During Cell Polarization"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Sophie Dumont (Harvard University)
"Mechanical force regulates mitotic spindle size by a mechanochemical switch at the poles"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanisms of Chromosome Movement
Discussion Leader: Trisha Davis (University of Washington)
9:00 am - 9:20 am Trisha Davis (University of Washington)
"The Ndc80 and Dam1 complexes: Attachment to the dynamic end of microtubules"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Maria Schumacher
"Structural mechanisms of plasmid DNA segregation"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Susana A. Ribeiro (University of Edinburgh)
"Condensin regulates the stiffness of the vertebrate centromere"
10:50 am - 11:00 am Discussion
11:00 am - 11:25 am Duane Compton (Dartmouth University)
"Deviant kinetochore-microtubule dynamics underlies chromosomal instability in cancer cells"
11:25 am - 11:45 am Discussion
11:45 am - 12:10 pm Ted Salmon (University of North Carolina)
"Molecular Architecture of the Mammalian Kinetochore"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of Motor Proteins
Discussion Leader: Enrique de la Cruz (Yale University)
7:30 pm - 7:50 pm Enrique de la Cruz (Yale University)
"Everything I need to know about helicases, I learned from myosin"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Trina A. Schroer (Johns Hopkins Univ)
"Identification of a membrane-binding domain of dynacti"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Jon Scholey (University of California, Davis)
"Prometaphase spindle maintenance by antagonistic sliding motors: Factors required for a robust steady state"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm François Nédélec (EMBL)
"Chromatin shapes the Xenopus spindle"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1R13GM087743-01 from NIGMS. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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