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Conference Program
 
Mycotoxins & Phycotoxins
June 21-26, 2009
Colby-Sawyer College
New London, NH

The Gordon Research Conference on Mycotoxins and Phycotoxins offers an international forum for the presentation of leading-edge research on fungal, algal, and cyanobacterial toxins and the organisms that produce them. This multidisciplinary gathering will encompass the biology, ecology, genetics, chemistry and the public health and economic impacts of these natural hazards. In 2009, the conference will convene at Colby-Sawyer College in New London, New Hampshire, June 21-26. The goals of the conference are to assemble a critical mass of leading-edge scientists and students, and to create an atmosphere for creative thinking to advance knowledge of the complex problems presented by these naturally occurring organisms and toxins. Considerable effort is made to provide opportunities for participants, outstanding scientists and aspiring students alike, to interact in relaxed surroundings that promote the free exchange of ideas on topics vital to the future of research on the societal and environmental impacts of mycotoxins and phycotoxins. The 2009 conference will have a particular emphasis on the influence of climate change on the biogeography of toxic algae, cyanobacteria and fungi; the genomics and proteomics of toxin production; the prediction and detection of hazardous events; and the public health and economic impacts of these natural hazards. The conference is unique in that it brings together a diverse multidisciplinary group of research scientists and students who are all ultimately focused on solving similar problems -- ensuring the health of the environment and the safety and security of the food supply.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmIntroductory comments by GRC site staff / conference overview by co-chairs Robert Dickey and Barbara Blackwell
7:40 pm - 9:30 pmToxic events in response to a changing world
Mycotoxins Discussion Leader: David Miller (Carleton University, Ottawa, Ontario, Canada)
Phycotoxins Discussion Leader: Stephanie Moore (National Oceanographic and Atmospheric Administration, Seattle, WA, USA)
7:40 pm - 7:50 pm Discussion Leaders overview
7:50 pm - 8:15 pm Takeshi Yasumoto (Okinawa Science and Technology Promotion Center, Naha City, Okinawa, Japan)
"Increase and diversification of HAB's in the changing world"
8:15 pm - 8:25 pm Discussion
8:25 pm - 8:50 pm Ron Riley (US Department of Agriculture, Agriculture Research Service, Athens, GA, USA)
"Through a glass darkly - mycotoxin research in a changing world"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Gregory Boyer (State University of New York, Syracuse, NY, USA)
"Freshwater cyanobacteria toxins in a changing world"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew hazards from new and known toxins
Phycotoxins Discussion Leader: Michael Quilliam (National Research Council, Halifax, Nova Scotia, Canada)
Mycotoxins Discussion Leader: Ken Voss (US Department of Agriculture, Agriculture Research Service, Athens, GA, USA)
9:00 am - 9:10 am Discussion Leaders overview
9:10 am - 9:35 am Alison Robertson (National Oceanographic and Atmospheric Administration, Seattle, WA, USA)
"Emerging toxins of the U.S. west coast"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Rudolph Krska (University of Natural Resources and Applied Life Sciences, Tulln, Austria)
"LC-MS/MS multitoxin determination for overall toxin estimation"
10:10 am - 10:20 am Discussion
10:20 am - 10:45 am Coffee Break / Group Photo
10:45 am - 11:10 am John Berry (Florida International University, Miami, FL, USA)
"Developmental toxins from freshwater cyanobacteria"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Olga Torres (Centro de Investigaciones en Nutricion y Salud, Guatemala City, Guatemala)
"Fumonisins in Guatemala: field to marketplace, human exposure and translation to human health"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Alfred Merrill (Georgia Institute of Technology, Atlanta, GA, USA)
"Novel sphingoid bases discovered through studies of perturbation of sphingolipid metabolism by fumonisins: potential roles in health and disease"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmPredictive technologies and models
Phycotoxins Discussion Leader: Vera Trainer (National Oceanographic and Atmospheric Administration, Seattle, WA, USA)
Mycotoxins Discussion Leader: James Pestka (Michigan State University, East Lansing, MI, USA)
7:30 pm - 7:40 pm Discussion Leaders Overview of Satellite Workshop: summary of presentations and demonstrations given at the satellite workshop (June 19-20, 2009, Mount Desert Island Biological Laboratory, Bar Harbor, ME, USA) by vice-chairs Vera Trainer and James Pestka
7:40 pm - 8:05 pm Linda Medlin (Observatoire Océanologique de Banyuls-sur-mer, Banyuls-sur-mer, France)
"Microarrays and biosensors as routine analytical tools: three EU projects (ALGADEC, FISH & CHIPS and MIDTAL): rRNA probes for toxic algae on solid phase cytometers, DNA microarrays and biosensors"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Naresh Magan (Cranfield University, Cranfield, Bedford, United Kingdom)
"Postharvest and HACCP models for management of mycotoxins"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Lisa Campbell (Texas A&M University, College Station, TX, USA)
"Automated imaging flow cytometry for early warning of harmful algal blooms"
9:15 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBiogeography and Ecology of Mycotoxins and Phycotoxins
Mycotoxins Discussion Leader: John Gilbert (Central Sciences Laboratory, Sand Hutton, York, United Kingdom)
Phycotoxins Discussion Leader: Don Anderson (Woods Hole Oceanographic Institute, Woods Hole, MA, USA)
9:00 am - 9:10 am Discussion Leaders overview
9:10 am - 9:35 am Uwe John (Alfred Wegner Institute for Polar and Marine Research, Bremerhaven, Germany)
"The evolution of the Alexandrium tamarense species complex in time and space: emphasis on the phenotypic and genotypic plasticity"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Todd Ward (US Department of Agriculture, Agriculture Research Service, Peoria, IL, USA)
"Biogeographic and population genetic analyses of trichothecene chemotype differences"
10:10 am - 10:20 am Discussion
10:20 am - 10:45 am Coffee Break
10:45 am - 11:10 am Linda Kohn (University of Toronto, Toronto, Ontario, Canada)
"Plant compounds, fungal endophytes and mycotoxins: testing models of stress, competition and facilitation"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Anthony Glenn and Charles Bacon (Russell Research Center, US Department of Agriculture, Athens, GA, USA)
"Microbial endophytes of maize: genetic and ecological impacts from interactions"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Juli Dyble-Bressie (National Oceanographic and Atmospheric Administration, Ann Arbor, MI, USA)
"Phylogeography and genetic diversity of toxic cyanobacterial HABs"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmDetection Technologies
Phycotoxins Discussion Leader: Stacey Etheridge (U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA)
Mycotoxins Discussion Leader: Hans-Ulrich Humpf (University of Müenster, Müenster, Germany)
7:30 pm - 7:40 pm Discussion Leaders overview
7:40 pm - 8:05 pm Betsy Yakes (U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA)
"Surface plasmon resonance biosensors as a versatile technique for screening antibodies and detecting mycotoxins and phycotoxins in food"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Corrado Fanelli (Rome University Sapienza, Rome, Italy)
"Innovative detection system of ochratoxin A by thin film diodes"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Ann Abraham (U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Dauphin Island, AL, USA)
"Detection of azaspiracids in outbreak implicated mussel products"
9:15 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanisms of Toxicity
Phycotoxins Discussion Leader: Kathi Lefebvre (National Oceanographic and Atmospheric Administration, Seattle, WA, USA)
Mycotoxins Discussion Leader: Wentzel Gelderblom (Medical Research Council, PROMEC Unit, Tygerberg, South Africa)
9:00 am - 9:10 am Discussion Leaders overview
9:10 am - 9:35 am Isabelle Oswald (Laboratoire de Pharmacologie-Toxicologie, Toulouse, France)
"The intestine as a target for deoxynivalenol and its metabolites: mechanism of action"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Kathleen Rein (Florida International University, Miami, FL, USA)
"Identification and toxicology of human metabolites of algal hepatotoxins"
10:10 am - 10:20 am Discussion
10:20 am - 10:45 am Coffee Break
10:45 am - 11:10 am Peter Mantle (Imperial College, London, United Kingdom)
"Fresh evaluation of nephrocarcinogenicity of ochratoxin A from recent animal and human evidence"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Mark Hahn (Woods Hole Oceangraphic Institute, Woods Hole, MA, USA)
"The transcriptional response to oxidative stress in vertebrate embryos: the zebrafish model and its application to research on phycotoxin bioactivation and toxicity"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Tom Rand (St. Mary's University, Halifax, Nova Scotia, Canada)
"Inflammatory gene expression in rodent lungs and primary lung cells exposed to low molecular weight fungal compounds"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting (Part I)
(Fill out Conference Evaluation Forms)
7:30 pm - 8:50 pmEconomic Impacts of Mycotoxins and Phycotoxins
Phycotoxins Discussion Leader: Porter Hoagland (Woods Hole Oceanographic Institute, Woods Hole, MA, USA)
Mycotoxins Discussion Leader: Felicia Wu (University of Pittsburgh, Pittsburgh, PA, USA)
7:30 pm - 7:40 pm Discussion Leaders overview
7:40 pm - 8:05 pm Art Schaafsma (University of Guelph, Ridgetown, Ontario, Canada)
"A tale of contrasting economic reaction to epidemic contamination by the same mycotoxin in corn and wheat in a common agri-system"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Hauke Kite-Powell and Erin Ralston (Woods Hole Oceanographic Institute, Woods Hole, MA, USA)
"Economic effects of HAB's and marine phycotoxins"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:30 pm"Hot Topics" and Student Poster Presentations
Discussion Leader: Fran Van Dolah (National Oceanographic and Atmospheric Administration, Charleston, SC, USA)
8:50 pm - 9:20 pm(TBA)
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting (Part II)
(Nominations for the next Vice Chair; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmGenomics, Proteomics and the Phylogenetic Basis of Toxicity
Phycotoxins Discussion Leader: Allen Place (University of Maryland, Baltimore, MD, USA)
Mycotoxins Discussion Leader: Gary Payne (North Carolina State University, Raleigh, NC, USA)
9:00 am - 9:10 am Discussion Leaders overview
9:10 am - 9:35 am Micaela S. Parker (Pacific North West Center for Human Health and Ocean Studies, University of Washington, Seattle, WA, USA)
"Comparative genomics reveals clues to the molecular underpinnings of Pseudo-nitzschia toxicity and worldwide success"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am John Linz (Michigan State University, East Lansing, MI, USA)
"Vesicles and pre-vacuolar compartments carry out the late steps in aflatoxin synthesis - implications to aflatoxin control"
10:10 am - 10:20 am Discussion
10:20 am - 10:45 am Coffee Break
10:45 am - 11:10 am Brett Neilen (University of New South Wales, Sydney, Australia)
"Molecular evolution of the saxitoxin gene cluster"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Nancy Alexander (US Department of Agriculture, Agriculture Research Service, Peoria, IL, USA)
"Elucidation of gene function in mycotoxin biosynthetic pathways"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Timothy Phillips (College of Veterinary Medicine, Texas A&M University, College Station, TX, USA)
"Reducing aflatoxin exposure in Ghana"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmPublic Health and Epidemiology: Outbreak Investigations
Phycotoxins Discussion Leader: Mark Poli (U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD, USA)
Mycotoxins Discussion Leader: Lauren Lewis (U.S. Centers for Disease Control and Prevention, Chamblee, GA, USA)
7:30 pm - 7:40 pm Discussion Leaders overview
7:40 pm - 8:05 pm Ray Granade (U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Dauphin Island, AL, USA)
"Ciguatera outbreak investigations and formulation of regulatory advisory levels"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Tineke Kuiper-Goodman (Bureau of Chemical Safety, Health Canada, Ottawa, Ontario, Canada)
"A 'blackswan' song: exposure modeling and revised risk metrics of ochratoxin A provide new insights on the role of this mycotoxin in Balkan endemic nephropathy"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Aurelia Tubaro (University of Trieste, Trieste, Italy)
"Human illness associated with Ostreopsis ovata blooms in the Mediterranean Sea"
9:15 pm - 9:25 pm Discussion
9:25 pm - 9:30 pm Closing remarks by Robert Dickey and Barbara Blackwell
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1R13ES017578-01 from the National Institute of Environmental Health Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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