Gordon Research Conferences
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Conference Program
 
Natural Products
July 26-31, 2009
Tilton School
Tilton, NH

The 58th Natural Products Gordon Research Conference will continue a tradition of excellence in a broad range of areas relating to natural products chemistry and isolation, novel synthetic methods, chemical biology, bioorganic and medicinal chemistry. While remaining true to its foundation of organic synthesis of natural products, the speakers in this years' outstanding lineup will deliver lectures in topics as diverse as catalytic synthetic methodology, the use of natural product like molecules as tools to probe and better understand biological systems, and recent advances in drug discovery. Continuing a trend that has held for many years, the conference will have geographically diverse representation and will include speakers from both academic and industrial settings around the world. Consistent with previous meetings, this year's Natural Products GRC will also include a series of poster presentations that will afford an ideal opportunity to exchange of findings and ideas in an informal setting. It is anticipated that the exciting topics, diverse range of speakers and attendees and highly interactive tradition of this conference will make this year's conference both memorable and enjoyable.

As in recent years, the 2009 Natural Products GRC will be held at the Tilton School in Tilton, New Hampshire. The accommodations at Tilton are comfortable, the staff is friendly and the setting will provide abundant opportunity for recreation and relaxation in the afternoons.

All conferees are encouraged to present poster presentations describing novel, unpublished work and should submit an abstract complete with title, authors and affiliation/address (one page) to both the Chair, Marvin M. Hansen and the 2009 Vice Chair, Jef K. De Brabander via e-mail. Jef De Brabander will be responsible for both organizing the poster sessions and for working with the Chair to select a few poster abstracts for short talk presentations.


Contributors
Abbott Laboratories
Albany Molecular Research, Inc.
Amgen, Inc.
Astrazeneca Pharmaceuticals
BASF Corporation
Bayer Schering Pharma
Boehringer Ingelheim Cares Foundation, Inc.
Bristol-Myers Squibb Company
Celgene
Cephalon, Inc.
Eli Lilly and Company
Genentech, Inc.
Gilead Sciences
GlaxoSmithKline
Gordon Research Conferences
Infinity Pharmaceuticals, Inc.
Lexicon Pharmaceuticals
Ontario Institute For Cancer Research
Pfizer, Inc.
Pfizer/GRC Chemistry Student Fellowships
Reata Pharmaceuticals, Inc.
Rigel, Inc.
Roche Palo Alto LLC
Sanofi-Aventis Deutschland GMBH
Schering-Plough Corporation
Sigma-Aldrich
Takeda San Diego, Inc.
Vertex Pharmaceuticals, Inc.
Wyeth Laboratories
Xenobe Research Institute

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmChair's Welcome by Marv Hansen (Eli Lilly and Company); Opening Remarks by GRC Site Staff
7:40 pm - 9:30 pmSynthesis and Synthetic Methodology
Discussion Leader: Jon Njardarson (Cornell University)
7:40 pm - 8:10 pm Kay Brummond (University of Pittsburgh)
"Exploiting Allenes in the Synthesis of Natural Product-like Compounds"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Ryan Looper (University of Utah)
"Propargyl Guanidine Cyclizations and Their Application to Natural Product Targets"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:25 pm Barry Trost (Stanford University)
"On the Impact of New Synthetic Methods for the Synthesis of Bioactive Targets"
9:25 pm - 9:30 pm Discussion
9:30 pm Chair's Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:45 amCatalysis and Synthetic Methodology
Discussion Leader: Kathy Lee (Wyeth Pharmaceuticals)
9:00 am - 9:35 am Greg Dudley (Florida State University)
"A New Fragmentation Reaction for the Synthesis of Functionalized Alkynes"
9:35 am - 9:40 am Discussion
9:40 am - 10:15 am Veronique Gouverneur (University of Oxford)
"New Methods for the Construction and Deconstruction of C-F Bonds"
10:15 am - 10:20 am Discussion
10:20 am - 10:45 am Coffee Break / Group Photo
10:45 am - 12:30 pmCatalysis and Synthesis
Discussion Leader: Matthew Bourbeau (Amgen)
10:45 am - 11:25 am John Hartwig (University of Illinois)
"Discovery and Understanding of Transition Metal-Catalyzed Reactions for Organic Synthesis"
11:25 am - 11:30 am Discussion
11:30 am - 11:55 am Jason Tedrow (Amgen)
"A Templated Strategy for the Assembly of Hydroxyethylamine-Based Protease Inhibitors for the Synthesis of a BACE Clinical Candidate"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:25 pm Alfredo Castro (Infinity Pharmaceuticals)
"Role of the Hedgehog Pathway in Cancer: Harnessing Nature's Antagonist, Cyclopamine, To Make a Drug - IPI-926"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmChemical Biology
Discussion Leader: Angela Koehler (Broad Institute of Harvard and MIT)
7:30 pm - 7:55 pm Jennifer Kohler (UT Southwestern Medical Center at Dallas)
"Capturing Glycoconjugate Interactions With Photoactivatable Crosslinking Sugars"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:35 pm Laura Kiessling (University of Wisconsin-Madison)
"Chemical Probes of Carbohydrate Biosynthesis in Mycobacteria"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:25 pm Stuart Schreiber (Broad Institute of Harvard and MIT)
"The Gap Between Scientists' Aspirations and Society's Expectations"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 amMedicinal Chemistry
Discussion Leader: John Duncia (Bristol-Myers Squibb)
9:00 am - 9:30 am Milan Bruncko (Abbott Laboratories)
"N-Aryl-benzimidazolones as Novel Small Molecule HSP-90 Inhibitors"
9:30 am - 9:35 am Discussion
9:35 am - 10:05 am Thomas Magee (Pfizer)
"Erythromycin Semisynthesis Leading to Next Generation Macrolide Antibiotics: The Discovery of Clinical Candidate PF-04287881"
10:05 am - 10:10 am Discussion
10:10 am - 10:30 am Coffee Break
10:30 am - 12:30 pmChemistry and Biology of Natural Products
Discussion Leader: Jon Rainier (University of Utah)
10:30 am - 11:05 am David Sherman (University of Michigan)
"Chemical Diversity and Metabolic Versatility in Microbial Natural Product Biosynthesis"
11:05 am - 11:10 am Discussion
11:10 am - 11:45 am Rolf Müller (Universität des Saarlandes)
"Chemistry and Biotechnology of Myxobacteria - Promising Resources for Novel Bioactive Natural Products"
11:45 am - 11:50 am Discussion
11:50 am - 12:25 pm Carole Bewley (National Institutes of Health)
"Targeting Sponge-microbe Symbioses: An Unconventional Approach for Natural Products Discovery"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmNatural Products Synthesis
Discussion Leader: John D'Angelo (Alfred University)
7:30 pm - 8:10 pm Raymond Funk (Penn State University)
"Total Synthesis of Structurally Challenging Heterocyclic Natural Products"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Chuo Chen (UT Southwestern Medical Center)
"Synthesis of Marine Natural Products"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:25 pm Amos Smith (University of Pennsylvania)
"Recent Advances in Complex Natural and Unnatural Products"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:40 amAsymmetric and Organic Synthesis
Discussion Leader: Rebecca Hoye (Macalester College)
9:00 am - 9:35 am Michael Krische (University of Texas at Austin)
"Asymmetric Synthesis via C-C Bond Forming Hydrogenation and Transfer-Hydrogenation"
9:35 am - 9:40 am Discussion
9:40 am - 10:15 am Kyoko Nozaki (University of Tokyo)
"Carbon Monoxide and Carbon Dioxide as a C1 Synthon in Organic Synthesis"
10:15 am - 10:20 am Discussion
10:20 am - 10:40 am Coffee Break
10:40 am - 12:30 pmSynthesis, Chemistry and Natural Products
Discussion Leader: Jennifer Riggs (Celgene)
10:40 am - 11:05 am Artis Klapars (Merck and Company)
"Catalytic Asymmetric Reactions in the Synthesis of Complex Drug Targets"
11:05 am - 11:10 am Discussion
11:10 am - 11:45 am Richard Taylor (Notre Dame University)
"New Sources of Chemical Diversity Inspired by Polyketide Biosynthesis"
11:45 am - 11:50 am Discussion
11:50 am - 12:25 pm Markus Kalesse (Universität Hannover)
"Leads From Natural Products - From Proteasom Inhibitors to Antiinfectives"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:30 pm - 9:30 pmMethodology and Synthesis
Discussion Leader: Debbie Mohler (James Madison University)
7:30 pm - 8:05 pm Zhu-Jun Yao (Shanghai Institute of Organic Chemistry)
"Comprehension and Application of the Chemical Intelligence From Bioactive Natural Products"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Scott Frank (Eli Lilly and Company)
"Practical Approaches to the Assembly of Aminotetrazole Containing Drug Candidates"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:25 pm William Roush (The Scripps Research Institute, Florida)
"New Methodology for the Stereocontrolled Synthesis of Natural Products"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:45 amSynthesis, Chemistry and Biology of Natural Products I
Discussion Leader: Steve Castle (Brigham Young University)
9:00 am - 9:20 am Paul Floreancig (University of Pittsburgh)
"Applications of Oxidative Carbon-Hydrogen Bond Activation Reactions to Natural Product Synthesis"
9:20 am - 9:25 am Discussion
9:25 am - 9:45 am Chris Vanderwal (University of California-Irvine)
"Complex Molecule Synthesis Inspired by the Zincke Ring-Opening of Pyridines"
9:45 am - 9:50 am Discussion
9:50 am - 10:20 am Michael VanNieuwenhze (Indiana University)
"Combating Bacterial Resistance with Peptide Antibiotics that Inhibit Bacterial Cell Wall Biosynthesis"
10:20 am - 10:25 am Discussion
10:25 am - 10:45 am Coffee Break
10:45 am - 12:30 pmSynthesis, Chemistry and Biology of Natural Products II
Discussion Leader: Marianne Carlsen (Lexicon Pharmaceuticals)
10:45 am - 11:15 am Martin Banwell (Australian National University)
"Chemoenzymatic Methods for the Assembly of Biologically Active Natural Products and Related Compounds"
11:15 am - 11:20 am Discussion
11:20 am - 11:50 am Paul Hergenrother (University of Illinois)
"Direct Procaspase Activation as an Anti-cancer Strategy: Compound Identification, Mechanism of Action, and a Phase I Clinical Trial"
11:50 am - 11:55 am Discussion
11:55 am - 12:25 pm Peter Seeberger (Swiss Federal Institute of Technology - ETH)
"Chemistry and Biology of Carbohydrates"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
2:00 pm - 4:00 pmAnnual Academic vs Industrial All-Stars Softball Game
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmNatural Product Synthesis and Medicinal Chemistry
Discussion Leader: Chris Vanderwal (University of California-Irvine)
7:30 pm - 8:10 pm Dirk Trauner (Ludwig-Maximilians-Universität, Munich)
"Building Molecules to Tackle Cancer and Blindness"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Rob Webb (RW Consulting)
"Neurotrophin-Drug Conjugates For the Treatment of Pain"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:25 pm Peter Wipf (University of Pittsburgh)
"Natural Products and Beyond"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

 
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