Conference Program
 
Phagocytes
Innate Immune Cell-Pathogen Interactions
June 7-12, 2009
Waterville Valley Resort
Waterville Valley, NH
Chair:
Linda C. McPhail

Vice Chair:
Sergio Grinstein

Related Meeting Information
The Phagocytes Gordon Research Conference was held in conjunction with the Phagocytes Gordon-Kenan Research Seminar. Please refer to the Phagocytes GKRS web page for more information.

Innate immune cells (neutrophils, macrophages, dendritic cells) play an essential role in host defense and inflammation. The theme of this meeting is Innate Immune Cell:Pathogen Interactions. Topics will cover the regulation and molecular basis of the function of these cells with a focus on the impact of their interaction with microorganisms, microbial products, and cytokines. The spectrum of phagocyte function, from diapedisis to phagocytosis and killing, as well as the role of innate immune cell responses to infection in the etiology of acute and chronic diseases, will be included. Invited speakers will be a mixture of leaders in the field and younger scientists, with an emphasis on the latest, most exciting findings. In addition to the invited lectures, there will be poster sessions for attendees to present and discuss their work, which are also a very important component of the meeting. There are slots in the program for late-breaking presentations and shorter talks, which will be selected from abstracts submitted for the poster sessions. We encourage early application for maximum consideration. There will be ample time for discussions and informal interactions among conferees.

We encourage the application and attendance of scientists from a diversity of backgrounds and experience. In particular, women, minorities and younger scientists in the early stages of their careers should consider application, and this Conference has funds to help support registration and travel for these attendees. For those scientists with disabilities, we also have funds to help support any extra costs associated with any special travel arrangements. Please contact the Chair to request consideration for these funds.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNOVEL TECHNOLOGIES
7:40 pm - 7:55 pm Discussion Leader: Sam Silverstein (Columbia University)
"Introduction"
7:55 pm - 8:45 pm Lecture in memory of Zanvil Cohn: Joel Swanson (University of Michigan)
"Conditional Signaling for Phagocytosis and Pinocytosis"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Jackson Egen (NIAID/NIH)
"In vivo visualization of phagocyte function during the host response to infection"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCELL MIGRATION
9:00 am - 9:15 am Discussion Leader: Klaus Ley (La Jolla Institute for Allergy and Immunology)
"Introduction"
9:15 am - 9:40 am Klaus Ley (La Jolla Institute for Allergy and Immunology)
"PSGL-1-dependent activation of neutrophils and monocytes"
9:40 am - 9:50 am Discussion
9:50 am - 10:00 am Short Talk: Christoph Riethmüller (University of Münster)
"Transcellular diapedesis of neutrophils is possible close to intact endothelial junctions as shown by force microscopy"
10:00 am - 10:05 am Discussion
10:05 am - 10:25 am Coffee Break / Group Photo
10:25 am - 10:50 am Tobias Meyer (Stanford University)
"Modular control of endothelial cell migration"
10:50 am - 11:00 am Discussion
11:00 am - 11:25 am Chuck Parkos (Emory University)
"Molecular basis of JAM-A function"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Martha Cathcart (Cleveland Clinic)
"Signal activated phospholipases control monocyte chemotaxis"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Short Talk: Paige Volk (University of Iowa)
"Role of NADPH oxidase-derived reactive oxygen species in neutrophil chemotaxis signaling"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmPATTERN RECOGNITION RECEPTORS
7:30 pm - 7:45 pm Discussion Leader: David Underhill (Cedars-Sinai Medical Center)
"Introduction"
7:45 pm - 8:10 pm Kate Fitzgerald (University of Massachusetts Medical School)
"DNA sensing in the innate immune response"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Paul Heyworth (Schering-Plough)
"Role of the C-type Lectin MDL-1 in Infectious and Inflammatory Disease"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Nick Gay (University of Cambridge)
"Structure and mechanism of signal transduction by the TLRs"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPHAGOCYTOSIS/EXOCYTOSIS
9:00 am - 9:15 am Discussion Leader: Joel Swanson (University of Michigan)
"Introduction"
9:15 am - 9:40 am Julie Magarian Blander (Mount Sinai School of Medicine)
"Innate controls of Treg and TH17 cell differentiation"
9:40 am - 9:50 am Discussion
9:50 am - 10:00 am Short Talk: Margolein van Egmond (VU University Medical Center)
“Immunoglobulin A - FcγRI interactions induce neutrophil migration through release of leukotriene B4”
10:00 am - 10:05 am Discussion
10:05 am - 10:25 am Coffee Break
10:25 am - 10:50 am Helen Yin (University of Texas Southwestern Medical Center)
"Essential and Unique Roles of Phosphatidylinositol-4-Phosphate-5-Kinases in Phagocytosis"
10:50 am - 11:00 am Discussion
11:00 am - 11:25 am Nathalie Franc (The Scripps Research Institute)
"Genetic dissection of the molecular mechanisms of phagocytosis in Drosophila"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Sergio Catz (The Scripps Research Institute)
"Molecular Mechanisms of Neutrophil Granule Dynamics and Secretion"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Short Talk: Barbara Kazmierczak (Yale University)
"Specific recognition of translocation-competent Type 3 secretion system during Pseudomonas aeruginosa pulmonary infection"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmINNATE AND ADAPTIVE IMMUNITY
7:30 pm - 7:45 pm Discussion Leader: Hidde Ploegh (Whitehead Institute for Biomedical Research)
"Introduction"
7:45 pm - 8:10 pm Hidde Ploegh (Whitehead Institute for Biomedical Research)
"New chemical tools to study movement and function of phagocytic receptors and TLRs"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Steffen Jung (The Weizmann Institute of Science)
"Differential Origins and Functions of Intestinal Mononuclear Phagocytes"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Sankar Ghosh (Columbia University)
"New insights into innate immune responses to Salmonella"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmREDOX REGULATION
9:00 am - 9:15 am Discussion Leader: Mary Dinauer (Indiana University School of Medicine)
"Introduction"
9:15 am - 9:40 am Ariel Savina (Institut Curie)
"Role of NADPH oxidase NOX2 in antigen cross presentation in Dendritic Cells"
9:40 am - 9:50 am Discussion
9:50 am - 10:00 am Short Talk: Jessica Moreland (University of Iowa)
"Neutrophil NADPH oxidase is functional in unstimulated cells"
10:00 am - 10:05 am Discussion
10:05 am - 10:25 am Coffee Break
10:25 am - 10:50 am Erzsebet Ligeti (Semmelweis University, Budapest)
"Antibacterial effect of PMN-derived microvesicles"
10:50 am - 11:00 am Discussion
11:00 am - 11:25 am Rachel Levy (Ben-Gurion University of the Negev)
"The diverse role of cytosolic phospholipase A2alfa in phagocytic cells"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Bob Clark (University of Texas Health Sciences Center - San Antonio)
"Feed-Forward Redox Regulation of NOX2 Activation by Hydrogen Peroxide"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Short Talk: Franck Fieschi (Joseph Fourier University)
"Conformational changes in p47phox upon activation followed by mass spectrometry derived approaches: toward a revised version of the molecular activation of the neutrophilic NADPH oxidase"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmPATHOGEN EFFECTS ON INNATE IMMUNE CELLS
7:30 pm - 7:45 pm Discussion Leader: Lee-Ann Allen (University of Iowa)
"Introduction"
7:45 pm - 8:10 pm David Mosser (University of Maryland)
"Monocyte and macrophage heterogeneity during infectious diseases"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Lynda Stuart (Massachusetts General Hospital)
"Sensing from within - Phagosome dependent microbial recognition"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Lalita Ramakrishnan (University of Washington)
"Monitoring and modulating phagocyte-mycobacterium interactions in the zebrafish"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmINNATE IMMUNE CELLS IN INFLAMMATION
9:00 am - 9:15 am Discussion Leader: Bill Nauseef (University of Iowa)
"Introduction"
9:15 am - 9:40 am Donna Bratton (National Jewish Medical and Research Center)
"NADPH Oxidase-dependent Generation of Lysophosphatidylserine Enhances Macrophage Clearance of Activated and Dying Neutrophils"
9:40 am - 9:50 am Discussion
9:50 am - 10:00 am Short Talk: Emily Elliott (University of California San Francisco)
"Syk-dependent Neutrophil Effector Functions are Essential for the Development of Antibody Mediated Arthritis"
10:00 am - 10:05 am Discussion
10:05 am - 10:25 am Coffee Break
10:25 am - 10:50 am Charles Serhan (Brigham and Women's Hospital / Harvard Medical School)
"Maresins: A Novel Family of Potent Anti-Inflammatory and Pro-Resolving Mediators From Macrophages"
10:50 am - 11:00 am Discussion
11:00 am - 11:25 am Moira Whyte (University of Sheffield)
"Regulation of neutrophil function and apoptosis by hypoxia"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Luigina Romani (University of Perugia)
"Balancing inflammation and tolerance to opportunistic fungi"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm Short Talk: Madhavi Rane (University of Louisville)
"Akt-mediated NF-E2 phosphorylation induces NFκB activation and neutrophil-mediated acute lung injury in rats"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmINNATE IMMUNE CELLS AND DISEASE
7:30 pm - 7:45 pm Discussion Leader: Peter Ward (University of Michigan)
"Introduction"
7:45 pm - 8:10 pm Joseph El-Khoury (Harvard Medical School)
"Scavenger and Toll-like receptors in fungal infections: Brothers in Arms"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Gwen Randolph (Mount Sinai School of Medicine)
"Fate of monocyte-derived cells in atherosclerosis"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Guillermina Girardi (Weill Medical College)
"Activation of Neutrophils by the Tissue factor - Factor VIIa-PAR-2 Axis Mediates Fetal Death in Antiphospholipid Syndrome"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible [in part] by (1R13 AI082741-01) from the National Institute of Allergy and Infectious Diseases (NIAID) and the National Heart, Lung, And Blood Institute (NHLBI). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.