Gordon Research Conferences
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Conference Program
 
Phosphorylation & G-Protein Mediated Signaling Networks
June 7-12, 2009
University of New England
Biddeford, ME

The 2009 Gordon Research Conference on Phosphorylation and G Protein Signaling Networks will present cutting edge research on molecular mechanisms that underlie the action of many hormones, neurotransmitters, growth factors, and sensory stimuli. Organized sessions will discuss new research advances on the structure of G protein-coupled receptors (GPCR), regulation of GPCR, G protein-independent signaling of GPCR, G protein-regulating proteins, subcellular targeting of signaling proteins, G protein-regulated effectors, GPCR-promoted signaling into Ras-regulated networks, structural bases of G protein signaling, and drug discovery. The invited speakers apply biochemical, structural, cell biological, genetic, physiological, and therapeutic approaches to address mechanisms of cell signaling and their relationships to human disease and potential therapeutic interventions. The meeting will provide an excellent opportunity for junior scientists and graduate students to present their research in poster format and exchange ideas with leaders of the field. Approximately ten poster presenters will be selected for short talks. A collegial atmosphere, ample informal gatherings, and the programmed conference presentations and discussions will provide an ideal forum for exchange of ideas, development of cross-disciplinary collaborations, and immersion of young scientists in the process of scientific inquiry and discovery.


SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm REGULATION OF GPCR
Discussion Leader: Richard Clark (University of Texas Health Science Center Houston)
7:40 pm - 8:05 pmJeffrey Benovic (Thomas Jefferson University)
"Regulation of CXCR4 signaling and trafficking"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:40 pmJoAnn Trejo (University of California, San Deigo)
"Protease-selective signaling by protease-activated receptor-1"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmLaura Bohn (Scripps Institute, Florida)
"Serotonin 2A receptor responsiveness as a function of agonist and beta-arrestin2 in vivo"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pm NOVEL GPCR-PROMOTED SIGNALING PATHWAYS
Discussion Leader: John Northup (National Institute of Health)
9:00 am - 9:25 amKodi Ravichandran (University of Virginia)
"Eating the dead: adhesion family GPCR member BAI1 in apoptotic cell clearance"
9:25 am - 9:40 am Discussion
9:40 am - 10:00 amRandy Hall (Emory University)
"Signaling by the Adhesion Receptor GPR56"
10:00 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 amDianqing Wu (Yale University)
"Chemoattractant signaling in myeloid cells"
11:05 am - 11:20 am Discussion
11:20 am - 11:35 amSteve Cappell (University of North Carolina)
"Screening the essential genome to identify novel regulators of G protein signaling"
11:35 am - 11:40 am Discussion
11:40 am - 11:55 amAmantha Thathiah (Catholic Univ. of Leuven)
"The orphan G protein-coupled receptor GPR3 mediates Abeta peptide production: relevance to Alzheimer’s disease"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:15 pmMikel Garcia-Marcos (University California, San Diego)
"GIV, a novel non-receptor GEF for Gαi that regulates cell migration and cancer metastasis"
12:15 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm SUBCELLULAR TARGETING
Discussion Leader: Barry Willardson (Brigham Young University)
7:30 pm - 7:55 pmCarmen Dessauer (University of Texas Health Science Center Houston)
"A novel adenylyl cyclase-mAKAP signaling complex regulates cAMP levels in cardiac myocytes"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmRennolds Ostrom (University of Tennessee Health Science Center)
"Heterogeneity of signaling by adenylyl cyclase isoforms: from cells to disease"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmTobias Meyer (Stanford University)
"Modular characteristics of the signaling system controlling cell migration"
9:15 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm G PROTEIN REGULATING PROTEINS
Discussion Leader: Henrik Dohlman (University of North Carolina)
9:00 am - 9:25 amKen Blumer (Washington University)
"RGS function and regulation"
9:25 am - 9:40 am Discussion
9:40 am -10:00 amKirill Martemyanov (University of Minnesota)
"Functional dynamics of R7 RGS protein complexes"
10:00 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 amJohn Hepler (Emory University)
"RGS14 as an integrator of unconventional G protein and MAP kinase signaling important for hippocampal function"
11:05 am - 11:20 am Discussion
11:20 am - 11:40 amSteve Lanier (Medical University of South Carolina)
"Activators of G-protein Signaling"
11:40 am - 11:55 am Discussion
11:55 am - 12:10 pmMorwenna Porter (Yale University)
"A membrane binding subunit required for the function and subcellular localization of just one of two R7 RGS proteins in C. elegans"
12:10 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm STRUCTURAL BASIS OF G PROTEIN SIGNALING
Discussion Leader: Ron Taussig (University of Texas Southwestern Dallas)
7:30 pm - 7:55 pmJohn Tesmer (University of Michigan)
"The receptor docking site of G protein-coupled receptor kinases"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmJohn Sondek (University of North Carolina)
"Regulation of phospholipase C by heterotrimeric G proteins and small GTPases"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmRoger Sunahara (University of Michigan)
"Allosteric regulation of ligand binding to GPCRs by G proteins"
9:15 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm INTERPLAY OF GPCR & RAS GTPASE SIGNALING
Discussion Leader: Nick Dulin (University of Chicago)
9:00 am - 9:25 amJoan Heller Brown (University of California, San Diego)
"GPCR mediated Rho activation on the pathway to Ras GTPases"
9:25 am - 9:40 am Discussion
9:40 am -10:05 amStefan Offermanns (University of Heidelberg)
"G-protein-mediated signaling in vascular physiology and pathology"
10:05 am - 10:20 am Discussion
10:20 am Coffee Break
10:40 am - 10:50 amBusiness Meeting: Part I
(Nominations for the next Vice Chair)
10:50 am - 11:10 amXY Huang (Cornell Medical School)
"Suppression of tumor angiogenesis by Gα13 haploinsufficiency"
11:10 am - 11:25 am Discussion
11:25 am - 11:45 amBrendan Manning (Harvard University)
"Regulation and function of the TSC-mTOR signaling network"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:15 pm Natalia Riobo (Thomas Jefferson University)
"Sonic hedgehog induces fibroblast migration through a non-canonical pathway"
12:15 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting: Part II
(Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm STRUCTURE OF G PROTEIN-COUPLED RECEPTORS
Discussion Leader: Roger Sunahara (University of Michigan)
7:30 pm - 7:55 pmGebhard Schertler (Cambridge University)
"Structure of the 3rd intracellular loop of the beta1 adrenergic receptor: implications for pharmacology"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:55 pmBrian Kobilka (Stanford University)
Keynote Lecture: "Structural insights into G protein coupled receptor activation"
8:55 pm - 9:10 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm EFFECTORS AND DOWNSTREAM SIGNALING PATHWAYS
Discussion Leader: Rob Nicholas (University of North Carolina)
9:00 am - 9:25 amJames Putney (NIEHS)
"Cell biology and regulation of store-operated calcium entry"
9:25 am - 9:40 am Discussion
9:40 am -10:00 amJin Zhang (Johns Hopkins University)
"Capturing kinases in action in single living cells and on proteome chips"
10:00 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 amHeidi Hamm (Vanderbilt University)
"Dynamics of G protein activation by GPCRs"
11:05 am - 11:20 am Discussion
11:20 am - 11:40 amPaul Sternweis (University of Texas Southwestern Dallas)
"Regulation of RGS-RhoGEFs by G13 novel adenylyl cyclase-mAKAP signaling complex regulates cAMP levels in cardiac myocytes"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pmP. Jeffrey Conn (Vanderbilt University)
"Allosteric modulators of GPCRs as a novel approach for treatment of CNS disorders"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm GPCR DRUG DISCOVERY
Discussion Leader: David Roman (University of Iowa)
7:30 pm - 7:45 pmYaping Tu (Creighton University)
"Breast cancer migration and invasion depend on proteosome degradation of regulator of G protein signaling 4"
7:45 pm - 7:50 pm Discussion
7:50 pm - 8:05 pmChris Evelyn (University of Michigan)
"The Effect of the RhoA Transcriptional Pathway Inhibitor, CCG-1423, Upon Global PC-3 Prostate Cancer Cell Gene Expression"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmArthur Christopoulos (Monash University)
"Allosteric modulators of GPCRs: mechanisms and challenges"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmLarry Sklar (University of New Mexico)
"Small molecule discovery in signaling systems with HTS multiplex flow cytometry"
9:15 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible in part by 1 R13 GM 087764 - 01 from the National Institute of General Medical Sciences & the National Institute of Neurological Disorders And Stroke (NINDS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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