Conference Program
 
Physical Virology
February 15-20, 2009
Hotel Galvez
Galveston, TX
Chair:
Adam Zlotnick

Vice Chair:
Bogdan Dragnea

Viruses have self-organizing, symmetrical, and monodisperse architectures. These structures are dynamic and, in some cases, the dynamics are regulatable. These properties make viruses successful parasites. A growing community of scientists in diverse fields has now turned the tables on viruses, taking advantage of viruses as therapeutic vectors, imaging agents, scaffolding for nanostructures, components in larger constructions, and as microreactors. There have been tremendous advances in the design of new materials by using biological self-assembly and concepts derived from biological models. The underlying science has been investigated by mathematicians, physicists, chemists, material scientists, and biologists. This diversity is a strength because of the breadth of perspectives but poses challenges because of the poor communication between disciplines. The field is changing at a pace that will be hard to maintain unless we find a common ground. The goal of this conference is to bring together, for a first time, the physical, biological, and materials perspectives that are rapidly shaping the field of viruses as physical functional systems.


Contributors
This conference is supported by grants from the Army Research Office (ARO) and the NIH (1 R13 GM087009-01); and corporate contributions from FEI Company ("Tools for Nanotech") and Wyatt Technology ("Light scattering for the masses").

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmStructure
Discussion Leader: Wah Chiu (Baylor College of Medicine)
7:40 pm - 8:10 pm Michael G. Rossmann (Purdue University)
"Using antibodies to track conformational changes of flaviviruses"
8:10 pm - 8:25 pm Discussion
8:25 pm - 8:55 pm Grant Jensen (California Institute of Technology)
"Electron cryotomographic studies of HIV-1 maturation"
8:55 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Poster Talk: Yizhi Tao (Rice U.)
"Unique capsid organization of a dsRNA virus revises the model for capsid assembly"
9:20 pm - 9:30 pm Poster Talk: Xiangan Liu (Baylor College of Medicine)
"Cryo-EM Reveals the Structure of the Capsid Protein and Symmetry Mismatch of the Portal Vertex in Cyanophage P-SSP7"
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPhysical and mechanical properties of supra-molecular structures
Discussion Leader: Charles Knobler (University of California - Los Angeles)
9:00 am - 9:35 am Gijs Wuite (Vrije Univ, Netherlands)
"Exploring the nano-mechanics of viruses"
9:35 am - 9:50 am Discussion
9:50 am - 10:00 am Poster Talk: Carolina Carrasco Pulido (Universidad Autonoma de Madrid)
"Tailoring of the mechanical properties of a virus by protein engineering"
10:00 am Coffee Break / Group Photo
10:30 am - 11:05 am Roya Zandi (University of California - Riverside)
"Nonequilibrium growth, retrovirus assembly and conical structures"
11:05 am - 11:20 am Discussion
11:20 am - 11:55 am Rob Phillips (California Institute of Technology)
"How Viruses Make New Viruses: A Single Molecule View"
11:55 am - 12:10 pm Discussion
12:10 pm - 12:20 pm Poster Talk: Ian Molineux (University of Texas)
"Studies on the mechanisms used in vivo for phage DNA ejection into the infected cell"
12:20 pm - 12:30 pm Poster Talk: Siyang Sun (Purdue University)
"The Structure of the Phage T4 DNA packaging Motor Suggests a Mechanism Dependent on Electrostatic Forces"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of self-assembly
Discussion Leader: Peter Prevelige (University of Alabama - Birmingham)
7:30 pm - 8:05 pm Carlos Catalano (University of Washington)
"Assembly and Maturation of the Lambda Procapsid"
8:05 pm - 8:20 pm Discussion
8:20 pm - 8:55 pm Stephen Granick (University of Illinois - Urbana Champaign)
"Self-assembly: nanoparticles, phospholipids, colloids"
8:55 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Poster Talk: Laura Palomares (Universidad Nacional Autonoma de Mexico)
"Assembly kinetics of rotavirus VP6: From tubes to icosahedral structures"
9:20 pm - 9:30 pm Poster Talk: Alan Rein (National Cancer Institute)
"On the Role of RNA in retrovirus particle structure"
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTheoretical properties of regular structures and their assembly
Discussion Leader: Charles L. Brooks III (University of Michigan)
9:00 am - 9:10 am Introduction
9:10 am - 9:45 am William Klug (University of California - Los Angeles)
"Structural mechanics of viral shells: stretching continuum models to their limits"
9:45 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:00 am Michael Hagan (Brandeis University)
"From solid nanoparticles to flexible polyanions -- the role of the packaged cargo in capsid assembly"
11:00 am - 11:15 am Discussion
11:15 am - 11:45 am Reidun Twarock (University of York, UK)
"Hidden symmetries in virus architecture and their implications for structural transitions and function"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Poster Talk: Alain Mermet (University Lyon 1)
"Collective vibrational modes of viruses"
12:10 pm - 12:20 pm Poster Talk: Michael Widom (Carnegie Mellon University)
"Capsid faceting as a soft-mode transition"
12:20 pm - 12:30 pm Poster Talk: Xiangyun Qiu (National Institutes of Health)
"Charting the Structure and Energetics of Packaged DNA in Bacteriophages"
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmDynamical properties of viruses
Discussion Leader: Peter Stockley (University of Leeds, UK)
7:30 pm - 8:05 pm John E. Johnson (Scripps Research Institute)
"Unexpected twists in virus maturation: how bacteriophage subunits shape an energy landscape"
8:05 pm - 8:20 pm Discussion
8:20 pm - 8:55 pm Max Nibert (Harvard University)
"Peptide release for membrane penetration by reovirus"
8:55 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Poster Talk: Yorgo Modis (Yale University)
"Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation and its implications for membrane fusion"
9:20 pm - 9:30 pm Poster Talk: Deborah Kuzmanovic (University of Michigan)
"Structural analysis of the phage MS2 components using Small Angle Neutron Scattering"
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBio-inorganic virus-based materials: electronics / photonics / catalysis
Discussion Leader: David Evans (John Innes Institute, UK)
9:00 am - 9:40 am Trevor Douglas (Montana State University)
"Capsids for synthetic encapsulation: polymers, molecules and nanosolids"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:05 am Jeroen Cornelissen (Radboud University, Netherlands)
"Viruses as supramolecular containers and scaffolds"
11:05 am - 11:20 am Discussion
11:20 am - 11:55 am Matt Francis (University of California - Berkeley)
"Building new materials from synthetically modified viral capsids"
11:55 am - 12:10 pm Discussion
12:10 pm - 12:20 pm Poster Talk: Stella Aniagyei (Indiana University)
"Towards targeted delivery of the anti-cancer drug cisplatin using virus-based platforms"
12:20 pm - 12:30 pm Poster Talk: Harry Bermudez (Umass)
"Functionality in bacteriophages: using asymmetry to add responsiveness"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBiomedical approaches based on virus structure and properties
Discussion Leader: Mavis Agbandje-McKenna (University of Florida)
7:30 pm - 8:05 pm Marianne Manchester (Scripps Research Institute)
"Exploiting the natural properties of viral nanoparticles for biomedical therapeutics"
8:05 pm - 8:20 pm Discussion
8:20 pm - 8:55 pm Robert L. Garcea (University of Colorado - Boulder)
"The Structural Biology of Papillomaviruses in Relation to Vaccine Development"
8:55 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Poster Talk: Chris Broomell (Montana State University)
"Enhancement of protection against respiratory infection following treatment with protein cage nanoparticles"
9:20 pm - 9:30 pm Poster Talk: Aravind Asokan (University of North Carolina at Chapel Hill)
"Engineering new viral tropisms by rational manipulation of capsid surface topology"
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmConnecting nano to mesoscale, metamaterials
Discussion Leader: M.G. Finn (Scripps Research Institute)
9:00 am - 9:40 am Samuel Stupp (Northwestern University)
"Self-Assembly of Virus Mimics and Hierarchical Structures"
9:40 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:05 am Sharon Glotzer (University of Michigan)
"Relating Building Block Shape and Complexity for Assembly"
11:05 am - 11:20 am Discussion
11:20 am - 11:55 am Ichiro Yamashita (Matsushita Electronics, Japan)
"Nanodevice fabrication using protein supramolecule and biomineralization"
11:55 am - 12:10 pm Discussion
12:10 pm - 12:20 pm Poster Talk: Christoph Schmidt (Georg-August-Universitaet)
"Shell mechanics of viral capsids"
12:20 pm - 12:30 pm Poster Talk: Mime Kobayashi (NAIST)
"Fabrication of nano-scaled structures using genetically engineered tobacco mosaic virus"
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmThe next step / late breaking results
Discussion Leader: Mark J. Young (Montana State University)
7:30 pm - 8:05 pm Otto Sankey / Kong-Thon Tsen (Arizona State University)
"Simulations and theory of virus inactivation by driving mechanical motion with ultra-fast light pulses"
8:05 pm - 8:20 pm Discussion
8:20 pm - 8:55 pm Seung-Wuk Lee (University of California - Berkeley)
"Genetically Engineered Viruses for Tissue Regenerating Materials"
8:55 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Closing Short Talk: Brian Bothner (Montana State Univeristy)
"Stability and Dynamics of Protein Cages from an Extremophile"
9:20 pm - 9:30 pm Closing Short Talk: Roger Hendrix (University of Pittsburgh)
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1 R13 GM087009-01 from the National Institute of General Medical Sciences, and the National Institute of Biomedical Imaging and BioEngineering. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.