Gordon Research Conferences
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Conference Program
 
Viruses & Cells
June 7-12, 2009
Il Ciocco Hotel and Resort
Lucca (Barga), Italy

The 2009 Viruses and Cells Gordon Conference, the premier conference in the field of virology, will cover all aspects of virus infection, from entry into the cell through replication and assembly, to uncovering the molecular basis of pathogenesis, to prevention and therapy. The 2009 meeting will held at the GRC conference site, Il Ciocco in Barga, Italy from June 7-12, 2009.

The invited speakers will present cutting edge findings on the dynamic interactions of viruses with the cells and organisms they infect as well as host counter responses to infection. Topics will include: entry and receptors; assembly, budding and release, dynamics of cellular trafficking, viral replication & gene expression, immune response & pathogenesis, cellular inhibition of virus replication; innate immune response & virus counter response; exploiting host functions, and epidemiology, prevention & therapy. Discussion leaders, who are expert in the topics covered in each session, will lead lively and open discussions following each presentation. In addition to the invited speakers, shorter talks will be chosen from among the abstracts that are submitted for poster sessions at the time of registration. Selections will be made to highlight exciting new developments in virus research with the emphasis on the selection of younger scientists for these presentations. The evening poster sessions are a prominent and important aspect of this conference providing yet another opportunity for participants to present and discuss their research findings in a congenial atmosphere. The conference will bring together investigators at the forefront of the field, young investigators launching their independent research careers, as well as postdoctoral fellows and graduate students and investigators from industry to discuss new ideas and to foster collaborations.


Contributors
GORDON RESEARCH CONFERENCES
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
ABBOTT LABS
APATH, LLC
CARL STORM FELLOWSHIPS
CELL PRESS/ELSEVIER
This generous support has made possible numerous travel fellowships for young investigators, evening receptions and speaker registration and travel reimbursements. We thank you for your support and interest in Virology.

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
5:00 pm - 6:00 pmWelcome Reception
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmEntry and Receptors
Discussion Leaders: Gabriella Campadelli-Fiume (University of Bologna) & Roberto Cattaneo (Mayo Clinic)
7:35 pm - 7:55 pm Yves Gaudin (CNRS)
"Structural organization and working of VSV fusion machinery"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Ari Helenius (Swiss Federal Institute of Technology)
"A systems approach to virus entry"
8:25 pm - 8:35 pm Discussion
8:35 pm - 8:55 pm Thilo Stehle (University of Tuebingen)
"Structural Analyses of Viral Attachment Strategies"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:15 pm Virginia Young (Fox Chase Cancer Center)
"Measles virus trafficking in, and spread among, neurons of the CNS"
9:15 pm - 9:25 pm Theodore Jardetzky (Stanford University)
"Epstein-Barr Virus Entry Glycoprotein Structures, Interactions and Inhibition"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAssembly, Budding, Release
Discussion Leaders: Anette Schneemann (Scripps Research Institute) & Carol Carter (Stony Brook University)
9:00 am - 9:20 am Joel Baines (Cornell University)
"Function and regulation of the HSV-1 nuclear envelopment complex"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Thomas Wileman (University of East Anglia)
"Mechanism of endoplasmic reticulum stacking and collapse during virus replication"
10:00 am - 10:45 am Coffee Break / Group Photo
10:45 am - 11:05 am Cristina Risco (National Biotechnology Center, Madrid)
"Virus factories in 3D"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 am Walther Mothes (Yale University)
"Retroviral Assembly is directed towards sites of cell-cell contact"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Laura Menotti (University of Bologna)
"An oncolytic HSV-1 retargeted to HER-2-positive cells inhibits human tumor growth in mice"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Colin Parrish (Cornell University)
"Parvovirus capsid interactions with transferrin receptors and antibodies"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm John Young (Salk Institute)
"Cellular Factor Involvement in Early Steps of Retrovirus Replication"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmDynamics of cellular trafficking
Discussion Leaders: Peter Sarnow (Stanford University) & Greg Smith (Northwestern University)
5:30 pm - 5:50 pm Lynn Enquist (Princeton University)
"Imaging herpesvirus infection of PNS neurons"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Julie Pfeiffer (University of Texas Southwestern Medical Center)
"Multiple host barriers restrict poliovirus trafficking in mice"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Peter O'Hare (Marie Curie Research Institute)
"VP1-2, a player of many parts in herpesvirus exits and entrances"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Thomas Hope (Northwestern University)
"Running the Gauntlet: Cytoplasmic trafficking and restriction of HIV"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
9:30 pmPoster Session A
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmViral replication & gene expression
Discussion Leaders: Robert Kalejta (University of Wisconsin) & Sean Whelan (Harvard University)
9:00 am - 9:20 am Bert Semler (University of California, Irvine)
"Viral subversion of host functions during picornavirus replication"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Paula Traktman (Medical College of Wisconsin)
"Vaccinia DNA Replication: Opportunities and Challenges for a cytoplasmic DNA Virus"
10:00 am - 10:30 am Coffee Break
10:30 am - 10:50 am Peter Nagy (University of Kentucky)
"The functions of host factors in the viral replicase complex"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Juan Ortin (Centro Nacional de Biotecnología - CSIC)
"Replication and transcription of Influenza virus RNPs"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Raychel Chambers (University of Rochester Medical Center)
"Trafficking of Sendai virus nucleocapsids by intracellular vesicles on microtubules"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Cornelius de Haan (Utrecht University)
"Dynamics of coronavirus replication complexes"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Angela Erazo (University of Pittsburgh)
"Alphaherpesviruses induce specific phosphorylation of the nuclear matrix protein, matrin 3"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Hendirk Huthoff (Guy's Hospital)
"RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmImmune Response & pathogenesis
Discussion Leaders: Katherine Spindler (University of Michigan) & Edward Mocarski (MedImmune Vaccines)
5:30 pm - 5:50 pm Sujan Shresta (La Jolla Institute for Allergy and Immunology)
"Protective versus Pathogenic Immune Response to Dengue Virus"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Tatyana Golovkina (University of Chicago)
"Retrovirus evasion of the host immune defenses"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Sara Cherry (University of Pennsylvania)
"Identification of host factors involved in viral infection"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Hisashi Arase (Osaka University)
"Regulation of herpesvirus infection by paired receptors"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
9:30 pmPoster Session B
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCellular inhibition of virus replication & virus countermeasures
Discussion Leaders: Sandra Weller (University of Connecticut) & Ellen Fanning (Vanderbilt University)
9:00 am - 9:20 am Thomas Stamminger (University Erlangen-Nuremberg)
"Interplay between HCMV infection and host defense by PML nuclear bodies"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Stacey Schultz-Cherry (University of Wisconsin)
"Regulation of Viral Replication: A Battle between the Virus and the Host"
10:00 am - 10:25 am Coffee Break
10:25 am - 10:45 am Business Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
10:45 am - 11:05 am Herbert Virgin IV (Washington University)
"Pathogenic virome-genome interactions: new paradigms and new players"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 am Ellen Fanning (Vanderbilt University)
"SV40 infection: using a burglar alarm to take over the store"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Klaus Osterrieder (Institute for Virology, Berlin)
"Herpesvirus tumor formation - the role of telomerase"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Stacy Horner (University of Washington)
"Molecular mechanism of HCV NS3/4A protease targeting of IPS-1 and the RIG-I pathway"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Andrew Greenstein (Gilead Sciences)
"Quantitative cell-by-cell measurements of resistance using fluorescent HCV replicon cell lines"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmInnate immune response & virus counter response
Discussion Leaders: Karen Mossman (McMaster University) & Joanna Shisler (University of Illinois)
5:30 pm - 5:50 pm Ganes Sen (Cleveland Clinic)
"New branches of double-stranded RNA signaling pathways"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Antonella Casola (University of Texas Medical Branch)
"Modulation of innate immunity by human metapneumovirus glycoproteins"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Karla Kirkegaard (Stanford University)
"Viral RNA replication complexes and cytoplasmic membranes"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Edward Mocarski (MedImmune Vaccines)
"Cytomegalovirus control of cell death pathways"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
9:30 pmPoster Session C
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmExploiting host functions
Discussion Leaders: Michael Gale (University of Washington) & James Alwine (University of Pennsylvania)
9:00 am - 9:20 am Bernard Roizman (University of Chicago)
"HSV-1 ICP0 on the warpath: The nuclear engagements"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Michael Katze (University of Washington)
"Can Systems Biology Approaches Prevent the Next Pandemic and Help us Develop a Successful AIDS Vaccine?"
9:50 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:50 am Tom Shenk (Princeton University)
"Genesis of the human cytomegalovirus cytoplasmic assembly zone"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Peter Sarnow (Stanford University)
"Modulation of hepatitis C virus gene expression by microRNA miR-122"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Curt Horvath (Northwestern University)
"Activation and Inhibition of Antiviral Responses by Paramyxoviruses"
11:40 am - 11:45 am Discussion
11:45 am - 11:55 am Andrew Mehle (University of California, Berkeley)
"Jumping species: strategies used by avian influenza and the 2009 swine influenza viruses"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Ken Cadwell (Washington University)
"Virus-host interactions and contributions of the Crohn's disease susceptibility gene ATG16L1"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm James Alwine (University of Pennsylvania)
"The ER chaperone BiP, is needed for nuclear lamin reorganization"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 5:30 pmFree Time
5:30 pm - 7:30 pmEpidemiology, prevention & therapy
Discussion Leaders: Teresa Compton (Novartis Institutes for BioMedical Research) & Marianne Manchester (Scripps Research Institue)
5:30 pm - 5:50 pm Diane Griffin (Johns Hopkins University)
"Measles: new insights into prevention and control"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Nicholas Grassly (Imperial College London)
"Systemic and mucosal immunity induced by oral poliovirus vaccines in India"
6:20 pm - 6:25 pm Discussion
6:25 pm - 6:45 pm Marianne Manchester (Scripps Research Institute)
"Tissue imaging and targeted therapeutics using viral nanoparticles (VNPs)"
6:45 pm - 6:50 pm Discussion
6:50 pm - 7:10 pm Teresa Compton (Novartis Institutes for BioMedical Research)
"Exploiting the virus-host interface for antiviral drug discovery"
7:10 pm - 7:15 pm Discussion
7:15 pm - 7:25 pm Christine Posavad (University of Washington)
"Detailed Characterization of T Cell Responses to HSV-2 in Immune Seronegative Persons"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
9:00 pm - 11:00 pmDisco
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible [in part] by (1R13AI082725-01) from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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