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Vitamin B12 & Corphins
Gordon Research Conference

Organometallic Magic of Life on Earth: From Microorganisms to Humans

Dates

August 2-7, 2009

Location

Magdalen College
Oxford, United Kingdom

Organizers

Chair:
Bernhard Kraeutler

Vice Chair:
Catherine L. Drennan

Meeting Description

The 2009 Gordon Research Conference on Vitamin B12 and Corphins will cover a most intriguing vitamin (B12) and the corphins, the central catalysts of biological methane cycles. The two classes of fascinating compounds have in common, their origin in micro-organisms and their roles as unique bio-organometallic catalysts. They sustain most known forms of life. B12 does so even on the level of us humans. This GRC will thus deal with a very interdisciplinary area, and will bring together leading scientists coming from a broad range of the medical and the natural sciences. The Gordon Research Conference on Vitamin B12 and Corphins will provide deep insights into a majority of the important medical, genetic, microbiological, biochemical, enzymatic, structural and chemical aspects of vitamin B12 and of the corphins. A concise selection of the newest and hottest fundamental and applied studies in these areas is presented and will be discussed.

The GRC on Vitamin B12 and Corphins was founded as recently as in 2003. The upcoming 4th meeting will be held at Magdalen College of the University of Oxford (UK) during the week of Aug. 2-7, 2009. The program of this GRC features an outstanding group of scientists at the forefront of research, and brings together a mix of established and younger scientists. All the speakers and poster presenters are encouraged to present and emphasize unpublished work to the greatest possible extent. All conferees are invited to present posters. Poster presenters should submit an abstract with the title, authors, affiliation, and address by email to the Chair, Bernhard Kraeutler. After review of the poster abstracts by the organizers, six individuals will be invited to present 15-minute seminars, in addition to the standard poster presentations. The conference is limited to 150 registrations. Early submission of applications is encouraged.

Contributors

Meeting Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
5:30 pmWelcome Reception on the Cloisters Lawn
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmB12: NEW DEVELOPMENTS IN MEDICINE & BIOLOGY
Discussion Leader: Wilfred van der Donk (University of Illinois, Urbana, USA)
7:40 pm - 8:20 pm Roy Gravel (University of Calgary, Alberta, Canada)
"Human Disorders of Vitamin B12 Utilization: Eight Complementation Groups, Eight Genes"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm Martin Warren (University of Kent, Canterbury, UK)
"Biosynthesis of the Corrin Ring"
9:15 pm - 9:30 pm Discussion
MONDAY
8:00 am - 9:00 amBreakfast
9:00 am - 12:30 pmB12: TRANSPORT & UPTAKE IN HUMANS
Discussion Leader: Ebba Nexø (Aarhus University Hospital, Denmark)
9:00 am - 9:30 am David Alpers (Washington University School of Medicine, St. Louis, USA)
"Gastric Intrinsic Factor: Lessons from its Biology and Structure"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Roger Schibli (ETH Hönggerberg, Zürich, Switzerland)
"Development of B12 Derivatives for Selective Cancer Cell Targeting"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break / Group Photo
11:00 am - 11:30 am Søren Moestrup (University of Aarhus, Denmark)
"Membrane Proteins Determining the Transport of Cbl between the Intracellular and Extracellular Compartments"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Edward Quadros (SUNY Downstate Medical Center, Brooklyn, USA)
"The Transcobalamin Receptor Mediated Cellular Uptake of Vitamin B12"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session (Group A)
6:00 pmDinner
7:30 pm - 9:30 pmB12-UPTAKE AND USE IN BACTERIA
Discussion Leaders: Charles Grissom (University of Utah, Salt Lake City, USA) and Helga Refsum (University of Oslo, Norway)
7:30 pm - 7:55 pm Christof Holliger (École Polytechnique Fédéral de Lausanne, Switzerland)
"Maturation and Export of the Corrinoid-Containing Tetrachloroethene Reductive Dehalogenase"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Michael Wiener (University of Virginia, Charlottesville, USA)
"Active Transport of Corrinoids Across the Gram-Negative Bacterial Outer Membrane: New Structural and Functional Results"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:55 pm Atica Moosa (University of the Witwatersrand)
"The metabolism of vitamin B12 in Mycobacterium tuberculosis: role of alternate B12 cofactors"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:20 pm Katrine Hygum (Aarhus University Hospital)
"In mice transcobalamin stands in for haptocorrin"
9:20 pm - 9:30 pm Discussion
TUESDAY
8:00 am - 9:00 amBreakfast
9:00 am - 12:30 pmB12 IN MEDICINE & TOXICOLOGY
Discussion Leader: Ralph Green (University of California, Sacramento, USA)
9:00 am - 9:30 am Frank Rutsch (Universitätsklinikum Münster, Germany)
"New Insights into Lysosomal Cobalamin Trafficking: Lessons Learned from CbIF Disease"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Joshua Miller (University of California, Davis)
"Physiological doses of cyanocobalamin are modified or degraded in the gastrointestinal tract"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:30 am Jacob Selhub (Tufts University, Boston, USA)
"Folic Acid Intake and the Exacerbation of B12 Deficiency"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Lawrence Solomon (Yale University, New Haven, USA)
"Oxidant Stress as a Cause of 'Functional' Cobalamin Deficiency and its Possible Clinical Significance"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session (Group A)
6:00 pmDinner
7:30 pm - 9:30 pmB12: STRUCTURES, SPECTROSCOPY AND THEORY
Discussion Leader: Tetsuo Toraya (University of Okayama, Japan)
7:30 pm - 7:55 pm Sergey Fedosov (University of Aarhus, Denmark)
"Exotic Blue Corrinoid - the Major Product of Near Physiological Hydrolysis of Vitamin B12"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:20 pm Alex Jones (University of Manchester, UK)
"Catalysis in Adenosylcobalamin-Dependent Ethanolamine Ammonia Lyase - a Magnetic Field Effects Study"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm David Smith (Rudjer Boskovic Institute, Zagreb, Croatia)
"A Computational Perspective on Glycerol Dehydration: To B12 or not to B12"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Kazunari Yoshizawa (Kyushu University, Fukuoka, Japan)
"Computational Mutation of the Structure and Reactivity of B12- Dependent Diol Dehydratase"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
8:00 am - 9:00 amBreakfast
9:00 am - 12:30 pmMECHANISMS OF B12-ENZYMES I: MUTASES
Discussion Leader: Wolfgang Buckel (University of Marburg, Germany)
9:00 am - 9:30 am Bernard T. Golding (University of Newcastle, UK)
"The Evolution of Mechanistic Ideas for Coenzyme B12"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Antonio Pierik (Philipps University, Marburg, Germany)
"Chasing and Catching Radicals by EPR"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:30 am Naoki Shibata (University of Hyogo, Japan)
"Crystal Structure Analysis and Insight into the Reaction Mechanism of Ethanolamine Ammonia-Lyase"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Kurt Warncke (Emory University, Atlanta, USA)
"Molecular Mechanistic Features of Coenzyme B12-Dependent Enzyme Catalysis Revealed by Time-Resolved Electron Paramagnetic Resonance (EPR) and Optical Absorption Spectroscopy"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session (Group B)
6:00 pmDinner
7:30 pm - 9:30 pmMECHANISMS OF B12-ENZYMES II: RIBONUCLEOTIDE REDUCTASE
Discussion Leader: Kenneth Brown (Ohio University, Athens, USA)
7:30 pm - 8:10 pm Catherine L. Drennan (Massachusetts Institute of Technology, Cambridge, USA)
"Crystallographic Snapshots of a Class II Ribonucleotide Reductase"
8:10 pm - 8:25 pm Discussion
8:25 pm - 8:45 pm Gary J. Gerfen (Yeshiva University, New York, USA)
"Studies of Allostery and Inhibition in B12-Dependent Ribonucleoside Triphosphate Reductase"
8:45 pm - 8:55 pm Discussion
8:55 pm -9:20 pm Derek Logan (Lund University, Sweden)
"Structural Studies on B12 Bond Cleavage in Class II Ribonucleotide Reductases"
9:20 pm - 9:30 pm Discussion
THURSDAY
8:00 am - 9:00 amBreakfast
9:00 am - 12:30 pmCORPHINS
Discussion Leaders: Rudolf K. Thauer (University of Marburg, Germany) and Yoshio Hisaeda (Kyushu University, Fukuoka, Japan)
9:00 am - 9:30 am Bernhard Jaun (ETH Zürich, Switzerland)
"New Insights into the Catalytic Mechanism of Methyl-Coenzyme M Reductase"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Stephen Ragsdale (University of Michigan, Ann Arbor, USA)
"Evidence for Organometallic and Radical Intermediates in Corphin-Dependent Methane Synthesis"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
10:50 am - 11:05 am Michael Gray (University of Wisconsin, Madison)
"CbiZ is required for salvaging of pseudocobalamin in Rhodobacter sphaeroides"
11:05 am - 11:15 am Discussion
11:15 am - 11:30 am Yan Kung (MIT, Cambridge, USA)
"Crystal structure of a protein complex involved in B12-dependent methyl transfer"
11:30 am - 11:40 am Discussion
11:40 am - 11:55 am Keishiro Tahara (Kyushu Univeristy)
"A New B12 Catalytic System Using Organic Polymeric Scaffold"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:20 pm Kirsten Wolthers (University of Manchester)
"Catalysis linked to domain dynamics in adenosylcobalamin dependent ornithine 4,5-aminomutase"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 5:30 pmPoster Session (Group B)
5:30 pmReception on the Cloisters Lawn
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmPERSPECTIVE & PROSPECTS
Discussion Leader: Bernhard Kräutler (University of Innsbruck, Austria)
7:30 pm - 8:15 pm Robert Doyle (Syracuse University, Syracuse, USA)
"Exploring the Implications of Vitamin B12 Conjugation to Insulin on Insulin Receptor Binding and Cellular Uptake"
8:15 pm - 8:30 pm Discussion
8:30 pm - 9:15 pm Ruma Banerjee (University of Michigan, Ann Arbor, USA)
"The Tinkers, Tailors and Mailmen in Mammalian Vitamin B12 Assimilation"
9:15 pm - 9:30 pm Discussion
FRIDAY
8:00 am - 9:00 amBreakfast
9:00 amDepart

Funding for this conference was made possible by 1 R13 DK084586-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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