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Conference Program
 
Aging, Biology of
Determinants of Health-Span: From Cells to Humans
August 22-27, 2010
Les Diablerets Conference Center
Les Diablerets, Switzerland

Related Meeting Information
The Aging, Biology of Gordon Research Conference was held in conjunction with the Aging, Biology of Gordon-Kenan Research Seminar. Please refer to the Aging, Biology of GKRS web page for more information.

Aging is a multifactorial and complex process that results from changes at the genetic, biochemical and physiological level. Our understanding of those changes in cellular and animal models of aging and age-related disorders has advanced vertiginously during recent years. The current challenge of this field is now two-fold: to continue and complete the molecular dissection of the factors that contribute to aging and to promote the translation of these novel findings into interventions to improve the health-span of our aging human population.

This Gordon Research Conference is an ideal venue for both experts and newcomers to the field of aging research. Given recent developments that have placed biology of aging at the frontiers of science, this conference is extremely timely. The conference will bring together leading international experts with a broad range of interests related to diverse aspect of biology of aging, and create a high quality scientific forum in which findings on the basic mechanisms of aging and their implementation into interventions to promote human health will be scientifically explored.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmAGING RESEARCH: GETTING ALL THE PIECES TOGETHER
Discussion Leaders: Ana Maria Cuervo (Albert Einstein), Rafael de Cabo (NIA) and Pidder Jansen-Duerr (Austrian Academy of Sciences)
7:40 pm - 8:00 pmHolly Brown-Borg (Univ. North Dakota, Grand Forks, USA)
"Introductory remarks: Resistance to neurodegeneration in long-living Ames dwarf mice"
8:00 pm - 9:00 pmKeynote Speaker: George Martin (Univ. Washington, Seattle, USA)
"Twelve Modalities of Gene Action that Escape the Force of Natural Selection and thus contribute to Senescent Phenotypes"
9:00 pm - 9:15 pm Discussion
9:30 pm Welcome Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCELLULAR SENESCENCE, DNA MODIFICATIONS AND DAMAGE
9:00 am - 9:15 amDiscussion Leader: Estella Medrano (Baylor College of Medicine, Houston, USA)
9:15 am - 9:35 amValter Longo (Univ. Southern California)
"Nutrient signaling and age-dependent genomic instability: from yeast to humans"
9:35 am - 9:45 am Discussion
9:45 am - 10:05 amXiaoling Li (NIH/NIEHS, Research Triangle Park, NC, USA)
"Metabolic regulation by SIRT1"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 amMichael Goligorsky (New York Medical College, Valhalla, USA)
"Stress-Induced Premature Senescence of Endothelial Progenitor Cells"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 amJiri Bartek (Danish Cancer Society Copenhagen, Denmark)
"DNA damage signaling: Mechanisms and roles in aging and cancer"
11:35 am - 11:45 am Discussion
11:45 am - 12:00 pm Peter Adams (Cruk Beatson Labs, Glasgow, UK)
"Regulation of chromatin structure in senescent cells by histone chaperones"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Sonia Franco (Johns Hopkins University, Baltimore, USA)
"PARP1 and the ATM network genetically interact to regulate cellular senescence and premature aging"
12:20 pm - 12:25 pm Discussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmCELL DEATH AND AGING
5:30 pm - 5:45 pmDiscussion Leader: Beatrix Grubeck-Loebenstein (Institute for Biomedical Aging Research, Innsbruck, Austria)
5:45 pm - 6:05 pmFrank Madeo (Univ. Graz, Graz, Austria)
"Inhibition of necrosis promotes longevity"
6:05 pm - 6:15 pm Discussion
6:15 pm - 6:35 pmJulie K. Andersen (Buck Institute, Novato, USA)
"Oxidative stress and Parkinson's disease:aging as a contributing factor"
6:35 pm - 6:45 pm Discussion
6:45 pm - 7:00 pmRichard Miller (U. Michigan, Ann Arbor, USA)
"Resistance to ER and Oxidative Stresses in Long-Lived Mutant Mice"
7:00 pm - 7:10 pm Discussion
7:10 pm - 7:25 pm Fabrizio D'adda Di Fagagna (IFOM, Milan, Italy)
"Telomeric DNA damage is irreparable and causes persistent DNA damage response activation and cellular senescence"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMITOCHONDRIA AND CELLULAR OXIDATIVE STRESS
9:00 am - 9:15 amDiscussion Leader: Karin Scharfetter-Kochanek (University of Ulm, Germany)
9:15 am - 9:35 amAleksandra Trifonovic (University of Cologne, Cologne, Germany)
"Molecular mechanisms of ageing caused by mitochondrial dysfunction"
9:35 am - 9:45 am Discussion
9:45 am - 10:05 amJennifer Gamble (University of Sydney, Newtown, Australia)
"Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 amHolly van Remmen (South Texas Veterans HCS, UTHSCSA San Antonio, USA )
"Mitochondrial oxidative stress and neuromuscular degeneration"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 amNektarios Tavernarakis (Forth IMBB, Crete, Greece)
"Prohibitin, mitochondrial energy metabolism and ageing in C. elegans"
11:35 am - 11:45 am Discussion
11:45 am - 12:05 pm Eric Verdin (Gladstone Institute of Virology and Immunology)
"Mitochondrial Sirtuins and Aging"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:30 pm Open discussion / Burning questions
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
5:30 pm - 7:30 pmSTEM CELLS AND AGING
5:30 pm - 5:35 pmDiscussion Leader: Anne Brunet (Stanford University, USA)
5:35 pm - 5:55 pmThomas A. Rando (Stanford University, Stanford, USA)
"Epigenetic profiling and functional significance of muscle stem cell aging"
5:55 pm - 6:05 pm Discussion
6:05 pm - 6:20 pmJohannes Grillari (University of Applied Live Sciences, Vienna, AU)
"MicroRNA-31 is elevated in the serum of elderly and inhibits osteogenic differentiation of mesenchymal stem cells"
6:20 pm - 6:25 pm Discussion
6:25 pm - 6:45 pmGerald de Haan (University Medical Center Groningen, The Netherlands)
"Aging of hematopoietic stem cells"
6:45 pm - 6:55 pm Discussion
6:55 pm - 7:10 pmVictoria Rafalski (Stanford University, Stanford, CA)
"The function of the Sirt1 deacetylase in adult neural stem cells"
7:10 pm - 7:15 pm Discussion
7:15 pm - 7:25 pmJudith Haenderler (University of Dusseldorf, Dusseldorf, Germany)
"Endothelial cell aging: molecules and mechanisms"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAGING AS A HOMEOSTATIC DEFECT
9:00 am - 9:15 amDiscussion Leader: Gordon Lithgow (Buck Institute, Novato, USA)
9:15 am - 9:35 amWilliam E. Balch (Scripps, La Jolla, USA)
"Proteostasis: Balancing the Yin and Yang in Health and Aging"
9:35 am - 9:45 am Discussion
9:45 am - 10:05 amJudith Frydman (Stanford University, Stanford, USA)
"Mechanisms controlling protein quality control and aggregation during aging"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 amDavid Rubinsztein (University of Cambridge, UK)
"Autophagy and Neurodegeneration"
11:05 am - 11:15 am Discussion
11:15 am - 11:30 amAlicia Melendez (Queens College, New York, USA)
"Autophagy and lifespan"
11:30 am - 11:35 am Discussion
11:35 am - 11:55 amKelvin Davies (University Southern California, Los Angeles, USA)
"Inducibility of the proteasome In oxidative stress, disease, and ageing"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:20 pm Marion Schmidt (Albert Einstein College of Medicine, New York, USA)
"The Impact of Proteasome Function on Chronological and Replicative Lifespan in Saccharomyces cerevisiae"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmMETABOLIC ADAPTATION TO AGING
5:30 pm - 5:40 pmDiscussion Leader: Heidi A. Tissenbaum (Univ. Massachusetts, Worcester, USA)
5:40 pm - 6:00 pmShin-ichiro Imai (Washington Univ., St. Louis, USA)
"A New Development in the NAD World: SIRT1, NAMPT-Mediated NAD Biosynthesis, and Their Importance for Metabolism and Aging"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:30 pmPlacido Navas (Centro Andaluz Biologia del Desarrollo, Seville, Spain)
"Coenzyme Q connects respiration to metabolism in aging"
6:30 pm - 6:35 pm Discussion
6:35 pm - 6:55 pmPankaj Kapahi (Buck Institute, Novato, USA)
"The role of metabolic changes under dietary restriction in determining lifespan"
6:55 pm - 7:05 pm Discussion
7:05 pm - 7:25 pmMarcia Haigis (Harvard University, Cambridge, USA)
"Mitochondrial sirtuins work in concert"
7:25 pm - 7:30 pm Discussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHUMAN AGING AND UPDATE OF HUMAN LONGITUDINAL STUDIES
9:00 am - 9:15 am Discussion Leader: Luigi Ferrucci (National Institute on Aging, Baltimore, USA)
9:15 am - 9:35 amEdward Lakatta (National Institute on Aging, Baltimore, USA)
"Age associated reductions in cardiovascular reserve: perspectives from humans to molecules"
9:35 am - 9:45 am Discussion
9:45 am - 10:05 amAlexander Buerkle (University of Konstanz, Konstanz, Germany)
"Towards biomarkers of human ageing: The EU FP7 project MARK-AGE"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:05 amWerner Zwerschke (Institute for Biomedical Aging Research, Innsbruck, Austria)
"Impact of long-term caloric restriction on adipose-derived stem cells in formerly obese women"
11:05 am - 11:15 am Discussion
11:15 am - 11:35 amBonnie Blomberg (University of Miami, Miami, USA)
"The aging human B cell response"
11:35 am - 11:45 am Discussion
11:45 am - 12:05 pmRudi Westendorp (Univ. Leiden, Leiden City The Netherlands)
"Hematopoietic capacity and exceptional survival: the Leiden Longevity Study"
12:05 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
5:30 pm - 6:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
6:00 pm - 7:30 pmINSULIN ACTION AND LONGEVITY: DEBATE
Discussion Leaders: Heidi Scrable (Mayo Clinic), Nir Barzilai ( Albert Einstein) and James Kirkland (Mayo Clinic)
6:00 pm - 6:25 pm Presentation 3 poster winners (5 min each + 2 min disc)
6:25 pm - 6:45 pmCynthia Kenyon (University of California, San Francisco, USA)
"Genetic pathways that influence the lifespan of C. elegans"
6:45 pm - 6:55 pm Discussion
6:55 pm - 7:15 pmPinchas Cohen (University of California, Los Angeles, USA)
"Insulin vs. IGF-1 sensitivity and mammalian’s longevity"
7:15 pm - 7:30 pm Discussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible by 1 R13 AG37190-01 from NIA. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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