| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | KEYNOTE PRESENTATIONS: B CELL BIOLOGY |
| Discussion Leader: Don Capra (Oklahoma Medical Research Foundation) |
| 7:40 pm - 7:50 pm | Don Capra (Oklahoma Medical Research Foundation)
"Opening remarks" |
| 7:50 pm - 8:30 pm | Klaus Rajewsky (Harvard Medical School)
"Antibodies as determinants of B cell development, maintenance and response" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | Jason Cyster (University of California-San Francisco)
"Lymphocyte migration and the humoral immune response" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ANTIBODY REPERTOIRES AND DIVERSIFICATION MECHANISMS |
| Discussion Leader: Fred Alt (Harvard Medical School) |
| 9:00 am - 9:15 am | Fred Alt (Harvard Medical School)
"Opening remarks" |
| 9:15 am - 9:35 am | Michael Neuberger (MRC Laboratory of Molecular Biology, Cambridge)
"DNA deamination in the generation of high affinity antibodies" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Short talk (selected from abstracts) |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break / Group Photo |
| 10:30 am - 10:50 am | Nina Papavasiliou (Rockefeller University)
"New approaches to the identification of AID cofactors" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Patrick Wilson (University of Chicago)
"Plasmablasts: the workhorses of human B cell memory" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | James Marks (University of California - San Francisco) |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Marie-Paule Lefranc (Université Montpellier)
"Standardized sequence and structure analysis of antibodies using IMGT®" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MOLECULAR RECOGNITION BY ANTIBODIES AND FcγRs |
| Discussion Leader: Dennis Burton (The Scripps Research Institute) |
| 7:30 pm - 7:45 pm | Dennis Burton (The Scripps Research Institute)
"Opening remarks" |
| 7:45 pm - 8:05 pm | Ian Wilson (The Scripps Research Institute)
"Antibody recognition of pandemic influenza viruses" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Dinakar Salunke (National Institute of Immunology, New Delhi)
"Revisiting tenets of specificity and recognition in the humoral immune response" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Mark Hogarth (Burnet Institute, Melbourne)
"The interplay between Fc receptor organization and IgA or IgG binding in leukocyte activation and inhibition: lessons for future therapeutics?" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Wayne Marasco (Harvard Medical School)
"The basis and bias of human anti-influenza antibody responses" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | FUNCTIONAL EFFECTS OF FcγRs AND COMPLEMENT |
| Discussion Leader: Jenny Woof (University of Dundee Medical School) |
| 9:00 am - 9:15 am | Jenny Woof (University of Dundee Medical School)
"Opening remarks" |
| 9:15 am - 9:35 am | John Cambier (National Jewish Health, Denver)
"Multiple access points to the SHIP/Dok signaling pathways and their functional reports" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Short talk (selected from abstracts) |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Raphael Clynes (Columbia University)
"Fc receptors and modulation of adaptive immunity" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Jeanette Leusen (University Medical Center Utrecht)
"Biology of Fc receptors: impact on therapeutic antibodies" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Louis Weiner (Georgetown University Medical Center)
"Antibody-initiated cancer immunotherapy" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Short talk (selected from abstracts) |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | FcRn AND IgG DYNAMICS |
| Discussion Leader: John Desjarlais (Xencor, Inc.) |
| 7:30 pm - 7:45 pm | John Desjarlais (Xencor, Inc.)
"Opening remarks" |
| 7:45 pm - 8:05 pm | Richard Blumberg (Harvard University)
"Role of FcRn in antigen presentation by dendritic cells" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Inger Sandlie (University of Oslo)
"The half-lives of human IgG subclasses" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | William Dall'Acqua (MedImmune, LLC)
"Modulating the pharmacokinetic properties of therapeutic IgGs via Fc engineering: the YTE platform" |
| 9:05 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | IMAGING OF ANTIBODIES AND ANTIBODY-RELATED PROCESSES |
| Discussion Leader: Ira Mellman (Genentech, Inc.) |
| 9:00 am - 9:15 am | Ira Mellman (Genentech, Inc.)
"Opening remarks" |
| 9:15 am - 9:35 am | Anna Wu (University of California - Los Angeles)
"ImmunoPET- in vivo immunohistochemistry?" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Short talk (selected from abstracts) |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Michael Carroll (Harvard Medical School)
"B cell acquisition of lymph-borne antigens within LNs" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Raimund Ober (University of Texas at Dallas)
"Imaging antibody trafficking in cells at the single molecule level in 3D" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Diane Lidke (University of New Mexico)
"Correlating FcεRI signaling with receptor dynamics using single quantum dot tracking" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Short talk (selected from abstracts) |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | B CELL TOLERANCE |
| Discussion Leader: John Cambier (National Jewish Health, Denver) |
| 7:30 pm - 7:45 pm | John Cambier (National Jewish Health, Denver)
"Opening remarks" |
| 7:45 pm - 8:05 pm | David Nemazee (The Scripps Research Institute)
"Self/nonself discrimination in mouse B cells" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Robert Rickert (Burnham Institute)
"Signaling pathways regulating B cell tolerance and autoantibody production" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Eric Meffre (Yale University)
"Human B cell tolerance checkpoints in health and autoimmune diseases" |
| 9:05 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ANTIBODY FRAGMENTS AND NOVEL PROTEIN SCAFFOLDS |
| Discussion Leader: Paul Carter (VLST Corporation) |
| 9:00 am - 9:15 am | Paul Carter (VLST Corporation)
"Opening remarks" |
| 9:15 am - 9:35 am | Andreas Plückthun (University of Zürich)
"Protein engineering solutions to tumor targeting" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Short talk (selected from abstracts) |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Dane Wittrup (Massachusetts Institute of Technology)
"Efficient EGFR downregulation with heterodimers of Fn3 scaffold-based binding domains" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Dominik Ruettinger (Micromet, Inc.)
"Cancer therapy with T cell engaging BiTE antibodies" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Kerry Chester / Richard Begent (University College London)
"Recombinant antibodies and fusion proteins for cancer imaging and therapy" |
| 12:00 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Short talk (selected from abstracts) |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | THERAPEUTIC ANTIBODIES |
| Discussion Leader: Andrew Chan (Genentech, Inc.) |
| 7:30 pm - 7:45 pm | Andrew Chan (Genentech, Inc.)
"Opening remarks" |
| 7:45 pm - 8:05 pm | Philip Thorpe (University of Texas Southwestern Medical Center)
"Targeting phosphatidylserine in the tumor microenvironment to destroy tumor blood vessels and induce tumor immunity" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | TBA |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Gene Kinney (Janssen Alzheimer Immunotherapy R&D)
"The use of anti-Aβ immunotherapy for the treatment of Alzheimer's disease" |
| 9:05 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |